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In vitro hepatotoxicity of Petasites hybridus extract (Ze 339) depends on the concentration, the cytochrome activity of the cell system, and the species used.

Forsch K, Schöning V, Assmann GM, Moser C, Siewert B, Butterweck V, Drewe J.

Phytother Res. 2019 Oct 20. doi: 10.1002/ptr.6516. [Epub ahead of print]


Editorial: Quantifying and Addressing Bias Associated With Imperfect Observation Processes in Epidemiological Studies.

Vergne T, Drewe JA.

Front Vet Sci. 2019 Sep 13;6:310. doi: 10.3389/fvets.2019.00310. eCollection 2019. No abstract available.


No Clinically Relevant Interactions of St. John's Wort Extract Ze 117 Low in Hyperforin With Cytochrome P450 Enzymes and P-glycoprotein.

Zahner C, Kruttschnitt E, Uricher J, Lissy M, Hirsch M, Nicolussi S, Krähenbühl S, Drewe J.

Clin Pharmacol Ther. 2019 Aug;106(2):432-440. doi: 10.1002/cpt.1392. Epub 2019 Mar 23.


St John's wort extract influences membrane fluidity and composition of phosphatidylcholine and phosphatidylethanolamine in rat C6 glioblastoma cells.

Keksel N, Bussmann H, Unger M, Drewe J, Boonen G, Häberlein H, Franken S.

Phytomedicine. 2019 Feb 15;54:66-76. doi: 10.1016/j.phymed.2018.06.013. Epub 2018 Jun 28.


Non-immunological toxicological mechanisms of metamizole-associated neutropenia in HL60 cells.

Rudin D, Lanzilotto A, Bachmann F, Housecroft CE, Constable EC, Drewe J, Haschke M, Krähenbühl S.

Biochem Pharmacol. 2019 May;163:345-356. doi: 10.1016/j.bcp.2019.01.011. Epub 2019 Jan 14.


Metabolic switch induced by Cimicifuga racemosa extract prevents mitochondrial damage and oxidative cell death.

Rabenau M, Unger M, Drewe J, Culmsee C.

Phytomedicine. 2019 Jan;52:107-116. doi: 10.1016/j.phymed.2018.09.177. Epub 2018 Sep 17.


Effects of Cimicifuga racemosa extract Ze450 on mitochondria in models of oxidative stress in neuronal cells.

Rabenau M, Unger M, Drewe J, Culmsee C.

Data Brief. 2018 Oct 26;21:1872-1879. doi: 10.1016/j.dib.2018.10.092. eCollection 2018 Dec.


Prediction of clinically relevant drug-induced liver injury from structure using machine learning.

Hammann F, Schöning V, Drewe J.

J Appl Toxicol. 2019 Mar;39(3):412-419. doi: 10.1002/jat.3741. Epub 2018 Oct 16. Review.


The hepatotoxic potential of protein kinase inhibitors predicted with Random Forest and Artificial Neural Networks.

Schöning V, Krähenbühl S, Drewe J.

Toxicol Lett. 2018 Dec 15;299:145-148. doi: 10.1016/j.toxlet.2018.10.009. Epub 2018 Oct 10.


Acute Effects of Glucose and Fructose Administration on the Neural Correlates of Cognitive Functioning in Healthy Subjects: A Pilot Study.

Zanchi D, Meyer-Gerspach AC, Schmidt A, Suenderhauf C, Depoorter A, Drewe J, Beglinger C, Wölnerhanssen BK, Borgwardt S.

Front Psychiatry. 2018 Mar 12;9:71. doi: 10.3389/fpsyt.2018.00071. eCollection 2018.


Development of an in vitro screening method of acute cytotoxicity of the pyrrolizidine alkaloid lasiocarpine in human and rodent hepatic cell lines by increasing susceptibility.

Forsch K, Schöning V, Disch L, Siewert B, Unger M, Drewe J.

J Ethnopharmacol. 2018 May 10;217:134-139. doi: 10.1016/j.jep.2018.02.018. Epub 2018 Feb 14.


Effects of a fixed herbal drug combination (Ze 185) to an experimental acute stress setting in healthy men - An explorative randomized placebo-controlled double-blind study.

Meier S, Haschke M, Zahner C, Kruttschnitt E, Drewe J, Liakoni E, Hammann F, Gaab J.

Phytomedicine. 2018 Jan 15;39:85-92. doi: 10.1016/j.phymed.2017.12.005. Epub 2017 Dec 12.


In Vitro and In Situ Absorption and Metabolism of Sesquiterpenes from Petasites hybridus Extracts.

Disch L, Forsch K, Siewert B, Drewe J, Fricker G.

Planta Med. 2018 Jul;84(11):795-805. doi: 10.1055/s-0044-100401. Epub 2018 Jan 16.


Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid Obesity: The SM-BOSS Randomized Clinical Trial.

Peterli R, Wölnerhanssen BK, Peters T, Vetter D, Kröll D, Borbély Y, Schultes B, Beglinger C, Drewe J, Schiesser M, Nett P, Bueter M.

JAMA. 2018 Jan 16;319(3):255-265. doi: 10.1001/jama.2017.20897.


Quantitative interferon-gamma responses predict future disease progression in badgers naturally infected with Mycobacterium bovis.

Buzdugan SN, Chambers MA, Delahay RJ, Drewe JA.

Epidemiol Infect. 2017 Nov;145(15):3204-3213. doi: 10.1017/S0950268817001960. Epub 2017 Oct 11.


Green tea effects on cognition, mood and human brain function: A systematic review.

Mancini E, Beglinger C, Drewe J, Zanchi D, Lang UE, Borgwardt S.

Phytomedicine. 2017 Oct 15;34:26-37. doi: 10.1016/j.phymed.2017.07.008. Epub 2017 Jul 27. Review.


In Vitro and In Situ Characterization of Triterpene Glycosides From Cimicifuga racemosa Extract.

Disch L, Forsch K, Siewert B, Drewe J, Fricker G.

J Pharm Sci. 2017 Dec;106(12):3642-3650. doi: 10.1016/j.xphs.2017.07.023. Epub 2017 Aug 4.


The impact of gut hormones on the neural circuit of appetite and satiety: A systematic review.

Zanchi D, Depoorter A, Egloff L, Haller S, Mählmann L, Lang UE, Drewe J, Beglinger C, Schmidt A, Borgwardt S.

Neurosci Biobehav Rev. 2017 Sep;80:457-475. doi: 10.1016/j.neubiorev.2017.06.013. Epub 2017 Jun 29. Review.


The Circadian Rhythm of Copeptin, the C-Terminal Portion of Arginine Vasopressin.

Beglinger S, Drewe J, Christ-Crain M.

J Biomark. 2017;2017:4737082. doi: 10.1155/2017/4737082. Epub 2017 Jun 1.


Regulation of bone mineral density in the grey squirrel, Sciurus carolinensis: Bioavailability of calcium oxalate, and implications for bark stripping.

Nichols CP, Gregory NG, Goode N, Gill RMA, Drewe JA.

J Anim Physiol Anim Nutr (Berl). 2018 Feb;102(1):330-336. doi: 10.1111/jpn.12740. Epub 2017 Jun 12.


Pharmacokinetics of Transdermal Etofenamate and Diclofenac in Healthy Volunteers.

Drago S, Imboden R, Schlatter P, Buylaert M, Krähenbühl S, Drewe J.

Basic Clin Pharmacol Toxicol. 2017 Nov;121(5):423-429. doi: 10.1111/bcpt.12818. Epub 2017 Jun 27.


Inference of the infection status of individuals using longitudinal testing data from cryptic populations: Towards a probabilistic approach to diagnosis.

Buzdugan SN, Vergne T, Grosbois V, Delahay RJ, Drewe JA.

Sci Rep. 2017 Apr 19;7(1):1111. doi: 10.1038/s41598-017-00806-4.


Social and environmental factors affect tuberculosis related mortality in wild meerkats.

Patterson S, Drewe JA, Pfeiffer DU, Clutton-Brock TH.

J Anim Ecol. 2017 May;86(3):442-450. doi: 10.1111/1365-2656.12649. Epub 2017 Apr 3.


Laparoscopic Sleeve Gastrectomy Versus Roux-Y-Gastric Bypass for Morbid Obesity-3-Year Outcomes of the Prospective Randomized Swiss Multicenter Bypass Or Sleeve Study (SM-BOSS).

Peterli R, Wölnerhanssen BK, Vetter D, Nett P, Gass M, Borbély Y, Peters T, Schiesser M, Schultes B, Beglinger C, Drewe J, Bueter M.

Ann Surg. 2017 Mar;265(3):466-473. doi: 10.1097/SLA.0000000000001929.


Anti-inflammatory effects of the petasin phyto drug Ze339 are mediated by inhibition of the STAT pathway.

Steiert SA, Zissler UM, Chaker AM, Esser-von-Bieren J, Dittlein D, Guerth F, Jakwerth CA, Piontek G, Zahner C, Drewe J, Traidl-Hoffmann C, Schmidt-Weber CB, Gilles S.

Biofactors. 2017 May 6;43(3):388-399. doi: 10.1002/biof.1349. Epub 2017 Jan 31.


Development and evaluation of a diagnostic cytokine-release assay for Mycobacterium suricattae infection in meerkats (Suricata suricatta).

Clarke C, Patterson SJ, Drewe JA, van Helden PD, Miller MA, Parsons SD.

BMC Vet Res. 2017 Jan 4;13(1):2. doi: 10.1186/s12917-016-0927-x.


Active animal health surveillance in European Union Member States: gaps and opportunities.

Bisdorff B, Schauer B, Taylor N, Rodríguez-Prieto V, Comin A, Brouwer A, Dórea F, Drewe J, Hoinville L, Lindberg A, Martinez Avilés M, Martínez-López B, Peyre M, Pinto Ferreira J, Rushton J, VAN Schaik G, Stärk KD, Staubach C, Vicente-Rubiano M, Witteveen G, Pfeiffer D, Häsler B.

Epidemiol Infect. 2017 Mar;145(4):802-817. doi: 10.1017/S0950268816002697. Epub 2016 Dec 12.


Effect of L-Tryptophan and L-Leucine on Gut Hormone Secretion, Appetite Feelings and Gastric Emptying Rates in Lean and Non-Diabetic Obese Participants: A Randomized, Double-Blind, Parallel-Group Trial.

Meyer-Gerspach AC, Häfliger S, Meili J, Doody A, Rehfeld JF, Drewe J, Beglinger C, Wölnerhanssen B.

PLoS One. 2016 Nov 22;11(11):e0166758. doi: 10.1371/journal.pone.0166758. eCollection 2016.


Differential effects of L-tryptophan and L-leucine administration on brain resting state functional networks and plasma hormone levels.

Zanchi D, Meyer-Gerspach AC, Suenderhauf C, Janach K, le Roux CW, Haller S, Drewe J, Beglinger C, Wölnerhanssen BK, Borgwardt S.

Sci Rep. 2016 Oct 20;6:35727. doi: 10.1038/srep35727.


Gut hormone secretion, gastric emptying, and glycemic responses to erythritol and xylitol in lean and obese subjects.

Wölnerhanssen BK, Cajacob L, Keller N, Doody A, Rehfeld JF, Drewe J, Peterli R, Beglinger C, Meyer-Gerspach AC.

Am J Physiol Endocrinol Metab. 2016 Jun 1;310(11):E1053-61. doi: 10.1152/ajpendo.00037.2016. Epub 2016 Apr 26.


Time controlled pulsatile transdermal delivery of nicotine: A phase I feasibility trial in male smokers.

Hammann F, Kummer O, Guercioni S, Imanidis G, Drewe J.

J Control Release. 2016 Jun 28;232:248-54. doi: 10.1016/j.jconrel.2016.04.017. Epub 2016 Apr 14.


Mechanisms Regulating Insulin Response to Intragastric Glucose in Lean and Non-Diabetic Obese Subjects: A Randomized, Double-Blind, Parallel-Group Trial.

Meyer-Gerspach AC, Cajacob L, Riva D, Herzog R, Drewe J, Beglinger C, Wölnerhanssen BK.

PLoS One. 2016 Mar 4;11(3):e0150803. doi: 10.1371/journal.pone.0150803. eCollection 2016.


Diagnosis of tuberculosis in groups of badgers: an exploration of the impact of trapping efficiency, infection prevalence and the use of multiple tests.

Buzdugan SN, Chambers MA, Delahay RJ, Drewe JA.

Epidemiol Infect. 2016 Jun;144(8):1717-27. doi: 10.1017/S0950268815003210. Epub 2016 Jan 6.


Beyond aggression: Androgen-receptor blockade modulates social interaction in wild meerkats.

delBarco-Trillo J, Greene LK, Goncalves IB, Fenkes M, Wisse JH, Drewe JA, Manser MB, Clutton-Brock T, Drea CM.

Horm Behav. 2016 Feb;78:95-106. doi: 10.1016/j.yhbeh.2015.11.001. Epub 2015 Nov 3.


Whole genome sequence analysis of Mycobacterium suricattae.

Dippenaar A, Parsons SDC, Sampson SL, van der Merwe RG, Drewe JA, Abdallah AM, Siame KK, Gey van Pittius NC, van Helden PD, Pain A, Warren RM.

Tuberculosis (Edinb). 2015 Dec;95(6):682-688. doi: 10.1016/ Epub 2015 Oct 13.


Evaluation of the usefulness at national level of the dairy cattle health and production recording systems in Great Britain.

Velasova M, Drewe JA, Gibbons J, Green M, Guitian J.

Vet Rec. 2015 Sep 26;177(12):304. doi: 10.1136/vr.103034. Epub 2015 Sep 15.


Bovine tuberculosis: how likely is a skin test reactor to be uninfected?

Drewe JA.

Vet Rec. 2015 Sep 12;177(10):256-7. doi: 10.1136/vr.h4760. No abstract available.


UPLC TOF MS for sensitive quantification of naturally occurring pyrrolizidine alkaloids in Petasites hybridus extract (Ze 339).

Schenk A, Siewert B, Toff S, Drewe J.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Aug 1;997:23-9. doi: 10.1016/j.jchromb.2015.05.027. Epub 2015 May 28.


Risk factors for visible lesions or positive laboratory tests in bovine tuberculosis reactor cattle in Northern Ireland.

O'Hagan MJ, Courcier EA, Drewe JA, Gordon AW, McNair J, Abernethy DA.

Prev Vet Med. 2015 Jul 1;120(3-4):283-90. doi: 10.1016/j.prevetmed.2015.04.005. Epub 2015 Apr 16.


Peste des petits ruminants virus in Heilongjiang province, China, 2014.

Wang J, Wang M, Wang S, Liu Z, Shen N, Si W, Sun G, Drewe JA, Cai X.

Emerg Infect Dis. 2015 Apr;21(4):677-80. doi: 10.3201/eid2104.141627.


A systematic review of non-hormonal treatments of vasomotor symptoms in climacteric and cancer patients.

Drewe J, Bucher KA, Zahner C.

Springerplus. 2015 Feb 10;4:65. doi: 10.1186/s40064-015-0808-y. eCollection 2015.


Antidiabetic effects of the Cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice.

Moser C, Vickers SP, Brammer R, Cheetham SC, Drewe J.

Phytomedicine. 2014 Sep 25;21(11):1382-9. doi: 10.1016/j.phymed.2014.06.002. Epub 2014 Jul 8.


Effect of a test meal on meal responses of satiation hormones and their association to insulin resistance in obese adolescents.

Beglinger S, Meyer-Gerspach AC, Graf S, Zumsteg U, Drewe J, Beglinger C, Gutzwiller JP.

Obesity (Silver Spring). 2014 Sep;22(9):2047-52. doi: 10.1002/oby.20805. Epub 2014 Jun 13.


A study of the relationship between serum bile acids and propranolol pharmacokinetics and pharmacodynamics in patients with liver cirrhosis and in healthy controls.

Taegtmeyer AB, Haschke M, Tchambaz L, Buylaert M, Tschöpl M, Beuers U, Drewe J, Krähenbühl S.

PLoS One. 2014 Jun 6;9(6):e97885. doi: 10.1371/journal.pone.0097885. eCollection 2014.


Serum hepcidin concentrations correlate with ferritin in patients with inflammatory bowel disease.

Mecklenburg I, Reznik D, Fasler-Kan E, Drewe J, Beglinger C, Hruz P; Swiss IBD Cohort Study Group.

J Crohns Colitis. 2014 Nov;8(11):1392-7. doi: 10.1016/j.crohns.2014.04.008. Epub 2014 May 11.


Green tea extract enhances parieto-frontal connectivity during working memory processing.

Schmidt A, Hammann F, Wölnerhanssen B, Meyer-Gerspach AC, Drewe J, Beglinger C, Borgwardt S.

Psychopharmacology (Berl). 2014 Oct;231(19):3879-88. doi: 10.1007/s00213-014-3526-1. Epub 2014 Mar 19.


Data mining for potential adverse drug-drug interactions.

Hammann F, Drewe J.

Expert Opin Drug Metab Toxicol. 2014 May;10(5):665-71. doi: 10.1517/17425255.2014.894507. Epub 2014 Mar 4. Review.


Gamma-linolenic acid levels correlate with clinical efficacy of evening primrose oil in patients with atopic dermatitis.

Simon D, Eng PA, Borelli S, Kägi R, Zimmermann C, Zahner C, Drewe J, Hess L, Ferrari G, Lautenschlager S, Wüthrich B, Schmid-Grendelmeier P.

Adv Ther. 2014 Feb;31(2):180-8. doi: 10.1007/s12325-014-0093-0. Epub 2014 Jan 17.


Novel cause of tuberculosis in meerkats, South Africa.

Parsons SD, Drewe JA, Gey van Pittius NC, Warren RM, van Helden PD.

Emerg Infect Dis. 2013 Dec;19(12):2004-7. doi: 10.3201/eid1912.130268.

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