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Items: 43

1.

Evidence for the Validity of Pyridoxic Acid (PDA) as a Plasma-Based Endogenous Probe for OAT1 and OAT3 Function in Healthy Subjects.

Shen H, Holenarsipur VK, Mariappan TT, Drexler DM, Cantone JL, Rajanna P, Singh Gautam S, Zhang Y, Gan J, Shipkova PA, Marathe P, Humphreys WG.

J Pharmacol Exp Ther. 2019 Jan;368(1):136-145. doi: 10.1124/jpet.118.252643. Epub 2018 Oct 25.

PMID:
30361237
2.

Synergistic inhibition of Aβ production by combinations of γ-secretase modulators.

Robertson AS, Iben LG, Wei C, Meredith JE Jr, Drexler DM, Banks M, Vite GD, Olson RE, Thompson LA, Albright CF, Ahlijanian MK, Toyn JH.

Eur J Pharmacol. 2017 Oct 5;812:104-112. doi: 10.1016/j.ejphar.2017.07.019. Epub 2017 Jul 8.

PMID:
28690193
3.

Comparative Evaluation of Plasma Bile Acids, Dehydroepiandrosterone Sulfate, Hexadecanedioate, and Tetradecanedioate with Coproporphyrins I and III as Markers of OATP Inhibition in Healthy Subjects.

Shen H, Chen W, Drexler DM, Mandlekar S, Holenarsipur VK, Shields EE, Langish R, Sidik K, Gan J, Humphreys WG, Marathe P, Lai Y.

Drug Metab Dispos. 2017 Aug;45(8):908-919. doi: 10.1124/dmd.117.075531. Epub 2017 Jun 2.

PMID:
28576766
4.

Tiered analytics for purity assessment of macrocyclic peptides in drug discovery: Analytical consideration and method development.

Qian Cutrone JJ, Huang XS, Kozlowski ES, Bao Y, Wang Y, Poronsky CS, Drexler DM, Tymiak AA.

J Pharm Biomed Anal. 2017 May 10;138:166-174. doi: 10.1016/j.jpba.2017.01.056. Epub 2017 Feb 3.

PMID:
28213177
5.

Robust Translation of γ-Secretase Modulator Pharmacology across Preclinical Species and Human Subjects.

Toyn JH, Boy KM, Raybon J, Meredith JE Jr, Robertson AS, Guss V, Hoque N, Sweeney F, Zhuo X, Clarke W, Snow K, Denton RR, Zuev D, Thompson LA, Morrison J, Grace J, Berisha F, Furlong M, Wang JS, Lentz KA, Padmanabha R, Cook L, Wei C, Drexler DM, Macor JE, Albright CF, Gasior M, Olson RE, Hong Q, Soares HD, AbuTarif M, Ahlijanian MK.

J Pharmacol Exp Ther. 2016 Jul;358(1):125-37. doi: 10.1124/jpet.116.232249. Epub 2016 Apr 20.

6.

The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers.

Soares HD, Gasior M, Toyn JH, Wang JS, Hong Q, Berisha F, Furlong MT, Raybon J, Lentz KA, Sweeney F, Zheng N, Akinsanya B, Berman RM, Thompson LA, Olson RE, Morrison J, Drexler DM, Macor JE, Albright CF, Ahlijanian MK, AbuTarif M.

J Pharmacol Exp Ther. 2016 Jul;358(1):138-50. doi: 10.1124/jpet.116.232256. Epub 2016 Apr 20.

7.

The utility of stable isotope labeled (SIL) analogues in the bioanalysis of endogenous compounds by LC-MS applied to the study of bile acids in a metabolomics assay.

Zheng JJ, Shields EE, Snow KJ, Nelson DM, Olah TV, Reily MD, Robertson DG, Shipkova PA, Stryker SA, Xin B, Drexler DM.

Anal Biochem. 2016 Jun 15;503:71-8. doi: 10.1016/j.ab.2016.03.011. Epub 2016 Mar 28.

PMID:
27033006
8.

Phosphocholine conjugation: an unexpected in vivo conjugation pathway associated with hepatitis c ns5b inhibitors featuring a bicyclo[1.1.1]pentane.

Zhuo X, Cantone JL, Wang Y, Leet JE, Drexler DM, Yeung KS, Huang XS, Eastman KJ, Parcella KE, Mosure KW, Soars MG, Kadow JF, Johnson BM.

Drug Metab Dispos. 2016 Aug;44(8):1332-1340. doi: 10.1124/dmd.115.069062. Epub 2016 Mar 9.

PMID:
26961241
9.

Application of Cassette Ultracentrifugation Using Non-labeled Compounds and Liquid Chromatography-Tandem Mass Spectrometry Analysis for High-Throughput Protein Binding Determination.

Kieltyka K, McAuliffe B, Cianci C, Drexler DM, Shou W, Zhang J.

J Pharm Sci. 2016 Mar;105(3):1036-42. doi: 10.1016/S0022-3549(15)00177-X. Epub 2016 Jan 27.

PMID:
26886323
10.

Ionization sources and mass analyzers in MS imaging.

Tsai YH, Menger RF, Drexler DM, Yost RA, Garrett TJ.

Bioanalysis. 2015;7(20):2629-37. doi: 10.4155/bio.15.187. Epub 2015 Oct 29.

PMID:
26511148
11.

Beyond classical derivatization: analyte 'derivatives' in the bioanalysis of endogenous and exogenous compounds.

Barnaby OS, Benitex Y, Cantone JL, McNaney CA, Olah TV, Drexler DM.

Bioanalysis. 2015 Oct;7(19):2501-13. doi: 10.4155/bio.15.171. Epub 2015 Oct 15.

PMID:
26466806
12.

Coupling Laser Diode Thermal Desorption with Acoustic Sample Deposition to Improve Throughput of Mass Spectrometry-Based Screening.

Haarhoff Z, Wagner A, Picard P, Drexler DM, Zvyaga T, Shou W.

J Biomol Screen. 2016 Feb;21(2):165-75. doi: 10.1177/1087057115607184. Epub 2015 Sep 29.

PMID:
26420787
13.

Acoustic Sample Deposition MALDI-MS (ASD-MALDI-MS): A Novel Process Flow for Quality Control Screening of Compound Libraries.

Chin J, Wood E, Peters GS, Drexler DM.

J Lab Autom. 2016 Feb;21(1):204-7. doi: 10.1177/2211068215594769. Epub 2015 Jul 22.

PMID:
26203056
14.

Bioanalysis of acetylcarnitine in cerebrospinal fluid by HILIC-mass spectrometry.

Holder BR, McNaney CA, Luchetti D, Schaeffer E, Drexler DM.

Biomed Chromatogr. 2015 Sep;29(9):1375-9. doi: 10.1002/bmc.3433. Epub 2015 Feb 24.

PMID:
25712252
15.

Strategy to improve the quantitative LC-MS analysis of molecular ions resistant to gas-phase collision induced dissociation: application to disulfide-rich cyclic peptides.

Ciccimaro E, Ranasinghe A, D'Arienzo C, Xu C, Onorato J, Drexler DM, Josephs JL, Poss M, Olah T.

Anal Chem. 2014 Dec 2;86(23):11523-7. doi: 10.1021/ac502678y. Epub 2014 Nov 18.

PMID:
25371986
16.

Labware additives identified to be selective monoamine oxidase-B inhibitors.

Stewart J, Drexler DM, Leet JE, McNaney CA, Herbst JJ.

J Biomol Screen. 2014 Dec;19(10):1409-14. doi: 10.1177/1087057114551523. Epub 2014 Oct 8.

PMID:
25296658
17.

Stable isotope labeling by amino acids in cell culture-based liquid chromatography-mass spectrometry assay to measure microtubule dynamics in neuronal cell cultures.

Polson C, Cantone JL, Wei C, Drexler DM, Meredith JE Jr.

Anal Biochem. 2014 Dec 1;466:65-71. doi: 10.1016/j.ab.2014.08.011. Epub 2014 Aug 28.

PMID:
25175011
18.

Bioanalysis of (1R,4R,5S,6R)-4-amino-2-oxabicyclo[3.1.0]hexane-4,6-dicarboxylic acid (LY379268) in rat plasma using derivatization liquid chromatography/mass spectrometry.

Benitex Y, Luan FN, Shields E, McNaney CA, Morgan DG, Olah TV, Drexler DM.

Bioanalysis. 2014;6(14):1901-5. doi: 10.4155/bio.14.103.

PMID:
25158962
19.

Identification and Preclinical Pharmacology of the γ-Secretase Modulator BMS-869780.

Toyn JH, Thompson LA, Lentz KA, Meredith JE Jr, Burton CR, Sankaranararyanan S, Guss V, Hall T, Iben LG, Krause CM, Krause R, Lin XA, Pierdomenico M, Polson C, Robertson AS, Denton RR, Grace JE, Morrison J, Raybon J, Zhuo X, Snow K, Padmanabha R, Agler M, Esposito K, Harden D, Prack M, Varma S, Wong V, Zhu Y, Zvyaga T, Gerritz S, Marcin LR, Higgins MA, Shi J, Wei C, Cantone JL, Drexler DM, Macor JE, Olson RE, Ahlijanian MK, Albright CF.

Int J Alzheimers Dis. 2014;2014:431858. doi: 10.1155/2014/431858. Epub 2014 Jul 8.

20.

Analysis of L-serine-O-phosphate in cerebrospinal spinal fluid by derivatization-liquid chromatography/mass spectrometry.

McNaney CA, Benitex Y, Luchetti D, Labasi JM, Olah TV, Morgan DG, Drexler DM.

Anal Biochem. 2014 May 1;452:10-2. doi: 10.1016/j.ab.2014.02.007. Epub 2014 Feb 15.

PMID:
24534252
21.

Honey bees, neonicotinoids and bee incident reports: the Canadian situation.

Cutler GC, Scott-Dupree CD, Drexler DM.

Pest Manag Sci. 2014 May;70(5):779-83. doi: 10.1002/ps.3613. Epub 2013 Aug 19.

PMID:
23873722
22.

Addressing the need for biomarker liquid chromatography/mass spectrometry assays: a protocol for effective method development for the bioanalysis of endogenous compounds in cerebrospinal fluid.

Benitex Y, McNaney CA, Luchetti D, Schaeffer E, Olah TV, Morgan DG, Drexler DM.

Rapid Commun Mass Spectrom. 2013 Aug 30;27(16):1882-6. doi: 10.1002/rcm.6639.

PMID:
23857934
23.

Screening and characterization of reactive compounds with in vitro peptide-trapping and liquid chromatography/high-resolution accurate mass spectrometry.

Wei C, Chupak LS, Philip T, Johnson BM, Gentles R, Drexler DM.

J Biomol Screen. 2014 Feb;19(2):297-307. doi: 10.1177/1087057113492852. Epub 2013 Jun 24.

PMID:
23796688
24.

Utility of high-resolution accurate MS to eliminate interferences in the bioanalysis of ribavirin and its phosphate metabolites.

Wei C, Grace JE Jr, Zvyaga TA, Drexler DM.

Bioanalysis. 2012 Aug;4(15):1895-905. doi: 10.4155/bio.12.151.

PMID:
22943620
25.

Cassette incubation followed by bioanalysis using high-resolution MS for in vitro ADME screening assays.

Zhang J, Maloney J, Drexler DM, Cai X, Stewart J, Mayer C, Herbst J, Weller H, Shou WZ.

Bioanalysis. 2012 Mar;4(5):581-93. doi: 10.4155/bio.12.2.

PMID:
22409555
26.

Tissue analysis by imaging MS.

Oppenheimer SR, Drexler DM.

Bioanalysis. 2012 Jan;4(1):95-112. doi: 10.4155/bio.11.282. Review.

PMID:
22191597
27.

Advances in mass spectrometry applied to pharmaceutical metabolomics.

Drexler DM, Reily MD, Shipkova PA.

Anal Bioanal Chem. 2011 Mar;399(8):2645-53. doi: 10.1007/s00216-010-4370-8. Epub 2010 Nov 25. Review.

PMID:
21107980
28.

Simultaneous bioanalysis of a phosphate prodrug and its parent compound using a multiplexed LC-MS method.

Browning MR, Drexler DM, Olah TV, Morgan DG.

Bioanalysis. 2010 Apr;2(4):745-53. doi: 10.4155/bio.10.25.

PMID:
21083272
29.

Utility of quantitative whole-body autoradiography (QWBA) and imaging mass spectrometry (IMS) by matrix-assisted laser desorption/ionization (MALDI) in the assessment of ocular distribution of drugs.

Drexler DM, Tannehill-Gregg SH, Wang L, Brock BJ.

J Pharmacol Toxicol Methods. 2011 Mar-Apr;63(2):205-8. doi: 10.1016/j.vascn.2010.10.003. Epub 2010 Oct 29.

PMID:
21040797
30.

Analysis of large peptides by MALDI using a linear quadrupole ion trap with mass range extension.

Magparangalan DP, Garrett TJ, Drexler DM, Yost RA.

Anal Chem. 2010 Feb 1;82(3):930-4. doi: 10.1021/ac9021488.

PMID:
20063857
31.

Extraction, identification, and functional characterization of a bioactive substance from automated compound-handling plastic tips.

Watson J, Greenough EB, Leet JE, Ford MJ, Drexler DM, Belcastro JV, Herbst JJ, Chatterjee M, Banks M.

J Biomol Screen. 2009 Jun;14(5):566-72. doi: 10.1177/1087057109336594. Epub 2009 May 21.

PMID:
19470712
32.

Application of quantitative LC-MS surrogate peptide methodology in the analysis of the amyloid beta peptide (Abeta) biosynthetic intermediate protein APP-betaCTF.

Cantone JL, Xu-Lin A, Toyn JH, Drexler DM.

J Neurosci Methods. 2009 Jun 15;180(2):255-60. doi: 10.1016/j.jneumeth.2009.03.018. Epub 2009 Mar 31.

PMID:
19464516
33.

A high-throughput bioanalytical platform using automated infusion for tandem mass spectrometric method optimization and its application in a metabolic stability screen.

Kieltyka K, Zhang J, Li S, Vath M, Baglieri C, Ferraro C, Zvyaga TA, Drexler DM, Weller HN, Shou WZ.

Rapid Commun Mass Spectrom. 2009 Jun;23(11):1579-91. doi: 10.1002/rcm.4037.

PMID:
19399765
34.

Normalization strategies for metabonomic analysis of urine samples.

Warrack BM, Hnatyshyn S, Ott KH, Reily MD, Sanders M, Zhang H, Drexler DM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Feb 15;877(5-6):547-52. doi: 10.1016/j.jchromb.2009.01.007. Epub 2009 Jan 14.

PMID:
19185549
35.

The amyloid-beta rise and gamma-secretase inhibitor potency depend on the level of substrate expression.

Burton CR, Meredith JE, Barten DM, Goldstein ME, Krause CM, Kieras CJ, Sisk L, Iben LG, Polson C, Thompson MW, Lin XA, Corsa J, Fiedler T, Pierdomenico M, Cao Y, Roach AH, Cantone JL, Ford MJ, Drexler DM, Olson RE, Yang MG, Bergstrom CP, McElhone KE, Bronson JJ, Macor JE, Blat Y, Grafstrom RH, Stern AM, Seiffert DA, Zaczek R, Albright CF, Toyn JH.

J Biol Chem. 2008 Aug 22;283(34):22992-3003. doi: 10.1074/jbc.M804175200. Epub 2008 Jun 23.

36.

Application of ion trap technology to liquid chromatography/mass spectrometry quantitation of large peptides.

Shipkova P, Drexler DM, Langish R, Smalley J, Salyan ME, Sanders M.

Rapid Commun Mass Spectrom. 2008 May;22(9):1359-66. doi: 10.1002/rcm.3511.

PMID:
18381620
37.

An automated liquid chromatography-mass spectrometry process to determine metabolic stability half-life and intrinsic clearance of drug candidates by substrate depletion.

McNaney CA, Drexler DM, Hnatyshyn SY, Zvyaga TA, Knipe JO, Belcastro JV, Sanders M.

Assay Drug Dev Technol. 2008 Feb;6(1):121-9. doi: 10.1089/adt.2007.103.

PMID:
18336089
38.

Cytotoxic xanthones from Psorospermum molluscum from the Madagascar rain forest.

Leet JE, Liu X, Drexler DM, Cantone JL, Huang S, Mamber SW, Fairchild CR, Hussain R, Newman DJ, Kingston DG.

J Nat Prod. 2008 Mar;71(3):460-3. doi: 10.1021/np070523l. Epub 2008 Feb 5.

39.

Qualitative and quantitative characterization of the amyloid beta peptide (Abeta) population in biological matrices using an immunoprecipitation-LC/MS assay.

Ford MJ, Cantone JL, Polson C, Toyn JH, Meredith JE, Drexler DM.

J Neurosci Methods. 2008 Mar 15;168(2):465-74. doi: 10.1016/j.jneumeth.2007.11.019. Epub 2007 Nov 29.

PMID:
18187205
40.

An automated high throughput liquid chromatography-mass spectrometry process to assess the metabolic stability of drug candidates.

Drexler DM, Belcastro JV, Dickinson KE, Edinger KJ, Hnatyshyn SY, Josephs JL, Langish RA, McNaney CA, Santone KS, Shipkova PA, Tymiak AA, Zvyaga TA, Sanders M.

Assay Drug Dev Technol. 2007 Apr;5(2):247-64.

PMID:
17477833
41.

Utility of imaging mass spectrometry (IMS) by matrix-assisted laser desorption ionization (MALDI) on an ion trap mass spectrometer in the analysis of drugs and metabolites in biological tissues.

Drexler DM, Garrett TJ, Cantone JL, Diters RW, Mitroka JG, Prieto Conaway MC, Adams SP, Yost RA, Sanders M.

J Pharmacol Toxicol Methods. 2007 May-Jun;55(3):279-88. Epub 2006 Dec 5.

PMID:
17222568
42.

An empirical process for the design of high-throughput screening deck filters.

Pearce BC, Sofia MJ, Good AC, Drexler DM, Stock DA.

J Chem Inf Model. 2006 May-Jun;46(3):1060-8.

PMID:
16711725
43.

Mass spectrometry techniques for qualitative and quantitative analysis of biomarkers.

Drexler DM, Feyen JH, Sanders M.

Drug Discov Today Technol. 2004 Sep;1(1):17-23. doi: 10.1016/j.ddtec.2004.08.010.

PMID:
24981263

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