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Items: 15

1.

Correction: An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors.

Indarte M, Puentes R, Maruggi M, Ihle NT, Grandjean G, Scott M, Ahmed Z, Meuillet EJ, Zhang S, Lemos R Jr, Du-Cuny L, Layng FIAL, Correa RG, Bankston LA, Liddington RC, Kirkpatrick L, Powis G.

Cancer Res. 2019 Oct 15;79(20):5457. doi: 10.1158/0008-5472.CAN-19-2586. No abstract available.

PMID:
31615811
2.

An Inhibitor of the Pleckstrin Homology Domain of CNK1 Selectively Blocks the Growth of Mutant KRAS Cells and Tumors.

Indarte M, Puentes R, Maruggi M, Ihle NT, Grandjean G, Scott M, Ahmed Z, Meuillet EJ, Zang S, Lemos R Jr, Du-Cuny L, Layng FIAL, Correa RG, Bankston LA, Liddington RC, Kirkpatrick L, Powis G.

Cancer Res. 2019 Jun 15;79(12):3100-3111. doi: 10.1158/0008-5472.CAN-18-2372. Epub 2019 Apr 30. Erratum in: Cancer Res. 2019 Oct 15;79(20):5457.

PMID:
31040156
3.

Novel inhibitors induce large conformational changes of GAB1 pleckstrin homology domain and kill breast cancer cells.

Chen L, Du-Cuny L, Moses S, Dumas S, Song Z, Rezaeian AH, Lin HK, Meuillet EJ, Zhang S.

PLoS Comput Biol. 2015 Jan 8;11(1):e1004021. doi: 10.1371/journal.pcbi.1004021. eCollection 2015 Jan.

4.

From laptop to benchtop to bedside: structure-based drug design on protein targets.

Chen L, Morrow JK, Tran HT, Phatak SS, Du-Cuny L, Zhang S.

Curr Pharm Des. 2012;18(9):1217-39. Review.

5.

A critical assessment of combined ligand- and structure-based approaches to HERG channel blocker modeling.

Du-Cuny L, Chen L, Zhang S.

J Chem Inf Model. 2011 Nov 28;51(11):2948-60. doi: 10.1021/ci200271d. Epub 2011 Oct 13.

6.

Development of sulfonamide AKT PH domain inhibitors.

Ahad AM, Zuohe S, Du-Cuny L, Moses SA, Zhou LL, Zhang S, Powis G, Meuillet EJ, Mash EA.

Bioorg Med Chem. 2011 Mar 15;19(6):2046-54. doi: 10.1016/j.bmc.2011.01.049. Epub 2011 Feb 1.

7.

Recent development of anticancer therapeutics targeting Akt.

Morrow JK, Du-Cuny L, Chen L, Meuillet EJ, Mash EA, Powis G, Zhang S.

Recent Pat Anticancer Drug Discov. 2011 Jan;6(1):146-59. Review.

8.

Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor.

Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Jacoby JJ, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, Powis G.

Mol Cancer Ther. 2010 Mar;9(3):706-17. doi: 10.1158/1535-7163.MCT-09-0985. Epub 2010 Mar 2.

9.

Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues.

Chen LS, Du-Cuny L, Vethantham V, Hawke DH, Manley JL, Zhang S, Gandhi V.

Biochem Pharmacol. 2010 Mar 1;79(5):669-77. doi: 10.1016/j.bcp.2009.09.028. Epub 2009 Oct 6.

10.

Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain.

Du-Cuny L, Song Z, Moses S, Powis G, Mash EA, Meuillet EJ, Zhang S.

Bioorg Med Chem. 2009 Oct 1;17(19):6983-92. doi: 10.1016/j.bmc.2009.08.022. Epub 2009 Aug 19.

11.
12.

In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT.

Moses SA, Ali MA, Zuohe S, Du-Cuny L, Zhou LL, Lemos R, Ihle N, Skillman AG, Zhang S, Mash EA, Powis G, Meuillet EJ.

Cancer Res. 2009 Jun 15;69(12):5073-81. doi: 10.1158/0008-5472.CAN-08-3839. Epub 2009 Jun 2.

13.

Discovery of a novel class of AKT pleckstrin homology domain inhibitors.

Mahadevan D, Powis G, Mash EA, George B, Gokhale VM, Zhang S, Shakalya K, Du-Cuny L, Berggren M, Ali MA, Jana U, Ihle N, Moses S, Franklin C, Narayan S, Shirahatti N, Meuillet EJ.

Mol Cancer Ther. 2008 Sep;7(9):2621-32. doi: 10.1158/1535-7163.MCT-07-2276.

14.

A potentiometric titration method for the crystallization of drug-like organic molecules.

Du-Cuny L, Huwyler J, Fischer H, Kansy M.

Int J Pharm. 2007 Sep 5;342(1-2):161-7. Epub 2007 May 21.

PMID:
17587517
15.

Computational aqueous solubility prediction for drug-like compounds in congeneric series.

Du-Cuny L, Huwyler J, Wiese M, Kansy M.

Eur J Med Chem. 2008 Mar;43(3):501-12. Epub 2007 May 6.

PMID:
17574307

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