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Items: 1 to 50 of 455

1.

Small Molecular Modulators of JMJD1C Preferentially Inhibit Growth of Leukemia Cells.

Xu X, Wang L, Hu L, Dirks WG, Zhao Y, Wei Z, Chen D, Li Z, Wang Z, Han Y, Wei L, Drexler HG, Hu Z.

Int J Cancer. 2019 Jul 4. doi: 10.1002/ijc.32552. [Epub ahead of print]

PMID:
31271662
2.

The LL-100 panel: 100 cell lines for blood cancer studies.

Quentmeier H, Pommerenke C, Dirks WG, Eberth S, Koeppel M, MacLeod RAF, Nagel S, Steube K, Uphoff CC, Drexler HG.

Sci Rep. 2019 Jun 3;9(1):8218. doi: 10.1038/s41598-019-44491-x.

3.

Deregulated expression of NKL homeobox genes in T-cell lymphomas.

Nagel S, Pommerenke C, MacLeod RAF, Meyer C, Kaufmann M, Fähnrich S, Drexler HG.

Oncotarget. 2019 May 14;10(35):3227-3247. doi: 10.18632/oncotarget.26929. eCollection 2019 May 14.

4.

Epstein-Barr virus (EBV) activates NKL homeobox gene HLX in DLBCL.

Nagel S, Uphoff CC, Dirks WG, Pommerenke C, Meyer C, Drexler HG.

PLoS One. 2019 May 29;14(5):e0216898. doi: 10.1371/journal.pone.0216898. eCollection 2019.

5.

NKL homeobox gene NKX2-2 is aberrantly expressed in Hodgkin lymphoma.

Nagel S, MacLeod RAF, Pommerenke C, Meyer C, Kaufmann M, Drexler HG.

Oncotarget. 2018 Dec 25;9(101):37480-37496. doi: 10.18632/oncotarget.26459. eCollection 2018 Dec 25.

6.

Screening human cell lines for viral infections applying RNA-Seq data analysis.

Uphoff CC, Pommerenke C, Denkmann SA, Drexler HG.

PLoS One. 2019 Jan 10;14(1):e0210404. doi: 10.1371/journal.pone.0210404. eCollection 2019.

7.

NKL homeobox gene activities in B-cell development and lymphomas.

Nagel S, MacLeod RAF, Meyer C, Kaufmann M, Drexler HG.

PLoS One. 2018 Oct 11;13(10):e0205537. doi: 10.1371/journal.pone.0205537. eCollection 2018.

8.

IG-MYC + neoplasms with precursor B-cell phenotype are molecularly distinct from Burkitt lymphomas.

Wagener R, López C, Kleinheinz K, Bausinger J, Aukema SM, Nagel I, Toprak UH, Seufert J, Altmüller J, Thiele H, Schneider C, Kolarova J, Park J, Hübschmann D, Murga Penas EM, Drexler HG, Attarbaschi A, Hovland R, Kjeldsen E, Kneba M, Kontny U, de Leval L, Nürnberg P, Oschlies I, Oscier D, Schlegelberger B, Stilgenbauer S, Wössmann W, Schlesner M, Burkhardt B, Klapper W, Jaffe ES, Küppers R, Siebert R.

Blood. 2018 Nov 22;132(21):2280-2285. doi: 10.1182/blood-2018-03-842088. Epub 2018 Oct 3.

PMID:
30282799
9.

RBFOX2 and alternative splicing in B-cell lymphoma.

Quentmeier H, Pommerenke C, Bernhart SH, Dirks WG, Hauer V, Hoffmann S, Nagel S, Siebert R, Uphoff CC, Zaborski M, Drexler HG; ICGC MMML-Seq Consortium.

Blood Cancer J. 2018 Aug 10;8(8):77. doi: 10.1038/s41408-018-0114-3. No abstract available.

10.

Aberrant activity of NKL homeobox gene NKX3-2 in a T-ALL subset.

Nagel S, Meyer C, Kaufmann M, Zaborski M, MacLeod RAF, Drexler HG.

PLoS One. 2018 May 10;13(5):e0197194. doi: 10.1371/journal.pone.0197194. eCollection 2018.

11.

Aberrant expression of NKL homeobox gene HLX in Hodgkin lymphoma.

Nagel S, Pommerenke C, Meyer C, Kaufmann M, MacLeod RAF, Drexler HG.

Oncotarget. 2018 Feb 16;9(18):14338-14353. doi: 10.18632/oncotarget.24512. eCollection 2018 Mar 6.

12.

Suitability of Yin Yang 1 transcript and protein levels for biomarker studies in B cell non-Hodgkin lymphoma.

Arribas Arranz J, Winter DN, Drexler HG, Eberth S.

Biomark Res. 2018 Mar 13;6:11. doi: 10.1186/s40364-018-0126-y. eCollection 2018.

13.

Hodgkin lymphoma cell lines: to separate the wheat from the chaff.

Drexler HG, Pommerenke C, Eberth S, Nagel S.

Biol Chem. 2018 May 24;399(6):511-523. doi: 10.1515/hsz-2017-0321. Review.

PMID:
29533902
14.

MiR-130a is aberrantly overexpressed in adult acute myeloid leukemia with t(8;21) and its suppression induces AML cell death.

Ding C, Chen SN, Macleod RAF, Drexler HG, Nagel S, Wu DP, Sun AN, Dai HP.

Ups J Med Sci. 2018 Mar;123(1):19-27. doi: 10.1080/03009734.2018.1440037. Epub 2018 Mar 1.

15.

A new ETV6-NTRK3 cell line model reveals MALAT1 as a novel therapeutic target - a short report.

Chen S, Nagel S, Schneider B, Dai H, Geffers R, Kaufmann M, Meyer C, Pommerenke C, Thress KS, Li J, Quentmeier H, Drexler HG, MacLeod RAF.

Cell Oncol (Dordr). 2018 Feb;41(1):93-101. doi: 10.1007/s13402-017-0356-2. Epub 2017 Nov 8.

PMID:
29119387
16.

NKL homeobox gene MSX1 acts like a tumor suppressor in NK-cell leukemia.

Nagel S, Pommerenke C, Meyer C, Kaufmann M, MacLeod RAF, Drexler HG.

Oncotarget. 2017 Jun 21;8(40):66815-66832. doi: 10.18632/oncotarget.18609. eCollection 2017 Sep 15.

17.

Cytogenetically cryptic ZMYM2-FLT3 and DIAPH1-PDGFRB gene fusions in myeloid neoplasms with eosinophilia.

Jawhar M, Naumann N, Knut M, Score J, Ghazzawi M, Schneider B, Kreuzer KA, Hallek M, Drexler HG, Chacko J, Wallis L, Fabarius A, Metzgeroth G, Hofmann WK, Chase A, Tapper W, Reiter A, Cross NCP.

Leukemia. 2017 Oct;31(10):2271-2273. doi: 10.1038/leu.2017.240. Epub 2017 Jul 28. No abstract available.

18.

Peripheral T-cell lymphoma cell line T8ML-1 highlights conspicuous targeting of PVRL2 by t(14;19)(q11.2;q13.3).

Ehrentraut S, Nagel S, Pommerenke C, Dirks WG, Quentmeier H, Kaufmann M, Meyer C, Zaborski M, Geffers R, Fujiwara H, Drexler HG, MacLeod RAF.

Haematologica. 2017 Sep;102(9):e356-e359. doi: 10.3324/haematol.2017.168203. Epub 2017 Jun 28. No abstract available.

19.

Induction of endoplasmic reticulum calcium pump expression during early leukemic B cell differentiation.

Aït Ghezali L, Arbabian A, Roudot H, Brouland JP, Baran-Marszak F, Salvaris E, Boyd A, Drexler HG, Enyedi A, Letestu R, Varin-Blank N, Papp B.

J Exp Clin Cancer Res. 2017 Jun 26;36(1):87. doi: 10.1186/s13046-017-0556-7.

20.

KDM3B shows tumor-suppressive activity and transcriptionally regulates HOXA1 through retinoic acid response elements in acute myeloid leukemia.

Xu X, Nagel S, Quentmeier H, Wang Z, Pommerenke C, Dirks WG, Macleod RAF, Drexler HG, Hu Z.

Leuk Lymphoma. 2018 Jan;59(1):204-213. doi: 10.1080/10428194.2017.1324156. Epub 2017 May 25.

PMID:
28540746
21.

Epigenetically induced ectopic expression of UNCX impairs the proliferation and differentiation of myeloid cells.

Daniele G, Simonetti G, Fusilli C, Iacobucci I, Lonoce A, Palazzo A, Lomiento M, Mammoli F, Marsano RM, Marasco E, Mantovani V, Quentmeier H, Drexler HG, Ding J, Palumbo O, Carella M, Nadarajah N, Perricone M, Ottaviani E, Baldazzi C, Testoni N, Papayannidis C, Ferrari S, Mazza T, Martinelli G, Storlazzi CT.

Haematologica. 2017 Jul;102(7):1204-1214. doi: 10.3324/haematol.2016.163022. Epub 2017 Apr 14.

22.

NKL homeobox gene activities in hematopoietic stem cells, T-cell development and T-cell leukemia.

Nagel S, Pommerenke C, Scherr M, Meyer C, Kaufmann M, Battmer K, MacLeod RA, Drexler HG.

PLoS One. 2017 Feb 2;12(2):e0171164. doi: 10.1371/journal.pone.0171164. eCollection 2017.

23.

Identification of a tumor suppressor network in T-cell leukemia.

Nagel S, Pommerenke C, Meyer C, Kaufmann M, MacLeod RAF, Drexler HG.

Leuk Lymphoma. 2017 Sep;58(9):2196–2207. doi: 10.1080/10428194.2017.1283029. Epub 2017 Jan 31.

PMID:
28142295
24.

Cytogenetic Harvesting of Cancer Cells and Cell Lines.

MacLeod RA, Kaufmann ME, Drexler HG.

Methods Mol Biol. 2017;1541:43-58.

PMID:
27910013
25.

Diffuse Large B Cell Lymphoma Cell Line U-2946: Model for MCL1 Inhibitor Testing.

Quentmeier H, Drexler HG, Hauer V, MacLeod RA, Pommerenke C, Uphoff CC, Zaborski M, Berglund M, Enblad G, Amini RM.

PLoS One. 2016 Dec 1;11(12):e0167599. doi: 10.1371/journal.pone.0167599. eCollection 2016.

26.

False and mycoplasma-contaminated leukemia-lymphoma cell lines: time for a reappraisal.

Drexler HG, Dirks WG, MacLeod RA, Uphoff CC.

Int J Cancer. 2017 Mar 1;140(5):1209-1214. doi: 10.1002/ijc.30530.

27.

Alterations of microRNA and microRNA-regulated messenger RNA expression in germinal center B-cell lymphomas determined by integrative sequencing analysis.

Hezaveh K, Kloetgen A, Bernhart SH, Mahapatra KD, Lenze D, Richter J, Haake A, Bergmann AK, Brors B, Burkhardt B, Claviez A, Drexler HG, Eils R, Haas S, Hoffmann S, Karsch D, Klapper W, Kleinheinz K, Korbel J, Kretzmer H, Kreuz M, Küppers R, Lawerenz C, Leich E, Loeffler M, Mantovani-Loeffler L, López C, McHardy AC, Möller P, Rohde M, Rosenstiel P, Rosenwald A, Schilhabel M, Schlesner M, Scholz I, Stadler PF, Stilgenbauer S, Sungalee S, Szczepanowski M, Trümper L, Weniger MA, Siebert R, Borkhardt A, Hummel M, Hoell JI; ICGC MMML-Seq Project.

Haematologica. 2016 Nov;101(11):1380-1389. Epub 2016 Jul 6.

28.

Immunophenotypic, cytogenetic, and mutational characterization of cell lines derived from myelodysplastic syndrome patients after progression to acute myeloid leukemia.

Palau A, Mallo M, Palomo L, Rodríguez-Hernández I, Diesch J, Campos D, Granada I, Juncà J, Drexler HG, Solé F, Buschbeck M.

Genes Chromosomes Cancer. 2017 Mar;56(3):243-252. doi: 10.1002/gcc.22430. Epub 2016 Nov 21.

PMID:
27750403
29.

Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma.

Mansouri L, Noerenberg D, Young E, Mylonas E, Abdulla M, Frick M, Asmar F, Ljungström V, Schneider M, Yoshida K, Skaftason A, Pandzic T, Gonzalez B, Tasidou A, Waldhueter N, Rivas-Delgado A, Angelopoulou M, Ziepert M, Arends CM, Couronné L, Lenze D, Baldus CD, Bastard C, Okosun J, Fitzgibbon J, Dörken B, Drexler HG, Roos-Weil D, Schmitt CA, Munch-Petersen HD, Zenz T, Hansmann ML, Strefford JC, Enblad G, Bernard OA, Ralfkiaer E, Erlanson M, Korkolopoulou P, Hultdin M, Papadaki T, Grønbæk K, Lopez-Guillermo A, Ogawa S, Küppers R, Stamatopoulos K, Stavroyianni N, Kanellis G, Rosenwald A, Campo E, Amini RM, Ott G, Vassilakopoulos TP, Hummel M, Rosenquist R, Damm F.

Blood. 2016 Dec 8;128(23):2666-2670. Epub 2016 Sep 26.

30.

Subclones in B-lymphoma cell lines: isogenic models for the study of gene regulation.

Quentmeier H, Pommerenke C, Ammerpohl O, Geffers R, Hauer V, MacLeod RA, Nagel S, Romani J, Rosati E, Rosén A, Uphoff CC, Zaborski M, Drexler HG.

Oncotarget. 2016 Sep 27;7(39):63456-63465. doi: 10.18632/oncotarget.11524.

31.

Deregulation of polycomb repressor complex 1 modifier AUTS2 in T-cell leukemia.

Nagel S, Pommerenke C, Meyer C, Kaufmann M, Drexler HG, MacLeod RA.

Oncotarget. 2016 Jul 19;7(29):45398-45413. doi: 10.18632/oncotarget.9982.

32.

Chromosome 11q23 aberrations activating FOXR1 in B-cell lymphoma.

Pommerenke C, Hauer V, Zaborski M, MacLeod RA, Nagel S, Amini RM, Berglund M, Geffers R, Drexler HG, Quentmeier H.

Blood Cancer J. 2016 Jun 10;6:e433. doi: 10.1038/bcj.2016.43. No abstract available.

33.

Enhanced whole exome sequencing by higher DNA insert lengths.

Pommerenke C, Geffers R, Bunk B, Bhuju S, Eberth S, Drexler HG, Quentmeier H.

BMC Genomics. 2016 May 25;17:399. doi: 10.1186/s12864-016-2698-y.

34.

Th17 cytokine differentiation and loss of plasticity after SOCS1 inactivation in a cutaneous T-cell lymphoma.

Ehrentraut S, Schneider B, Nagel S, Pommerenke C, Quentmeier H, Geffers R, Feist M, Kaufmann M, Meyer C, Kadin ME, Drexler HG, MacLeod RA.

Oncotarget. 2016 Jun 7;7(23):34201-16. doi: 10.18632/oncotarget.9077.

35.

Malignant hematopoietic cell lines: in vitro models for double-hit B-cell lymphomas.

Drexler HG, Eberth S, Nagel S, MacLeod RA.

Leuk Lymphoma. 2016 May;57(5):1015-20. doi: 10.3109/10428194.2015.1108414. Epub 2016 Jan 4. Review.

PMID:
26727417
36.

Genomic Landscape of Primary Mediastinal B-Cell Lymphoma Cell Lines.

Dai H, Ehrentraut S, Nagel S, Eberth S, Pommerenke C, Dirks WG, Geffers R, Kalavalapalli S, Kaufmann M, Meyer C, Faehnrich S, Chen S, Drexler HG, MacLeod RA.

PLoS One. 2015 Nov 23;10(11):e0139663. doi: 10.1371/journal.pone.0139663. eCollection 2015.

37.

Aberrant expression of homeobox gene SIX1 in Hodgkin lymphoma.

Nagel S, Meyer C, Kaufmann M, Drexler HG, MacLeod RA.

Oncotarget. 2015 Nov 24;6(37):40112-26. doi: 10.18632/oncotarget.5556.

38.

DNA methylome analysis in Burkitt and follicular lymphomas identifies differentially methylated regions linked to somatic mutation and transcriptional control.

Kretzmer H, Bernhart SH, Wang W, Haake A, Weniger MA, Bergmann AK, Betts MJ, Carrillo-de-Santa-Pau E, Doose G, Gutwein J, Richter J, Hovestadt V, Huang B, Rico D, Jühling F, Kolarova J, Lu Q, Otto C, Wagener R, Arnolds J, Burkhardt B, Claviez A, Drexler HG, Eberth S, Eils R, Flicek P, Haas S, Humme M, Karsch D, Kerstens HHD, Klapper W, Kreuz M, Lawerenz C, Lenzek D, Loeffler M, López C, MacLeod RAF, Martens JHA, Kulis M, Martín-Subero JI, Möller P, Nage I, Picelli S, Vater I, Rohde M, Rosenstiel P, Rosolowski M, Russell RB, Schilhabel M, Schlesner M, Stadler PF, Szczepanowski M, Trümper L, Stunnenberg HG, Küppers R, Ammerpohl O, Lichter P, Siebert R, Hoffmann S, Radlwimmer B.

Nat Genet. 2015 Nov;47(11):1316-1325. doi: 10.1038/ng.3413. Epub 2015 Oct 5.

39.

Aberrantly Expressed OTX Homeobox Genes Deregulate B-Cell Differentiation in Hodgkin Lymphoma.

Nagel S, Ehrentraut S, Meyer C, Kaufmann M, Drexler HG, MacLeod RA.

PLoS One. 2015 Sep 25;10(9):e0138416. doi: 10.1371/journal.pone.0138416. eCollection 2015.

40.

Establishment and genetic characterization of a novel mixed-phenotype acute leukemia cell line with EP300-ZNF384 fusion.

Ping N, Qiu H, Wang Q, Dai H, Ruan C, Ehrentraut S, Drexler HG, MacLeod RA, Chen S.

J Hematol Oncol. 2015 Aug 21;8:100. doi: 10.1186/s13045-015-0197-2.

41.

The PCBP1 gene encoding poly(rC) binding protein I is recurrently mutated in Burkitt lymphoma.

Wagener R, Aukema SM, Schlesner M, Haake A, Burkhardt B, Claviez A, Drexler HG, Hummel M, Kreuz M, Loeffler M, Rosolowski M, López C, Möller P, Richter J, Rohde M, Betts MJ, Russell RB, Bernhart SH, Hoffmann S, Rosenstiel P, Schilhabel M, Szczepanowski M, Trümper L, Klapper W, Siebert R; ICGC MMML-Seq-Project; "Molecular Mechanisms in Malignant Lymphomas" Network Project of the Deutsche Krebshilfe.

Genes Chromosomes Cancer. 2015 Sep;54(9):555-64. doi: 10.1002/gcc.22268. Epub 2015 Jul 14.

PMID:
26173642
42.

NFkB is activated by multiple mechanisms in hairy cell leukemia.

Nagel S, Ehrentraut S, Meyer C, Kaufmann M, Drexler HG, MacLeod RA.

Genes Chromosomes Cancer. 2015 Jul;54(7):418-32. doi: 10.1002/gcc.22253. Epub 2015 May 7.

PMID:
25960206
43.

Prevalence and characterization of murine leukemia virus contamination in human cell lines.

Uphoff CC, Lange S, Denkmann SA, Garritsen HS, Drexler HG.

PLoS One. 2015 Apr 30;10(4):e0125622. doi: 10.1371/journal.pone.0125622. eCollection 2015.

44.

BCL6--regulated by AhR/ARNT and wild-type MEF2B--drives expression of germinal center markers MYBL1 and LMO2.

Ding J, Dirks WG, Ehrentraut S, Geffers R, MacLeod RA, Nagel S, Pommerenke C, Romani J, Scherr M, Vaas LA, Zaborski M, Drexler HG, Quentmeier H.

Haematologica. 2015 Jun;100(6):801-9. doi: 10.3324/haematol.2014.120048. Epub 2015 Mar 13.

45.

High frequency of cryptic chromosomal rearrangements involving the LMO2 gene in T-cell acute lymphoblastic leukemia.

Wu L, Xu Y, Wang Q, Ruan C, Drexler HG, Wu D, MacLeod RA, Chen S.

Haematologica. 2015 Jun;100(6):e233-6. doi: 10.3324/haematol.2014.120089. Epub 2015 Feb 14. No abstract available.

46.

Analysis of mutational signatures in exomes from B-cell lymphoma cell lines suggest APOBEC3 family members to be involved in the pathogenesis of primary effusion lymphoma.

Wagener R, Alexandrov LB, Montesinos-Rongen M, Schlesner M, Haake A, Drexler HG, Richter J, Bignell GR, McDermott U, Siebert R.

Leukemia. 2015 Jul;29(7):1612-5. doi: 10.1038/leu.2015.22. Epub 2015 Feb 4. No abstract available.

PMID:
25650088
47.

Evaluation of methods to detect CALR mutations in myeloproliferative neoplasms.

Jones AV, Ward D, Lyon M, Leung W, Callaway A, Chase A, Dent CL, White HE, Drexler HG, Nangalia J, Mattocks C, Cross NC.

Leuk Res. 2015 Jan;39(1):82-7. doi: 10.1016/j.leukres.2014.11.019. Epub 2014 Nov 29.

PMID:
25499808
48.

Malignant hematopoietic cell lines: in vitro models for the study of primary mediastinal B-cell lymphomas.

Drexler HG, Ehrentraut S, Nagel S, Eberth S, MacLeod RA.

Leuk Res. 2015 Jan;39(1):18-29. doi: 10.1016/j.leukres.2014.11.002. Epub 2014 Nov 21. Review.

PMID:
25480038
49.

MARIMO cells harbor a CALR mutation but are not dependent on JAK2/STAT5 signaling.

Kollmann K, Nangalia J, Warsch W, Quentmeier H, Bench A, Boyd E, Scott M, Drexler HG, Green AR.

Leukemia. 2015 Feb;29(2):494-7. doi: 10.1038/leu.2014.285. Epub 2014 Sep 24. No abstract available.

50.

Localization of MLH3 at the centrosomes.

Roesner LM, Mielke C, Faehnrich S, Merkhoffer Y, Dittmar KE, Drexler HG, Dirks WG.

Int J Mol Sci. 2014 Aug 11;15(8):13932-7. doi: 10.3390/ijms150813932.

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