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OSCA/TMEM63 are an Evolutionarily Conserved Family of Mechanically Activated Ion Channels.

Murthy SE, Dubin AE, Whitwam T, Jojoa-Cruz S, Cahalan SM, Mousavi SAR, Ward AB, Patapoutian A.

Elife. 2018 Nov 1;7. pii: e41844. doi: 10.7554/eLife.41844.


The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice.

Murthy SE, Loud MC, Daou I, Marshall KL, Schwaller F, Kühnemund J, Francisco AG, Keenan WT, Dubin AE, Lewin GR, Patapoutian A.

Sci Transl Med. 2018 Oct 10;10(462). pii: eaat9897. doi: 10.1126/scitranslmed.aat9897.


Structure of the human volume regulated anion channel.

Kefauver JM, Saotome K, Dubin AE, Pallesen J, Cottrell CA, Cahalan SM, Qiu Z, Hong G, Crowley CS, Whitwam T, Lee WH, Ward AB, Patapoutian A.

Elife. 2018 Aug 10;7. pii: e38461. doi: 10.7554/eLife.38461.


Piezos thrive under pressure: mechanically activated ion channels in health and disease.

Murthy SE, Dubin AE, Patapoutian A.

Nat Rev Mol Cell Biol. 2017 Dec;18(12):771-783. doi: 10.1038/nrm.2017.92. Epub 2017 Oct 4. Review.


Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization.

Dubin AE, Murthy S, Lewis AH, Brosse L, Cahalan SM, Grandl J, Coste B, Patapoutian A.

Neuron. 2017 Apr 19;94(2):266-270.e3. doi: 10.1016/j.neuron.2017.03.039.


Editorial Note to: Endogenous Piezo1 Can Confound Mechanically Activated Channel Identification and Characterization.

Dubin AE, Murthy S, Lewis AH, Brosse L, Cahalan SM, Grandl J, Coste B, Patapoutian A.

Neuron. 2017 Apr 19;94(2):265. doi: 10.1016/j.neuron.2017.03.041. No abstract available.


LRRC8 Proteins Form Volume-Regulated Anion Channels that Sense Ionic Strength.

Syeda R, Qiu Z, Dubin AE, Murthy SE, Florendo MN, Mason DE, Mathur J, Cahalan SM, Peters EC, Montal M, Patapoutian A.

Cell. 2016 Jan 28;164(3):499-511. doi: 10.1016/j.cell.2015.12.031.


Chemical activation of the mechanotransduction channel Piezo1.

Syeda R, Xu J, Dubin AE, Coste B, Mathur J, Huynh T, Matzen J, Lao J, Tully DC, Engels IH, Petrassi HM, Schumacher AM, Montal M, Bandell M, Patapoutian A.

Elife. 2015 May 22;4. doi: 10.7554/eLife.07369.


Piezo2 is the major transducer of mechanical forces for touch sensation in mice.

Ranade SS, Woo SH, Dubin AE, Moshourab RA, Wetzel C, Petrus M, Mathur J, Bégay V, Coste B, Mainquist J, Wilson AJ, Francisco AG, Reddy K, Qiu Z, Wood JN, Lewin GR, Patapoutian A.

Nature. 2014 Dec 4;516(7529):121-5. doi: 10.1038/nature13980.


SWELL1, a plasma membrane protein, is an essential component of volume-regulated anion channel.

Qiu Z, Dubin AE, Mathur J, Tu B, Reddy K, Miraglia LJ, Reinhardt J, Orth AP, Patapoutian A.

Cell. 2014 Apr 10;157(2):447-458. doi: 10.1016/j.cell.2014.03.024.


Piezo2 is required for Merkel-cell mechanotransduction.

Woo SH, Ranade S, Weyer AD, Dubin AE, Baba Y, Qiu Z, Petrus M, Miyamoto T, Reddy K, Lumpkin EA, Stucky CL, Patapoutian A.

Nature. 2014 May 29;509(7502):622-6. doi: 10.1038/nature13251. Epub 2014 Apr 6.


Inflammatory signals enhance piezo2-mediated mechanosensitive currents.

Dubin AE, Schmidt M, Mathur J, Petrus MJ, Xiao B, Coste B, Patapoutian A.

Cell Rep. 2012 Sep 27;2(3):511-7. doi: 10.1016/j.celrep.2012.07.014. Epub 2012 Aug 23.


Piezo proteins are pore-forming subunits of mechanically activated channels.

Coste B, Xiao B, Santos JS, Syeda R, Grandl J, Spencer KS, Kim SE, Schmidt M, Mathur J, Dubin AE, Montal M, Patapoutian A.

Nature. 2012 Feb 19;483(7388):176-81. doi: 10.1038/nature10812.


Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype.

Blasius AL, Dubin AE, Petrus MJ, Lim BK, Narezkina A, Criado JR, Wills DN, Xia Y, Moresco EM, Ehlers C, Knowlton KU, Patapoutian A, Beutler B.

Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19413-8. doi: 10.1073/pnas.1117020108. Epub 2011 Nov 15.


TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin.

Miyamoto T, Petrus MJ, Dubin AE, Patapoutian A.

Nat Commun. 2011 Jun 28;2:369. doi: 10.1038/ncomms1371.


Nociceptors: the sensors of the pain pathway.

Dubin AE, Patapoutian A.

J Clin Invest. 2010 Nov;120(11):3760-72. doi: 10.1172/JCI42843. Epub 2010 Nov 1. Review.


Piezo1 and Piezo2 are essential components of distinct mechanically activated cation channels.

Coste B, Mathur J, Schmidt M, Earley TJ, Ranade S, Petrus MJ, Dubin AE, Patapoutian A.

Science. 2010 Oct 1;330(6000):55-60. doi: 10.1126/science.1193270. Epub 2010 Sep 2.


Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis.

Dubin AE, Herr DR, Chun J.

J Neurosci. 2010 May 26;30(21):7300-9. doi: 10.1523/JNEUROSCI.6151-09.2010.


Nociceptive signals induce trafficking of TRPA1 to the plasma membrane.

Schmidt M, Dubin AE, Petrus MJ, Earley TJ, Patapoutian A.

Neuron. 2009 Nov 25;64(4):498-509. doi: 10.1016/j.neuron.2009.09.030.


TRPV1 and TRPA1 mediate peripheral nitric oxide-induced nociception in mice.

Miyamoto T, Dubin AE, Petrus MJ, Patapoutian A.

PLoS One. 2009 Oct 29;4(10):e7596. doi: 10.1371/journal.pone.0007596.


Roles of transient receptor potential channels in pain.

Stucky CL, Dubin AE, Jeske NA, Malin SA, McKemy DD, Story GM.

Brain Res Rev. 2009 Apr;60(1):2-23. doi: 10.1016/j.brainresrev.2008.12.018. Epub 2008 Dec 31. Review.


HCN channels as targets for drug discovery.

Maher MP, Wu NT, Guo HQ, Dubin AE, Chaplan SR, Wickenden AD.

Comb Chem High Throughput Screen. 2009 Jan;12(1):64-72. Review.


TRPV1 is activated by both acidic and basic pH.

Dhaka A, Uzzell V, Dubin AE, Mathur J, Petrus M, Bandell M, Patapoutian A.

J Neurosci. 2009 Jan 7;29(1):153-8. doi: 10.1523/JNEUROSCI.4901-08.2009.


Identification of transmembrane domain 5 as a critical molecular determinant of menthol sensitivity in mammalian TRPA1 channels.

Xiao B, Dubin AE, Bursulaya B, Viswanath V, Jegla TJ, Patapoutian A.

J Neurosci. 2008 Sep 24;28(39):9640-51. doi: 10.1523/JNEUROSCI.2772-08.2008.


N-pyridin-3-yl- and N-quinolin-3-yl-benzamides: modulators of human vanilloid receptor 1 (TRPV1).

Jetter MC, McNally JJ, Youngman MA, McDonnell ME, Dubin AE, Nasser N, Zhang SP, Codd EE, Colburn RW, Stone DR, Brandt MR, Flores CM, Dax SL.

Bioorg Med Chem Lett. 2008 Apr 15;18(8):2730-4. doi: 10.1016/j.bmcl.2008.02.075. Epub 2008 Mar 5. Erratum in: Bioorg Med Chem Lett. 2008 Jul 15;18(14):4254.


An ion channel essential for sensing chemical damage.

Macpherson LJ, Xiao B, Kwan KY, Petrus MJ, Dubin AE, Hwang S, Cravatt B, Corey DP, Patapoutian A.

J Neurosci. 2007 Oct 17;27(42):11412-5.


Heteroaryl beta-tetralin ureas as novel antagonists of human TRPV1.

Jetter MC, Youngman MA, McNally JJ, McDonnell ME, Zhang SP, Dubin AE, Nasser N, Codd EE, Flores CM, Dax SL.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6160-3. Epub 2007 Sep 12.


Pharmacology and antitussive efficacy of 4-(3-trifluoromethyl-pyridin-2-yl)-piperazine-1-carboxylic acid (5-trifluoromethyl-pyridin-2-yl)-amide (JNJ17203212), a transient receptor potential vanilloid 1 antagonist in guinea pigs.

Bhattacharya A, Scott BP, Nasser N, Ao H, Maher MP, Dubin AE, Swanson DM, Shankley NP, Wickenden AD, Chaplan SR.

J Pharmacol Exp Ther. 2007 Nov;323(2):665-74. Epub 2007 Aug 9.


Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines.

Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A.

Nature. 2007 Feb 1;445(7127):541-5. Epub 2007 Jan 21.


Role of peripheral hyperpolarization-activated cyclic nucleotide-modulated channel pacemaker channels in acute and chronic pain models in the rat.

Luo L, Chang L, Brown SM, Ao H, Lee DH, Higuera ES, Dubin AE, Chaplan SR.

Neuroscience. 2007 Feb 23;144(4):1477-85. Epub 2006 Dec 29.


The role of pacemaker currents in neuropathic pain.

Brown SM, Dubin AE, Chaplan SR.

Pain Pract. 2004 Sep;4(3):182-93.


More than cool: promiscuous relationships of menthol and other sensory compounds.

Macpherson LJ, Hwang SW, Miyamoto T, Dubin AE, Patapoutian A, Story GM.

Mol Cell Neurosci. 2006 Aug;32(4):335-43. Epub 2006 Jul 7.


GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5.

Lee CW, Rivera R, Gardell S, Dubin AE, Chun J.

J Biol Chem. 2006 Aug 18;281(33):23589-97. Epub 2006 Jun 14.


High-throughput random mutagenesis screen reveals TRPM8 residues specifically required for activation by menthol.

Bandell M, Dubin AE, Petrus MJ, Orth A, Mathur J, Hwang SW, Patapoutian A.

Nat Neurosci. 2006 Apr;9(4):493-500. Epub 2006 Mar 5.


Emerging medicinal roles for lysophospholipid signaling.

Gardell SE, Dubin AE, Chun J.

Trends Mol Med. 2006 Feb;12(2):65-75. Epub 2006 Jan 10. Review.


Identifying modulators of hERG channel activity using the PatchXpress planar patch clamp.

Dubin AE, Nasser N, Rohrbacher J, Hermans AN, Marrannes R, Grantham C, Van Rossem K, Cik M, Chaplan SR, Gallacher D, Xu J, Guia A, Byrne NG, Mathes C.

J Biomol Screen. 2005 Mar;10(2):168-81.


Selective blockade of the capsaicin receptor TRPV1 attenuates bone cancer pain.

Ghilardi JR, Röhrich H, Lindsay TH, Sevcik MA, Schwei MJ, Kubota K, Halvorson KG, Poblete J, Chaplan SR, Dubin AE, Carruthers NI, Swanson D, Kuskowski M, Flores CM, Julius D, Mantyh PW.

J Neurosci. 2005 Mar 23;25(12):3126-31.


Identification and biological evaluation of 4-(3-trifluoromethylpyridin-2-yl)piperazine-1-carboxylic acid (5-trifluoromethylpyridin-2-yl)amide, a high affinity TRPV1 (VR1) vanilloid receptor antagonist.

Swanson DM, Dubin AE, Shah C, Nasser N, Chang L, Dax SL, Jetter M, Breitenbucher JG, Liu C, Mazur C, Lord B, Gonzales L, Hoey K, Rizzolio M, Bogenstaetter M, Codd EE, Lee DH, Zhang SP, Chaplan SR, Carruthers NI.

J Med Chem. 2005 Mar 24;48(6):1857-72.


N-isoquinolin-5-yl-N'-aralkyl-urea and -amide antagonists of human vanilloid receptor 1.

Jetter MC, Youngman MA, McNally JJ, Zhang SP, Dubin AE, Nasser N, Dax SL.

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3053-6.


Fluorescence imaging of electrically stimulated cells.

Burnett P, Robertson JK, Palmer JM, Ryan RR, Dubin AE, Zivin RA.

J Biomol Screen. 2003 Dec;8(6):660-7.


7-Hydroxynaphthalen-1-yl-urea and -amide antagonists of human vanilloid receptor 1.

McDonnell ME, Zhang SP, Nasser N, Dubin AE, Dax SL.

Bioorg Med Chem Lett. 2004 Jan 19;14(2):531-4.


Neuronal hyperpolarization-activated pacemaker channels drive neuropathic pain.

Chaplan SR, Guo HQ, Lee DH, Luo L, Liu C, Kuei C, Velumian AA, Butler MP, Brown SM, Dubin AE.

J Neurosci. 2003 Feb 15;23(4):1169-78.


Inactivation of olfactory sensilla of a single morphological type differentially affects the response of Drosophila to odors.

Park SK, Shanbhag SR, Dubin AE, de Bruyne M, Wang Q, Yu P, Shimoni N, D'Mello S, Carlson JR, Harris GL, Steinbrecht RA, Pikielny CW.

J Neurobiol. 2002 Jun 5;51(3):248-60.


Synthesis and in vitro evaluation of a novel iodinated resiniferatoxin derivative that is an agonist at the human vanilloid VR1 receptor.

McDonnell ME, Zhang SP, Dubin AE, Dax SL.

Bioorg Med Chem Lett. 2002 Apr 22;12(8):1189-92.


Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors.

Brady CA, Stanford IM, Ali I, Lin L, Williams JM, Dubin AE, Hope AG, Barnes NM.

Neuropharmacology. 2001 Aug;41(2):282-4.


The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit.

Dubin AE, Huvar R, D'Andrea MR, Pyati J, Zhu JY, Joy KC, Wilson SJ, Galindo JE, Glass CA, Luo L, Jackson MR, Lovenberg TW, Erlander MG.

J Biol Chem. 1999 Oct 22;274(43):30799-810.


Involvement of genes encoding a K+ channel (ether a go-go) and a Na+ channel (smellblind) in Drosophila olfaction.

Dubin AE, Liles MM, Seligman F, Le T, Tolli J, Harris GL.

Ann N Y Acad Sci. 1998 Nov 30;855:212-22. Review.


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