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Items: 1 to 50 of 295

1.

Approved LXR agonists exert unspecific effects on pancreatic β-cell function.

Maczewsky J, Kaiser J, Krippeit-Drews P, Drews G.

Endocrine. 2020 Mar 7. doi: 10.1007/s12020-020-02241-4. [Epub ahead of print]

PMID:
32146655
2.

Interactions between Atorvastatin and the Farnesoid X Receptor Impair Insulinotropic Effects of Bile Acids and Modulate Diabetogenic Risk.

Hoffmeister T, Kaiser J, Lüdtke S, Drews G, Düfer M.

Mol Pharmacol. 2020 Mar;97(3):202-211. doi: 10.1124/mol.119.118083. Epub 2020 Jan 7.

PMID:
31911428
3.

PET/MRI enables simultaneous in vivo quantification of β-cell mass and function.

Michelotti FC, Bowden G, Küppers A, Joosten L, Maczewsky J, Nischwitz V, Drews G, Maurer A, Gotthardt M, Schmid AM, Pichler BJ.

Theranostics. 2020 Jan 1;10(1):398-410. doi: 10.7150/thno.33410. eCollection 2020.

4.

Glucose Responsiveness of β-Cells Depends on Fatty Acids.

Gerst F, Singer C, Noack K, Graf D, Kaiser G, Panse M, Kovarova M, Schleicher E, Häring HU, Drews G, Ullrich S.

Exp Clin Endocrinol Diabetes. 2019 Apr 15. doi: 10.1055/a-0884-2919. [Epub ahead of print]

PMID:
30986881
5.

A paper-based, cell-free biosensor system for the detection of heavy metals and date rape drugs.

Gräwe A, Dreyer A, Vornholt T, Barteczko U, Buchholz L, Drews G, Ho UL, Jackowski ME, Kracht M, Lüders J, Bleckwehl T, Rositzka L, Ruwe M, Wittchen M, Lutter P, Müller K, Kalinowski J.

PLoS One. 2019 Mar 6;14(3):e0210940. doi: 10.1371/journal.pone.0210940. eCollection 2019.

6.

ATP binding without hydrolysis switches sulfonylurea receptor 1 (SUR1) to outward-facing conformations that activate KATP channels.

Sikimic J, McMillen TS, Bleile C, Dastvan F, Quast U, Krippeit-Drews P, Drews G, Bryan J.

J Biol Chem. 2019 Mar 8;294(10):3707-3719. doi: 10.1074/jbc.RA118.005236. Epub 2018 Dec 26.

7.

TGR5 Activation Promotes Stimulus-Secretion Coupling of Pancreatic β-Cells via a PKA-Dependent Pathway.

Maczewsky J, Kaiser J, Gresch A, Gerst F, Düfer M, Krippeit-Drews P, Drews G.

Diabetes. 2019 Feb;68(2):324-336. doi: 10.2337/db18-0315. Epub 2018 Nov 8.

8.

Opaque-2 Regulates a Complex Gene Network Associated with Cell Differentiation and Storage Functions of Maize Endosperm.

Zhan J, Li G, Ryu CH, Ma C, Zhang S, Lloyd A, Hunter BG, Larkins BA, Drews GN, Wang X, Yadegari R.

Plant Cell. 2018 Oct;30(10):2425-2446. doi: 10.1105/tpc.18.00392. Epub 2018 Sep 27.

9.

ATP mediates a negative autocrine signal on stimulus-secretion coupling in mouse pancreatic β-cells.

Bauer C, Kaiser J, Sikimic J, Krippeit-Drews P, Düfer M, Drews G.

Endocrine. 2019 Feb;63(2):270-283. doi: 10.1007/s12020-018-1731-0. Epub 2018 Sep 18.

PMID:
30229397
10.

FERTILIZATION-INDEPENDENT SEED-Polycomb Repressive Complex 2 Plays a Dual Role in Regulating Type I MADS-Box Genes in Early Endosperm Development.

Zhang S, Wang D, Zhang H, Skaggs MI, Lloyd A, Ran D, An L, Schumaker KS, Drews GN, Yadegari R.

Plant Physiol. 2018 May;177(1):285-299. doi: 10.1104/pp.17.00534. Epub 2018 Mar 9.

11.

Energy depletion and not ROS formation is a crucial step of glucolipotoxicity (GLTx) in pancreatic beta cells.

Barroso Oquendo M, Layer N, Wagner R, Krippeit-Drews P, Drews G.

Pflugers Arch. 2018 Mar;470(3):537-547. doi: 10.1007/s00424-017-2094-8. Epub 2017 Dec 7.

PMID:
29218453
12.

Atrial Natriuretic Peptide Affects Stimulus-Secretion Coupling of Pancreatic β-Cells.

Undank S, Kaiser J, Sikimic J, Düfer M, Krippeit-Drews P, Drews G.

Diabetes. 2017 Nov;66(11):2840-2848. doi: 10.2337/db17-0392. Epub 2017 Sep 1.

13.

The LXR Ligand T0901317 Acutely Inhibits Insulin Secretion by Affecting Mitochondrial Metabolism.

Maczewsky J, Sikimic J, Bauer C, Krippeit-Drews P, Wolke C, Lendeckel U, Barthlen W, Drews G.

Endocrinology. 2017 Jul 1;158(7):2145-2154. doi: 10.1210/en.2016-1941.

PMID:
28449117
14.

SUPPRESSOR OF FRIGIDA (SUF4) Supports Gamete Fusion via Regulating Arabidopsis EC1 Gene Expression.

Resentini F, Cyprys P, Steffen JG, Alter S, Morandini P, Mizzotti C, Lloyd A, Drews GN, Dresselhaus T, Colombo L, Sprunck S, Masiero S.

Plant Physiol. 2017 Jan;173(1):155-166. doi: 10.1104/pp.16.01024. Epub 2016 Dec 5.

15.

[The Influence of Laparoscopic Fundoplication on Reflux-Associated Cough].

Drews G, Rudolph F, Martinenko O, Kühne P, Schreiber J.

Zentralbl Chir. 2016 Oct;141(5):545-551. Epub 2014 Nov 6. German.

PMID:
25377517
16.

The Angiotensin-(1-7)/Mas Axis Improves Pancreatic β-Cell Function in Vitro and in Vivo.

Sahr A, Wolke C, Maczewsky J, Krippeit-Drews P, Tetzner A, Drews G, Venz S, Gürtler S, van den Brandt J, Berg S, Döring P, Dombrowski F, Walther T, Lendeckel U.

Endocrinology. 2016 Dec;157(12):4677-4690. Epub 2016 Oct 7.

PMID:
27715254
17.

Evidence against a Ca(2+)-induced potentiation of dehydrogenase activity in pancreatic beta-cells.

Drews G, Bauer C, Edalat A, Düfer M, Krippeit-Drews P.

Pflugers Arch. 2015 Nov;467(11):2389-97. doi: 10.1007/s00424-015-1707-3. Epub 2015 Apr 18.

PMID:
25893711
18.

Mitochondrial succinate dehydrogenase is involved in stimulus-secretion coupling and endogenous ROS formation in murine beta cells.

Edalat A, Schulte-Mecklenbeck P, Bauer C, Undank S, Krippeit-Drews P, Drews G, Düfer M.

Diabetologia. 2015 Jul;58(7):1532-41. doi: 10.1007/s00125-015-3577-9. Epub 2015 Apr 15.

PMID:
25874444
19.

Human Islets Exhibit Electrical Activity on Microelectrode Arrays (MEA).

Schönecker S, Kraushaar U, Guenther E, Gerst F, Ullrich S, Häring HU, Königsrainer A, Barthlen W, Drews G, Krippeit-Drews P.

Exp Clin Endocrinol Diabetes. 2015 May;123(5):296-8. doi: 10.1055/s-0035-1547217. Epub 2015 Apr 8.

PMID:
25853706
20.

RNA sequencing of laser-capture microdissected compartments of the maize kernel identifies regulatory modules associated with endosperm cell differentiation.

Zhan J, Thakare D, Ma C, Lloyd A, Nixon NM, Arakaki AM, Burnett WJ, Logan KO, Wang D, Wang X, Drews GN, Yadegari R.

Plant Cell. 2015 Mar;27(3):513-31. doi: 10.1105/tpc.114.135657. Epub 2015 Mar 17.

21.

Role of FXR in β-cells of lean and obese mice.

Schittenhelm B, Wagner R, Kähny V, Peter A, Krippeit-Drews P, Düfer M, Drews G.

Endocrinology. 2015 Apr;156(4):1263-71. doi: 10.1210/en.2014-1751. Epub 2015 Jan 19.

PMID:
25599407
22.

Temporal patterns of gene expression in developing maize endosperm identified through transcriptome sequencing.

Li G, Wang D, Yang R, Logan K, Chen H, Zhang S, Skaggs MI, Lloyd A, Burnett WJ, Laurie JD, Hunter BG, Dannenhoffer JM, Larkins BA, Drews GN, Wang X, Yadegari R.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7582-7. doi: 10.1073/pnas.1406383111. Epub 2014 May 12.

23.

Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays.

Schönecker S, Kraushaar U, Düfer M, Sahr A, Härdtner C, Guenther E, Walther R, Lendeckel U, Barthlen W, Krippeit-Drews P, Drews G.

Integr Biol (Camb). 2014 May;6(5):540-4. doi: 10.1039/c3ib40261d.

PMID:
24658612
24.

MYB64 and MYB119 are required for cellularization and differentiation during female gametogenesis in Arabidopsis thaliana.

Rabiger DS, Drews GN.

PLoS Genet. 2013;9(9):e1003783. doi: 10.1371/journal.pgen.1003783. Epub 2013 Sep 19.

25.

The intracytoplasmic membranes of purple bacteria--assembly of energy-transducing complexes.

Drews G.

J Mol Microbiol Biotechnol. 2013;23(1-2):35-47. doi: 10.1159/000346518. Epub 2013 Apr 18. Review.

PMID:
23615194
26.

Comprehensive developmental profiles of gene activity in regions and subregions of the Arabidopsis seed.

Belmonte MF, Kirkbride RC, Stone SL, Pelletier JM, Bui AQ, Yeung EC, Hashimoto M, Fei J, Harada CM, Munoz MD, Le BH, Drews GN, Brady SM, Goldberg RB, Harada JJ.

Proc Natl Acad Sci U S A. 2013 Jan 29;110(5):E435-44. doi: 10.1073/pnas.1222061110. Epub 2013 Jan 14.

27.

The significance of the nuclear farnesoid X receptor (FXR) in β cell function.

Düfer M, Hörth K, Krippeit-Drews P, Drews G.

Islets. 2012 Sep-Oct;4(5):333-8. doi: 10.4161/isl.22383. Epub 2012 Sep 1. Review.

28.

Glitazones exert multiple effects on β-cell stimulus-secretion coupling.

Düfer M, Noack K, Edalat A, Krippeit-Drews P, Drews G.

Mol Pharmacol. 2013 Jan;83(1):51-60. doi: 10.1124/mol.112.081638. Epub 2012 Sep 28.

PMID:
23024191
29.

Role of K(ATP) channels in β-cell resistance to oxidative stress.

Drews G, Düfer M.

Diabetes Obes Metab. 2012 Oct;14 Suppl 3:120-8. doi: 10.1111/j.1463-1326.2012.01644.x. Review.

PMID:
22928572
30.

H₂O₂ lowers the cytosolic Ca²⁺ concentration via activation of cGMP-dependent protein kinase Iα.

Müller PM, Gnügge R, Dhayade S, Thunemann M, Krippeit-Drews P, Drews G, Feil R.

Free Radic Biol Med. 2012 Oct 15;53(8):1574-83. doi: 10.1016/j.freeradbiomed.2012.08.011. Epub 2012 Aug 15.

PMID:
22922339
31.

Bile acids acutely stimulate insulin secretion of mouse β-cells via farnesoid X receptor activation and K(ATP) channel inhibition.

Düfer M, Hörth K, Wagner R, Schittenhelm B, Prowald S, Wagner TF, Oberwinkler J, Lukowski R, Gonzalez FJ, Krippeit-Drews P, Drews G.

Diabetes. 2012 Jun;61(6):1479-89. doi: 10.2337/db11-0815. Epub 2012 Apr 9.

32.

The female gametophyte.

Drews GN, Koltunow AM.

Arabidopsis Book. 2011;9:e0155. doi: 10.1199/tab.0155. Epub 2011 Dec 26.

33.

Rapid functional evaluation of beta-cells by extracellular recording of membrane potential oscillations with microelectrode arrays.

Pfeiffer T, Kraushaar U, Düfer M, Schönecker S, Haspel D, Günther E, Drews G, Krippeit-Drews P.

Pflugers Arch. 2011 Dec;462(6):835-40. doi: 10.1007/s00424-011-1029-z. Epub 2011 Sep 24.

PMID:
21947556
34.

Identification of genes expressed in the angiosperm female gametophyte.

Drews GN, Wang D, Steffen JG, Schumaker KS, Yadegari R.

J Exp Bot. 2011 Mar;62(5):1593-9. doi: 10.1093/jxb/erq385. Epub 2010 Nov 30. Review.

PMID:
21118822
35.

Activation of the AMP-activated protein kinase enhances glucose-stimulated insulin secretion in mouse β-cells.

Düfer M, Noack K, Krippeit-Drews P, Drews G.

Islets. 2010 May-Jun;2(3):156-63. doi: 10.4161/isl.2.3.11412.

PMID:
21099309
36.

BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells.

Düfer M, Neye Y, Hörth K, Krippeit-Drews P, Hennige A, Widmer H, McClafferty H, Shipston MJ, Häring HU, Ruth P, Drews G.

Diabetologia. 2011 Feb;54(2):423-32. doi: 10.1007/s00125-010-1936-0. Epub 2010 Oct 28.

37.

Oxidative stress and beta-cell dysfunction.

Drews G, Krippeit-Drews P, Düfer M.

Pflugers Arch. 2010 Sep;460(4):703-18. doi: 10.1007/s00424-010-0862-9. Epub 2010 Jul 23. Review.

PMID:
20652307
38.

Identification of transcription-factor genes expressed in the Arabidopsis female gametophyte.

Wang D, Zhang C, Hearn DJ, Kang IH, Punwani JA, Skaggs MI, Drews GN, Schumaker KS, Yadegari R.

BMC Plant Biol. 2010 Jun 16;10:110. doi: 10.1186/1471-2229-10-110.

39.

The Gq/G11-mediated signaling pathway is critical for autocrine potentiation of insulin secretion in mice.

Sassmann A, Gier B, Gröne HJ, Drews G, Offermanns S, Wettschureck N.

J Clin Invest. 2010 Jun;120(6):2184-93. doi: 10.1172/JCI41541. Epub 2010 May 3.

40.

Global analysis of gene activity during Arabidopsis seed development and identification of seed-specific transcription factors.

Le BH, Cheng C, Bui AQ, Wagmaister JA, Henry KF, Pelletier J, Kwong L, Belmonte M, Kirkbride R, Horvath S, Drews GN, Fischer RL, Okamuro JK, Harada JJ, Goldberg RB.

Proc Natl Acad Sci U S A. 2010 May 4;107(18):8063-70. doi: 10.1073/pnas.1003530107. Epub 2010 Apr 12.

41.

Electrophysiology of islet cells.

Drews G, Krippeit-Drews P, Düfer M.

Adv Exp Med Biol. 2010;654:115-63. doi: 10.1007/978-90-481-3271-3_7. Review.

PMID:
20217497
42.

Overexpression of kinase-negative protein kinase Cdelta in pancreatic beta-cells protects mice from diet-induced glucose intolerance and beta-cell dysfunction.

Hennige AM, Ranta F, Heinzelmann I, Düfer M, Michael D, Braumüller H, Lutz SZ, Lammers R, Drews G, Bosch F, Häring HU, Ullrich S.

Diabetes. 2010 Jan;59(1):119-27. doi: 10.2337/db09-0512. Epub 2009 Oct 13.

43.

Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.

Gier B, Krippeit-Drews P, Sheiko T, Aguilar-Bryan L, Bryan J, Düfer M, Drews G.

J Clin Invest. 2009 Nov;119(11):3246-56. doi: 10.1172/JCI38817. Epub 2009 Oct 1.

44.

Physiological significance of SK4 channels in pancreatic β-cell oscillations.

Drews G.

Islets. 2009 Sep-Oct;1(2):148-50. doi: 10.4161/isl.1.2.9056.

PMID:
21099262
45.

Enhanced glucose tolerance by SK4 channel inhibition in pancreatic beta-cells.

Düfer M, Gier B, Wolpers D, Krippeit-Drews P, Ruth P, Drews G.

Diabetes. 2009 Aug;58(8):1835-43. doi: 10.2337/db08-1324. Epub 2009 Apr 28.

46.

Activation of the Na+/K+-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells.

Düfer M, Haspel D, Krippeit-Drews P, Aguilar-Bryan L, Bryan J, Drews G.

Pflugers Arch. 2009 Apr;457(6):1351-60. doi: 10.1007/s00424-008-0592-4. Epub 2008 Oct 3.

PMID:
18836740
47.

Regulation of calcineurin activity in insulin-secreting cells: stimulation by Hsp90 during glucocorticoid-induced apoptosis.

Ranta F, Düfer M, Stork B, Wesselborg S, Drews G, Häring HU, Lang F, Ullrich S.

Cell Signal. 2008 Oct;20(10):1780-6. doi: 10.1016/j.cellsig.2008.06.003. Epub 2008 Jun 18.

PMID:
18611438
48.

AGL61 interacts with AGL80 and is required for central cell development in Arabidopsis.

Steffen JG, Kang IH, Portereiko MF, Lloyd A, Drews GN.

Plant Physiol. 2008 Sep;148(1):259-68. doi: 10.1104/pp.108.119404. Epub 2008 Jul 3.

49.

The MYB98 subcircuit of the synergid gene regulatory network includes genes directly and indirectly regulated by MYB98.

Punwani JA, Rabiger DS, Lloyd A, Drews GN.

Plant J. 2008 Aug;55(3):406-14. doi: 10.1111/j.1365-313X.2008.03514.x. Epub 2008 Apr 12.

50.

The AGL62 MADS domain protein regulates cellularization during endosperm development in Arabidopsis.

Kang IH, Steffen JG, Portereiko MF, Lloyd A, Drews GN.

Plant Cell. 2008 Mar;20(3):635-47. doi: 10.1105/tpc.107.055137. Epub 2008 Mar 11.

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