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Items: 29

1.

The experimental power of FR900359 to study Gq-regulated biological processes.

Schrage R, Schmitz AL, Gaffal E, Annala S, Kehraus S, Wenzel D, Büllesbach KM, Bald T, Inoue A, Shinjo Y, Galandrin S, Shridhar N, Hesse M, Grundmann M, Merten N, Charpentier TH, Martz M, Butcher AJ, Slodczyk T, Armando S, Effern M, Namkung Y, Jenkins L, Horn V, Stößel A, Dargatz H, Tietze D, Imhof D, Galés C, Drewke C, Müller CE, Hölzel M, Milligan G, Tobin AB, Gomeza J, Dohlman HG, Sondek J, Harden TK, Bouvier M, Laporte SA, Aoki J, Fleischmann BK, Mohr K, König GM, Tüting T, Kostenis E.

Nat Commun. 2015 Dec 14;6:10156. doi: 10.1038/ncomms10156.

2.

The key role of peltate glandular trichomes in symbiota comprising clavicipitaceous fungi of the genus periglandula and their host plants.

Steiner U, Kucht SH, Ahimsa-Müller MA, Grundmann N, Li SM, Drewke C, Leistner E.

Toxins (Basel). 2015 Apr 16;7(4):1355-73. doi: 10.3390/toxins7041355.

3.

Decoding signaling and function of the orphan G protein-coupled receptor GPR17 with a small-molecule agonist.

Hennen S, Wang H, Peters L, Merten N, Simon K, Spinrath A, Blättermann S, Akkari R, Schrage R, Schröder R, Schulz D, Vermeiren C, Zimmermann K, Kehraus S, Drewke C, Pfeifer A, König GM, Mohr K, Gillard M, Müller CE, Lu QR, Gomeza J, Kostenis E.

Sci Signal. 2013 Oct 22;6(298):ra93. doi: 10.1126/scisignal.2004350.

4.

Applying label-free dynamic mass redistribution technology to frame signaling of G protein-coupled receptors noninvasively in living cells.

Schröder R, Schmidt J, Blättermann S, Peters L, Janssen N, Grundmann M, Seemann W, Kaufel D, Merten N, Drewke C, Gomeza J, Milligan G, Mohr K, Kostenis E.

Nat Protoc. 2011 Oct 20;6(11):1748-60. doi: 10.1038/nprot.2011.386.

PMID:
22015845
5.

Conjugated linoleic acids mediate insulin release through islet G protein-coupled receptor FFA1/GPR40.

Schmidt J, Liebscher K, Merten N, Grundmann M, Mielenz M, Sauerwein H, Christiansen E, Due-Hansen ME, Ulven T, Ullrich S, Gomeza J, Drewke C, Kostenis E.

J Biol Chem. 2011 Apr 8;286(14):11890-4. doi: 10.1074/jbc.C110.200477. Epub 2011 Feb 21.

6.

Selective orthosteric free fatty acid receptor 2 (FFA2) agonists: identification of the structural and chemical requirements for selective activation of FFA2 versus FFA3.

Schmidt J, Smith NJ, Christiansen E, Tikhonova IG, Grundmann M, Hudson BD, Ward RJ, Drewke C, Milligan G, Kostenis E, Ulven T.

J Biol Chem. 2011 Mar 25;286(12):10628-40. doi: 10.1074/jbc.M110.210872. Epub 2011 Jan 10.

7.

Structure-Activity Study of Dihydrocinnamic Acids and Discovery of the Potent FFA1 (GPR40) Agonist TUG-469.

Christiansen E, Due-Hansen ME, Urban C, Merten N, Pfleiderer M, Karlsen KK, Rasmussen SS, Steensgaard M, Hamacher A, Schmidt J, Drewke C, Petersen RK, Kristiansen K, Ullrich S, Kostenis E, Kassack MU, Ulven T.

ACS Med Chem Lett. 2010 Jul 2;1(7):345-9. doi: 10.1021/ml100106c. eCollection 2010 Oct 14.

8.

Deconvolution of complex G protein-coupled receptor signaling in live cells using dynamic mass redistribution measurements.

Schröder R, Janssen N, Schmidt J, Kebig A, Merten N, Hennen S, Müller A, Blättermann S, Mohr-Andrä M, Zahn S, Wenzel J, Smith NJ, Gomeza J, Drewke C, Milligan G, Mohr K, Kostenis E.

Nat Biotechnol. 2010 Sep;28(9):943-9. doi: 10.1038/nbt.1671. Epub 2010 Aug 15.

PMID:
20711173
9.

Ginkgo biloba and ginkgotoxin.

Leistner E, Drewke C.

J Nat Prod. 2010 Jan;73(1):86-92. doi: 10.1021/np9005019.

PMID:
20041670
10.

Influence of antivitamins ginkgotoxin 5'-phosphate and deoxypyridoxine 5'-phosphate on human pyridoxine 5'-phosphate oxidase.

Salamon N, Gurgui C, Leistner E, Drewke C.

Planta Med. 2009 May;75(6):563-7. doi: 10.1055/s-0029-1185482. Epub 2009 Mar 13.

PMID:
19288402
11.

The C-terminal tail of CRTH2 is a key molecular determinant that constrains Galphai and downstream signaling cascade activation.

Schröder R, Merten N, Mathiesen JM, Martini L, Kruljac-Letunic A, Krop F, Blaukat A, Fang Y, Tran E, Ulven T, Drewke C, Whistler J, Pardo L, Gomeza J, Kostenis E.

J Biol Chem. 2009 Jan 9;284(2):1324-36. doi: 10.1074/jbc.M806867200. Epub 2008 Nov 14.

12.

Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes.

Christiansen E, Urban C, Merten N, Liebscher K, Karlsen KK, Hamacher A, Spinrath A, Bond AD, Drewke C, Ullrich S, Kassack MU, Kostenis E, Ulven T.

J Med Chem. 2008 Nov 27;51(22):7061-4. doi: 10.1021/jm8010178.

PMID:
18947221
13.

Biosynthesis and accumulation of ergoline alkaloids in a mutualistic association between Ipomoea asarifolia (Convolvulaceae) and a clavicipitalean fungus.

Markert A, Steffan N, Ploss K, Hellwig S, Steiner U, Drewke C, Li SM, Boland W, Leistner E.

Plant Physiol. 2008 May;147(1):296-305. doi: 10.1104/pp.108.116699. Epub 2008 Mar 14.

14.

The Pdx1 family is structurally and functionally conserved between Arabidopsis thaliana and Ginkgo biloba.

Leuendorf JE, Genau A, Szewczyk A, Mooney S, Drewke C, Leistner E, Hellmann H.

FEBS J. 2008 Mar;275(5):960-9. doi: 10.1111/j.1742-4658.2008.06275.x.

15.

Clavicipitaceous fungi associated with ergoline alkaloid-containing convolvulaceae.

Ahimsa-Müller MA, Markert A, Hellwig S, Knoop V, Steiner U, Drewke C, Leistner E.

J Nat Prod. 2007 Dec;70(12):1955-60. Epub 2007 Nov 22.

PMID:
18031017
16.

The human pyridoxal kinase, a plausible target for ginkgotoxin from Ginkgo biloba.

Kästner U, Hallmen C, Wiese M, Leistner E, Drewke C.

FEBS J. 2007 Feb;274(4):1036-45. Epub 2007 Jan 19.

17.

Analysis of the Arabidopsis rsr4-1/pdx1-3 mutant reveals the critical function of the PDX1 protein family in metabolism, development, and vitamin B6 biosynthesis.

Wagner S, Bernhardt A, Leuendorf JE, Drewke C, Lytovchenko A, Mujahed N, Gurgui C, Frommer WB, Leistner E, Fernie AR, Hellmann H.

Plant Cell. 2006 Jul;18(7):1722-35. Epub 2006 Jun 9.

18.

Molecular characterization of a seed transmitted clavicipitaceous fungus occurring on dicotyledoneous plants (Convolvulaceae).

Steiner U, Ahimsa-Müller MA, Markert A, Kucht S, Gross J, Kauf N, Kuzma M, Zych M, Lamshöft M, Furmanowa M, Knoop V, Drewke C, Leistner E.

Planta. 2006 Aug;224(3):533-44. Epub 2006 Mar 9.

PMID:
16525783
19.
20.

Biosynthesis of vitamin B6 and structurally related derivatives.

Drewke C, Leistner E.

Vitam Horm. 2001;61:121-55. Review.

PMID:
11153264
21.

Biosynthesis of 4'-O-methylpyridoxine (Ginkgotoxin) from primary precursors.

Fiehe K, Arenz A, Drewke C, Hemscheidt T, Williamson RT, Leistner E.

J Nat Prod. 2000 Feb;63(2):185-9.

PMID:
10691705
22.

Occurrence of neurotoxic 4'-O-methylpyridoxine in Ginkgo biloba leaves, Ginkgo medications and Japanese Ginkgo food.

Arenz A, Klein M, Fiehe K, Gross J, Drewke C, Hemscheidt T, Leistner E.

Planta Med. 1996 Dec;62(6):548-51.

PMID:
17252495
23.

4-O-phosphoryl-L-threonine, a substrate of the pdxC(serC) gene product involved in vitamin B6 biosynthesis.

Drewke C, Klein M, Clade D, Arenz A, Müller R, Leistner E.

FEBS Lett. 1996 Jul 22;390(2):179-82.

24.

Isolation of a gene encoding cysteine synthase from Flavobacterium K3-15.

Müller R, Kuttler E, Lanz C, Drewke C, Schmidt K.

FEMS Microbiol Lett. 1996 Mar 1;136(3):305-8.

PMID:
8867384
25.

Purification and characterization of the pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating) from Escherichia coli.

Notheis C, Drewke C, Leistner E.

Biochim Biophys Acta. 1995 Mar 15;1247(2):265-71.

PMID:
7696318
26.

Growth response to 4-hydroxy-L-threonine of Escherichia coli mutants blocked in vitamin B6 biosynthesis.

Drewke C, Notheis C, Hansen U, Leistner E, Hemscheidt T, Hill RE, Spenser ID.

FEBS Lett. 1993 Mar 1;318(2):125-8.

28.

Overexpression, purification and properties of alcohol dehydrogenase IV from Saccharomyces cerevisiae.

Drewke C, Ciriacy M.

Biochim Biophys Acta. 1988 May 6;950(1):54-60.

PMID:
3282541
29.

Cloning and characterization of the DAS gene encoding the major methanol assimilatory enzyme from the methylotrophic yeast Hansenula polymorpha.

Janowicz ZA, Eckart MR, Drewke C, Roggenkamp RO, Hollenberg CP, Maat J, Ledeboer AM, Visser C, Verrips CT.

Nucleic Acids Res. 1985 May 10;13(9):3043-62.

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