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Items: 11


High Proliferation Rate and a Compromised Spindle Assembly Checkpoint Confers Sensitivity to the MPS1 Inhibitor BOS172722 in Triple-Negative Breast Cancers.

Anderhub SJ, Mak GW, Gurden MD, Faisal A, Drosopoulos K, Walsh K, Woodward HL, Innocenti P, Westwood IM, Naud S, Hayes A, Theofani E, Filosto S, Saville H, Burke R, van Montfort RLM, Raynaud FI, Blagg J, Hoelder S, Eccles SA, Linardopoulos S.

Mol Cancer Ther. 2019 Oct;18(10):1696-1707. doi: 10.1158/1535-7163.MCT-18-1203.


Integration of RNAi and Small Molecule Screens to Identify Targets for Drug Development.

Drosopoulos K, Linardopoulos S.

Methods Mol Biol. 2019;1953:33-42. doi: 10.1007/978-1-4939-9145-7_3.


Integrated genomics and functional validation identifies malignant cell specific dependencies in triple negative breast cancer.

Patel N, Weekes D, Drosopoulos K, Gazinska P, Noel E, Rashid M, Mirza H, Quist J, Brasó-Maristany F, Mathew S, Ferro R, Pereira AM, Prince C, Noor F, Francesch-Domenech E, Marlow R, de Rinaldis E, Grigoriadis A, Linardopoulos S, Marra P, Tutt ANJ.

Nat Commun. 2018 Mar 13;9(1):1044. doi: 10.1038/s41467-018-03283-z.


RNAi screen reveals synthetic lethality between cyclin G-associated kinase and FBXW7 by inducing aberrant mitoses.

Dolly SO, Gurden MD, Drosopoulos K, Clarke P, de Bono J, Kaye S, Workman P, Linardopoulos S.

Br J Cancer. 2017 Sep 26;117(7):954-964. doi: 10.1038/bjc.2017.277. Epub 2017 Aug 22.


APC/C is an essential regulator of centrosome clustering.

Drosopoulos K, Tang C, Chao WC, Linardopoulos S.

Nat Commun. 2014 Apr 22;5:3686. doi: 10.1038/ncomms4686.


Integration of RNAi and small molecule screens to identify targets for drug development.

Drosopoulos K, Linardopoulos S.

Methods Mol Biol. 2013;986:97-104. doi: 10.1007/978-1-62703-311-4_7.


A cancer-associated aurora A mutant is mislocalized and misregulated due to loss of interaction with TPX2.

Bibby RA, Tang C, Faisal A, Drosopoulos K, Lubbe S, Houlston R, Bayliss R, Linardopoulos S.

J Biol Chem. 2009 Nov 27;284(48):33177-84. doi: 10.1074/jbc.M109.032722. Epub 2009 Oct 2.


Quercetin enhances TRAIL-mediated apoptosis in colon cancer cells by inducing the accumulation of death receptors in lipid rafts.

Psahoulia FH, Drosopoulos KG, Doubravska L, Andera L, Pintzas A.

Mol Cancer Ther. 2007 Sep;6(9):2591-9.


Multifaceted targeting in cancer: the recent cell death players meet the usual oncogene suspects.

Drosopoulos K, Pintzas A.

Expert Opin Ther Targets. 2007 May;11(5):641-59. Review.


Microarray analysis of the differential transformation mediated by Kirsten and Harvey Ras oncogenes in a human colorectal adenocarcinoma cell line.

Roberts ML, Drosopoulos KG, Vasileiou I, Stricker M, Taoufik E, Maercker C, Guialis A, Alexis MN, Pintzas A.

Int J Cancer. 2006 Feb 1;118(3):616-27.


Transformation by oncogenic RAS sensitizes human colon cells to TRAIL-induced apoptosis by up-regulating death receptor 4 and death receptor 5 through a MEK-dependent pathway.

Drosopoulos KG, Roberts ML, Cermak L, Sasazuki T, Shirasawa S, Andera L, Pintzas A.

J Biol Chem. 2005 Jun 17;280(24):22856-67. Epub 2005 Mar 8.

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