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Functional cross-talk between allosteric effects of activating and inhibiting ligands underlies PKM2 regulation.

Macpherson JA, Theisen A, Masino L, Fets L, Driscoll PC, Encheva V, Snijders AP, Martin SR, Kleinjung J, Barran PE, Fraternali F, Anastasiou D.

Elife. 2019 Jul 2;8. pii: e45068. doi: 10.7554/eLife.45068.


What makes a planet habitable?

Shahar A, Driscoll P, Weinberger A, Cody G.

Science. 2019 May 3;364(6439):434-435. doi: 10.1126/science.aaw4326. No abstract available.


An Improved Method for Measuring Absolute Metabolite Concentrations in Small Biofluid or Tissue Samples.

Fernando T, Sawala A, Bailey AP, Gould AP, Driscoll PC.

J Proteome Res. 2019 Apr 5;18(4):1503-1512. doi: 10.1021/acs.jproteome.8b00773. Epub 2019 Feb 22.


Reply to 'Do sulfate radicals really enable a non-enzymatic Krebs cycle precursor?'

Keller MA, Kampjut D, Harrison SA, Driscoll PC, Ralser M.

Nat Ecol Evol. 2019 Feb;3(2):139-140. doi: 10.1038/s41559-018-0792-z. No abstract available.


MCT2 mediates concentration-dependent inhibition of glutamine metabolism by MOG.

Fets L, Driscoll PC, Grimm F, Jain A, Nunes PM, Gounis M, Doglioni G, Papageorgiou G, Ragan TJ, Campos S, Silva Dos Santos M, MacRae JI, O'Reilly N, Wright AJ, Benes CH, Courtney KD, House D, Anastasiou D.

Nat Chem Biol. 2018 Nov;14(11):1032-1042. doi: 10.1038/s41589-018-0136-y. Epub 2018 Oct 8.


Dynamic Allostery in PLCγ1 and Its Modulation by a Cancer Mutation Revealed by MD Simulation and NMR.

Koss H, Bunney TD, Esposito D, Martins M, Katan M, Driscoll PC.

Biophys J. 2018 Jul 3;115(1):31-45. doi: 10.1016/j.bpj.2018.05.031.


The Habitability of Proxima Centauri b: Environmental States and Observational Discriminants.

Meadows VS, Arney GN, Schwieterman EW, Lustig-Yaeger J, Lincowski AP, Robinson T, Domagal-Goldman SD, Deitrick R, Barnes RK, Fleming DP, Luger R, Driscoll PE, Quinn TR, Crisp D.

Astrobiology. 2018 Feb;18(2):133-189. doi: 10.1089/ast.2016.1589. Epub 2018 Feb 12.


Developmental diet regulates Drosophila lifespan via lipid autotoxins.

Stefana MI, Driscoll PC, Obata F, Pengelly AR, Newell CL, MacRae JI, Gould AP.

Nat Commun. 2017 Nov 9;8(1):1384. doi: 10.1038/s41467-017-01740-9.


Transition From Pediatric to Adult Care by Young Adults With Chronic Granulomatous Disease: The Patient's Viewpoint.

Margolis R, Wiener L, Pao M, Malech HL, Holland SM, Driscoll P.

J Adolesc Health. 2017 Dec;61(6):716-721. doi: 10.1016/j.jadohealth.2017.06.017. Epub 2017 Sep 22.


An engineered photoswitchable mammalian pyruvate kinase.

Gehrig S, Macpherson JA, Driscoll PC, Symon A, Martin SR, MacRae JI, Kleinjung J, Fraternali F, Anastasiou D.

FEBS J. 2017 Sep;284(18):2955-2980. doi: 10.1111/febs.14175. Epub 2017 Aug 16.


Nonenzymatic gluconeogenesis-like formation of fructose 1,6-bisphosphate in ice.

Messner CB, Driscoll PC, Piedrafita G, De Volder MFL, Ralser M.

Proc Natl Acad Sci U S A. 2017 Jul 11;114(28):7403-7407. doi: 10.1073/pnas.1702274114. Epub 2017 Jun 26.


Glucose Catabolism in Liver Tumors Induced by c-MYC Can Be Sustained by Various PKM1/PKM2 Ratios and Pyruvate Kinase Activities.

Méndez-Lucas A, Li X, Hu J, Che L, Song X, Jia J, Wang J, Xie C, Driscoll PC, Tschaharganeh DF, Calvisi DF, Yuneva M, Chen X.

Cancer Res. 2017 Aug 15;77(16):4355-4364. doi: 10.1158/0008-5472.CAN-17-0498. Epub 2017 Jun 19.


The definite risks and questionable benefits of liberal pre-hospital spinal immobilisation.

Purvis TA, Carlin B, Driscoll P.

Am J Emerg Med. 2017 Jun;35(6):860-866. doi: 10.1016/j.ajem.2017.01.045. Epub 2017 Jan 26. Review.


Beating the Odds: Successful Establishment of a Phase II/III Clinical Research Trial in Resource-Poor Liberia during the Largest-Ever Ebola Outbreak.

Doe-Anderson J, Baseler B, Driscoll P, Johnson M, Lysander J, McNay L, Njoh WS, Smolskis M, Wehrlen L, Zuckerman J.

Contemp Clin Trials Commun. 2016 Dec 15;4:68-73. doi: 10.1016/j.conctc.2016.06.008. Epub 2016 Jun 24.


A practical approach to Events Medicine provision.

Smith SP, Cosgrove JF, Driscoll PJ, Smith A, Butler J, Goode P, Waldmann C, Vallis CJ, Topham F, Mythen MM.

Emerg Med J. 2017 Aug;34(8):538-542. doi: 10.1136/emermed-2016-205805. Epub 2016 Sep 9.


Measuring IgA Anti-β2-Glycoprotein I and IgG/IgA Anti-Domain I Antibodies Adds Value to Current Serological Assays for the Antiphospholipid Syndrome.

Pericleous C, Ferreira I, Borghi O, Pregnolato F, McDonnell T, Garza-Garcia A, Driscoll P, Pierangeli S, Isenberg D, Ioannou Y, Giles I, Meroni PL, Rahman A.

PLoS One. 2016 Jun 2;11(6):e0156407. doi: 10.1371/journal.pone.0156407. eCollection 2016.


Mechanism of Action of Secreted Newt Anterior Gradient Protein.

Grassme KS, Garza-Garcia A, Delgado JP, Godwin JW, Kumar A, Gates PB, Driscoll PC, Brockes JP.

PLoS One. 2016 Apr 21;11(4):e0154176. doi: 10.1371/journal.pone.0154176. eCollection 2016.


Differences in Trait Impulsivity Indicate Diversification of Dog Breeds into Working and Show Lines.

Fadel FR, Driscoll P, Pilot M, Wright H, Zulch H, Mills D.

Sci Rep. 2016 Mar 10;6:22162. doi: 10.1038/srep22162.


Undergraduate radiology teaching in a UK medical school: a systematic evaluation of current practice.

Jacob J, Paul L, Hedges W, Hutchison P, Cameron E, Matthews D, Whiten S, Driscoll P.

Clin Radiol. 2016 May;71(5):476-83. doi: 10.1016/j.crad.2015.11.021. Epub 2016 Feb 16.


Finding the fifth intercostal space for chest drain insertion: guidelines and ultrasound.

Bowness JS, Nicholls K, Kilgour PM, Ferris J, Whiten S, Parkin I, Mooney J, Driscoll P.

Emerg Med J. 2015 Dec;32(12):951-4. doi: 10.1136/emermed-2015-205222. Epub 2015 Oct 5.


Tidal Heating of Earth-like Exoplanets around M Stars: Thermal, Magnetic, and Orbital Evolutions.

Driscoll PE, Barnes R.

Astrobiology. 2015 Sep;15(9):739-60. doi: 10.1089/ast.2015.1325.


Exposed: The Many and Varied Roles of Phospholipase C γ SH2 Domains.

Driscoll PC.

J Mol Biol. 2015 Aug 28;427(17):2731-3. doi: 10.1016/j.jmb.2015.06.002. Epub 2015 Jun 23. No abstract available.


Flexible stoichiometry and asymmetry of the PIDDosome core complex by heteronuclear NMR spectroscopy and mass spectrometry.

Nematollahi LA, Garza-Garcia A, Bechara C, Esposito D, Morgner N, Robinson CV, Driscoll PC.

J Mol Biol. 2015 Feb 27;427(4):737-752. doi: 10.1016/j.jmb.2014.11.021. Epub 2014 Dec 18.


Guidelines for chest drain insertion may not prevent damage to abdominal viscera.

Bowness J, Kilgour PM, Whiten S, Parkin I, Mooney J, Driscoll P.

Emerg Med J. 2015 Aug;32(8):620-5. doi: 10.1136/emermed-2014-203689. Epub 2014 Nov 21.


Proof-of-concept study demonstrating the pathogenicity of affinity-purified IgG antibodies directed to domain I of β2-glycoprotein I in a mouse model of anti-phospholipid antibody-induced thrombosis.

Pericleous C, Ruiz-Limón P, Romay-Penabad Z, Marín AC, Garza-Garcia A, Murfitt L, Driscoll PC, Latchman DS, Isenberg DA, Giles I, Ioannou Y, Rahman A, Pierangeli SS.

Rheumatology (Oxford). 2015 Apr;54(4):722-7. doi: 10.1093/rheumatology/keu360. Epub 2014 Sep 30.


Structural studies of death receptors.

Driscoll PC.

Methods Enzymol. 2014;545:201-42. doi: 10.1016/B978-0-12-801430-1.00009-3. Review.


Ligand-dependent dynamics of the active-site lid in bacterial dimethylarginine dimethylaminohydrolase.

Rasheed M, Richter C, Chisty LT, Kirkpatrick J, Blackledge M, Webb MR, Driscoll PC.

Biochemistry. 2014 Feb 18;53(6):1092-104. doi: 10.1021/bi4015924. Epub 2014 Feb 7.


Characterizing the sublanguage of online breast cancer forums for medications, symptoms, and emotions.

Elhadad N, Zhang S, Driscoll P, Brody S.

AMIA Annu Symp Proc. 2014 Nov 14;2014:516-25. eCollection 2014.


Volume determination with two standards allows absolute quantification and improved chemometric analysis of metabolites by NMR from submicroliter samples.

Ragan TJ, Bailey AP, Gould AP, Driscoll PC.

Anal Chem. 2013 Dec 17;85(24):12046-54. doi: 10.1021/ac403111s. Epub 2013 Nov 22.


Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 1: Brachial arterial blood sampling: safe or not?

Kilgour P, Driscoll P.

Emerg Med J. 2013 Oct;30(10):858-9. doi: 10.1136/emermed-2013-203100.1. Review.


Structural and functional characterization of the recombinant death domain from death-associated protein kinase.

Dioletis E, Dingley AJ, Driscoll PC.

PLoS One. 2013 Jul 29;8(7):e70095. doi: 10.1371/journal.pone.0070095. Print 2013.


Defining a positive circumferential resection margin in oesophageal cancer and its implications for adjuvant treatment.

O'Neill JR, Stephens NA, Save V, Kamel HM, Phillips HA, Driscoll PJ, Paterson-Brown S.

Br J Surg. 2013 Jul;100(8):1055-63. doi: 10.1002/bjs.9145. Epub 2013 Apr 24.


Surgical management of emergency and elective giant paraesophageal hiatus hernias.

Shaikh I, Macklin P, Driscoll P, de Beaux A, Couper G, Paterson-Brown S.

J Laparoendosc Adv Surg Tech A. 2013 Feb;23(2):100-5. doi: 10.1089/lap.2012.0199. Epub 2012 Dec 31.


Targeting VEGF signalling via the neuropilin co-receptor.

Djordjevic S, Driscoll PC.

Drug Discov Today. 2013 May;18(9-10):447-55. doi: 10.1016/j.drudis.2012.11.013. Epub 2012 Dec 8. Review.


Structural and functional integration of the PLCγ interaction domains critical for regulatory mechanisms and signaling deregulation.

Bunney TD, Esposito D, Mas-Droux C, Lamber E, Baxendale RW, Martins M, Cole A, Svergun D, Driscoll PC, Katan M.

Structure. 2012 Dec 5;20(12):2062-75. doi: 10.1016/j.str.2012.09.005. Epub 2012 Oct 11.


In support of the BMRB.

Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, Cross TA, Dames S, Kessler H, Lange O, Madl T, Reif B, Sattler M, Eliezer D, Fersht A, Forman-Kay J, Kay LE, Fraser J, Gross J, Kortemme T, Sali A, Fujiwara T, Gardner K, Luo X, Rizo-Rey J, Rosen M, Gil RR, Ho C, Rule G, Gronenborn AM, Ishima R, Klein-Seetharaman J, Tang P, van der Wel P, Xu Y, Grzesiek S, Hiller S, Seelig J, Laue ED, Mott H, Nietlispach D, Barsukov I, Lian LY, Middleton D, Blumenschein T, Moore G, Campbell I, Schnell J, Vakonakis IJ, Watts A, Conte MR, Mason J, Pfuhl M, Sanderson MR, Craven J, Williamson M, Dominguez C, Roberts G, Günther U, Overduin M, Werner J, Williamson P, Blindauer C, Crump M, Driscoll P, Frenkiel T, Golovanov A, Matthews S, Parkinson J, Uhrin D, Williams M, Neuhaus D, Oschkinat H, Ramos A, Shaw DE, Steinbeck C, Vendruscolo M, Vuister GW, Walters KJ, Weinstein H, Wüthrich K, Yokoyama S.

Nat Struct Mol Biol. 2012 Sep;19(9):854-60. doi: 10.1038/nsmb.2371. No abstract available.


Characterization of Vibrio cholerae Hfq provides novel insights into the role of the Hfq C-terminal region.

Vincent HA, Henderson CA, Ragan TJ, Garza-Garcia A, Cary PD, Gowers DM, Malfois M, Driscoll PC, Sobott F, Callaghan AJ.

J Mol Biol. 2012 Jun 29;420(1-2):56-69. doi: 10.1016/j.jmb.2012.03.028. Epub 2012 Apr 3.


Imaging and resuscitation in trauma.

Exadaktylos AK, de Moya MA, Lecky F, Driscoll P, Zimmermann H, Wallis LA, Novelline RA.

Emerg Med Int. 2011;2011:313404. doi: 10.1155/2011/313404. Epub 2011 Dec 26. No abstract available.


Letter 2: Routine colonoscopy following acute uncomplicated diverticulitis (Br J Surg 2011; 98: 1630-1634).

Colvin HS, Velineni R, Robertson AG, Yalamarthi S, Driscoll PJ.

Br J Surg. 2012 Feb;99(2):300; author reply 300-1. doi: 10.1002/bjs.8671. No abstract available.


Swiss multidisciplinary and multilingual experience of the Advanced Trauma Life Support course: lessons for Europe.

Maeder MB, Germann S, Banz VM, Amsler F, Driscoll P, Zimmermann H, Exadaktylos AK.

Eur J Emerg Med. 2012 Aug;19(4):220-5. doi: 10.1097/MEJ.0b013e32834b0098.


Evaluating the conformation of recombinant domain I of β(2)-glycoprotein I and its interaction with human monoclonal antibodies.

Pericleous C, Miles J, Esposito D, Garza-Garcia A, Driscoll PC, Lambrianides A, Latchman D, Isenberg D, Rahman A, Ioannou Y, Giles I.

Mol Immunol. 2011 Oct;49(1-2):56-63. doi: 10.1016/j.molimm.2011.07.024. Epub 2011 Sep 6.


Anaplastic lymphoma kinase spares organ growth during nutrient restriction in Drosophila.

Cheng LY, Bailey AP, Leevers SJ, Ragan TJ, Driscoll PC, Gould AP.

Cell. 2011 Aug 5;146(3):435-47. doi: 10.1016/j.cell.2011.06.040.


Sustaining recovery through the night: impact of a peer-run warm line.

Dalgin RS, Maline S, Driscoll P.

Psychiatr Rehabil J. 2011 Summer;35(1):65-8. doi: 10.2975/35.1.2011.65.68.


Evidence for the local evolution of mechanisms underlying limb regeneration in salamanders.

Garza-Garcia AA, Driscoll PC, Brockes JP.

Integr Comp Biol. 2010 Oct;50(4):528-35. doi: 10.1093/icb/icq022. Epub 2010 Apr 21.


A combinatorial method to enable detailed investigation of protein-protein interactions.

Maclagan K, Tommasi R, Laurine E, Prodromou C, Driscoll PC, Pearl LH, Reich S, Savva R.

Future Med Chem. 2011 Mar;3(3):271-82. doi: 10.4155/fmc.10.289.


Solution NMR investigation of the CD95/FADD homotypic death domain complex suggests lack of engagement of the CD95 C terminus.

Esposito D, Sankar A, Morgner N, Robinson CV, Rittinger K, Driscoll PC.

Structure. 2010 Oct 13;18(10):1378-90. doi: 10.1016/j.str.2010.08.006.


'Effectiveness of Continuing Professional Development' project: a summary of findings.

Schostak J, Davis M, Hanson J, Schostak J, Brown T, Driscoll P, Starke I, Jenkins N.

Med Teach. 2010;32(7):586-92. doi: 10.3109/0142159X.2010.489129.


Testing the validity of the ATLS classification of hypovolaemic shock.

Guly HR, Bouamra O, Little R, Dark P, Coats T, Driscoll P, Lecky FE.

Resuscitation. 2010 Sep;81(9):1142-7. doi: 10.1016/j.resuscitation.2010.04.007.


A multilayered approach to complex surface patterning.

Driscoll PF, Milkani E, Lambert CR, McGimpsey WG.

Langmuir. 2010 Mar 2;26(5):3731-8. doi: 10.1021/la902966b.


Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.

Jarvis A, Allerston CK, Jia H, Herzog B, Garza-Garcia A, Winfield N, Ellard K, Aqil R, Lynch R, Chapman C, Hartzoulakis B, Nally J, Stewart M, Cheng L, Menon M, Tickner M, Djordjevic S, Driscoll PC, Zachary I, Selwood DL.

J Med Chem. 2010 Mar 11;53(5):2215-26. doi: 10.1021/jm901755g.

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