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Items: 1 to 50 of 87

1.

Fhit-Fdxr interaction in the mitochondria: modulation of reactive oxygen species generation and apoptosis in cancer cells.

Druck T, Cheung DG, Park D, Trapasso F, Pichiorri F, Gaspari M, Palumbo T, Aqeilan RI, Gaudio E, Okumura H, Iuliano R, Raso C, Green K, Huebner K, Croce CM.

Cell Death Dis. 2019 Feb 15;10(3):147. doi: 10.1038/s41419-019-1414-7.

2.

The ubiquitous 'cancer mutational signature' 5 occurs specifically in cancers with deleted FHIT alleles.

Volinia S, Druck T, Paisie CA, Schrock MS, Huebner K.

Oncotarget. 2017 Nov 6;8(60):102199-102211. doi: 10.18632/oncotarget.22321. eCollection 2017 Nov 24.

3.

Identification of Fhit as a post-transcriptional effector of Thymidine Kinase 1 expression.

Kiss DL, Waters CE, Ouda IM, Saldivar JC, Karras JR, Amin ZA, Mahrous S, Druck T, Bundschuh RA, Schoenberg DR, Huebner K.

Biochim Biophys Acta Gene Regul Mech. 2017 Mar;1860(3):374-382. doi: 10.1016/j.bbagrm.2017.01.005. Epub 2017 Jan 14.

4.

Wwox-Brca1 interaction: role in DNA repair pathway choice.

Schrock MS, Batar B, Lee J, Druck T, Ferguson B, Cho JH, Akakpo K, Hagrass H, Heerema NA, Xia F, Parvin JD, Aldaz CM, Huebner K.

Oncogene. 2017 Apr 20;36(16):2215-2227. doi: 10.1038/onc.2016.389. Epub 2016 Nov 21.

5.

Fhit and Wwox loss-associated genome instability: A genome caretaker one-two punch.

Schrock MS, Karras JR, Guggenbiller MJ, Druck T, Batar B, Huebner K.

Adv Biol Regul. 2017 Jan;63:167-176. doi: 10.1016/j.jbior.2016.09.008. Epub 2016 Sep 26.

PMID:
27773744
6.

Fhit loss-associated initiation and progression of neoplasia in vitro.

Karras JR, Schrock MS, Batar B, Zhang J, La Perle K, Druck T, Huebner K.

Cancer Sci. 2016 Nov;107(11):1590-1598. doi: 10.1111/cas.13032. Epub 2016 Oct 3.

7.

Reduction in squamous cell carcinomas in mouse skin by dietary zinc supplementation.

Sun J, Shen R, Schrock MS, Liu J, Pan X, Quimby D, Zanesi N, Druck T, Fong LY, Huebner K.

Cancer Med. 2016 Aug;5(8):2032-42. doi: 10.1002/cam4.768. Epub 2016 May 17.

8.

Exome-wide single-base substitutions in tissues and derived cell lines of the constitutive Fhit knockout mouse.

Paisie CA, Schrock MS, Karras JR, Zhang J, Miuma S, Ouda IM, Waters CE, Saldivar JC, Druck T, Huebner K.

Cancer Sci. 2016 Apr;107(4):528-35. doi: 10.1111/cas.12887. Epub 2016 Feb 23.

9.

Fhit deficiency-induced global genome instability promotes mutation and clonal expansion.

Miuma S, Saldivar JC, Karras JR, Waters CE, Paisie CA, Wang Y, Jin V, Sun J, Druck T, Zhang J, Huebner K.

PLoS One. 2013 Nov 14;8(11):e80730. doi: 10.1371/journal.pone.0080730. eCollection 2013.

10.

Effect of zinc supplementation on N-nitrosomethylbenzylamine-induced forestomach tumor development and progression in tumor suppressor-deficient mouse strains.

Sun J, Liu J, Pan X, Quimby D, Zanesi N, Druck T, Pfeifer GP, Croce CM, Fong LY, Huebner K.

Carcinogenesis. 2011 Mar;32(3):351-8. doi: 10.1093/carcin/bgq251. Epub 2010 Nov 19.

11.

Hits, Fhits and Nits: beyond enzymatic function.

Huebner K, Saldivar JC, Sun J, Shibata H, Druck T.

Adv Enzyme Regul. 2011;51(1):208-17. doi: 10.1016/j.advenzreg.2010.09.003. Epub 2010 Oct 28. Review.

12.

Nit1 and Fhit tumor suppressor activities are additive.

Sun J, Okumura H, Yearsley M, Frankel W, Fong LY, Druck T, Huebner K.

J Cell Biochem. 2009 Aug 15;107(6):1097-106. doi: 10.1002/jcb.22207.

13.

Correlation of fragile histidine triad (Fhit) protein structural features with effector interactions and biological functions.

Pichiorri F, Okumura H, Nakamura T, Garrison PN, Gasparini P, Suh SS, Druck T, McCorkell KA, Barnes LD, Croce CM, Huebner K.

J Biol Chem. 2009 Jan 9;284(2):1040-9. doi: 10.1074/jbc.M806638200. Epub 2008 Nov 12.

14.

Fhit-deficient hematopoietic stem cells survive hydroquinone exposure carrying precancerous changes.

Ishii H, Mimori K, Ishikawa K, Okumura H, Pichiorri F, Druck T, Inoue H, Vecchione A, Saito T, Mori M, Huebner K.

Cancer Res. 2008 May 15;68(10):3662-70. doi: 10.1158/0008-5472.CAN-07-5687.

15.

Influence of a nonfragile FHIT transgene on murine tumor susceptibility.

McCorkell KA, Mancini R, Siprashvili Z, Barnoski BL, Iliopoulos D, Siracusa LD, Zanesi N, Croce CM, Fong LY, Druck T, Huebner K.

Cytogenet Genome Res. 2007;118(2-4):196-203.

PMID:
18000371
16.

Wwox suppresses prostate cancer cell growth through modulation of ErbB2-mediated androgen receptor signaling.

Qin HR, Iliopoulos D, Nakamura T, Costinean S, Volinia S, Druck T, Sun J, Okumura H, Huebner K.

Mol Cancer Res. 2007 Sep;5(9):957-65. Epub 2007 Aug 17.

17.

Inhibition of breast cancer cell growth in vitro and in vivo: effect of restoration of Wwox expression.

Iliopoulos D, Fabbri M, Druck T, Qin HR, Han SY, Huebner K.

Clin Cancer Res. 2007 Jan 1;13(1):268-74.

18.

Fhit modulates the DNA damage checkpoint response.

Ishii H, Mimori K, Inoue H, Inageta T, Ishikawa K, Semba S, Druck T, Trapasso F, Tani K, Vecchione A, Croce CM, Mori M, Huebner K.

Cancer Res. 2006 Dec 1;66(23):11287-92.

19.

Epigenetic modulation of endogenous tumor suppressor expression in lung cancer xenografts suppresses tumorigenicity.

Cantor JP, Iliopoulos D, Rao AS, Druck T, Semba S, Han SY, McCorkell KA, Lakshman TV, Collins JE, Wachsberger P, Friedberg JS, Huebner K.

Int J Cancer. 2007 Jan 1;120(1):24-31.

20.

Biological functions of mammalian Nit1, the counterpart of the invertebrate NitFhit Rosetta stone protein, a possible tumor suppressor.

Semba S, Han SY, Qin HR, McCorkell KA, Iliopoulos D, Pekarsky Y, Druck T, Trapasso F, Croce CM, Huebner K.

J Biol Chem. 2006 Sep 22;281(38):28244-53. Epub 2006 Jul 24.

21.

A role for the WWOX gene in prostate cancer.

Qin HR, Iliopoulos D, Semba S, Fabbri M, Druck T, Volinia S, Croce CM, Morrison CD, Klein RD, Huebner K.

Cancer Res. 2006 Jul 1;66(13):6477-81.

22.

Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential.

Semba S, Trapasso F, Fabbri M, McCorkell KA, Volinia S, Druck T, Iliopoulos D, Pekarsky Y, Ishii H, Garrison PN, Barnes LD, Croce CM, Huebner K.

Oncogene. 2006 May 11;25(20):2860-72.

PMID:
16407838
23.

Roles of FHIT and WWOX fragile genes in cancer.

Iliopoulos D, Guler G, Han SY, Druck T, Ottey M, McCorkell KA, Huebner K.

Cancer Lett. 2006 Jan 28;232(1):27-36. Epub 2005 Oct 12. Review.

PMID:
16225988
24.

Fragile genes as biomarkers: epigenetic control of WWOX and FHIT in lung, breast and bladder cancer.

Iliopoulos D, Guler G, Han SY, Johnston D, Druck T, McCorkell KA, Palazzo J, McCue PA, Baffa R, Huebner K.

Oncogene. 2005 Feb 24;24(9):1625-33.

PMID:
15674328
25.

Fhit-deficient normal and cancer cells are mitomycin C and UVC resistant.

Ottey M, Han SY, Druck T, Barnoski BL, McCorkell KA, Croce CM, Raventos-Suarez C, Fairchild CR, Wang Y, Huebner K.

Br J Cancer. 2004 Nov 1;91(9):1669-77.

26.

Functional association between Wwox tumor suppressor protein and p73, a p53 homolog.

Aqeilan RI, Pekarsky Y, Herrero JJ, Palamarchuk A, Letofsky J, Druck T, Trapasso F, Han SY, Melino G, Huebner K, Croce CM.

Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4401-6.

27.

CpG methylation in the Fhit regulatory region: relation to Fhit expression in murine tumors.

Han SY, Iliopoulos D, Druck T, Guler G, Grubbs CJ, Pereira M, Zhang Z, You M, Lubet RA, Fong LY, Huebner K.

Oncogene. 2004 May 13;23(22):3990-8.

PMID:
15007387
28.

Expression of FRA16D/WWOX and FRA3B/FHIT genes in hematopoietic malignancies.

Ishii H, Vecchione A, Furukawa Y, Sutheesophon K, Han SY, Druck T, Kuroki T, Trapasso F, Nishimura M, Saito Y, Ozawa K, Croce CM, Huebner K, Furukawa Y.

Mol Cancer Res. 2003 Nov;1(13):940-7.

29.
30.

Characterization of a familial RCC-associated t(2;3)(q33;q21) chromosome translocation.

Podolski J, Byrski T, Zajaczek S, Druck T, Zimonjic DB, Popescu NC, Kata G, Borowka A, Gronwald J, Lubinski J, Huebner K.

J Hum Genet. 2001;46(12):685-93.

PMID:
11776380
31.

The DIRC1 gene at chromosome 2q33 spans a familial RCC-associated t(2;3)(q33;q21) chromosome translocation.

Druck T, Podolski J, Byrski T, Wyrwicz L, Zajaczek S, Kata G, Borowka A, Lubinski J, Huebner K.

J Hum Genet. 2001;46(10):583-9.

PMID:
11587072
32.

The tumor spectrum in FHIT-deficient mice.

Zanesi N, Fidanza V, Fong LY, Mancini R, Druck T, Valtieri M, RĂ¼diger T, McCue PA, Croce CM, Huebner K.

Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10250-5. Epub 2001 Aug 21.

33.

Fragile histidine triad expression delays tumor development and induces apoptosis in human pancreatic cancer.

Dumon KR, Ishii H, Vecchione A, Trapasso F, Baldassarre G, Chakrani F, Druck T, Rosato EF, Williams NN, Baffa R, During MJ, Huebner K, Croce CM.

Cancer Res. 2001 Jun 15;61(12):4827-36.

34.

Sequence conservation at human and mouse orthologous common fragile regions, FRA3B/FHIT and Fra14A2/Fhit.

Shiraishi T, Druck T, Mimori K, Flomenberg J, Berk L, Alder H, Miller W, Huebner K, Croce CM.

Proc Natl Acad Sci U S A. 2001 May 8;98(10):5722-7. Epub 2001 Apr 24.

35.

Analyzing the FHIT Gene by RT-PCR, Western Blotting, and Immunohistochemistry.

Baffa R, Calviello CM, Druck T, Gomella LG.

Methods Mol Med. 2001;53:81-93. doi: 10.1385/1-59259-144-2:081.

PMID:
21318789
36.

Muir-Torre-like syndrome in Fhit-deficient mice.

Fong LY, Fidanza V, Zanesi N, Lock LF, Siracusa LD, Mancini R, Siprashvili Z, Ottey M, Martin SE, Druck T, McCue PA, Croce CM, Huebner K.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4742-7.

37.

Cancer-specific chromosome alterations in the constitutive fragile region FRA3B.

Mimori K, Druck T, Inoue H, Alder H, Berk L, Mori M, Huebner K, Croce CM.

Proc Natl Acad Sci U S A. 1999 Jun 22;96(13):7456-61. Erratum in: Proc Natl Acad Sci U S A 1999 Sep 14;96(19):10944.

38.

FHITness and cancer.

Druck T, Berk L, Huebner K.

Oncol Res. 1998;10(7):341-5. Review.

PMID:
10063967
39.

The role of deletions at the FRA3B/FHIT locus in carcinogenesis.

Huebner K, Druck T, Siprashvili Z, Croce CM, Kovatich A, McCue PA.

Recent Results Cancer Res. 1998;154:200-15.

PMID:
10027001
40.

Molecular alterations to human chromosome 3p loci in neuroendocrine lung tumors.

Kovatich A, Friedland DM, Druck T, Hadaczek P, Huebner K, Comis RL, Hauck W, McCue PA.

Cancer. 1998 Sep 15;83(6):1109-17.

PMID:
9740075
41.

The murine Fhit locus: isolation, characterization, and expression in normal and tumor cells.

Pekarsky Y, Druck T, Cotticelli MG, Ohta M, Shou J, Mendrola J, Montgomery JC, Buchberg AM, Siracusa LD, Manenti G, Fong LY, Dragani TA, Croce CM, Huebner K.

Cancer Res. 1998 Aug 1;58(15):3401-8.

42.

Absence or reduction of Fhit expression in most clear cell renal carcinomas.

Hadaczek P, Siprashvili Z, Markiewski M, Domagala W, Druck T, McCue PA, Pekarsky Y, Ohta M, Huebner K, Lubinski J.

Cancer Res. 1998 Jul 15;58(14):2946-51.

43.

Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans.

Pekarsky Y, Campiglio M, Siprashvili Z, Druck T, Sedkov Y, Tillib S, Draganescu A, Wermuth P, Rothman JH, Huebner K, Buchberg AM, Mazo A, Brenner C, Croce CM.

Proc Natl Acad Sci U S A. 1998 Jul 21;95(15):8744-9.

44.

Sequence of the FRA3B common fragile region: implications for the mechanism of FHIT deletion.

Inoue H, Ishii H, Alder H, Snyder E, Druck T, Huebner K, Croce CM.

Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14584-9.

45.

Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.

Prasad R, Zhadanov AB, Sedkov Y, Bullrich F, Druck T, Rallapalli R, Yano T, Alder H, Croce CM, Huebner K, Mazo A, Canaani E.

Oncogene. 1997 Jul 31;15(5):549-60.

46.

The FHIT gene, a multiple tumor suppressor gene encompassing the carcinogen sensitive chromosome fragile site, FRA3B.

Huebner K, Hadaczek P, Siprashvili Z, Druck T, Croce CM.

Biochim Biophys Acta. 1997 Jun 7;1332(3):M65-70. Review. No abstract available.

PMID:
9196019
47.

Gene structure, promoter activity, and chromosomal location of the DR-nm23 gene, a related member of the nm23 gene family.

Martinez R, Venturelli D, Perrotti D, Veronese ML, Kastury K, Druck T, Huebner K, Calabretta B.

Cancer Res. 1997 Mar 15;57(6):1180-7.

48.

Positions of chromosome 3p14.2 fragile sites (FRA3B) within the FHIT gene.

Zimonjic DB, Druck T, Ohta M, Kastury K, Croce CM, Popescu NC, Huebner K.

Cancer Res. 1997 Mar 15;57(6):1166-70.

49.

Identification of a conserved family of Meis1-related homeobox genes.

Steelman S, Moskow JJ, Muzynski K, North C, Druck T, Montgomery JC, Huebner K, Daar IO, Buchberg AM.

Genome Res. 1997 Feb;7(2):142-56.

50.

Structure and expression of the human FHIT gene in normal and tumor cells.

Druck T, Hadaczek P, Fu TB, Ohta M, Siprashvili Z, Baffa R, Negrini M, Kastury K, Veronese ML, Rosen D, Rothstein J, McCue P, Cotticelli MG, Inoue H, Croce CM, Huebner K.

Cancer Res. 1997 Feb 1;57(3):504-12.

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