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Items: 1 to 50 of 286

1.

Low-Grade Inflammation as a Predictor of Antidepressant and Anti-Inflammatory Therapy Response in MDD Patients: A Systematic Review of the Literature in Combination With an Analysis of Experimental Data Collected in the EU-MOODINFLAME Consortium.

Arteaga-Henríquez G, Simon MS, Burger B, Weidinger E, Wijkhuijs A, Arolt V, Birkenhager TK, Musil R, Müller N, Drexhage HA.

Front Psychiatry. 2019 Jul 9;10:458. doi: 10.3389/fpsyt.2019.00458. eCollection 2019.

2.

Inflammatory cytokines and growth factors were not associated with psychosis liability or childhood trauma.

Counotte J, Bergink V, Pot-Kolder R, Drexhage HA, Hoek HW, Veling W.

PLoS One. 2019 Jul 5;14(7):e0219139. doi: 10.1371/journal.pone.0219139. eCollection 2019.

3.

Effects of Air Pollution on Lung Innate Lymphoid Cells: Review of In Vitro and In Vivo Experimental Studies.

Estrella B, Naumova EN, Cepeda M, Voortman T, Katsikis PD, Drexhage HA.

Int J Environ Res Public Health. 2019 Jul 2;16(13). pii: E2347. doi: 10.3390/ijerph16132347. Review.

4.

Markers of neuroinflammation influence measures of cortical thickness in bipolar depression.

Poletti S, Leone G, Hoogenboezem TA, Ghiglino D, Vai B, de Wit H, Wijkhuijs AJM, Locatelli C, Colombo C, Drexhage HA, Benedetti F.

Psychiatry Res Neuroimaging. 2019 Mar 30;285:64-66. doi: 10.1016/j.pscychresns.2019.01.009. Epub 2019 Jan 29.

PMID:
30785023
5.

Genetic and environmental influences on circulating NK and T cells and their relation to bipolar disorder.

Snijders G, Brouwer R, Kemner S, Bootsman F, Drexhage HA, Hillegers MHJ.

Int J Bipolar Disord. 2019 Feb 10;7(1):4. doi: 10.1186/s40345-018-0139-3.

6.

Editorial: Activation and de-activation of inflammatory pathways. The disequilibrium of immune-neuro-endocrine networks in psychiatric disorders.

Drexhage HA.

Brain Behav Immun. 2019 May;78:5-6. doi: 10.1016/j.bbi.2019.01.007. Epub 2019 Jan 22.

PMID:
30682504
7.

The circulating levels of CD4+ t helper cells are higher in bipolar disorder as compared to major depressive disorder.

Becking K, Haarman BCM, Grosse L, Nolen WA, Claes S, Arolt V, Schoevers RA, Drexhage HA.

J Neuroimmunol. 2018 Jun 15;319:28-36. doi: 10.1016/j.jneuroim.2018.03.004. Epub 2018 Mar 21.

PMID:
29685287
8.

[The dysregulated brain - Consequences of spatial and temporal brain complexity for bipolar disorder pathophysiology and diagnosis].

Haarman BCM, Burger H, Drexhage HA, Nolen WA, Riemersma-Van der Lek RF.

Tijdschr Psychiatr. 2018;60(2):105-113. Dutch.

9.

Th17/T regulator cell balance and NK cell numbers in relation to psychosis liability and social stress reactivity.

Counotte J, Drexhage HA, Wijkhuijs JM, Pot-Kolder R, Bergink V, Hoek HW, Veling W.

Brain Behav Immun. 2018 Mar;69:408-417. doi: 10.1016/j.bbi.2017.12.015. Epub 2017 Dec 28.

PMID:
29289662
10.

Higher Baseline Proinflammatory Cytokines Mark Poor Antidepressant Response in Bipolar Disorder.

Benedetti F, Poletti S, Hoogenboezem TA, Locatelli C, de Wit H, Wijkhuijs AJM, Colombo C, Drexhage HA.

J Clin Psychiatry. 2017 Sep/Oct;78(8):e986-e993. doi: 10.4088/JCP.16m11310.

PMID:
28922589
11.

Immune dysregulation in offspring of a bipolar parent. Altered serum levels of immune growth factors at adolescent age.

Snijders G, Mesman E, de Wit H, Wijkhuijs A, Nolen WA, Drexhage HA, Hillegers MHJ.

Brain Behav Immun. 2017 Aug;64:116-123. doi: 10.1016/j.bbi.2017.04.004. Epub 2017 Apr 7.

PMID:
28392427
12.
13.

The seroprevalence of antithyroid peroxidase antibodies in bipolar families and bipolar twins: results from two longitudinal studies.

Snijders G, de Witte L, Mesman E, Kemner S, Vonk R, Brouwer R, Nolen WA, Drexhage HA, Hillegers MHJ.

Int J Bipolar Disord. 2017 Dec;5(1):1. doi: 10.1186/s40345-017-0070-z. Epub 2017 Jan 20.

14.

Th17 cells correlate positively to the structural and functional integrity of the brain in bipolar depression and healthy controls.

Poletti S, de Wit H, Mazza E, Wijkhuijs AJM, Locatelli C, Aggio V, Colombo C, Benedetti F, Drexhage HA.

Brain Behav Immun. 2017 Mar;61:317-325. doi: 10.1016/j.bbi.2016.12.020. Epub 2016 Dec 23.

PMID:
28025071
15.

The dysregulated brain: consequences of spatial and temporal brain complexity for bipolar disorder pathophysiology and diagnosis.

Haarman BC, Riemersma-Van der Lek RF, Burger H, Drexhage HA, Nolen WA.

Bipolar Disord. 2016 Dec;18(8):696-701. doi: 10.1111/bdi.12454. Epub 2016 Dec 20.

PMID:
27995725
16.

Brain-derived Neurotrophic Factor (BDNF) and gray matter volume in bipolar disorder.

Poletti S, Aggio V, Hoogenboezem TA, Ambrée O, de Wit H, Wijkhuijs AJ, Locatelli C, Colombo C, Arolt V, Drexhage HA, Benedetti F.

Eur Psychiatry. 2017 Feb;40:33-37. doi: 10.1016/j.eurpsy.2016.06.008. Epub 2016 Nov 10.

PMID:
27837670
17.

Blood-based immune-endocrine biomarkers of treatment response in depression.

Chan MK, Cooper JD, Bot M, Birkenhager TK, Bergink V, Drexhage HA, Steiner J, Rothermundt M, Penninx BW, Bahn S.

J Psychiatr Res. 2016 Dec;83:249-259. doi: 10.1016/j.jpsychires.2016.08.020. Epub 2016 Aug 31.

PMID:
27693950
18.

Contrasting expression pattern of RNA-sensing receptors TLR7, RIG-I and MDA5 in interferon-positive and interferon-negative patients with primary Sjögren's syndrome.

Maria NI, Steenwijk EC, IJpma AS, van Helden-Meeuwsen CG, Vogelsang P, Beumer W, Brkic Z, van Daele PL, van Hagen PM, van der Spek PJ, Drexhage HA, Versnel MA.

Ann Rheum Dis. 2017 Apr;76(4):721-730. doi: 10.1136/annrheumdis-2016-209589. Epub 2016 Sep 26.

PMID:
27672125
19.

Exaggerated Increases in Microglia Proliferation, Brain Inflammatory Response and Sickness Behaviour upon Lipopolysaccharide Stimulation in Non-Obese Diabetic Mice.

McGuiness B, Gibney SM, Beumer W, Versnel MA, Sillaber I, Harkin A, Drexhage HA.

Neuroimmunomodulation. 2016;23(3):137-150. Epub 2016 Aug 17.

20.

The Immune Pathogenesis of Type 1 Diabetes: Not Only Thinking Outside the Cell but Also Outside the Islet and Out of the Box.

Drexhage HA, Dik WA, Leenen PJ, Versnel MA.

Diabetes. 2016 Aug;65(8):2130-3. doi: 10.2337/dbi16-0030. No abstract available.

21.

Diffusion tensor imaging in euthymic bipolar disorder - A tract-based spatial statistics study.

Haarman BCM', Riemersma-Van der Lek RF, Burger H, de Groot JC, Drexhage HA, Nolen WA, Cerliani L.

J Affect Disord. 2016 Oct;203:281-291. doi: 10.1016/j.jad.2016.05.040. Epub 2016 Jun 1.

PMID:
27317921
22.

Corrigendum to "Volume, metabolites and neuroinflammation of the hippocampus in bipolar disorder - A combined magnetic resonance imaging and positron emission tomography study" [Brain Behav. Immun. (2015)].

Haarman BCM', Burger H, Doorduin J, Renken RJ, Sibeijn-Kuiper AJ, Marsman JC, de Vries EFJ, de Groot JC, Drexhage HA, Mendes R, Nolen WA, Riemersma-Van der Lek RF.

Brain Behav Immun. 2017 Mar;61:387-388. doi: 10.1016/j.bbi.2016.05.001. Epub 2016 Jun 13. No abstract available.

PMID:
27311765
23.

Inflammatory cytokines influence measures of white matter integrity in Bipolar Disorder.

Benedetti F, Poletti S, Hoogenboezem TA, Mazza E, Ambrée O, de Wit H, Wijkhuijs AJ, Locatelli C, Bollettini I, Colombo C, Arolt V, Drexhage HA.

J Affect Disord. 2016 Sep 15;202:1-9. doi: 10.1016/j.jad.2016.05.047. Epub 2016 May 24.

PMID:
27253210
24.

A dynamic course of T cell defects in individuals at risk for mood disorders.

Snijders G, Schiweck C, Mesman E, Grosse L, De Wit H, Nolen WA, Drexhage HA, Hillegers MHJ.

Brain Behav Immun. 2016 Nov;58:11-17. doi: 10.1016/j.bbi.2016.05.007. Epub 2016 May 12.

PMID:
27181178
25.

Stem Cell Factor (SCF) is a putative biomarker of antidepressant response.

Benedetti F, Poletti S, Hoogenboezem TA, Locatelli C, Ambrée O, de Wit H, Wijkhuijs AJ, Mazza E, Bulgarelli C, Vai B, Colombo C, Smeraldi E, Arolt V, Drexhage HA.

J Neuroimmune Pharmacol. 2016 Jun;11(2):248-58. doi: 10.1007/s11481-016-9672-y. Epub 2016 Apr 23.

PMID:
27108110
26.

Aberrant Levels of Hematopoietic/Neuronal Growth and Differentiation Factors in Euthyroid Women at Risk for Autoimmune Thyroid Disease.

Massolt ET, Effraimidis G, Korevaar TI, Wiersinga WM, Visser WE, Peeters RP, Drexhage HA.

PLoS One. 2016 Apr 19;11(4):e0153892. doi: 10.1371/journal.pone.0153892. eCollection 2016.

27.

Association of Increased Treg Cell Levels With Elevated Indoleamine 2,3-Dioxygenase Activity and an Imbalanced Kynurenine Pathway in Interferon-Positive Primary Sjögren's Syndrome.

Maria NI, van Helden-Meeuwsen CG, Brkic Z, Paulissen SM, Steenwijk EC, Dalm VA, van Daele PL, Martin van Hagen P, Kroese FG, van Roon JA, Harkin A, Dik WA, Drexhage HA, Lubberts E, Versnel MA.

Arthritis Rheumatol. 2016 Jul;68(7):1688-99. doi: 10.1002/art.39629.

28.

Study on inflammation-related genes and microRNAs, with special emphasis on the vascular repair factor HGF and miR-574-3p, in monocytes and serum of patients with T2D.

Baldeón Rojas L, Weigelt K, de Wit H, Ozcan B, van Oudenaren A, Sempértegui F, Sijbrands E, Grosse L, van Zonneveld AJ, Drexhage HA, Leenen PJ.

Diabetol Metab Syndr. 2016 Jan 15;8:6. doi: 10.1186/s13098-015-0113-5. eCollection 2016.

29.

Deficiencies of the T and natural killer cell system in major depressive disorder: T regulatory cell defects are associated with inflammatory monocyte activation.

Grosse L, Hoogenboezem T, Ambrée O, Bellingrath S, Jörgens S, de Wit HJ, Wijkhuijs AM, Arolt V, Drexhage HA.

Brain Behav Immun. 2016 May;54:38-44. doi: 10.1016/j.bbi.2015.12.003. Epub 2015 Dec 8.

PMID:
26674997
30.

Tryptophan pathway alterations in the postpartum period and in acute postpartum psychosis and depression.

Veen C, Myint AM, Burgerhout KM, Schwarz MJ, Schütze G, Kushner SA, Hoogendijk WJ, Drexhage HA, Bergink V.

J Affect Disord. 2016 Jan 1;189:298-305. doi: 10.1016/j.jad.2015.09.064. Epub 2015 Oct 22.

PMID:
26454336
31.

Inflammatory monocyte gene expression: trait or state marker in bipolar disorder?

Becking K, Haarman BC, van der Lek RF, Grosse L, Nolen WA, Claes S, Drexhage HA, Schoevers RA.

Int J Bipolar Disord. 2015 Dec;3(1):20. doi: 10.1186/s40345-015-0037-x. Epub 2015 Sep 17.

32.

S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression.

Ambrée O, Bergink V, Grosse L, Alferink J, Drexhage HA, Rothermundt M, Arolt V, Birkenhäger TK.

Int J Neuropsychopharmacol. 2015 Sep 12;19(3):pyv103. doi: 10.1093/ijnp/pyv103.

33.

Volume, metabolites and neuroinflammation of the hippocampus in bipolar disorder - A combined magnetic resonance imaging and positron emission tomography study.

Haarman BC, Burger H, Doorduin J, Renken RJ, Sibeijn-Kuiper AJ, Marsman JB, de Vries EF, de Groot JC, Drexhage HA, Mendes R, Nolen WA, Riemersma-Van der Lek RF.

Brain Behav Immun. 2016 Aug;56:21-33. doi: 10.1016/j.bbi.2015.09.004. Epub 2015 Sep 5. Erratum in: Brain Behav Immun. 2017 Mar;61:387-388.

PMID:
26348581
34.

Type 2 Diabetes Monocyte MicroRNA and mRNA Expression: Dyslipidemia Associates with Increased Differentiation-Related Genes but Not Inflammatory Activation.

Baldeón R L, Weigelt K, de Wit H, Ozcan B, van Oudenaren A, Sempértegui F, Sijbrands E, Grosse L, van Zonneveld AJ, Drexhage HA, Leenen PJ.

PLoS One. 2015 Jun 17;10(6):e0129421. doi: 10.1371/journal.pone.0129421. eCollection 2015.

35.

Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression. Restoration of T regulatory cell populations after antidepressant therapy.

Grosse L, Carvalho LA, Birkenhager TK, Hoogendijk WJ, Kushner SA, Drexhage HA, Bergink V.

Psychopharmacology (Berl). 2016 May;233(9):1679-88. doi: 10.1007/s00213-015-3943-9. Epub 2015 May 8.

PMID:
25953327
36.

Decreased serum level of miR-146a as sign of chronic inflammation in type 2 diabetic patients.

Baldeón R L, Weigelt K, de Wit H, Ozcan B, van Oudenaren A, Sempértegui F, Sijbrands E, Grosse L, Freire W, Drexhage HA, Leenen PJ.

PLoS One. 2014 Dec 12;9(12):e115209. doi: 10.1371/journal.pone.0115209. eCollection 2014.

37.

Feature-expression heat maps--a new visual method to explore complex associations between two variable sets.

Haarman BC, Riemersma-Van der Lek RF, Nolen WA, Mendes R, Drexhage HA, Burger H.

J Biomed Inform. 2015 Feb;53:156-61. doi: 10.1016/j.jbi.2014.10.003. Epub 2014 Oct 14.

38.

The gene expression profile of CD11c+ CD8α- dendritic cells in the pre-diabetic pancreas of the NOD mouse.

Beumer W, Welzen-Coppens JM, van Helden-Meeuwsen CG, Gibney SM, Drexhage HA, Versnel MA.

PLoS One. 2014 Aug 28;9(8):e103404. doi: 10.1371/journal.pone.0103404. eCollection 2014.

39.

Clinical characteristics of inflammation-associated depression: Monocyte gene expression is age-related in major depressive disorder.

Grosse L, Carvalho LA, Wijkhuijs AJ, Bellingrath S, Ruland T, Ambrée O, Alferink J, Ehring T, Drexhage HA, Arolt V.

Brain Behav Immun. 2015 Feb;44:48-56. doi: 10.1016/j.bbi.2014.08.004. Epub 2014 Aug 20.

PMID:
25150007
40.

Monocyte activation, brain-derived neurotrophic factor (BDNF), and S100B in bipolar offspring: a follow-up study from adolescence into adulthood.

Mesman E, Hillegers MH, Ambree O, Arolt V, Nolen WA, Drexhage HA.

Bipolar Disord. 2015 Feb;17(1):39-49. doi: 10.1111/bdi.12231. Epub 2014 Jul 17.

PMID:
25039314
41.

Neuroinflammation in bipolar disorder - A [(11)C]-(R)-PK11195 positron emission tomography study.

Haarman BC, Riemersma-Van der Lek RF, de Groot JC, Ruhé HG, Klein HC, Zandstra TE, Burger H, Schoevers RA, de Vries EF, Drexhage HA, Nolen WA, Doorduin J.

Brain Behav Immun. 2014 Aug;40:219-25. doi: 10.1016/j.bbi.2014.03.016. Epub 2014 Apr 3.

PMID:
24703991
42.

Inflammatory activation is associated with a reduced glucocorticoid receptor alpha/beta expression ratio in monocytes of inpatients with melancholic major depressive disorder.

Carvalho LA, Bergink V, Sumaski L, Wijkhuijs J, Hoogendijk WJ, Birkenhager TK, Drexhage HA.

Transl Psychiatry. 2014 Jan 14;4:e344. doi: 10.1038/tp.2013.118.

43.

Autoimmunity, inflammation, and psychosis: a search for peripheral markers.

Bergink V, Gibney SM, Drexhage HA.

Biol Psychiatry. 2014 Feb 15;75(4):324-31. doi: 10.1016/j.biopsych.2013.09.037. Epub 2013 Oct 19. Review.

PMID:
24286760
44.

Relationship between clinical features and inflammation-related monocyte gene expression in bipolar disorder - towards a better understanding of psychoimmunological interactions.

Haarman BC, Riemersma-Van der Lek RF, Burger H, Netkova M, Drexhage RC, Bootsman F, Mesman E, Hillegers MH, Spijker AT, Hoencamp E, Drexhage HA, Nolen WA.

Bipolar Disord. 2014 Mar;16(2):137-50. doi: 10.1111/bdi.12142. Epub 2013 Nov 29.

PMID:
24286609
45.

Possible impact of microglial cells and the monocyte-macrophage system on suicidal behavior.

Steiner J, Gos T, Bogerts B, Bielau H, Drexhage HA, Bernstein HG.

CNS Neurol Disord Drug Targets. 2013 Nov;12(7):971-9. Review.

PMID:
24040799
46.

MxA as a clinically applicable biomarker for identifying systemic interferon type I in primary Sjogren's syndrome.

Maria NI, Brkic Z, Waris M, van Helden-Meeuwsen CG, Heezen K, van de Merwe JP, van Daele PL, Dalm VA, Drexhage HA, Versnel MA.

Ann Rheum Dis. 2014 Jun;73(6):1052-9. doi: 10.1136/annrheumdis-2012-202552. Epub 2013 Jul 6.

47.

Evidence for a dysregulated immune system in the etiology of psychiatric disorders.

Gibney SM, Drexhage HA.

J Neuroimmune Pharmacol. 2013 Sep;8(4):900-20. doi: 10.1007/s11481-013-9462-8. Epub 2013 May 5. Review.

PMID:
23645137
48.
49.

The kinetics of plasmacytoid dendritic cell accumulation in the pancreas of the NOD mouse during the early phases of insulitis.

Welzen-Coppens JM, van Helden-Meeuwsen CG, Leenen PJ, Drexhage HA, Versnel MA.

PLoS One. 2013;8(1):e55071. doi: 10.1371/journal.pone.0055071. Epub 2013 Jan 25.

50.

Down-regulation of inflammation-protective microRNAs 146a and 212 in monocytes of patients with postpartum psychosis.

Weigelt K, Bergink V, Burgerhout KM, Pescatori M, Wijkhuijs A, Drexhage HA.

Brain Behav Immun. 2013 Mar;29:147-55. doi: 10.1016/j.bbi.2012.12.018. Epub 2013 Jan 4.

PMID:
23295264

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