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Association between AXL promoter methylation and lung function growth during adolescence.

Gao L, Urman R, Millstein J, Siegmund KD, Dubeau L, Breton CV.

Epigenetics. 2018 Oct 2:1-12. doi: 10.1080/15592294.2018.1529517. [Epub ahead of print]


Self-reported prenatal tobacco smoke exposure, AXL gene-body methylation, and childhood asthma phenotypes.

Gao L, Liu X, Millstein J, Siegmund KD, Dubeau L, Maguire RL, Jim Zhang J, Fuemmeler BF, Kollins SH, Hoyo C, Murphy SK, Breton CV.

Clin Epigenetics. 2018 Jul 20;10(1):98. doi: 10.1186/s13148-018-0532-x.


Mechanism of cytokinesis failure in ovarian cystadenomas with defective BRCA1 and P53 pathways.

Austria T, Marion C, Yu V, Widschwendter M, Hinton DR, Dubeau L.

Int J Cancer. 2018 Dec 1;143(11):2932-2942. doi: 10.1002/ijc.31659. Epub 2018 Oct 3.


Expression of protein disulfide isomerase family members correlates with tumor progression and patient survival in ovarian cancer.

Samanta S, Tamura S, Dubeau L, Mhawech-Fauceglia P, Miyagi Y, Kato H, Lieberman R, Buckanovich RJ, Lin YG, Neamati N.

Oncotarget. 2017 Oct 6;8(61):103543-103556. doi: 10.18632/oncotarget.21569. eCollection 2017 Nov 28.


Epigenetic regulation of AXL and risk of childhood asthma symptoms.

Gao L, Millstein J, Siegmund KD, Dubeau L, Maguire R, Gilliland FD, Murphy SK, Hoyo C, Breton CV.

Clin Epigenetics. 2017 Nov 7;9:121. doi: 10.1186/s13148-017-0421-8. eCollection 2017.


GRP78 haploinsufficiency suppresses acinar-to-ductal metaplasia, signaling, and mutant Kras-driven pancreatic tumorigenesis in mice.

Shen J, Ha DP, Zhu G, Rangel DF, Kobielak A, Gill PS, Groshen S, Dubeau L, Lee AS.

Proc Natl Acad Sci U S A. 2017 May 16;114(20):E4020-E4029. doi: 10.1073/pnas.1616060114. Epub 2017 May 1.


Effects of Prolonged GRP78 Haploinsufficiency on Organ Homeostasis, Behavior, Cancer and Chemotoxic Resistance in Aged Mice.

Lee AS, Brandhorst S, Rangel DF, Navarrete G, Cohen P, Longo VD, Chen J, Groshen S, Morgan TE, Dubeau L.

Sci Rep. 2017 Feb 1;7:40919. doi: 10.1038/srep40919.


Aberrant regulation of RANKL/OPG in women at high risk of developing breast cancer.

Kiechl S, Schramek D, Widschwendter M, Fourkala EO, Zaikin A, Jones A, Jaeger B, Rack B, Janni W, Scholz C, Willeit J, Weger S, Mayr A, Teschendorff A, Rosenthal A, Fraser L, Philpott S, Dubeau L, Keshtgar M, Roylance R, Jacobs IJ, Menon U, Schett G, Penninger JM.

Oncotarget. 2017 Jan 17;8(3):3811-3825. doi: 10.18632/oncotarget.14013.


Epigenetic reprogramming of fallopian tube fimbriae in BRCA mutation carriers defines early ovarian cancer evolution.

Bartlett TE, Chindera K, McDermott J, Breeze CE, Cooke WR, Jones A, Reisel D, Karegodar ST, Arora R, Beck S, Menon U, Dubeau L, Widschwendter M.

Nat Commun. 2016 May 24;7:11620. doi: 10.1038/ncomms11620.


Glucose-regulated protein 94 deficiency induces squamous cell metaplasia and suppresses PTEN-null driven endometrial epithelial tumor development.

Shen J, Yao L, Lin YG, DeMayo FJ, Lydon JP, Dubeau L, Lee AS.

Oncotarget. 2016 Mar 22;7(12):14885-97. doi: 10.18632/oncotarget.7450.


Osteoprotegerin (OPG), The Endogenous Inhibitor of Receptor Activator of NF-κB Ligand (RANKL), is Dysregulated in BRCA Mutation Carriers.

Widschwendter M, Burnell M, Fraser L, Rosenthal AN, Philpott S, Reisel D, Dubeau L, Cline M, Pan Y, Yi PC, Gareth Evans D, Jacobs IJ, Menon U, Wood CE, Dougall WC.

EBioMedicine. 2015 Sep 9;2(10):1331-9. doi: 10.1016/j.ebiom.2015.08.037. eCollection 2015 Oct.


A Mouse Model That Reproduces the Developmental Pathways and Site Specificity of the Cancers Associated With the Human BRCA1 Mutation Carrier State.

Liu Y, Yen HY, Austria T, Pettersson J, Peti-Peterdi J, Maxson R, Widschwendter M, Dubeau L.

EBioMedicine. 2015 Sep 9;2(10):1318-30. doi: 10.1016/j.ebiom.2015.08.034. eCollection 2015 Oct.


HOTAIR and its surrogate DNA methylation signature indicate carboplatin resistance in ovarian cancer.

Teschendorff AE, Lee SH, Jones A, Fiegl H, Kalwa M, Wagner W, Chindera K, Evans I, Dubeau L, Orjalo A, Horlings HM, Niederreiter L, Kaser A, Yang W, Goode EL, Fridley BL, Jenner RG, Berns EM, Wik E, Salvesen HB, Wisman GB, van der Zee AG, Davidson B, Trope CG, Lambrechts S, Vergote I, Calvert H, Jacobs IJ, Widschwendter M.

Genome Med. 2015 Oct 24;7:108. doi: 10.1186/s13073-015-0233-4.


Brca1 Mutations Enhance Mouse Reproductive Functions by Increasing Responsiveness to Male-Derived Scent.

Liu Y, Pike MC, Wu N, Lin YG, Mucowski S, Punj V, Tang Y, Yen HY, Stanczyk FZ, Enbom E, Austria T, Widschwendter M, Maxson R, Dubeau L.

PLoS One. 2015 Oct 21;10(10):e0139013. doi: 10.1371/journal.pone.0139013. eCollection 2015.


A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan.

Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD.

Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18.


Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism.

Palian BM, Rohira AD, Johnson SA, He L, Zheng N, Dubeau L, Stiles BL, Johnson DL.

PLoS Genet. 2014 Dec 11;10(12):e1004789. doi: 10.1371/journal.pgen.1004789. eCollection 2014 Dec. Erratum in: PLoS Genet. 2015 Mar;11(3):e1005055.


NEO212, temozolomide conjugated to perillyl alcohol, is a novel drug for effective treatment of a broad range of temozolomide-resistant gliomas.

Cho HY, Wang W, Jhaveri N, Lee DJ, Sharma N, Dubeau L, Schönthal AH, Hofman FM, Chen TC.

Mol Cancer Ther. 2014 Aug;13(8):2004-17. doi: 10.1158/1535-7163.MCT-13-0964. Epub 2014 Jul 3.


Coming into focus: the nonovarian origins of ovarian cancer.

Dubeau L, Drapkin R.

Ann Oncol. 2013 Nov;24 Suppl 8:viii28-viii35. doi: 10.1093/annonc/mdt308. Review.


The sex hormone system in carriers of BRCA1/2 mutations: a case-control study.

Widschwendter M, Rosenthal AN, Philpott S, Rizzuto I, Fraser L, Hayward J, Intermaggio MP, Edlund CK, Ramus SJ, Gayther SA, Dubeau L, Fourkala EO, Zaikin A, Menon U, Jacobs IJ.

Lancet Oncol. 2013 Nov;14(12):1226-32. doi: 10.1016/S1470-2045(13)70448-0. Epub 2013 Oct 17.


The endoplasmic reticulum stress marker, glucose-regulated protein-78 (GRP78) in visceral adipocytes predicts endometrial cancer progression and patient survival.

Matsuo K, Gray MJ, Yang DY, Srivastava SA, Tripathi PB, Sonoda LA, Yoo EJ, Dubeau L, Lee AS, Lin YG.

Gynecol Oncol. 2013 Mar;128(3):552-9. doi: 10.1016/j.ygyno.2012.11.024. Epub 2012 Nov 28.


Alterations in Brca1 expression in mouse ovarian granulosa cells have short-term and long-term consequences on estrogen-responsive organs.

Yen HY, Gabet Y, Liu Y, Martin A, Wu NL, Pike MC, Frenkel B, Maxson R, Dubeau L.

Lab Invest. 2012 Jun;92(6):802-11. doi: 10.1038/labinvest.2012.58. Epub 2012 Apr 9.


Genome-scale screen for DNA methylation-based detection markers for ovarian cancer.

Campan M, Moffitt M, Houshdaran S, Shen H, Widschwendter M, Daxenbichler G, Long T, Marth C, Laird-Offringa IA, Press MF, Dubeau L, Siegmund KD, Wu AH, Groshen S, Chandavarkar U, Roman LD, Berchuck A, Pearce CL, Laird PW.

PLoS One. 2011;6(12):e28141. doi: 10.1371/journal.pone.0028141. Epub 2011 Dec 7.


Role of BRCA1 in controlling mitotic arrest in ovarian cystadenoma cells.

Yu VM, Marion CM, Austria TM, Yeh J, Schönthal AH, Dubeau L.

Int J Cancer. 2012 Jun 1;130(11):2495-504. doi: 10.1002/ijc.26309. Epub 2011 Aug 29.


Pathological characteristics of BRCA-associated breast cancers in Hispanics.

Lagos-Jaramillo VI, Press MF, Ricker CN, Dubeau L, Mai PL, Weitzel JN.

Breast Cancer Res Treat. 2011 Nov;130(1):281-9. doi: 10.1007/s10549-011-1570-7. Epub 2011 May 21.


BRCA genes: lessons learned from experimental and clinical cancer.

Muggia F, Safra T, Dubeau L.

Ann Oncol. 2011 Jan;22 Suppl 1:i7-10. doi: 10.1093/annonc/mdq659.


Changes in the mouse estrus cycle in response to BRCA1 inactivation suggest a potential link between risk factors for familial and sporadic ovarian cancer.

Hong H, Yen HY, Brockmeyer A, Liu Y, Chodankar R, Pike MC, Stanczyk FZ, Maxson R, Dubeau L.

Cancer Res. 2010 Jan 1;70(1):221-8. doi: 10.1158/0008-5472.CAN-09-3232. Epub 2009 Dec 22.


Essential role of the unfolded protein response regulator GRP78/BiP in protection from neuronal apoptosis.

Wang M, Ye R, Barron E, Baumeister P, Mao C, Luo S, Fu Y, Luo B, Dubeau L, Hinton DR, Lee AS.

Cell Death Differ. 2010 Mar;17(3):488-98. doi: 10.1038/cdd.2009.144. Epub 2009 Oct 9.


HOXA methylation in normal endometrium from premenopausal women is associated with the presence of ovarian cancer: a proof of principle study.

Widschwendter M, Apostolidou S, Jones AA, Fourkala EO, Arora R, Pearce CL, Frasco MA, Ayhan A, Zikan M, Cibula D, Iyibozkurt CA, Yavuz E, Hauser-Kronberger C, Dubeau L, Menon U, Jacobs IJ.

Int J Cancer. 2009 Nov 1;125(9):2214-8. doi: 10.1002/ijc.24599.


Hemimethylation footprints of DNA demethylation in cancer.

Shao C, Lacey M, Dubeau L, Ehrlich M.

Epigenetics. 2009 Apr 1;4(3):165-75. Epub 2009 Apr 23.


Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice.

Yoo CB, Chuang JC, Byun HM, Egger G, Yang AS, Dubeau L, Long T, Laird PW, Marquez VE, Jones PA.

Cancer Prev Res (Phila). 2008 Sep;1(4):233-40. doi: 10.1158/1940-6207.CAPR-07-0008. Epub 2008 Mar 19.


The cell of origin of ovarian epithelial tumours.

Dubeau L.

Lancet Oncol. 2008 Dec;9(12):1191-7. doi: 10.1016/S1470-2045(08)70308-5. Review.


BRCA1-induced ovarian oncogenesis.

Dubeau L.

Adv Exp Med Biol. 2008;622:89-97. doi: 10.1007/978-0-387-68969-2_8. Review. No abstract available.


Enhanced RNA polymerase III-dependent transcription is required for oncogenic transformation.

Johnson SA, Dubeau L, Johnson DL.

J Biol Chem. 2008 Jul 11;283(28):19184-91. doi: 10.1074/jbc.M802872200. Epub 2008 May 1.


Critical role of the stress chaperone GRP78/BiP in tumor proliferation, survival, and tumor angiogenesis in transgene-induced mammary tumor development.

Dong D, Ni M, Li J, Xiong S, Ye W, Virrey JJ, Mao C, Ye R, Wang M, Pen L, Dubeau L, Groshen S, Hofman FM, Lee AS.

Cancer Res. 2008 Jan 15;68(2):498-505. doi: 10.1158/0008-5472.CAN-07-2950.


Increased chromosomal stability in cultures of ovarian tumours of low malignant potential compared to cystadenomas.

Yu J, Roy D, Brockmeyer AD, Dubeau L.

Br J Cancer. 2007 Jun 18;96(12):1908-13. Epub 2007 May 22.


Triplet repeat mutation length gains correlate with cell-type specific vulnerability in Huntington disease brain.

Shelbourne PF, Keller-McGandy C, Bi WL, Yoon SR, Dubeau L, Veitch NJ, Vonsattel JP, Wexler NS; US-Venezuela Collaborative Research Group, Arnheim N, Augood SJ.

Hum Mol Genet. 2007 May 15;16(10):1133-42. Epub 2007 Apr 4.


The receptor tyrosine kinase EphB4 is overexpressed in ovarian cancer, provides survival signals and predicts poor outcome.

Kumar SR, Masood R, Spannuth WA, Singh J, Scehnet J, Kleiber G, Jennings N, Deavers M, Krasnoperov V, Dubeau L, Weaver FA, Sood AK, Gill PS.

Br J Cancer. 2007 Apr 10;96(7):1083-91. Epub 2007 Mar 13.


Quantitative analysis of associations between DNA hypermethylation, hypomethylation, and DNMT RNA levels in ovarian tumors.

Ehrlich M, Woods CB, Yu MC, Dubeau L, Yang F, Campan M, Weisenberger DJ, Long T, Youn B, Fiala ES, Laird PW.

Oncogene. 2006 Apr 27;25(18):2636-45.


Associations of tumor necrosis factor G-308A with childhood asthma and wheezing.

Li YF, Gauderman WJ, Avol E, Dubeau L, Gilliland FD.

Am J Respir Crit Care Med. 2006 May 1;173(9):970-6. Epub 2006 Feb 2.


TNF-308 modifies the effect of second-hand smoke on respiratory illness-related school absences.

Wenten M, Berhane K, Rappaport EB, Avol E, Tsai WW, Gauderman WJ, McConnell R, Dubeau L, Gilliland FD.

Am J Respir Crit Care Med. 2005 Dec 15;172(12):1563-8. Epub 2005 Sep 15.


Intercellular adhesion molecule-1 and childhood asthma.

Li YF, Tsao YH, Gauderman WJ, Conti DV, Avol E, Dubeau L, Gilliland FD.

Hum Genet. 2005 Sep;117(5):476-84. Epub 2005 Jul 14.


A DNA repeat, NBL2, is hypermethylated in some cancers but hypomethylated in others.

Nishiyama R, Qi L, Tsumagari K, Weissbecker K, Dubeau L, Champagne M, Sikka S, Nagai H, Ehrlich M.

Cancer Biol Ther. 2005 Apr;4(4):440-8. Epub 2005 Apr 21.


Cell-nonautonomous induction of ovarian and uterine serous cystadenomas in mice lacking a functional Brca1 in ovarian granulosa cells.

Chodankar R, Kwang S, Sangiorgi F, Hong H, Yen HY, Deng C, Pike MC, Shuler CF, Maxson R, Dubeau L.

Curr Biol. 2005 Mar 29;15(6):561-5.


Frequent DNA hypomethylation of human juxtacentromeric BAGE loci in cancer.

Grunau C, Sanchez C, Ehrlich M, van der Bruggen P, Hindermann W, Rodriguez C, Krieger S, Dubeau L, Fiala E, De Sario A.

Genes Chromosomes Cancer. 2005 May;43(1):11-24.


Spontaneous and controllable activation of suicide gene expression driven by the stress-inducible grp78 promoter resulting in eradication of sizable human tumors.

Dong D, Dubeau L, Bading J, Nguyen K, Luna M, Yu H, Gazit-Bornstein G, Gordon EM, Gomer C, Hall FL, Gambhir SS, Lee AS.

Hum Gene Ther. 2004 Jun;15(6):553-61.


Detection of residual subclinical ovarian carcinoma after completion of adjuvant chemotherapy.

Nouriani M, Bahador A, Berek JS, Cheng JP, Chi DS, Cliby WA, Del Priore G, Dodson MK, Duggan BD, Gershenson DM, Lentz SE, Penson RT, Robinson WR, Rodriguez M, Roman LD, Yu MC, Zempolich K, Dubeau L.

Clin Cancer Res. 2004 Apr 15;10(8):2681-6.


Aneuploidy and telomere attrition are independent determinants of crisis in SV40-transformed epithelial cells.

Velicescu M, Yu J, Herbert BS, Shay JW, Granada E, Dubeau L.

Cancer Res. 2003 Sep 15;63(18):5813-20.


The TATA-binding protein as a regulator of cellular transformation.

Johnson SA, Dubeau L, White RJ, Johnson DL.

Cell Cycle. 2003 Sep-Oct;2(5):442-4. Review.


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