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Reactive oxygen species play a dominant role in all pathways of rapid quinolone-mediated killing.

Hong Y, Li Q, Gao Q, Xie J, Huang H, Drlica K, Zhao X.

J Antimicrob Chemother. 2019 Dec 3. pii: dkz485. doi: 10.1093/jac/dkz485. [Epub ahead of print]


Post-stress bacterial cell death mediated by reactive oxygen species.

Hong Y, Zeng J, Wang X, Drlica K, Zhao X.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):10064-10071. doi: 10.1073/pnas.1901730116. Epub 2019 Apr 4.


Sequential evolution of virulence and resistance during clonal spread of community-acquired methicillin-resistant Staphylococcus aureus.

Copin R, Sause WE, Fulmer Y, Balasubramanian D, Dyzenhaus S, Ahmed JM, Kumar K, Lees J, Stachel A, Fisher JC, Drlica K, Phillips M, Weiser JN, Planet PJ, Uhlemann AC, Altman DR, Sebra R, van Bakel H, Lighter J, Torres VJ, Shopsin B.

Proc Natl Acad Sci U S A. 2019 Jan 29;116(5):1745-1754. doi: 10.1073/pnas.1814265116. Epub 2019 Jan 11. Erratum in: Proc Natl Acad Sci U S A. 2019 Feb 25;:.


Suppression of Reactive Oxygen Species Accumulation Accounts for Paradoxical Bacterial Survival at High Quinolone Concentration.

Luan G, Hong Y, Drlica K, Zhao X.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e01622-17. doi: 10.1128/AAC.01622-17. Print 2018 Mar.


Fluoroquinolone-Gyrase-DNA Cleaved Complexes.

Luan G, Drlica K.

Methods Mol Biol. 2018;1703:269-281. doi: 10.1007/978-1-4939-7459-7_19.


Tuning of the Lethal Response to Multiple Stressors with a Single-Site Mutation during Clinical Infection by Staphylococcus aureus.

Kumar K, Chen J, Drlica K, Shopsin B.

mBio. 2017 Oct 24;8(5). pii: e01476-17. doi: 10.1128/mBio.01476-17.


Contribution of reactive oxygen species to thymineless death in Escherichia coli.

Hong Y, Li L, Luan G, Drlica K, Zhao X.

Nat Microbiol. 2017 Dec;2(12):1667-1675. doi: 10.1038/s41564-017-0037-y. Epub 2017 Oct 2.


Fluoroquinolones as imaging agents for bacterial infection.

Naqvi SAR, Drlica K.

Dalton Trans. 2017 Oct 31;46(42):14452-14460. doi: 10.1039/c7dt01189j. Review.


Dimethyl Sulfoxide Protects Escherichia coli from Rapid Antimicrobial-Mediated Killing.

Mi H, Wang D, Xue Y, Zhang Z, Niu J, Hong Y, Drlica K, Zhao X.

Antimicrob Agents Chemother. 2016 Jul 22;60(8):5054-8. doi: 10.1128/AAC.03003-15. Print 2016 Aug.


Resveratrol Antagonizes Antimicrobial Lethality and Stimulates Recovery of Bacterial Mutants.

Liu Y, Zhou J, Qu Y, Yang X, Shi G, Wang X, Hong Y, Drlica K, Zhao X.

PLoS One. 2016 Apr 5;11(4):e0153023. doi: 10.1371/journal.pone.0153023. eCollection 2016.


Suppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.

Malik M, Mustaev A, Schwanz HA, Luan G, Shah N, Oppegard LM, de Souza EC, Hiasa H, Zhao X, Kerns RJ, Drlica K.

Nucleic Acids Res. 2016 Apr 20;44(7):3304-16. doi: 10.1093/nar/gkw161. Epub 2016 Mar 16.


Involvement of Holliday junction resolvase in fluoroquinolone-mediated killing of Mycobacterium smegmatis.

Long Q, Du Q, Fu T, Drlica K, Zhao X, Xie J.

Antimicrob Agents Chemother. 2015 Mar;59(3):1782-5. doi: 10.1128/AAC.04434-14. Epub 2014 Dec 22.


Ribosomal elongation factor 4 promotes cell death associated with lethal stress.

Li L, Hong Y, Luan G, Mosel M, Malik M, Drlica K, Zhao X.

mBio. 2014 Dec 9;5(6):e01708. doi: 10.1128/mBio.01708-14.


Moving forward with reactive oxygen species involvement in antimicrobial lethality.

Zhao X, Hong Y, Drlica K.

J Antimicrob Chemother. 2015 Mar;70(3):639-42. doi: 10.1093/jac/dku463. Epub 2014 Nov 23. Review.


Mutant prevention concentration of tigecycline for clinical isolates of Streptococcus pneumoniae and Staphylococcus aureus.

Hesje CK, Drlica K, Blondeau JM.

J Antimicrob Chemother. 2015 Feb;70(2):494-7. doi: 10.1093/jac/dku389. Epub 2014 Oct 16.


Bypassing fluoroquinolone resistance with quinazolinediones: studies of drug-gyrase-DNA complexes having implications for drug design.

Drlica K, Mustaev A, Towle TR, Luan G, Kerns RJ, Berger JM.

ACS Chem Biol. 2014 Dec 19;9(12):2895-904. doi: 10.1021/cb500629k. Epub 2014 Nov 4.


Lethal synergy involving bicyclomycin: an approach for reviving old antibiotics.

Malik M, Li L, Zhao X, Kerns RJ, Berger JM, Drlica K.

J Antimicrob Chemother. 2014 Dec;69(12):3227-35. doi: 10.1093/jac/dku285. Epub 2014 Jul 31.


Reactive oxygen species and the bacterial response to lethal stress.

Zhao X, Drlica K.

Curr Opin Microbiol. 2014 Oct;21:1-6. doi: 10.1016/j.mib.2014.06.008. Epub 2014 Jul 30. Review.


Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding.

Mustaev A, Malik M, Zhao X, Kurepina N, Luan G, Oppegard LM, Hiasa H, Marks KR, Kerns RJ, Berger JM, Drlica K.

J Biol Chem. 2014 May 2;289(18):12300-12. doi: 10.1074/jbc.M113.529164. Epub 2014 Feb 4.


Superoxide-mediated protection of Escherichia coli from antimicrobials.

Mosel M, Li L, Drlica K, Zhao X.

Antimicrob Agents Chemother. 2013 Nov;57(11):5755-9. doi: 10.1128/AAC.00754-13. Epub 2013 Aug 26.


YihE kinase is a central regulator of programmed cell death in bacteria.

Dorsey-Oresto A, Lu T, Mosel M, Wang X, Salz T, Drlica K, Zhao X.

Cell Rep. 2013 Feb 21;3(2):528-37. doi: 10.1016/j.celrep.2013.01.026. Epub 2013 Feb 14.


Minimal inhibitory and mutant prevention concentrations of azithromycin, clarithromycin and erythromycin for clinical isolates of Streptococcus pneumoniae.

Metzler K, Drlica K, Blondeau JM.

J Antimicrob Chemother. 2013 Mar;68(3):631-5. doi: 10.1093/jac/dks461. Epub 2012 Nov 20.


Induction of mycobacterial resistance to quinolone class antimicrobials.

Malik M, Chavda K, Zhao X, Shah N, Hussain S, Kurepina N, Kreiswirth BN, Kerns RJ, Drlica K.

Antimicrob Agents Chemother. 2012 Jul;56(7):3879-87. doi: 10.1128/AAC.00474-12. Epub 2012 May 7.


A toxin-antitoxin module in Bacillus subtilis can both mitigate and amplify effects of lethal stress.

Wu X, Wang X, Drlica K, Zhao X.

PLoS One. 2011;6(8):e23909. doi: 10.1371/journal.pone.0023909. Epub 2011 Aug 29.


Synthesis and evaluation of 1-cyclopropyl-2-thioalkyl-8-methoxy fluoroquinolones.

Marks KR, Malik M, Mustaev A, Hiasa H, Drlica K, Kerns RJ.

Bioorg Med Chem Lett. 2011 Aug 1;21(15):4585-8. doi: 10.1016/j.bmcl.2011.05.112. Epub 2011 Jun 6.


Fluoroquinolone and quinazolinedione activities against wild-type and gyrase mutant strains of Mycobacterium smegmatis.

Malik M, Marks KR, Mustaev A, Zhao X, Chavda K, Kerns RJ, Drlica K.

Antimicrob Agents Chemother. 2011 May;55(5):2335-43. doi: 10.1128/AAC.00033-11. Epub 2011 Mar 7.


Mutant prevention concentration-based pharmacokinetic/pharmacodynamic indices as dosing targets for suppressing the enrichment of levofloxacin-resistant subpopulations of Staphylococcus aureus.

Liang B, Bai N, Cai Y, Wang R, Drlica K, Zhao X.

Antimicrob Agents Chemother. 2011 May;55(5):2409-12. doi: 10.1128/AAC.00975-10. Epub 2011 Feb 22.


Effect of N-1/c-8 ring fusion and C-7 ring structure on fluoroquinolone lethality.

Malik M, Marks KR, Schwanz HA, German N, Drlica K, Kerns RJ.

Antimicrob Agents Chemother. 2010 Dec;54(12):5214-21. doi: 10.1128/AAC.01054-10. Epub 2010 Sep 20.


Comparison of in vitro activities of fluoroquinolone-like 2,4- and 1,3-diones.

Oppegard LM, Streck KR, Rosen JD, Schwanz HA, Drlica K, Kerns RJ, Hiasa H.

Antimicrob Agents Chemother. 2010 Jul;54(7):3011-4. doi: 10.1128/AAC.00190-10. Epub 2010 Apr 19.


Escherichia coli genes that reduce the lethal effects of stress.

Han X, Dorsey-Oresto A, Malik M, Wang JY, Drlica K, Zhao X, Lu T.

BMC Microbiol. 2010 Feb 4;10:35. doi: 10.1186/1471-2180-10-35.


Contribution of reactive oxygen species to pathways of quinolone-mediated bacterial cell death.

Wang X, Zhao X, Malik M, Drlica K.

J Antimicrob Chemother. 2010 Mar;65(3):520-4. doi: 10.1093/jac/dkp486. Epub 2010 Jan 12.


Novel approach for comparing the abilities of quinolones to restrict the emergence of resistant mutants during quinolone exposure.

Malik M, Hoatam G, Chavda K, Kerns RJ, Drlica K.

Antimicrob Agents Chemother. 2010 Jan;54(1):149-56. doi: 10.1128/AAC.01035-09. Epub 2009 Oct 5.


Quinolones: action and resistance updated.

Drlica K, Hiasa H, Kerns R, Malik M, Mustaev A, Zhao X.

Curr Top Med Chem. 2009;9(11):981-98. Review.


Superoxide protects Escherichia coli from bleomycin mediated lethality.

Burger RM, Drlica K.

J Inorg Biochem. 2009 Sep;103(9):1273-7. doi: 10.1016/j.jinorgbio.2009.07.009. Epub 2009 Jul 17.


Lon protease is essential for paradoxical survival of Escherichia coli exposed to high concentrations of quinolone.

Malik M, Capecci J, Drlica K.

Antimicrob Agents Chemother. 2009 Jul;53(7):3103-5. doi: 10.1128/AAC.00019-09. Epub 2009 May 4.


In vitro model of mycobacterial growth arrest using nitric oxide with limited air.

Hussain S, Malik M, Shi L, Gennaro ML, Drlica K.

Antimicrob Agents Chemother. 2009 Jan;53(1):157-61. doi: 10.1128/AAC.00442-08. Epub 2008 Oct 27.


Hypernegative supercoiling inhibits growth by causing RNA degradation.

Baaklini I, Usongo V, Nolent F, Sanscartier P, Hraiky C, Drlica K, Drolet M.

J Bacteriol. 2008 Nov;190(22):7346-56. doi: 10.1128/JB.00680-08. Epub 2008 Sep 12.


Use of gyrase resistance mutants to guide selection of 8-methoxy-quinazoline-2,4-diones.

German N, Malik M, Rosen JD, Drlica K, Kerns RJ.

Antimicrob Agents Chemother. 2008 Nov;52(11):3915-21. doi: 10.1128/AAC.00330-08. Epub 2008 Sep 2.


Depletion of RNase HI activity in Escherichia coli lacking DNA topoisomerase I leads to defects in DNA supercoiling and segregation.

Usongo V, Nolent F, Sanscartier P, Tanguay C, Broccoli S, Baaklini I, Drlica K, Drolet M.

Mol Microbiol. 2008 Aug;69(4):968-81. doi: 10.1111/j.1365-2958.2008.06334.x. Epub 2008 Jun 28.


A unified anti-mutant dosing strategy.

Zhao X, Drlica K.

J Antimicrob Chemother. 2008 Sep;62(3):434-6. doi: 10.1093/jac/dkn229. Epub 2008 Jun 10. Review.


Minimising moxifloxacin resistance with tuberculosis.

Drlica K, Zhao X, Kreiswirth B.

Lancet Infect Dis. 2008 May;8(5):273-5. doi: 10.1016/S1473-3099(08)70077-X. No abstract available.


Daptomycin inoculum effects and mutant prevention concentration with Staphylococcus aureus.

Quinn B, Hussain S, Malik M, Drlica K, Zhao X.

J Antimicrob Chemother. 2007 Dec;60(6):1380-3. Epub 2007 Sep 28.


Quinolone-mediated bacterial death.

Drlica K, Malik M, Kerns RJ, Zhao X.

Antimicrob Agents Chemother. 2008 Feb;52(2):385-92. Epub 2007 Aug 27. Review. No abstract available.


Mutant selection window hypothesis updated.

Drlica K, Zhao X.

Clin Infect Dis. 2007 Mar 1;44(5):681-8. Epub 2007 Jan 24. Review.


Flagellar and global gene regulation in Helicobacter pylori modulated by changes in DNA supercoiling.

Ye F, Brauer T, Niehus E, Drlica K, Josenhans C, Suerbaum S.

Int J Med Microbiol. 2007 Apr;297(2):65-81. Epub 2007 Feb 1.


The mutant selection window in rabbits infected with Staphylococcus aureus.

Cui J, Liu Y, Wang R, Tong W, Drlica K, Zhao X.

J Infect Dis. 2006 Dec 1;194(11):1601-8. Epub 2006 Oct 20.


Effect of anaerobic growth on quinolone lethality with Escherichia coli.

Malik M, Hussain S, Drlica K.

Antimicrob Agents Chemother. 2007 Jan;51(1):28-34. Epub 2006 Oct 16.


Bactericidal activity and target preference of a piperazinyl-cross-linked ciprofloxacin dimer with Staphylococcus aureus and Escherichia coli.

Zhao X, Quinn B, Kerns R, Drlica K.

J Antimicrob Chemother. 2006 Dec;58(6):1283-6. Epub 2006 Sep 26.


Lethal fragmentation of bacterial chromosomes mediated by DNA gyrase and quinolones.

Malik M, Zhao X, Drlica K.

Mol Microbiol. 2006 Aug;61(3):810-25. Epub 2006 Jun 27.

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