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Items: 1 to 50 of 169

1.

Application of Two-Dimensional Difference Gel Electrophoresis in Identification of Factors Responsible for Virulence of Staphylococcus aureus.

Bonar E, Chlebicka K, Dubin G, Wladyka B.

Methods Mol Biol. 2020;2069:139-154. doi: 10.1007/978-1-4939-9849-4_11.

PMID:
31523772
2.

Determinants of Acquisition and Clearance of Human Papillomavirus Infection in Previously Unexposed Young Women.

El-Zein M, Ramanakumar AV, Naud P, Roteli-Martins CM, de Carvalho NS, Colares de Borba P, Teixeira JC, Moscicki AB, Harper DM, Tyring SK, Ramjattan B, Dubin G, Franco EL; HPV-007 Study Group.

Sex Transm Dis. 2019 Oct;46(10):663-669. doi: 10.1097/OLQ.0000000000001053.

PMID:
31464859
3.

Production of Lysostaphin by Nonproprietary Method Utilizing a Promoter from Toxin-Antitoxin System.

Mądry A, Jendroszek A, Dubin G, Wladyka B.

Mol Biotechnol. 2019 Oct;61(10):774-782. doi: 10.1007/s12033-019-00203-4.

PMID:
31446565
4.

Development and characterization of a new inhibitor of heme oxygenase activity for cancer treatment.

Mucha O, Podkalicka P, Mikulski M, Barwacz S, Andrysiak K, Biela A, Mieczkowski M, Kachamakova-Trojanowska N, Ryszawy D, Białas A, Szelążek B, Grudnik P, Majewska E, Michalik K, Jakubiec K, Bień M, Witkowska N, Gluza K, Ekonomiuk D, Sitarz K, Gałęzowski M, Brzózka K, Dubin G, Józkowicz A, Dulak J, Łoboda A.

Arch Biochem Biophys. 2019 Aug 15;671:130-142. doi: 10.1016/j.abb.2019.07.002. Epub 2019 Jul 2.

PMID:
31276659
5.

Risk of newly detected infections and cervical abnormalities in adult women seropositive or seronegative for naturally acquired HPV-16/18 antibodies.

Rosillon D, Baril L, Del Rosario-Raymundo MR, Wheeler CM, Skinner SR, Garland SM, Salmeron J, Lazcano-Ponce E, Vallejos CS, Stoney T, Ter Harmsel B, Lim TYK, Quek SC, Minkina G, McNeil SA, Bouchard C, Fong KL, Money D, Ilancheran A, Savicheva A, Cruickshank M, Chatterjee A, Fiander A, Martens M, Bozonnat MC, Struyf F, Dubin G, Castellsagué X.

Cancer Med. 2019 Aug;8(10):4938-4953. doi: 10.1002/cam4.1879. Epub 2019 Jul 5.

6.

A ten-year study of immunogenicity and safety of the AS04-HPV-16/18 vaccine in adolescent girls aged 10-14 years.

Schwarz TF, Huang LM, Valencia A, Panzer F, Chiu CH, Decreux A, Poncelet S, Karkada N, Folschweiller N, Lin L, Dubin G, Struyf F.

Hum Vaccin Immunother. 2019;15(7-8):1970-1979. doi: 10.1080/21645515.2019.1625644. Epub 2019 Jul 17.

PMID:
31268383
7.

Crystal structure of Maternal Embryonic Leucine Zipper Kinase (MELK) in complex with dorsomorphin (Compound C).

Rembacz KP, Zrubek KM, Golik P, Michalik K, Bogusz J, Wladyka B, Romanowska M, Dubin G.

Arch Biochem Biophys. 2019 Aug 15;671:1-7. doi: 10.1016/j.abb.2019.05.014. Epub 2019 May 17.

PMID:
31108049
8.

Development of Chemical Tools to Monitor Human Kallikrein 13 (KLK13) Activity.

Gruba N, Bielecka E, Wysocka M, Wojtysiak A, Brzezińska-Bodal M, Sychowska K, Kalińska M, Magoch M, Pęcak A, Falkowski K, Wiśniewska M, Sąsiadek L, Płaza K, Kroll E, Pejkovska A, Rehders M, Brix K, Dubin G, Kantyka T, Potempa J, Lesner A.

Int J Mol Sci. 2019 Mar 28;20(7). pii: E1557. doi: 10.3390/ijms20071557.

9.

Development of a novel, high-affinity ssDNA trypsin inhibitor.

Malicki S, Ksiazek M, Majewski P, Pecak A, Mydel P, Grudnik P, Dubin G.

J Enzyme Inhib Med Chem. 2019 Dec;34(1):638-643. doi: 10.1080/14756366.2019.1569648.

10.

A fluorinated indole-based MDM2 antagonist selectively inhibits the growth of p53wt osteosarcoma cells.

Skalniak L, Twarda-Clapa A, Neochoritis CG, Surmiak E, Machula M, Wisniewska A, Labuzek B, Ali AM, Krzanik S, Dubin G, Groves M, Dömling A, Holak TA.

FEBS J. 2019 Apr;286(7):1360-1374. doi: 10.1111/febs.14774. Epub 2019 Feb 16.

PMID:
30715803
11.

Joint Genomic and Proteomic Analysis Identifies Meta-Trait Characteristics of Virulent and Non-virulent Staphylococcus aureus Strains.

Bonar EA, Bukowski M, Hydzik M, Jankowska U, Kedracka-Krok S, Groborz M, Dubin G, Akkerboom V, Miedzobrodzki J, Sabat AJ, Friedrich AW, Wladyka B.

Front Cell Infect Microbiol. 2018 Sep 6;8:313. doi: 10.3389/fcimb.2018.00313. eCollection 2018.

12.

Crystal structure of the FAS1 domain of the hyaluronic acid receptor stabilin-2.

Twarda-Clapa A, Labuzek B, Krzemien D, Musielak B, Grudnik P, Dubin G, Holak TA.

Acta Crystallogr D Struct Biol. 2018 Jul 1;74(Pt 7):695-701. doi: 10.1107/S2059798318007271. Epub 2018 Jun 27.

PMID:
29968679
13.

Gender-neutral vaccination provides improved control of human papillomavirus types 18/31/33/35 through herd immunity: Results of a community randomized trial (III).

Lehtinen M, Luostarinen T, Vänskä S, Söderlund-Strand A, Eriksson T, Natunen K, Apter D, Baussano I, Harjula K, Hokkanen M, Kuortti M, Palmroth J, Petäjä T, Pukkala E, Rekonen S, Siitari-Mattila M, Surcel HM, Tuomivaara L, Paavonen J, Nieminen P, Dillner J, Dubin G, Garnett G.

Int J Cancer. 2018 Nov 1;143(9):2299-2310. doi: 10.1002/ijc.31618. Epub 2018 Aug 10.

PMID:
29845626
14.

Structural basis for ADP-dependent glucokinase inhibition by 8-bromo-substituted adenosine nucleotide.

Grudnik P, Kamiński MM, Rembacz KP, Kuśka K, Madej M, Potempa J, Dawidowski M, Dubin G.

J Biol Chem. 2018 Jul 13;293(28):11088-11099. doi: 10.1074/jbc.RA117.001562. Epub 2018 May 21.

15.

A novel, dual pan-PIM/FLT3 inhibitor SEL24 exhibits broad therapeutic potential in acute myeloid leukemia.

Czardybon W, Windak R, Gołas A, Gałęzowski M, Sabiniarz A, Dolata I, Salwińska M, Guzik P, Zawadzka M, Gabor-Worwa E, Winnik B, Żurawska M, Kolasińska E, Wincza E, Bugaj M, Danielewicz M, Majewska E, Mazan M, Dubin G, Noyszewska-Kania M, Jabłońska E, Szydłowski M, Sewastianik T, Puła B, Szumera-Ciećkiewicz A, Prochorec-Sobieszek M, Mądro E, Lech-Marańda E, Warzocha K, Tamburini J, Juszczyński P, Brzózka K.

Oncotarget. 2018 Mar 30;9(24):16917-16931. doi: 10.18632/oncotarget.24747. eCollection 2018 Mar 30.

16.

Identification of small-molecule inhibitors of USP2a.

Tomala MD, Magiera-Mularz K, Kubica K, Krzanik S, Zieba B, Musielak B, Pustula M, Popowicz GM, Sattler M, Dubin G, Skalniak L, Holak TA.

Eur J Med Chem. 2018 Apr 25;150:261-267. doi: 10.1016/j.ejmech.2018.03.009. Epub 2018 Mar 5.

PMID:
29529503
17.

Unique Substrate Specificity of SplE Serine Protease from Staphylococcus aureus.

Stach N, Kalinska M, Zdzalik M, Kitel R, Karim A, Serwin K, Rut W, Larsen K, Jabaiah A, Firlej M, Wladyka B, Daugherty P, Stennicke H, Drag M, Potempa J, Dubin G.

Structure. 2018 Apr 3;26(4):572-579.e4. doi: 10.1016/j.str.2018.02.008. Epub 2018 Mar 8.

18.

Ethical Considerations for the Participation of Children of Minor Parents in Clinical Trials.

Ott MA, Crawley FP, Sáez-Llorens X, Owusu-Agyei S, Neubauer D, Dubin G, Poplazarova T, Begg N, Rosenthal SL.

Paediatr Drugs. 2018 Jun;20(3):215-222. doi: 10.1007/s40272-017-0280-y.

19.

Evaluation of HPV type-replacement in unvaccinated and vaccinated adolescent females-Post-hoc analysis of a community-randomized clinical trial (II).

Gray P, Palmroth J, Luostarinen T, Apter D, Dubin G, Garnett G, Eriksson T, Natunen K, Merikukka M, Pimenoff V, Söderlund-Strand A, Vänskä S, Paavonen J, Pukkala E, Dillner J, Lehtinen M.

Int J Cancer. 2018 Jun 15;142(12):2491-2500. doi: 10.1002/ijc.31281. Epub 2018 Feb 12.

20.

Crystal structure of ADP-dependent glucokinase from Methanocaldococcus jannaschii in complex with 5-iodotubercidin reveals phosphoryl transfer mechanism.

Tokarz P, Wiśniewska M, Kamiński MM, Dubin G, Grudnik P.

Protein Sci. 2018 Mar;27(3):790-797. doi: 10.1002/pro.3377. Epub 2018 Feb 2.

21.

Correction: Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies.

Pucelik B, Paczyński R, Dubin G, Pereira MM, Arnaut LG, Dąbrowski JM.

PLoS One. 2018 Jan 19;13(1):e0191777. doi: 10.1371/journal.pone.0191777. eCollection 2018.

22.

Modular endolysin of Burkholderia AP3 phage has the largest lysozyme-like catalytic subunit discovered to date and no catalytic aspartate residue.

Maciejewska B, Źrubek K, Espaillat A, Wiśniewska M, Rembacz KP, Cava F, Dubin G, Drulis-Kawa Z.

Sci Rep. 2017 Nov 6;7(1):14501. doi: 10.1038/s41598-017-14797-9.

23.

Spatial attributes of the four-helix bundle group of bacteriocins - The high-resolution structure of BacSp222 in solution.

Nowakowski M, Jaremko Ł, Wladyka B, Dubin G, Ejchart A, Mak P.

Int J Biol Macromol. 2018 Feb;107(Pt B):2715-2724. doi: 10.1016/j.ijbiomac.2017.10.158. Epub 2017 Oct 31.

24.

Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells.

Skalniak L, Zak KM, Guzik K, Magiera K, Musielak B, Pachota M, Szelazek B, Kocik J, Grudnik P, Tomala M, Krzanik S, Pyrc K, Dömling A, Dubin G, Holak TA.

Oncotarget. 2017 Aug 7;8(42):72167-72181. doi: 10.18632/oncotarget.20050. eCollection 2017 Sep 22.

25.

Impact of gender-neutral or girls-only vaccination against human papillomavirus-Results of a community-randomized clinical trial (I).

Lehtinen M, Söderlund-Strand A, Vänskä S, Luostarinen T, Eriksson T, Natunen K, Apter D, Baussano I, Harjula K, Hokkanen M, Kuortti M, Palmroth J, Petäjä T, Pukkala E, Rekonen S, Siitari-Mattila M, Surcel HM, Tuomivaara L, Paavonen J, Dillner J, Dubin G, Garnett G.

Int J Cancer. 2018 Mar 1;142(5):949-958. doi: 10.1002/ijc.31119. Epub 2017 Nov 9.

26.

Identification of novel mazEF/pemIK family toxin-antitoxin loci and their distribution in the Staphylococcus genus.

Bukowski M, Hyz K, Janczak M, Hydzik M, Dubin G, Wladyka B.

Sci Rep. 2017 Oct 18;7(1):13462. doi: 10.1038/s41598-017-13857-4.

27.

Structural analysis of PIM1 kinase complexes with ATP-competitive inhibitors.

Bogusz J, Zrubek K, Rembacz KP, Grudnik P, Golik P, Romanowska M, Wladyka B, Dubin G.

Sci Rep. 2017 Oct 17;7(1):13399. doi: 10.1038/s41598-017-13557-z.

28.

Properties of halogenated and sulfonated porphyrins relevant for the selection of photosensitizers in anticancer and antimicrobial therapies.

Pucelik B, Paczyński R, Dubin G, Pereira MM, Arnaut LG, Dąbrowski JM.

PLoS One. 2017 Oct 10;12(10):e0185984. doi: 10.1371/journal.pone.0185984. eCollection 2017. Erratum in: PLoS One. 2018 Jan 19;13(1):e0191777.

29.

Staphylococcus Aureus V8 protease disrupts the integrity of the airway epithelial barrier and impairs IL-6 production in vitro.

Murphy J, Ramezanpour M, Stach N, Dubin G, Psaltis AJ, Wormald PJ, Vreugde S.

Laryngoscope. 2018 Jan;128(1):E8-E15. doi: 10.1002/lary.26949. Epub 2017 Oct 10.

PMID:
28994126
30.

Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint.

Magiera-Mularz K, Skalniak L, Zak KM, Musielak B, Rudzinska-Szostak E, Berlicki Ł, Kocik J, Grudnik P, Sala D, Zarganes-Tzitzikas T, Shaabani S, Dömling A, Dubin G, Holak TA.

Angew Chem Int Ed Engl. 2017 Oct 23;56(44):13732-13735. doi: 10.1002/anie.201707707. Epub 2017 Sep 26.

31.

Ten-year follow-up of human papillomavirus vaccine efficacy against the most stringent cervical neoplasia end-point-registry-based follow-up of three cohorts from randomized trials.

Lehtinen M, Lagheden C, Luostarinen T, Eriksson T, Apter D, Harjula K, Kuortti M, Natunen K, Palmroth J, Petäjä T, Pukkala E, Siitari-Mattila M, Struyf F, Nieminen P, Paavonen J, Dubin G, Dillner J.

BMJ Open. 2017 Aug 18;7(8):e015867. doi: 10.1136/bmjopen-2017-015867.

32.

Structural Biology of the Immune Checkpoint Receptor PD-1 and Its Ligands PD-L1/PD-L2.

Zak KM, Grudnik P, Magiera K, Dömling A, Dubin G, Holak TA.

Structure. 2017 Aug 1;25(8):1163-1174. doi: 10.1016/j.str.2017.06.011. Review.

33.

Crystal structure of a low molecular weight activator Blm-pep with yeast 20S proteasome - insights into the enzyme activation mechanism.

Witkowska J, Giżyńska M, Grudnik P, Golik P, Karpowicz P, Giełdoń A, Dubin G, Jankowska E.

Sci Rep. 2017 Jul 21;7(1):6177. doi: 10.1038/s41598-017-05997-4.

34.

Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Death-Ligand 1 (PD-1/PD-L1) Interaction via Transiently Induced Protein States and Dimerization of PD-L1.

Guzik K, Zak KM, Grudnik P, Magiera K, Musielak B, Törner R, Skalniak L, Dömling A, Dubin G, Holak TA.

J Med Chem. 2017 Jul 13;60(13):5857-5867. doi: 10.1021/acs.jmedchem.7b00293. Epub 2017 Jun 23.

PMID:
28613862
35.

1,4,5-Trisubstituted Imidazole-Based p53-MDM2/MDMX Antagonists with Aliphatic Linkers for Conjugation with Biological Carriers.

Twarda-Clapa A, Krzanik S, Kubica K, Guzik K, Labuzek B, Neochoritis CG, Khoury K, Kowalska K, Czub M, Dubin G, Dömling A, Skalniak L, Holak TA.

J Med Chem. 2017 May 25;60(10):4234-4244. doi: 10.1021/acs.jmedchem.7b00104. Epub 2017 May 16.

PMID:
28482147
36.

Malassezia globosa MgMDL2 lipase: Crystal structure and rational modification of substrate specificity.

Lan D, Xu H, Xu J, Dubin G, Liu J, Iqbal Khan F, Wang Y.

Biochem Biophys Res Commun. 2017 Jun 24;488(2):259-265. doi: 10.1016/j.bbrc.2017.04.103. Epub 2017 Apr 20.

PMID:
28433636
37.

Lithocholic Acid Hydroxyamide Destabilizes Cyclin D1 and Induces G0/G1 Arrest by Inhibiting Deubiquitinase USP2a.

Magiera K, Tomala M, Kubica K, De Cesare V, Trost M, Zieba BJ, Kachamakova-Trojanowska N, Les M, Dubin G, Holak TA, Skalniak L.

Cell Chem Biol. 2017 Apr 20;24(4):458-470.e18. doi: 10.1016/j.chembiol.2017.03.002. Epub 2017 Mar 23.

38.

Structural Characterization of Human Coronavirus NL63 N Protein.

Szelazek B, Kabala W, Kus K, Zdzalik M, Twarda-Clapa A, Golik P, Burmistrz M, Florek D, Wladyka B, Pyrc K, Dubin G.

J Virol. 2017 May 12;91(11). pii: e02503-16. doi: 10.1128/JVI.02503-16. Print 2017 Jun 1.

39.

Rational design and synthesis of 1,5-disubstituted tetrazoles as potent inhibitors of the MDM2-p53 interaction.

Surmiak E, Neochoritis CG, Musielak B, Twarda-Clapa A, Kurpiewska K, Dubin G, Camacho C, Holak TA, Dömling A.

Eur J Med Chem. 2017 Jan 27;126:384-407. doi: 10.1016/j.ejmech.2016.11.029. Epub 2016 Nov 16.

PMID:
27907876
40.

Safety of the human papillomavirus (HPV)-16/18 AS04-adjuvanted vaccine in adolescents aged 12-15 years: Interim analysis of a large community-randomized controlled trial.

Lehtinen M, Eriksson T, Apter D, Hokkanen M, Natunen K, Paavonen J, Pukkala E, Angelo MG, Zima J, David MP, Datta S, Bi D, Struyf F, Dubin G.

Hum Vaccin Immunother. 2016 Dec;12(12):3177-3185. doi: 10.1080/21645515.2016.1183847.

41.

A Unique Mdm2-Binding Mode of the 3-Pyrrolin-2-one- and 2-Furanone-Based Antagonists of the p53-Mdm2 Interaction.

Surmiak E, Twarda-Clapa A, Zak KM, Musielak B, Tomala MD, Kubica K, Grudnik P, Madej M, Jablonski M, Potempa J, Kalinowska-Tluscik J, Dömling A, Dubin G, Holak TA.

ACS Chem Biol. 2016 Dec 16;11(12):3310-3318. Epub 2016 Oct 17.

PMID:
27709883
42.

Serologic response to porcine circovirus type 1 (PCV1) in infants vaccinated with the human rotavirus vaccine, Rotarix™: A retrospective laboratory analysis.

Han HH, Karkada N, Jayadeva G, Dubin G.

Hum Vaccin Immunother. 2017 Jan 2;13(1):237-244. doi: 10.1080/21645515.2016.1231262.

43.

Distinct 3D Architecture and Dynamics of the Human HtrA2(Omi) Protease and Its Mutated Variants.

Gieldon A, Zurawa-Janicka D, Jarzab M, Wenta T, Golik P, Dubin G, Lipinska B, Ciarkowski J.

PLoS One. 2016 Aug 29;11(8):e0161526. doi: 10.1371/journal.pone.0161526. eCollection 2016.

44.

Incidence and duration of type-specific human papillomavirus infection in high-risk HPV-naïve women: results from the control arm of a phase II HPV-16/18 vaccine trial.

Ramanakumar AV, Naud P, Roteli-Martins CM, de Carvalho NS, de Borba PC, Teixeira JC, Blatter M, Moscicki AB, Harper DM, Romanowski B, Tyring SK, Ramjattan B, Schuind A, Dubin G, Franco EL; HPV-007 Study Group.

BMJ Open. 2016 Aug 26;6(8):e011371. doi: 10.1136/bmjopen-2016-011371. Erratum in: BMJ Open. 2016 Sep 02;6(9):e011371corr1.

45.

Prior human papillomavirus-16/18 AS04-adjuvanted vaccination prevents recurrent high grade cervical intraepithelial neoplasia after definitive surgical therapy: Post-hoc analysis from a randomized controlled trial.

Garland SM, Paavonen J, Jaisamrarn U, Naud P, Salmerón J, Chow SN, Apter D, Castellsagué X, Teixeira JC, Skinner SR, Hedrick J, Limson G, Schwarz TF, Poppe WA, Bosch FX, de Carvalho NS, Germar MJ, Peters K, Del Rosario-Raymundo MR, Catteau G, Descamps D, Struyf F, Lehtinen M, Dubin G; HPV PATRICIA Study Group.

Int J Cancer. 2016 Dec 15;139(12):2812-2826. doi: 10.1002/ijc.30391. Epub 2016 Sep 9.

46.

Efficacy, safety, and immunogenicity of the human papillomavirus 16/18 AS04-adjuvanted vaccine in women older than 25 years: 7-year follow-up of the phase 3, double-blind, randomised controlled VIVIANE study.

Wheeler CM, Skinner SR, Del Rosario-Raymundo MR, Garland SM, Chatterjee A, Lazcano-Ponce E, Salmerón J, McNeil S, Stapleton JT, Bouchard C, Martens MG, Money DM, Quek SC, Romanowski B, Vallejos CS, Ter Harmsel B, Prilepskaya V, Fong KL, Kitchener H, Minkina G, Lim YKT, Stoney T, Chakhtoura N, Cruickshank ME, Savicheva A, da Silva DP, Ferguson M, Molijn AC, Quint WGV, Hardt K, Descamps D, Suryakiran PV, Karkada N, Geeraerts B, Dubin G, Struyf F; VIVIANE Study Group.

Lancet Infect Dis. 2016 Oct;16(10):1154-1168. doi: 10.1016/S1473-3099(16)30120-7. Epub 2016 Jun 28.

PMID:
27373900
47.

Inhibitors of programmed cell death 1 (PD-1): a patent review (2010-2015).

Zarganes-Tzitzikas T, Konstantinidou M, Gao Y, Krzemien D, Zak K, Dubin G, Holak TA, Dömling A.

Expert Opin Ther Pat. 2016 Sep;26(9):973-7. doi: 10.1080/13543776.2016.1206527. Epub 2016 Jul 6. No abstract available.

48.

Identification of Secreted Exoproteome Fingerprints of Highly-Virulent and Non-Virulent Staphylococcus aureus Strains.

Bonar E, Wojcik I, Jankowska U, Kedracka-Krok S, Bukowski M, Polakowska K, Lis MW, Kosecka-Strojek M, Sabat AJ, Dubin G, Friedrich AW, Miedzobrodzki J, Dubin A, Wladyka B.

Front Cell Infect Microbiol. 2016 May 6;6:51. doi: 10.3389/fcimb.2016.00051. eCollection 2016.

49.

Structural basis for small molecule targeting of the programmed death ligand 1 (PD-L1).

Zak KM, Grudnik P, Guzik K, Zieba BJ, Musielak B, Dömling A, Dubin G, Holak TA.

Oncotarget. 2016 May 24;7(21):30323-35. doi: 10.18632/oncotarget.8730.

50.

The outer-membrane export signal of Porphyromonas gingivalis type IX secretion system (T9SS) is a conserved C-terminal β-sandwich domain.

de Diego I, Ksiazek M, Mizgalska D, Koneru L, Golik P, Szmigielski B, Nowak M, Nowakowska Z, Potempa B, Houston JA, Enghild JJ, Thøgersen IB, Gao J, Kwan AH, Trewhella J, Dubin G, Gomis-Rüth FX, Nguyen KA, Potempa J.

Sci Rep. 2016 Mar 23;6:23123. doi: 10.1038/srep23123.

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