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Items: 1 to 50 of 60

1.

Irisin induces trophoblast differentiation via AMPK activation in the human placenta.

Drewlo S, Johnson E, Kilburn BA, Kadam L, Armistead B, Kohan-Ghadr HR.

J Cell Physiol. 2020 Feb 5. doi: 10.1002/jcp.29613. [Epub ahead of print]

PMID:
32020629
2.

Endocervical trophoblast for interrogating the fetal genome and assessing pregnancy health at five weeks.

Kadam L, Jain C, Kohan-Ghadr HR, Krawetz SA, Drewlo S, Armant DR.

Eur J Med Genet. 2019 Aug;62(8):103690. doi: 10.1016/j.ejmg.2019.103690. Epub 2019 Jun 18.

PMID:
31226440
3.

Rosiglitazone blocks first trimester in-vitro placental injury caused by NF-κB-mediated inflammation.

Kadam L, Kilburn B, Baczyk D, Kohan-Ghadr HR, Kingdom J, Drewlo S.

Sci Rep. 2019 Feb 14;9(1):2018. doi: 10.1038/s41598-018-38336-2.

4.

Stress Forces First Lineage Differentiation of Mouse Embryonic Stem Cells; Validation of a High-Throughput Screen for Toxicant Stress.

Li Q, Louden E, Zhou J, Drewlo S, Dai J, Puscheck EE, Chen K, Rappolee DA.

Stem Cells Dev. 2019 Jan 15;28(2):101-113. doi: 10.1089/scd.2018.0157. Epub 2019 Jan 7.

5.

Rosiglitazone augments antioxidant response in the human trophoblast and prevents apoptosis†.

Kohan-Ghadr HR, Kilburn BA, Kadam L, Johnson E, Kolb BL, Rodriguez-Kovacs J, Hertz M, Armant DR, Drewlo S.

Biol Reprod. 2019 Feb 1;100(2):479-494. doi: 10.1093/biolre/ioy186.

6.

Trophoblast retrieval and isolation from the cervix: origins of cervical trophoblasts and their potential value for risk assessment of ongoing pregnancies.

Moser G, Drewlo S, Huppertz B, Armant DR.

Hum Reprod Update. 2018 Jul 1;24(4):484-496. doi: 10.1093/humupd/dmy008. Review.

7.

Nifedipine Prevents Apoptosis of Alcohol-Exposed First-Trimester Trophoblast Cells.

Bolnick AD, Bolnick JM, Kohan-Ghadr HR, Kilburn BA, Hertz M, Dai J, Drewlo S, Armant DR.

Alcohol Clin Exp Res. 2018 Jan;42(1):53-60. doi: 10.1111/acer.13534. Epub 2017 Nov 22.

8.

SUMO-4: A novel functional candidate in the human placental protein SUMOylation machinery.

Baczyk D, Audette MC, Drewlo S, Levytska K, Kingdom JC.

PLoS One. 2017 May 17;12(5):e0178056. doi: 10.1371/journal.pone.0178056. eCollection 2017.

9.

Quo vadis, trophoblast? Exploring the new ways of an old cell lineage.

Drewlo S, Armant DR.

Placenta. 2017 Dec;60 Suppl 1:S27-S31. doi: 10.1016/j.placenta.2017.04.021. Epub 2017 Apr 26.

10.

Enhancement of trophoblast differentiation and survival by low molecular weight heparin requires heparin-binding EGF-like growth factor.

Bolnick AD, Bolnick JM, Kohan-Ghadr HR, Kilburn BA, Pasalodos OJ, Singhal PK, Dai J, Diamond MP, Armant DR, Drewlo S.

Hum Reprod. 2017 Jun 1;32(6):1218-1229. doi: 10.1093/humrep/dex069.

11.

Rosiglitazone Regulates TLR4 and Rescues HO-1 and NRF2 Expression in Myometrial and Decidual Macrophages in Inflammation-Induced Preterm Birth.

Kadam L, Gomez-Lopez N, Mial TN, Kohan-Ghadr HR, Drewlo S.

Reprod Sci. 2017 Dec;24(12):1590-1599. doi: 10.1177/1933719117697128. Epub 2017 Mar 21.

12.

Fetal genome profiling at 5 weeks of gestation after noninvasive isolation of trophoblast cells from the endocervical canal.

Jain CV, Kadam L, van Dijk M, Kohan-Ghadr HR, Kilburn BA, Hartman C, Mazzorana V, Visser A, Hertz M, Bolnick AD, Fritz R, Armant DR, Drewlo S.

Sci Transl Med. 2016 Nov 2;8(363):363re4.

PMID:
27807286
13.

Altered Biomarkers in Trophoblast Cells Obtained Noninvasively Prior to Clinical Manifestation of Perinatal Disease.

Bolnick JM, Kohan-Ghadr HR, Fritz R, Bolnick AD, Kilburn BA, Diamond MP, Armant DR, Drewlo S.

Sci Rep. 2016 Sep 23;6:32382. doi: 10.1038/srep32382.

14.

Genome-wide placental DNA methylation analysis of severely growth-discordant monochorionic twins reveals novel epigenetic targets for intrauterine growth restriction.

Roifman M, Choufani S, Turinsky AL, Drewlo S, Keating S, Brudno M, Kingdom J, Weksberg R.

Clin Epigenetics. 2016 Jun 21;8:70. doi: 10.1186/s13148-016-0238-x. eCollection 2016.

15.

Reduced homeobox protein MSX1 in human endometrial tissue is linked to infertility.

Bolnick AD, Bolnick JM, Kilburn BA, Stewart T, Oakes J, Rodriguez-Kovacs J, Kohan-Ghadr HR, Dai J, Diamond MP, Hirota Y, Drewlo S, Dey SK, Armant DR; NICHD National Cooperative Reproductive Medicine Network.

Hum Reprod. 2016 Sep;31(9):2042-50. doi: 10.1093/humrep/dew143. Epub 2016 Jun 16.

16.

The Impact of Myeloperoxidase and Activated Macrophages on Metaphase II Mouse Oocyte Quality.

Shaeib F, Khan SN, Thakur M, Kohan-Ghadr HR, Drewlo S, Saed GM, Pennathur S, Abu-Soud HM.

PLoS One. 2016 Mar 16;11(3):e0151160. doi: 10.1371/journal.pone.0151160. eCollection 2016.

17.

Trophoblast Retrieval and Isolation From the Cervix for Noninvasive, First Trimester, Fetal Gender Determination in a Carrier of Congenital Adrenal Hyperplasia.

Bolnick AD, Fritz R, Jain C, Kadam L, Bolnick JM, Kilburn BA, Singh M, Diamond MP, Drewlo S, Armant DR.

Reprod Sci. 2016 Jun;23(6):717-22. doi: 10.1177/1933719116632922. Epub 2016 Feb 25.

18.

An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment.

Xu Y, Romero R, Miller D, Kadam L, Mial TN, Plazyo O, Garcia-Flores V, Hassan SS, Xu Z, Tarca AL, Drewlo S, Gomez-Lopez N.

J Immunol. 2016 Mar 15;196(6):2476-2491. doi: 10.4049/jimmunol.1502055. Epub 2016 Feb 17.

19.

Apelin in Normal Pregnancy and Pregnancies Complicated by Placental Insufficiency.

Van Mieghem T, Doherty A, Baczyk D, Drewlo S, Baud D, Carvalho J, Kingdom J.

Reprod Sci. 2016 Aug;23(8):1037-43. doi: 10.1177/1933719116630422. Epub 2016 Feb 14.

PMID:
26880769
20.

Potential role of epigenetic mechanisms in regulation of trophoblast differentiation, migration, and invasion in the human placenta.

Kohan-Ghadr HR, Kadam L, Jain C, Armant DR, Drewlo S.

Cell Adh Migr. 2016 Mar 3;10(1-2):126-35. doi: 10.1080/19336918.2015.1098800. Epub 2016 Jan 8. Review.

21.

Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone.

St Louis D, Romero R, Plazyo O, Arenas-Hernandez M, Panaitescu B, Xu Y, Milovic T, Xu Z, Bhatti G, Mi QS, Drewlo S, Tarca AL, Hassan SS, Gomez-Lopez N.

J Immunol. 2016 Feb 1;196(3):1044-59. doi: 10.4049/jimmunol.1501962. Epub 2016 Jan 6.

22.

Development and Validation of a Rex1-RFP Potency Activity Reporter Assay That Quantifies Stress-Forced Potency Loss in Mouse Embryonic Stem Cells.

Li Q, Gomez-Lopez N, Drewlo S, Sanchez-Rodriguez E, Dai J, Puscheck EE, Rappolee DA.

Stem Cells Dev. 2016 Feb 15;25(4):320-8. doi: 10.1089/scd.2015.0169. Epub 2016 Jan 29.

23.

Current Theories on the Prevention of Severe Preeclampsia With Low-Molecular Weight Heparin.

McLaughlin K, Drewlo S, Parker JD, Kingdom JC.

Hypertension. 2015 Dec;66(6):1098-103. doi: 10.1161/HYPERTENSIONAHA.115.05770. Epub 2015 Oct 5. Review. No abstract available.

PMID:
26441469
24.

Trophoblast retrieval and isolation from the cervix (TRIC) is unaffected by early gestational age or maternal obesity.

Fritz R, Kohan-Ghadr HR, Sacher A, Bolnick AD, Kilburn BA, Bolnick JM, Diamond MP, Drewlo S, Armant DR.

Prenat Diagn. 2015 Dec;35(12):1218-22. doi: 10.1002/pd.4681. Epub 2015 Sep 20.

25.

The adipokine preadipocyte factor-1 is downregulated in preeclampsia and expressed in placenta.

Schrey S, Wurst U, Ebert T, Kralisch S, Drewlo S, Stepan H, Lössner U, Platz M, Kratzsch J, Stumvoll M, Fasshauer M.

Cytokine. 2015 Oct;75(2):338-43. doi: 10.1016/j.cyto.2015.07.021. Epub 2015 Aug 1.

PMID:
26242929
26.

Noninvasive detection of trophoblast protein signatures linked to early pregnancy loss using trophoblast retrieval and isolation from the cervix (TRIC).

Fritz R, Kohan-Ghadr HR, Bolnick JM, Bolnick AD, Kilburn BA, Diamond MP, Drewlo S, Armant DR.

Fertil Steril. 2015 Aug;104(2):339-46.e4. doi: 10.1016/j.fertnstert.2015.05.010. Epub 2015 Jun 11.

27.

The balancing act - PPAR-γ's roles at the maternal-fetal interface.

Kadam L, Kohan-Ghadr HR, Drewlo S.

Syst Biol Reprod Med. 2015 Apr;61(2):65-71. doi: 10.3109/19396368.2014.991881. Epub 2014 Dec 5. Review.

28.

Altered hemodynamics and hyperuricemia accompany an elevated sFlt-1/PlGF ratio before the onset of early severe preeclampsia.

Doherty A, Carvalho JC, Drewlo S, El-Khuffash A, Downey K, Dodds M, Kingdom J.

J Obstet Gynaecol Can. 2014 Aug;36(8):692-700. doi: 10.1016/S1701-2163(15)30511-9.

PMID:
25222164
29.

Unfractionated heparin and placental pathology in high-risk pregnancies: secondary analysis of a pilot randomized controlled trial.

D'Souza R, Keating S, Walker M, Drewlo S, Kingdom J.

Placenta. 2014 Oct;35(10):816-23. doi: 10.1016/j.placenta.2014.07.010. Epub 2014 Jul 24.

PMID:
25128485
30.

PPAR- γ Regulates Trophoblast Differentiation in the BeWo Cell Model.

Levytska K, Drewlo S, Baczyk D, Kingdom J.

PPAR Res. 2014;2014:637251. doi: 10.1155/2014/637251. Epub 2014 Feb 23.

31.

Serum levels of irisin in gestational diabetes mellitus during pregnancy and after delivery.

Ebert T, Stepan H, Schrey S, Kralisch S, Hindricks J, Hopf L, Platz M, Lossner U, Jessnitzer B, Drewlo S, Blüher M, Stumvoll M, Fasshauer M.

Cytokine. 2014 Feb;65(2):153-8. doi: 10.1016/j.cyto.2013.11.009. Epub 2013 Dec 16.

PMID:
24355429
32.

IFPA Meeting 2013 Workshop Report III: maternal placental immunological interactions, novel determinants of trophoblast cell fate, dual ex vivo perfusion of the human placenta.

Abumaree MH, Brownbill P, Burton G, Castillo C, Chamley L, Croy BA, Drewlo S, Dunk C, Girard S, Hansson S, Jones S, Jurisicova A, Lewis R, Letarte M, Parast M, Pehrson C, Rappolee D, Schneider H, Tannetta D, Varmuza S, Wadsack C, Wallace AE, Zenerino C, Lash GE.

Placenta. 2014 Feb;35 Suppl:S15-9. doi: 10.1016/j.placenta.2013.11.009. Epub 2013 Nov 28.

PMID:
24321780
33.

Leptin is differentially expressed and epigenetically regulated across monochorionic twin placenta with discordant fetal growth.

Schrey S, Kingdom J, Baczyk D, Fitzgerald B, Keating S, Ryan G, Drewlo S.

Mol Hum Reprod. 2013 Nov;19(11):764-72. doi: 10.1093/molehr/gat048. Epub 2013 Jul 4.

PMID:
23832168
34.

Emerging role of SUMOylation in placental pathology.

Baczyk D, Drewlo S, Kingdom JC.

Placenta. 2013 Jul;34(7):606-12. doi: 10.1016/j.placenta.2013.03.012. Epub 2013 Apr 28.

PMID:
23628505
35.

Heparin--not only thinning the blood.

Drewlo S.

Blood. 2013 Mar 14;121(11):1932-3. doi: 10.1182/blood-2013-01-480475.

PMID:
23493771
36.

Heme oxygenase-1 in placental development and pathology.

Levytska K, Kingdom J, Baczyk D, Drewlo S.

Placenta. 2013 Apr;34(4):291-8. doi: 10.1016/j.placenta.2013.01.004. Epub 2013 Feb 9. Review.

PMID:
23403148
37.

DREAM mediated regulation of GCM1 in the human placental trophoblast.

Baczyk D, Kibschull M, Mellstrom B, Levytska K, Rivas M, Drewlo S, Lye SJ, Naranjo JR, Kingdom JC.

PLoS One. 2013;8(1):e51837. doi: 10.1371/journal.pone.0051837. Epub 2013 Jan 3.

38.

Dual specificity phosphatase 9 (DUSP9) expression is down-regulated in the severe pre-eclamptic placenta.

Czikk MJ, Drewlo S, Baczyk D, Adamson SL, Kingdom J.

Placenta. 2013 Feb;34(2):174-81. doi: 10.1016/j.placenta.2012.11.029. Epub 2012 Dec 29.

PMID:
23276385
39.

Revisiting the housekeeping genes of human placental development and insufficiency syndromes.

Drewlo S, Levytska K, Kingdom J.

Placenta. 2012 Nov;33(11):952-4. doi: 10.1016/j.placenta.2012.09.007. Epub 2012 Sep 29.

PMID:
23026742
40.

The molecular role of connexin 43 in human trophoblast cell fusion.

Dunk CE, Gellhaus A, Drewlo S, Baczyk D, Pötgens AJ, Winterhager E, Kingdom JC, Lye SJ.

Biol Reprod. 2012 Apr 19;86(4):115. doi: 10.1095/biolreprod.111.096925. Print 2012 Apr.

41.

Heparin promotes soluble VEGF receptor expression in human placental villi to impair endothelial VEGF signaling.

Drewlo S, Levytska K, Sobel M, Baczyk D, Lye SJ, Kingdom JC.

J Thromb Haemost. 2011 Dec;9(12):2486-97. doi: 10.1111/j.1538-7836.2011.04526.x.

42.

Evidence implicating peroxisome proliferator-activated receptor-γ in the pathogenesis of preeclampsia.

McCarthy FP, Drewlo S, English FA, Kingdom J, Johns EJ, Kenny LC, Walsh SK.

Hypertension. 2011 Nov;58(5):882-7. doi: 10.1161/HYPERTENSIONAHA.111.179440. Epub 2011 Sep 19.

PMID:
21931072
43.

Is heparin a placental anticoagulant in high-risk pregnancies?

Kingdom JC, Drewlo S.

Blood. 2011 Nov 3;118(18):4780-8. doi: 10.1182/blood-2011-07-319749. Epub 2011 Aug 25. Review.

PMID:
21868576
44.

P1. Targeted gene arrays across the severely-discordant growth monochorionic twin placenta: Implications for angiogenesis and metabolic programming.

Schrey S, Baczyk D, Fitzgerald B, Keating S, Ryan G, Kingdom J, Drewlo S.

Pregnancy Hypertens. 2011 Jul-Oct;1(3-4):273. doi: 10.1016/j.preghy.2011.08.062. Epub 2011 Sep 29. No abstract available.

PMID:
26009091
45.

Peroxisome proliferator-activated receptor-γ as a potential therapeutic target in the treatment of preeclampsia.

McCarthy FP, Drewlo S, Kingdom J, Johns EJ, Walsh SK, Kenny LC.

Hypertension. 2011 Aug;58(2):280-6. doi: 10.1161/HYPERTENSIONAHA.111.172627. Epub 2011 Jun 20.

PMID:
21690483
46.

Angiogenic response of placental villi to heparin.

Sobel ML, Kingdom J, Drewlo S.

Obstet Gynecol. 2011 Jun;117(6):1375-83. doi: 10.1097/AOG.0b013e31821b5384.

PMID:
21606748
47.

Glial cell missing-1 mediates over-expression of tissue inhibitor of metalloproteinase-4 in severe pre-eclamptic placental villi.

Drewlo S, Czikk M, Baczyk D, Lye S, Kingdom J.

Hum Reprod. 2011 May;26(5):1025-34. doi: 10.1093/humrep/der053. Epub 2011 Mar 15.

PMID:
21406447
48.

Complex patterns of ADAM12 mRNA and protein splice variants in the human placenta.

Kokozidou M, Drewlo S, Bartz C, Raven G, Brandenburg LO, Wruck CJ, Pufe T.

Ann Anat. 2011 Mar;193(2):142-8. doi: 10.1016/j.aanat.2010.12.002. Epub 2011 Jan 26.

PMID:
21330122
49.

Vascular dysfunction in women with a history of preeclampsia and intrauterine growth restriction: insights into future vascular risk.

Yinon Y, Kingdom JC, Odutayo A, Moineddin R, Drewlo S, Lai V, Cherney DZ, Hladunewich MA.

Circulation. 2010 Nov 2;122(18):1846-53. doi: 10.1161/CIRCULATIONAHA.110.948455. Epub 2010 Oct 18.

PMID:
20956209
50.

Differential methylation of STOX1 in human placenta.

van Dijk M, Drewlo S, Oudejans CB.

Epigenetics. 2010 Nov-Dec;5(8):736-42. doi: 10.4161/epi.5.8.13084. Epub 2010 Nov 1.

PMID:
20716964

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