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Items: 21


Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β.

Hartley MA, Eren RO, Rossi M, Prevel F, Castiglioni P, Isorce N, Desponds C, Lye LF, Beverley SM, Drexler SK, Fasel N.

Microb Cell. 2018 Jan 14;5(3):137-149. doi: 10.15698/mic2018.03.619.


Nlrp6- and ASC-Dependent Inflammasomes Do Not Shape the Commensal Gut Microbiota Composition.

Mamantopoulos M, Ronchi F, Van Hauwermeiren F, Vieira-Silva S, Yilmaz B, Martens L, Saeys Y, Drexler SK, Yazdi AS, Raes J, Lamkanfi M, McCoy KD, Wullaert A.

Immunity. 2017 Aug 15;47(2):339-348.e4. doi: 10.1016/j.immuni.2017.07.011. Epub 2017 Aug 8.


Silencing of ASC in Cutaneous Squamous Cell Carcinoma.

Meier K, Drexler SK, Eberle FC, Lefort K, Yazdi AS.

PLoS One. 2016 Oct 21;11(10):e0164742. doi: 10.1371/journal.pone.0164742. eCollection 2016.


Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence.

Eren RO, Reverte M, Rossi M, Hartley MA, Castiglioni P, Prevel F, Martin R, Desponds C, Lye LF, Drexler SK, Reith W, Beverley SM, Ronet C, Fasel N.

Cell Host Microbe. 2016 Sep 14;20(3):318-328. doi: 10.1016/j.chom.2016.08.001. Epub 2016 Sep 1.


Investigating the Function of Coronin A in the Early Starvation Response of Dictyostelium discoideum by Aggregation Assays.

Drexler SK, Brogna F, Vinet A, Pieters J.

J Vis Exp. 2016 Jun 18;(112). doi: 10.3791/53972.


The two faces of the inflammasome adaptor ASC in epithelial skin carcinogenesis.

Yazdi AS, Drexler SK.

Clin Exp Rheumatol. 2015 Jul-Aug;33(4 Suppl 92):S94-6. Epub 2015 Oct 12. Review.


Neuropathic Pain Phenotype Does Not Involve the NLRP3 Inflammasome and Its End Product Interleukin-1β in the Mice Spared Nerve Injury Model.

Curto-Reyes V, Kirschmann G, Pertin M, Drexler SK, Decosterd I, Suter MR.

PLoS One. 2015 Jul 28;10(7):e0133707. doi: 10.1371/journal.pone.0133707. eCollection 2015.


Complex roles of inflammasomes in carcinogenesis.

Drexler SK, Yazdi AS.

Cancer J. 2013 Nov-Dec;19(6):468-72. doi: 10.1097/PPO.0000000000000004. Review.


Regulation of interleukin 1α secretion by inflammasomes.

Yazdi AS, Drexler SK.

Ann Rheum Dis. 2013 Apr;72 Suppl 2:ii96-9. doi: 10.1136/annrheumdis-2012-202252. Epub 2012 Dec 19. Review.


Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis.

Drexler SK, Bonsignore L, Masin M, Tardivel A, Jackstadt R, Hermeking H, Schneider P, Gross O, Tschopp J, Yazdi AS.

Proc Natl Acad Sci U S A. 2012 Nov 6;109(45):18384-9. doi: 10.1073/pnas.1209171109. Epub 2012 Oct 22.


Inflammasome activators induce interleukin-1α secretion via distinct pathways with differential requirement for the protease function of caspase-1.

Gross O, Yazdi AS, Thomas CJ, Masin M, Heinz LX, Guarda G, Quadroni M, Drexler SK, Tschopp J.

Immunity. 2012 Mar 23;36(3):388-400. doi: 10.1016/j.immuni.2012.01.018.


Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β.

Yazdi AS, Guarda G, Riteau N, Drexler SK, Tardivel A, Couillin I, Tschopp J.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19449-54. doi: 10.1073/pnas.1008155107. Epub 2010 Oct 25.


The role of the inflammasome in nonmyeloid cells.

Yazdi AS, Drexler SK, Tschopp J.

J Clin Immunol. 2010 Sep;30(5):623-7. doi: 10.1007/s10875-010-9437-y. Epub 2010 Jun 27. Review.


SIGIRR/TIR-8 is an inhibitor of Toll-like receptor signaling in primary human cells and regulates inflammation in models of rheumatoid arthritis.

Drexler SK, Kong P, Inglis J, Williams RO, Garlanda C, Mantovani A, Yazdi AS, Brennan F, Feldmann M, Foxwell BM.

Arthritis Rheum. 2010 Aug;62(8):2249-61. doi: 10.1002/art.27517.


Evidence for a DC-specific inhibitory mechanism that depends on MyD88 and SIGIRR.

Drexler SK, Wales J, Andreakos E, Kong P, Davis A, Garlanda C, Mantovani A, Hussell T, Feldmann M, Foxwell BM.

Scand J Immunol. 2010 Jun;71(6):393-402. doi: 10.1111/j.1365-3083.2010.02392.x.


Inflammatory caspases in innate immunity and inflammation.

Yazdi AS, Guarda G, D'Ombrain MC, Drexler SK.

J Innate Immun. 2010;2(3):228-37. doi: 10.1159/000283688. Epub 2010 Feb 10. Review.


The role of toll-like receptors in chronic inflammation.

Drexler SK, Foxwell BM.

Int J Biochem Cell Biol. 2010 Apr;42(4):506-18. doi: 10.1016/j.biocel.2009.10.009. Epub 2009 Oct 29. Review.


Cell signalling in macrophages, the principal innate immune effector cells of rheumatoid arthritis.

Drexler SK, Kong PL, Wales J, Foxwell BM.

Arthritis Res Ther. 2008;10(5):216. doi: 10.1186/ar2481. Epub 2008 Oct 10. Review.


Could toll-like receptors provide a missing link in chronic inflammation in rheumatoid arthritis? Lessons from a study on human rheumatoid tissue.

Sacre SM, Drexler SK, Andreakos E, Feldmann M, Brennan FM, Foxwell BM.

Ann Rheum Dis. 2007 Nov;66 Suppl 3:iii81-6. Review.


Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems.

Lundberg AM, Drexler SK, Monaco C, Williams LM, Sacre SM, Feldmann M, Foxwell BM.

Blood. 2007 Nov 1;110(9):3245-52. Epub 2007 Jul 27.


Toll-like receptors: a new target in rheumatoid arthritis?

Drexler SK, Sacre SM, Foxwell BM.

Expert Rev Clin Immunol. 2006 Jul;2(4):585-99. doi: 10.1586/1744666X.2.4.585.


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