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Reducing the serine availability complements the inhibition of the glutamine metabolism to block leukemia cell growth.

Polet F, Corbet C, Pinto A, Rubio LI, Martherus R, Bol V, Drozak X, Grégoire V, Riant O, Feron O.

Oncotarget. 2016 Jan 12;7(2):1765-76. doi: 10.18632/oncotarget.6426.


The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.

Corbet C, Draoui N, Polet F, Pinto A, Drozak X, Riant O, Feron O.

Cancer Res. 2014 Oct 1;74(19):5507-19. doi: 10.1158/0008-5472.CAN-14-0705. Epub 2014 Aug 1.


Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells.

Draoui N, Schicke O, Fernandes A, Drozak X, Nahra F, Dumont A, Douxfils J, Hermans E, Dogné JM, Corbau R, Marchand A, Chaltin P, Sonveaux P, Feron O, Riant O.

Bioorg Med Chem. 2013 Nov 15;21(22):7107-17. doi: 10.1016/j.bmc.2013.09.010. Epub 2013 Sep 13.


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