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Items: 22

1.

Continuous Hemodialysis Does Not Improve Graft Function During Ex Vivo Lung Perfusion Over 24 Hours.

Buchko MT, Himmat S, Stewart CJ, Hatami S, Dromparis P, Adam BA, Freed DH, Nagendran J.

Transplant Proc. 2019 Jul - Aug;51(6):2022-2028. doi: 10.1016/j.transproceed.2019.03.042. Epub 2019 Jul 11.

PMID:
31303418
2.

Ex vivo perfusion induces a time- and perfusate-dependent molecular repair response in explanted porcine lungs.

Dromparis P, Aboelnazar NS, Wagner S, Himmat S, White CW, Hatami S, Luc JGY, Rotich S, Freed DH, Nagendran J, Mengel M, Adam BA.

Am J Transplant. 2019 Apr;19(4):1024-1036. doi: 10.1111/ajt.15123. Epub 2018 Oct 8.

PMID:
30230229
3.

Recurrence and upstaging rates of T1 high-grade urothelial carcinoma of the bladder on repeat resection in a Canadian, resource-limited, healthcare system.

Kinnaird A, Dromparis P, Evans H.

Can Urol Assoc J. 2018 Aug;12(8):267-269. doi: 10.5489/cuaj.5039. Epub 2018 Apr 6.

4.

A Decrease in Hypoxic Pulmonary Vasoconstriction Correlates With Increased Inflammation During Extended Normothermic Ex Vivo Lung Perfusion.

Himmat S, Alzamil A, Aboelnazar N, Hatami S, White C, Dromparis P, Mengel M, Freed D, Nagendran J.

Artif Organs. 2018 Mar;42(3):271-279. doi: 10.1111/aor.13017. Epub 2017 Dec 20.

PMID:
29266272
5.

Negative pressure ventilation decreases inflammation and lung edema during normothermic ex-vivo lung perfusion.

Aboelnazar NS, Himmat S, Hatami S, White CW, Burhani MS, Dromparis P, Matsumura N, Tian G, Dyck JRB, Mengel M, Freed DH, Nagendran J.

J Heart Lung Transplant. 2018 Apr;37(4):520-530. doi: 10.1016/j.healun.2017.09.007. Epub 2017 Sep 14.

PMID:
29103845
6.

Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase.

Kinnaird A, Dromparis P, Saleme B, Gurtu V, Watson K, Paulin R, Zervopoulos S, Stenson T, Sutendra G, Pink DB, Carmine-Simmen K, Moore R, Lewis JD, Michelakis ED.

Eur Urol. 2016 Apr;69(4):734-744. doi: 10.1016/j.eururo.2015.09.014. Epub 2016 Feb 18.

PMID:
26433571
7.

A miR-208-Mef2 axis drives the decompensation of right ventricular function in pulmonary hypertension.

Paulin R, Sutendra G, Gurtu V, Dromparis P, Haromy A, Provencher S, Bonnet S, Michelakis ED.

Circ Res. 2015 Jan 2;116(1):56-69. doi: 10.1161/CIRCRESAHA.115.303910. Epub 2014 Oct 6.

PMID:
25287062
8.

Sirtuin 3 deficiency is associated with inhibited mitochondrial function and pulmonary arterial hypertension in rodents and humans.

Paulin R, Dromparis P, Sutendra G, Gurtu V, Zervopoulos S, Bowers L, Haromy A, Webster L, Provencher S, Bonnet S, Michelakis ED.

Cell Metab. 2014 Nov 4;20(5):827-839. doi: 10.1016/j.cmet.2014.08.011. Epub 2014 Oct 2.

9.

A nuclear pyruvate dehydrogenase complex is important for the generation of acetyl-CoA and histone acetylation.

Sutendra G, Kinnaird A, Dromparis P, Paulin R, Stenson TH, Haromy A, Hashimoto K, Zhang N, Flaim E, Michelakis ED.

Cell. 2014 Jul 3;158(1):84-97. doi: 10.1016/j.cell.2014.04.046.

10.

Pioglitazone inhibits HIF-1α-dependent angiogenesis in rats by paracrine and direct effects on endothelial cells.

Dromparis P, Sutendra G, Paulin R, Proctor S, Michelakis ED, McMurtry MS.

J Mol Med (Berl). 2014 May;92(5):497-507. doi: 10.1007/s00109-013-1115-0. Epub 2014 Jan 10.

11.

A metabolic remodeling in right ventricular hypertrophy is associated with decreased angiogenesis and a transition from a compensated to a decompensated state in pulmonary hypertension.

Sutendra G, Dromparis P, Paulin R, Zervopoulos S, Haromy A, Nagendran J, Michelakis ED.

J Mol Med (Berl). 2013 Nov;91(11):1315-27. doi: 10.1007/s00109-013-1059-4. Epub 2013 Jul 12.

PMID:
23846254
12.

Uncoupling protein 2 deficiency mimics the effects of hypoxia and endoplasmic reticulum stress on mitochondria and triggers pseudohypoxic pulmonary vascular remodeling and pulmonary hypertension.

Dromparis P, Paulin R, Sutendra G, Qi AC, Bonnet S, Michelakis ED.

Circ Res. 2013 Jul 5;113(2):126-36. doi: 10.1161/CIRCRESAHA.112.300699. Epub 2013 May 7.

PMID:
23652801
13.

Mitochondria in vascular health and disease.

Dromparis P, Michelakis ED.

Annu Rev Physiol. 2013;75:95-126. doi: 10.1146/annurev-physiol-030212-183804. Epub 2012 Nov 16. Review.

PMID:
23157555
14.

Attenuating endoplasmic reticulum stress as a novel therapeutic strategy in pulmonary hypertension.

Dromparis P, Paulin R, Stenson TH, Haromy A, Sutendra G, Michelakis ED.

Circulation. 2013 Jan 1;127(1):115-25. doi: 10.1161/CIRCULATIONAHA.112.133413. Epub 2012 Nov 13.

PMID:
23149668
15.

F2-isoprostanes: an emerging pulmonary arterial hypertension biomarker and potential link to the metabolic theory of pulmonary arterial hypertension?

Dromparis P, Michelakis ED.

Chest. 2012 Oct;142(4):816-820. doi: 10.1378/chest.12-0848. No abstract available.

PMID:
23032445
16.

Mitochondrial activation by inhibition of PDKII suppresses HIF1a signaling and angiogenesis in cancer.

Sutendra G, Dromparis P, Kinnaird A, Stenson TH, Haromy A, Parker JM, McMurtry MS, Michelakis ED.

Oncogene. 2013 Mar 28;32(13):1638-50. doi: 10.1038/onc.2012.198. Epub 2012 May 21.

PMID:
22614004
17.

Pyruvate dehydrogenase inhibition by the inflammatory cytokine TNFα contributes to the pathogenesis of pulmonary arterial hypertension.

Sutendra G, Dromparis P, Bonnet S, Haromy A, McMurtry MS, Bleackley RC, Michelakis ED.

J Mol Med (Berl). 2011 Aug;89(8):771-83. doi: 10.1007/s00109-011-0762-2. Epub 2011 Aug 2.

PMID:
21809123
18.

The role of Nogo and the mitochondria-endoplasmic reticulum unit in pulmonary hypertension.

Sutendra G, Dromparis P, Wright P, Bonnet S, Haromy A, Hao Z, McMurtry MS, Michalak M, Vance JE, Sessa WC, Michelakis ED.

Sci Transl Med. 2011 Jun 22;3(88):88ra55. doi: 10.1126/scitranslmed.3002194.

19.

The role of mitochondria in pulmonary vascular remodeling.

Dromparis P, Sutendra G, Michelakis ED.

J Mol Med (Berl). 2010 Oct;88(10):1003-10. doi: 10.1007/s00109-010-0670-x. Epub 2010 Aug 24. Review.

PMID:
20734021
20.

Metabolic modulation of glioblastoma with dichloroacetate.

Michelakis ED, Sutendra G, Dromparis P, Webster L, Haromy A, Niven E, Maguire C, Gammer TL, Mackey JR, Fulton D, Abdulkarim B, McMurtry MS, Petruk KC.

Sci Transl Med. 2010 May 12;2(31):31ra34. doi: 10.1126/scitranslmed.3000677.

21.

Dehydroepiandrosterone reverses systemic vascular remodeling through the inhibition of the Akt/GSK3-{beta}/NFAT axis.

Bonnet S, Paulin R, Sutendra G, Dromparis P, Roy M, Watson KO, Nagendran J, Haromy A, Dyck JR, Michelakis ED.

Circulation. 2009 Sep 29;120(13):1231-40. doi: 10.1161/CIRCULATIONAHA.109.848911. Epub 2009 Sep 14.

PMID:
19752325

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