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Items: 28


Genetic and Environmental Determinants of Immune Response to Cutaneous Melanoma.

Poźniak J, Nsengimana J, Laye JP, O'Shea SJ, Diaz JMS, Droop AP, Filia A, Harland M, Davies JR, Mell T, Randerson-Moor JA, Muralidhar S, Hogan SA, Freiberger SN, Levesque MP, Cook GP, Bishop DT, Newton-Bishop J.

Cancer Res. 2019 Feb 17. doi: 10.1158/0008-5472.CAN-18-2864. [Epub ahead of print]


Simulation of Heterogeneous Tumour Genomes with HeteroGenesis and In Silico Whole Exome Sequencing.

Tanner G, Westhead DR, Droop A, Stead LF.

Bioinformatics. 2019 Jan 4. doi: 10.1093/bioinformatics/bty1063. [Epub ahead of print]


Phenotype-independent DNA methylation changes in prostate cancer.

Pellacani D, Droop AP, Frame FM, Simms MS, Mann VM, Collins AT, Eaves CJ, Maitland NJ.

Br J Cancer. 2018 Oct;119(9):1133-1143. doi: 10.1038/s41416-018-0236-1. Epub 2018 Oct 15.


Disrupted alternative splicing for genes implicated in splicing and ciliogenesis causes PRPF31 retinitis pigmentosa.

Buskin A, Zhu L, Chichagova V, Basu B, Mozaffari-Jovin S, Dolan D, Droop A, Collin J, Bronstein R, Mehrotra S, Farkas M, Hilgen G, White K, Pan KT, Treumann A, Hallam D, Bialas K, Chung G, Mellough C, Ding Y, Krasnogor N, Przyborski S, Zwolinski S, Al-Aama J, Alharthi S, Xu Y, Wheway G, Szymanska K, McKibbin M, Inglehearn CF, Elliott DJ, Lindsay S, Ali RR, Steel DH, Armstrong L, Sernagor E, Urlaub H, Pierce E, Lührmann R, Grellscheid SN, Johnson CA, Lako M.

Nat Commun. 2018 Oct 12;9(1):4234. doi: 10.1038/s41467-018-06448-y.


KHS101 disrupts energy metabolism in human glioblastoma cells and reduces tumor growth in mice.

Polson ES, Kuchler VB, Abbosh C, Ross EM, Mathew RK, Beard HA, da Silva B, Holding AN, Ballereau S, Chuntharpursat-Bon E, Williams J, Griffiths HBS, Shao H, Patel A, Davies AJ, Droop A, Chumas P, Short SC, Lorger M, Gestwicki JE, Roberts LD, Bon RS, Allison SJ, Zhu S, Markowetz F, Wurdak H.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaar2718. doi: 10.1126/scitranslmed.aar2718.


Stanniocalcin 2 expression is associated with a favourable outcome in male breast cancer.

Coulson-Gilmer C, Humphries MP, Sundara Rajan S, Droop A, Jackson S, Condon A, Cserni G, Jordan LB, Jones LJ, Kanthan R, Di Benedetto A, Mottolese M, Provenzano E, Kulka J, Shaaban AM, Hanby AM, Speirs V.

J Pathol Clin Res. 2018 Oct;4(4):241-249. doi: 10.1002/cjp2.106. Epub 2018 Aug 23.


β-Catenin-mediated immune evasion pathway frequently operates in primary cutaneous melanomas.

Nsengimana J, Laye J, Filia A, O'Shea S, Muralidhar S, Poźniak J, Droop A, Chan M, Walker C, Parkinson L, Gascoyne J, Mell T, Polso M, Jewell R, Randerson-Moor J, Cook GP, Bishop DT, Newton-Bishop J.

J Clin Invest. 2018 May 1;128(5):2048-2063. doi: 10.1172/JCI95351. Epub 2018 Apr 16.


How to analyse the spatiotemporal tumour samples needed to investigate cancer evolution: A case study using paired primary and recurrent glioblastoma.

Droop A, Bruns A, Tanner G, Rippaus N, Morton R, Harrison S, King H, Ashton K, Syed K, Jenkinson MD, Brodbelt A, Chakrabarty A, Ismail A, Short S, Stead LF.

Int J Cancer. 2018 Apr 15;142(8):1620-1626. doi: 10.1002/ijc.31184. Epub 2017 Dec 14.


Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency.

Hurst CD, Alder O, Platt FM, Droop A, Stead LF, Burns JE, Burghel GJ, Jain S, Klimczak LJ, Lindsay H, Roulson JA, Taylor CF, Thygesen H, Cameron AJ, Ridley AJ, Mott HR, Gordenin DA, Knowles MA.

Cancer Cell. 2017 Nov 13;32(5):701-715.e7. doi: 10.1016/j.ccell.2017.08.005.


A Detailed Analysis of Gene Expression in Human Basal, Luminal, and Stromal Cell Populations from Benign Prostatic Hyperplasia Tissues and Comparisons with Cultured Basal Cells.

Rane JK, Droop AP, Maitland NJ.

Eur Urol. 2017 Jul;72(1):157-159. doi: 10.1016/j.eururo.2017.03.024. Epub 2017 Apr 3. No abstract available.


Upregulated WEE1 protects endothelial cells of colorectal cancer liver metastases.

Webster PJ, Littlejohns AT, Gaunt HJ, Young RS, Rode B, Ritchie JE, Stead LF, Harrison S, Droop A, Martin HL, Tomlinson DC, Hyman AJ, Appleby HL, Boxall S, Bruns AF, Li J, Prasad RK, Lodge JPA, Burke DA, Beech DJ.

Oncotarget. 2017 Jun 27;8(26):42288-42299. doi: 10.18632/oncotarget.15039.


A Case-Matched Gender Comparison Transcriptomic Screen Identifies eIF4E and eIF5 as Potential Prognostic Markers in Male Breast Cancer.

Humphries MP, Sundara Rajan S, Droop A, Suleman CAB, Carbone C, Nilsson C, Honarpisheh H, Cserni G, Dent J, Fulford L, Jordan LB, Jones JL, Kanthan R, Litwiniuk M, Di Benedetto A, Mottolese M, Provenzano E, Shousha S, Stephens M, Walker RA, Kulka J, Ellis IO, Jeffery M, Thygesen HH, Cappelletti V, Daidone MG, Hedenfalk IA, Fjällskog ML, Melisi D, Stead LF, Shaaban AM, Speirs V.

Clin Cancer Res. 2017 May 15;23(10):2575-2583. doi: 10.1158/1078-0432.CCR-16-1952. Epub 2016 Dec 16.


fqtools: an efficient software suite for modern FASTQ file manipulation.

Droop AP.

Bioinformatics. 2016 Jun 15;32(12):1883-4. doi: 10.1093/bioinformatics/btw088. Epub 2016 Feb 18.


Changes in plasma chemokine C-C motif ligand 2 levels during treatment with eicosapentaenoic acid predict outcome in patients undergoing surgery for colorectal cancer liver metastasis.

Volpato M, Perry SL, Marston G, Ingram N, Cockbain AJ, Burghel H, Mann J, Lowes D, Wilson E, Droop A, Randerson-Moor J, Coletta PL, Hull MA.

Oncotarget. 2016 May 10;7(19):28139-50. doi: 10.18632/oncotarget.8579.


qsubsec: a lightweight template system for defining sun grid engine workflows.

Droop AP.

Bioinformatics. 2016 Apr 15;32(8):1267-8. doi: 10.1093/bioinformatics/btv698. Epub 2015 Dec 3.


Elucidating drivers of oral epithelial dysplasia formation and malignant transformation to cancer using RNAseq.

Conway C, Graham JL, Chengot P, Daly C, Chalkley R, Ross L, Droop A, Rabbitts P, Stead LF.

Oncotarget. 2015 Nov 24;6(37):40186-201. doi: 10.18632/oncotarget.5529.


Prognostic microRNAs in high-grade glioma reveal a link to oligodendrocyte precursor differentiation.

Hayes J, Thygesen H, Droop A, Hughes TA, Westhead D, Lawler SE, Wurdak H, Short SC.

Oncoscience. 2014 Dec 26;2(3):252-62. eCollection 2015.


Prediction of clinical outcome in glioblastoma using a biologically relevant nine-microRNA signature.

Hayes J, Thygesen H, Tumilson C, Droop A, Boissinot M, Hughes TA, Westhead D, Alder JE, Shaw L, Short SC, Lawler SE.

Mol Oncol. 2015 Mar;9(3):704-14. doi: 10.1016/j.molonc.2014.11.004. Epub 2014 Nov 28.


Conserved two-step regulatory mechanism of human epithelial differentiation.

Rane JK, Droop AP, Pellacani D, Polson ES, Simms MS, Collins AT, Caves LS, Maitland NJ.

Stem Cell Reports. 2014 Feb 6;2(2):180-8. doi: 10.1016/j.stemcr.2014.01.001. eCollection 2014 Feb 11.


DNA hypermethylation in prostate cancer is a consequence of aberrant epithelial differentiation and hyperproliferation.

Pellacani D, Kestoras D, Droop AP, Frame FM, Berry PA, Lawrence MG, Stower MJ, Simms MS, Mann VM, Collins AT, Risbridger GP, Maitland NJ.

Cell Death Differ. 2014 May;21(5):761-73. doi: 10.1038/cdd.2013.202. Epub 2014 Jan 24.


Retinoic acid and androgen receptors combine to achieve tissue specific control of human prostatic transglutaminase expression: a novel regulatory network with broader significance.

Rivera-Gonzalez GC, Droop AP, Rippon HJ, Tiemann K, Pellacani D, Georgopoulos LJ, Maitland NJ.

Nucleic Acids Res. 2012 Jun;40(11):4825-40. doi: 10.1093/nar/gks143. Epub 2012 Feb 22.


Properties of biological mutation networks and their implications for ALife.

Droop AP, Hickinbotham SJ.

Artif Life. 2011 Fall;17(4):353-64. doi: 10.1162/artl_a_00043. Epub 2011 Jul 15.


The calcium sensor STIM1 is regulated by androgens in prostate stromal cells.

Berry PA, Birnie R, Droop AP, Maitland NJ, Collins AT.

Prostate. 2011 Nov;71(15):1646-55. doi: 10.1002/pros.21384. Epub 2011 Mar 22.


Gene expression profiling of human prostate cancer stem cells reveals a pro-inflammatory phenotype and the importance of extracellular matrix interactions.

Birnie R, Bryce SD, Roome C, Dussupt V, Droop A, Lang SH, Berry PA, Hyde CF, Lewis JL, Stower MJ, Maitland NJ, Collins AT.

Genome Biol. 2008;9(5):R83. doi: 10.1186/gb-2008-9-5-r83. Epub 2008 May 20.


Yeast ntr1/spp382 mediates prp43 function in postspliceosomes.

Boon KL, Auchynnikava T, Edwalds-Gilbert G, Barrass JD, Droop AP, Dez C, Beggs JD.

Mol Cell Biol. 2006 Aug;26(16):6016-23.


[Increased frequency of icterus in parenterally fed patients after a change of lipid emulsion].

Sluijter PP, Droop A, Timmer JG, Romijn JA, Strack van Schijndel RJ, Sauerwein HP.

Ned Tijdschr Geneeskd. 1999 Jun 19;143(25):1314-8. Dutch.


Visceral fat loss measured by magnetic resonance imaging in relation to changes in serum lipid levels of obese men and women.

Leenen R, van der Kooy K, Droop A, Seidell JC, Deurenberg P, Weststrate JA, Hautvast JG.

Arterioscler Thromb. 1993 Apr;13(4):487-94.


Waist-hip ratio is a poor predictor of changes in visceral fat.

van der Kooy K, Leenen R, Seidell JC, Deurenberg P, Droop A, Bakker CJ.

Am J Clin Nutr. 1993 Mar;57(3):327-33.


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