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Items: 1 to 50 of 357

1.

Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice.

Song Y, Koehler JA, Baggio LL, Powers AC, Sandoval DA, Drucker DJ.

Cell Metab. 2019 Aug 30. pii: S1550-4131(19)30438-3. doi: 10.1016/j.cmet.2019.08.009. [Epub ahead of print]

PMID:
31495689
2.

Gut microbiota confers host resistance to obesity by metabolizing dietary polyunsaturated fatty acids.

Miyamoto J, Igarashi M, Watanabe K, Karaki SI, Mukouyama H, Kishino S, Li X, Ichimura A, Irie J, Sugimoto Y, Mizutani T, Sugawara T, Miki T, Ogawa J, Drucker DJ, Arita M, Itoh H, Kimura I.

Nat Commun. 2019 Sep 5;10(1):4007. doi: 10.1038/s41467-019-11978-0.

3.

Physiological roles of the GIP receptor in murine brown adipose tissue.

Beaudry JL, Kaur KD, Varin EM, Baggio LL, Cao X, Mulvihill EE, Bates HE, Campbell JE, Drucker DJ.

Mol Metab. 2019 Aug 10. pii: S2212-8778(19)30617-9. doi: 10.1016/j.molmet.2019.08.006. [Epub ahead of print]

4.

Localization of Glucagon-Like Peptide-2 Receptor Expression in the Mouse.

Yusta B, Matthews D, Koehler JA, Pujadas G, Kaur KD, Drucker DJ.

Endocrinology. 2019 Aug 1;160(8):1950-1963. doi: 10.1210/en.2019-00398.

PMID:
31237617
5.

Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action.

Varin EM, Mulvihill EE, Baggio LL, Koehler JA, Cao X, Seeley RJ, Drucker DJ.

Cell Rep. 2019 Jun 11;27(11):3371-3384.e3. doi: 10.1016/j.celrep.2019.05.055.

6.

The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice.

Beaudry JL, Kaur KD, Varin EM, Baggio LL, Cao X, Mulvihill EE, Stern JH, Campbell JE, Scherer PE, Drucker DJ.

Mol Metab. 2019 Apr;22:37-48. doi: 10.1016/j.molmet.2019.01.011. Epub 2019 Feb 5.

7.

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease.

He S, Kahles F, Rattik S, Nairz M, McAlpine CS, Anzai A, Selgrade D, Fenn AM, Chan CT, Mindur JE, Valet C, Poller WC, Halle L, Rotllan N, Iwamoto Y, Wojtkiewicz GR, Weissleder R, Libby P, Fernández-Hernando C, Drucker DJ, Nahrendorf M, Swirski FK.

Nature. 2019 Feb;566(7742):115-119. doi: 10.1038/s41586-018-0849-9. Epub 2019 Jan 30.

8.

Fibroblast activation protein is dispensable for control of glucose homeostasis and body weight in mice.

Panaro BL, Coppage AL, Beaudry JL, Varin EM, Kaur K, Lai JH, Wu W, Liu Y, Bachovchin WW, Drucker DJ.

Mol Metab. 2019 Jan;19:65-74. doi: 10.1016/j.molmet.2018.10.011. Epub 2018 Nov 5.

9.

Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition.

Varin EM, Mulvihill EE, Beaudry JL, Pujadas G, Fuchs S, Tanti JF, Fazio S, Kaur K, Cao X, Baggio LL, Matthews D, Campbell JE, Drucker DJ.

Cell Metab. 2019 Feb 5;29(2):320-334.e5. doi: 10.1016/j.cmet.2018.10.001. Epub 2018 Nov 1.

PMID:
30393019
10.

Insulin Secretion Depends on Intra-islet Glucagon Signaling.

Svendsen B, Larsen O, Gabe MBN, Christiansen CB, Rosenkilde MM, Drucker DJ, Holst JJ.

Cell Rep. 2018 Oct 30;25(5):1127-1134.e2. doi: 10.1016/j.celrep.2018.10.018.

11.

Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents.

Kim T, Holleman CL, Nason S, Arble DM, Ottaway N, Chabenne J, Loyd C, Kim JA, Sandoval D, Drucker DJ, DiMarchi R, Perez-Tilve D, Habegger KM.

Diabetes. 2018 Nov;67(11):2157-2166. doi: 10.2337/db18-0068. Epub 2018 Aug 27.

12.

The Ascending GLP-1 Road From Clinical Safety to Reduction of Cardiovascular Complications.

Drucker DJ.

Diabetes. 2018 Sep;67(9):1710-1719. doi: 10.2337/dbi18-0008. Review.

13.

GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr-/- mice and is dispensable for the metabolic benefits ensuing after vertical sleeve gastrectomy.

Patel A, Yusta B, Matthews D, Charron MJ, Seeley RJ, Drucker DJ.

Mol Metab. 2018 Oct;16:45-54. doi: 10.1016/j.molmet.2018.06.006. Epub 2018 Jun 9.

14.

Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21.

Kim T, Nason S, Holleman C, Pepin M, Wilson L, Berryhill TF, Wende AR, Steele C, Young ME, Barnes S, Drucker DJ, Finan B, DiMarchi R, Perez-Tilve D, Tschöp M, Habegger KM.

Diabetes. 2018 Sep;67(9):1773-1782. doi: 10.2337/db17-1502. Epub 2018 Jun 20.

15.

Precision medicine in the management of type 2 diabetes.

Gloyn AL, Drucker DJ.

Lancet Diabetes Endocrinol. 2018 Nov;6(11):891-900. doi: 10.1016/S2213-8587(18)30052-4. Epub 2018 Apr 23. Review.

PMID:
29699867
16.

Mechanisms of Action and Therapeutic Application of Glucagon-like Peptide-1.

Drucker DJ.

Cell Metab. 2018 Apr 3;27(4):740-756. doi: 10.1016/j.cmet.2018.03.001. Review.

17.

Sitagliptin Accelerates Endothelial Regeneration after Vascular Injury Independent from GLP1 Receptor Signaling.

Remm F, Kränkel N, Lener D, Drucker DJ, Sopper S, Brenner C.

Stem Cells Int. 2018 Feb 8;2018:5284963. doi: 10.1155/2018/5284963. eCollection 2018.

18.

GLP-1 Receptor Expression Within the Human Heart.

Baggio LL, Yusta B, Mulvihill EE, Cao X, Streutker CJ, Butany J, Cappola TP, Margulies KB, Drucker DJ.

Endocrinology. 2018 Apr 1;159(4):1570-1584. doi: 10.1210/en.2018-00004.

19.

GLP-1 release and vagal afferent activation mediate the beneficial metabolic and chronotherapeutic effects of D-allulose.

Iwasaki Y, Sendo M, Dezaki K, Hira T, Sato T, Nakata M, Goswami C, Aoki R, Arai T, Kumari P, Hayakawa M, Masuda C, Okada T, Hara H, Drucker DJ, Yamada Y, Tokuda M, Yada T.

Nat Commun. 2018 Jan 9;9(1):113. doi: 10.1038/s41467-017-02488-y.

20.

Body weight homeostat that regulates fat mass independently of leptin in rats and mice.

Jansson JO, Palsdottir V, Hägg DA, Schéle E, Dickson SL, Anesten F, Bake T, Montelius M, Bellman J, Johansson ME, Cone RD, Drucker DJ, Wu J, Aleksic B, Törnqvist AE, Sjögren K, Gustafsson JÅ, Windahl SH, Ohlsson C.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):427-432. doi: 10.1073/pnas.1715687114. Epub 2017 Dec 26.

21.

Inactivation of the Glucose-Dependent Insulinotropic Polypeptide Receptor Improves Outcomes following Experimental Myocardial Infarction.

Ussher JR, Campbell JE, Mulvihill EE, Baggio LL, Bates HE, McLean BA, Gopal K, Capozzi M, Yusta B, Cao X, Ali S, Kim M, Kabir MG, Seino Y, Suzuki J, Drucker DJ.

Cell Metab. 2018 Feb 6;27(2):450-460.e6. doi: 10.1016/j.cmet.2017.11.003. Epub 2017 Dec 21.

22.

Discovery, characterization, and clinical development of the glucagon-like peptides.

Drucker DJ, Habener JF, Holst JJ.

J Clin Invest. 2017 Dec 1;127(12):4217-4227. doi: 10.1172/JCI97233. Epub 2017 Dec 1. Review.

23.

The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice.

Baggio LL, Ussher JR, McLean BA, Cao X, Kabir MG, Mulvihill EE, Mighiu AS, Zhang H, Ludwig A, Seeley RJ, Heximer SP, Drucker DJ.

Mol Metab. 2017 Nov;6(11):1339-1349. doi: 10.1016/j.molmet.2017.08.010. Epub 2017 Sep 1.

24.

Enteroendocrine L Cells Sense LPS after Gut Barrier Injury to Enhance GLP-1 Secretion.

Lebrun LJ, Lenaerts K, Kiers D, Pais de Barros JP, Le Guern N, Plesnik J, Thomas C, Bourgeois T, Dejong CHC, Kox M, Hundscheid IHR, Khan NA, Mandard S, Deckert V, Pickkers P, Drucker DJ, Lagrost L, Grober J.

Cell Rep. 2017 Oct 31;21(5):1160-1168. doi: 10.1016/j.celrep.2017.10.008.

25.

Cardiovascular Actions and Clinical Outcomes With Glucagon-Like Peptide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibitors.

Nauck MA, Meier JJ, Cavender MA, Abd El Aziz M, Drucker DJ.

Circulation. 2017 Aug 29;136(9):849-870. doi: 10.1161/CIRCULATIONAHA.117.028136. Review.

PMID:
28847797
26.

Erratum. Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1α1-67 in Patients With Type 2 Diabetes. Diabetes Care 2017;40:1073-1081.

Lovshin JA, Rajasekeran H, Lytvyn Y, Lovblom LE, Khan S, Alemu R, Locke A, Lai V, He H, Hittle L, Wang W, Drucker DJ, Cherney DZI.

Diabetes Care. 2017 Oct;40(10):1420-1421. doi: 10.2337/dc17-er10b. Epub 2017 Aug 25. No abstract available.

27.

The endogenous preproglucagon system is not essential for gut growth homeostasis in mice.

Wismann P, Barkholt P, Secher T, Vrang N, Hansen HB, Jeppesen PB, Baggio LL, Koehler JA, Drucker DJ, Sandoval DA, Jelsing J.

Mol Metab. 2017 Apr 27;6(7):681-692. doi: 10.1016/j.molmet.2017.04.007. eCollection 2017 Jul.

28.

Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathway.

Yusta B, Matthews D, Flock GB, Ussher JR, Lavoie B, Mawe GM, Drucker DJ.

Mol Metab. 2017 Mar 31;6(6):503-511. doi: 10.1016/j.molmet.2017.03.006. eCollection 2017 Jun.

29.

Dipeptidyl Peptidase 4 Inhibition Stimulates Distal Tubular Natriuresis and Increases in Circulating SDF-1α1-67 in Patients With Type 2 Diabetes.

Lovshin JA, Rajasekeran H, Lytvyn Y, Lovblom LE, Khan S, Alemu R, Locke A, Lai V, He H, Hittle L, Wang W, Drucker DJ, Cherney DZI.

Diabetes Care. 2017 Aug;40(8):1073-1081. doi: 10.2337/dc17-0061. Epub 2017 May 26. Erratum in: Diabetes Care. 2017 Aug 25;:.

PMID:
28550195
30.

The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.

Chambers AP, Sorrell JE, Haller A, Roelofs K, Hutch CR, Kim KS, Gutierrez-Aguilar R, Li B, Drucker DJ, D'Alessio DA, Seeley RJ, Sandoval DA.

Cell Metab. 2017 Apr 4;25(4):927-934.e3. doi: 10.1016/j.cmet.2017.02.008. Epub 2017 Mar 16.

31.

Enteroendocrine-derived glucagon-like peptide-2 controls intestinal amino acid transport.

Lee J, Koehler J, Yusta B, Bahrami J, Matthews D, Rafii M, Pencharz PB, Drucker DJ.

Mol Metab. 2017 Jan 17;6(3):245-255. doi: 10.1016/j.molmet.2017.01.005. eCollection 2017 Mar.

32.

β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation.

Panaro BL, Flock GB, Campbell JE, Beaudry JL, Cao X, Drucker DJ.

Diabetes. 2017 Jun;66(6):1626-1635. doi: 10.2337/db17-0017. Epub 2017 Mar 2.

33.

The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice.

Burmeister MA, Ayala JE, Smouse H, Landivar-Rocha A, Brown JD, Drucker DJ, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE.

Diabetes. 2017 Feb;66(2):372-384. doi: 10.2337/db16-1102. Epub 2016 Dec 1.

34.

Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis.

Mulvihill EE, Varin EM, Gladanac B, Campbell JE, Ussher JR, Baggio LL, Yusta B, Ayala J, Burmeister MA, Matthews D, Bang KWA, Ayala JE, Drucker DJ.

Cell Metab. 2017 Jan 10;25(1):152-165. doi: 10.1016/j.cmet.2016.10.007. Epub 2016 Nov 10.

35.

Vascular Biology of Glucagon Receptor Superfamily Peptides: Mechanistic and Clinical Relevance.

Pujadas G, Drucker DJ.

Endocr Rev. 2016 Dec;37(6):554-583. Epub 2016 Oct 12. Review.

PMID:
27732058
36.

Fibroblast activation protein (FAP) as a novel metabolic target.

Sánchez-Garrido MA, Habegger KM, Clemmensen C, Holleman C, Müller TD, Perez-Tilve D, Li P, Agrawal AS, Finan B, Drucker DJ, Tschöp MH, DiMarchi RD, Kharitonenkov A.

Mol Metab. 2016 Jul 16;5(10):1015-1024. doi: 10.1016/j.molmet.2016.07.003. eCollection 2016 Oct.

37.

Microbially produced glucagon-like peptide 1 improves glucose tolerance in mice.

Arora T, Wegmann U, Bobhate A, Lee YS, Greiner TU, Drucker DJ, Narbad A, Bäckhed F.

Mol Metab. 2016 Jun 22;5(8):725-730. doi: 10.1016/j.molmet.2016.06.006. eCollection 2016 Aug.

38.

Never Waste a Good Crisis: Confronting Reproducibility in Translational Research.

Drucker DJ.

Cell Metab. 2016 Sep 13;24(3):348-360. doi: 10.1016/j.cmet.2016.08.006.

39.

iNKT Cells Induce FGF21 for Thermogenesis and Are Required for Maximal Weight Loss in GLP1 Therapy.

Lynch L, Hogan AE, Duquette D, Lester C, Banks A, LeClair K, Cohen DE, Ghosh A, Lu B, Corrigan M, Stevanovic D, Maratos-Flier E, Drucker DJ, O'Shea D, Brenner M.

Cell Metab. 2016 Sep 13;24(3):510-519. doi: 10.1016/j.cmet.2016.08.003. Epub 2016 Sep 1.

40.

Stromal cell-derived factor-1 is upregulated by dipeptidyl peptidase-4 inhibition and has protective roles in progressive diabetic nephropathy.

Takashima S, Fujita H, Fujishima H, Shimizu T, Sato T, Morii T, Tsukiyama K, Narita T, Takahashi T, Drucker DJ, Seino Y, Yamada Y.

Kidney Int. 2016 Oct;90(4):783-96. doi: 10.1016/j.kint.2016.06.012. Epub 2016 Jul 27.

PMID:
27475229
41.

The Cardiovascular Biology of Glucagon-like Peptide-1.

Drucker DJ.

Cell Metab. 2016 Jul 12;24(1):15-30. doi: 10.1016/j.cmet.2016.06.009. Epub 2016 Jun 23. Review.

42.

Inhibition of Dipeptidyl Peptidase-4 Impairs Ventricular Function and Promotes Cardiac Fibrosis in High Fat-Fed Diabetic Mice.

Mulvihill EE, Varin EM, Ussher JR, Campbell JE, Bang KW, Abdullah T, Baggio LL, Drucker DJ.

Diabetes. 2016 Mar;65(3):742-54. doi: 10.2337/db15-1224. Epub 2015 Dec 15.

43.

Evolving Concepts and Translational Relevance of Enteroendocrine Cell Biology.

Drucker DJ.

J Clin Endocrinol Metab. 2016 Mar;101(3):778-86. doi: 10.1210/jc.2015-3449. Epub 2015 Dec 9. Review.

PMID:
26649620
44.

TCF1 links GIPR signaling to the control of beta cell function and survival.

Campbell JE, Ussher JR, Mulvihill EE, Kolic J, Baggio LL, Cao X, Liu Y, Lamont BJ, Morii T, Streutker CJ, Tamarina N, Philipson LH, Wrana JL, MacDonald PE, Drucker DJ.

Nat Med. 2016 Jan;22(1):84-90. doi: 10.1038/nm.3997. Epub 2015 Dec 7.

PMID:
26642437
45.

The past 10 years-new hormones, new functions, new endocrine organs.

Bouillon R, Drucker DJ, Ferrannini E, Grinspoon S, Rosen CJ, Zimmet P.

Nat Rev Endocrinol. 2015 Nov;11(11):681-6. doi: 10.1038/nrendo.2015.142. Epub 2015 Sep 1. Review.

PMID:
26323661
46.

FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.

Claussnitzer M, Dankel SN, Kim KH, Quon G, Meuleman W, Haugen C, Glunk V, Sousa IS, Beaudry JL, Puviindran V, Abdennur NA, Liu J, Svensson PA, Hsu YH, Drucker DJ, Mellgren G, Hui CC, Hauner H, Kellis M.

N Engl J Med. 2015 Sep 3;373(10):895-907. doi: 10.1056/NEJMoa1502214. Epub 2015 Aug 19.

47.

Phenotypic Characterization of MIP-CreERT1Lphi Mice With Transgene-Driven Islet Expression of Human Growth Hormone.

Oropeza D, Jouvet N, Budry L, Campbell JE, Bouyakdan K, Lacombe J, Perron G, Bergeron V, Neuman JC, Brar HK, Fenske RJ, Meunier C, Sczelecki S, Kimple ME, Drucker DJ, Screaton RA, Poitout V, Ferron M, Alquier T, Estall JL.

Diabetes. 2015 Nov;64(11):3798-807. doi: 10.2337/db15-0272. Epub 2015 Jul 7.

48.

Islet α cells and glucagon--critical regulators of energy homeostasis.

Campbell JE, Drucker DJ.

Nat Rev Endocrinol. 2015 Jun;11(6):329-38. doi: 10.1038/nrendo.2015.51. Epub 2015 Apr 7. Review.

PMID:
25850661
49.

Oxyntomodulin regulates resetting of the liver circadian clock by food.

Landgraf D, Tsang AH, Leliavski A, Koch CE, Barclay JL, Drucker DJ, Oster H.

Elife. 2015 Mar 30;4:e06253. doi: 10.7554/eLife.06253.

50.

GLP-1R agonists promote normal and neoplastic intestinal growth through mechanisms requiring Fgf7.

Koehler JA, Baggio LL, Yusta B, Longuet C, Rowland KJ, Cao X, Holland D, Brubaker PL, Drucker DJ.

Cell Metab. 2015 Mar 3;21(3):379-91. doi: 10.1016/j.cmet.2015.02.005.

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