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Items: 1 to 50 of 168

1.

How the gene behind Huntington's disease could be neutralized.

Drew L.

Nature. 2018 May;557(7707):S39-S41. doi: 10.1038/d41586-018-05176-z. No abstract available.

PMID:
29844556
2.

AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status.

Ma R, Xu L, Qu X, Che X, Zhang Y, Fan Y, Li C, Guo T, Hou K, Hu X, Drew L, Shen M, Cheung T, Liu Y.

Br J Cancer. 2018 May 14. doi: 10.1038/s41416-018-0086-x. [Epub ahead of print]

PMID:
29755114
3.

CSF1R+ Macrophages Sustain Pancreatic Tumor Growth through T Cell Suppression and Maintenance of Key Gene Programs that Define the Squamous Subtype.

Candido JB, Morton JP, Bailey P, Campbell AD, Karim SA, Jamieson T, Lapienyte L, Gopinathan A, Clark W, McGhee EJ, Wang J, Escorcio-Correia M, Zollinger R, Roshani R, Drew L, Rishi L, Arkell R, Evans TRJ, Nixon C, Jodrell DI, Wilkinson RW, Biankin AV, Barry ST, Balkwill FR, Sansom OJ.

Cell Rep. 2018 May 1;23(5):1448-1460. doi: 10.1016/j.celrep.2018.03.131.

4.

Fighting the inevitability of ageing.

Drew L.

Nature. 2018 Mar 8;555(7695):S15-S17. doi: 10.1038/d41586-018-02479-z. No abstract available.

PMID:
29517046
5.

Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4.

Degorce SL, Anjum R, Dillman KS, Drew L, Groombridge SD, Halsall CT, Lenz EM, Lindsay NA, Mayo MF, Pink JH, Robb GR, Scott JS, Stokes S, Xue Y.

Bioorg Med Chem. 2018 Feb 15;26(4):913-924. doi: 10.1016/j.bmc.2018.01.008. Epub 2018 Jan 17.

PMID:
29398441
6.

A Homogeneous Cell-Based Halide-Sensitive Yellow Fluorescence Protein Assay to Identify Modulators of the Cystic Fibrosis Transmembrane Conductance Regulator Ion Channel.

Smith E, Giuliano KA, Shumate J, Baillargeon P, McEwan B, Cullen MD, Miller JP, Drew L, Scampavia L, Spicer TP.

Assay Drug Dev Technol. 2017 Dec;15(8):395-406. doi: 10.1089/adt.2017.810. Epub 2017 Nov 27.

PMID:
29172645
7.

Discovery and Optimization of Pyrrolopyrimidine Inhibitors of Interleukin-1 Receptor Associated Kinase 4 (IRAK4) for the Treatment of Mutant MYD88L265P Diffuse Large B-Cell Lymphoma.

Scott JS, Degorce SL, Anjum R, Culshaw J, Davies RDM, Davies NL, Dillman KS, Dowling JE, Drew L, Ferguson AD, Groombridge SD, Halsall CT, Hudson JA, Lamont S, Lindsay NA, Marden SK, Mayo MF, Pease JE, Perkins DR, Pink JH, Robb GR, Rosen A, Shen M, McWhirter C, Wu D.

J Med Chem. 2017 Dec 28;60(24):10071-10091. doi: 10.1021/acs.jmedchem.7b01290. Epub 2017 Dec 11.

PMID:
29172502
8.

Drug development: Sprint finish.

Drew L.

Nature. 2017 Nov 23;551(7681). doi: 10.1038/d41586-017-06926-1. No abstract available.

PMID:
29168826
9.

Fighting the fatty liver.

Drew L.

Nature. 2017 Oct 11;550(7675):S102-S103. doi: 10.1038/550S102a. No abstract available.

PMID:
29019968
10.

Fatty liver disease: turning the tide.

Drew L.

Nature. 2017 Oct 11;550(7675):S101. doi: 10.1038/550S101a. No abstract available.

PMID:
29019967
11.

Neuroscience: The power of plasma.

Drew L.

Nature. 2017 Sep 27;549(7673):S26-S27. doi: 10.1038/549S26a. No abstract available.

PMID:
28953857
12.

Use of a High-Throughput Phenotypic Screening Strategy to Identify Amplifiers, a Novel Pharmacological Class of Small Molecules That Exhibit Functional Synergy with Potentiators and Correctors.

Giuliano KA, Wachi S, Drew L, Dukovski D, Green O, Bastos C, Cullen MD, Hauck S, Tait BD, Munoz B, Lee PS, Miller JP.

SLAS Discov. 2018 Feb;23(2):111-121. doi: 10.1177/2472555217729790. Epub 2017 Sep 12.

13.

Clinical devices and services: Repair shops.

Drew L, Scott A, Morgan B, Gruber K.

Nature. 2017 May 17;545(7654):S21-S24. doi: 10.1038/545S21a. No abstract available.

PMID:
28514414
15.

Microbiota: Reseeding the gut.

Drew L.

Nature. 2016 Dec 21;540(7634):S109-S112. doi: 10.1038/540S109a. No abstract available.

PMID:
28002392
16.

Two hundred steps.

Drew L.

Nature. 2016 Oct 27;538(7626):S2-S3. doi: 10.1038/538S2a. No abstract available.

PMID:
27783577
17.

Pharmacogenetics: The right drug for you.

Drew L.

Nature. 2016 Sep 8;537(7619):S60-2. doi: 10.1038/537S60a. No abstract available.

PMID:
27602742
18.

Family Characteristics Associated with Likelihood of Varicella Vaccination.

Weinmann S, Mullooly JP, Drew L, Chun CS.

Perm J. 2016 spring;20(2):54-8. doi: 10.7812/TPP/15-160. Epub 2016 Apr 15.

19.

Distinct Contribution of Adult-Born Hippocampal Granule Cells to Context Encoding.

Danielson NB, Kaifosh P, Zaremba JD, Lovett-Barron M, Tsai J, Denny CA, Balough EM, Goldberg AR, Drew LJ, Hen R, Losonczy A, Kheirbek MA.

Neuron. 2016 Apr 6;90(1):101-12. doi: 10.1016/j.neuron.2016.02.019. Epub 2016 Mar 10.

20.

Long-term outcomes for women after obstetric fistula repair in Lilongwe, Malawi: a qualitative study.

Drew LB, Wilkinson JP, Nundwe W, Moyo M, Mataya R, Mwale M, Tang JH.

BMC Pregnancy Childbirth. 2016 Jan 5;16:2. doi: 10.1186/s12884-015-0755-1.

21.

Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons.

Drew LJ, Kheirbek MA, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, Hen R.

Hippocampus. 2016 Jun;26(6):763-78. doi: 10.1002/hipo.22557. Epub 2016 Feb 8.

22.

5-HT1A receptors on mature dentate gyrus granule cells are critical for the antidepressant response.

Samuels BA, Anacker C, Hu A, Levinstein MR, Pickenhagen A, Tsetsenis T, Madroñal N, Donaldson ZR, Drew LJ, Dranovsky A, Gross CT, Tanaka KF, Hen R.

Nat Neurosci. 2015 Nov;18(11):1606-16. doi: 10.1038/nn.4116. Epub 2015 Sep 21.

23.
24.

Suppression of adult neurogenesis increases the acute effects of kainic acid.

Iyengar SS, LaFrancois JJ, Friedman D, Drew LJ, Denny CA, Burghardt NS, Wu MV, Hsieh J, Hen R, Scharfman HE.

Exp Neurol. 2015 Feb;264:135-49. doi: 10.1016/j.expneurol.2014.11.009. Epub 2014 Dec 2.

25.

Modulation of the maladaptive stress response to manage diseases of protein folding.

Roth DM, Hutt DM, Tong J, Bouchecareilh M, Wang N, Seeley T, Dekkers JF, Beekman JM, Garza D, Drew L, Masliah E, Morimoto RI, Balch WE.

PLoS Biol. 2014 Nov 18;12(11):e1001998. doi: 10.1371/journal.pbio.1001998. eCollection 2014 Nov.

26.

Quality-of-life outcomes with coronary artery bypass graft surgery in ischemic left ventricular dysfunction: a randomized trial.

Mark DB, Knight JD, Velazquez EJ, Wasilewski J, Howlett JG, Smith PK, Spertus JA, Rajda M, Yadav R, Hamman BL, Malinowski M, Naik A, Rankin G, Harding TM, Drew LA, Desvigne-Nickens P, Anstrom KJ.

Ann Intern Med. 2014 Sep 16;161(6):392-9. doi: 10.7326/M13-1380.

27.

Training Older Adults to Use Tablet Computers: Does It Enhance Cognitive Function?

Chan MY, Haber S, Drew LM, Park DC.

Gerontologist. 2016 Jun;56(3):475-84. doi: 10.1093/geront/gnu057. Epub 2014 Jun 13.

28.

Personal reflections on responses to alcohol and other drugs problems.

Drew L.

Drug Alcohol Rev. 2014 Jan;33(1):2-3. doi: 10.1111/dar.12080. Epub 2013 Nov 20. No abstract available.

PMID:
24256186
29.

Adult neurogenesis in the mammalian hippocampus: why the dentate gyrus?

Drew LJ, Fusi S, Hen R.

Learn Mem. 2013 Nov 19;20(12):710-29. doi: 10.1101/lm.026542.112. Review.

30.

The impact of sustained engagement on cognitive function in older adults: the Synapse Project.

Park DC, Lodi-Smith J, Drew L, Haber S, Hebrank A, Bischof GN, Aamodt W.

Psychol Sci. 2014 Jan;25(1):103-12. doi: 10.1177/0956797613499592. Epub 2013 Nov 8.

31.

Mitigation of cardiovascular toxicity in a series of CSF-1R inhibitors, and the identification of AZD7507.

Scott DA, Dakin LA, Daly K, Del Valle DJ, Diebold RB, Drew L, Ezhuthachan J, Gero TW, Ogoe CA, Omer CA, Redmond SP, Repik G, Thakur K, Ye Q, Zheng X.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4591-6. doi: 10.1016/j.bmcl.2013.06.031. Epub 2013 Jun 20.

PMID:
23842474
32.

Clozapine and agranulocytosis: re-assessing the risks.

Drew L.

Australas Psychiatry. 2013 Aug;21(4):335-7. doi: 10.1177/1039856213491990. Epub 2013 Jun 26.

PMID:
23804114
33.

Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus.

Kheirbek MA, Drew LJ, Burghardt NS, Costantini DO, Tannenholz L, Ahmari SE, Zeng H, Fenton AA, Hen R.

Neuron. 2013 Mar 6;77(5):955-68. doi: 10.1016/j.neuron.2012.12.038.

34.

Discovery and optimization of a novel series of potent mutant B-Raf(V600E) selective kinase inhibitors.

Vasbinder MM, Aquila B, Augustin M, Chen H, Cheung T, Cook D, Drew L, Fauber BP, Glossop S, Grondine M, Hennessy E, Johannes J, Lee S, Lyne P, Mörtl M, Omer C, Palakurthi S, Pontz T, Read J, Sha L, Shen M, Steinbacher S, Wang H, Wu A, Ye M.

J Med Chem. 2013 Mar 14;56(5):1996-2015. doi: 10.1021/jm301658d. Epub 2013 Feb 27.

PMID:
23398453
35.

An evaluation of stroke education in AVAIL registry hospitals.

West A, Cox M, Zimmer LO, Fedder W, Weber C, Drew L, Peterson ED, Bushnell C, Olson DM.

J Neurosci Nurs. 2012 Jun;44(3):115-23. doi: 10.1097/JNN.0b013e3182510657.

PMID:
22555348
36.

Longitudinal trajectories of metabolic control across adolescence: associations with parental involvement, adolescents' psychosocial maturity, and health care utilization.

King PS, Berg CA, Butner J, Drew LM, Foster C, Donaldson D, Murray M, Swinyard M, Wiebe DJ.

J Adolesc Health. 2012 May;50(5):491-6. doi: 10.1016/j.jadohealth.2011.09.007. Epub 2011 Dec 3.

37.

Mechanisms of acquired crizotinib resistance in ALK-rearranged lung Cancers.

Katayama R, Shaw AT, Khan TM, Mino-Kenudson M, Solomon BJ, Halmos B, Jessop NA, Wain JC, Yeo AT, Benes C, Drew L, Saeh JC, Crosby K, Sequist LV, Iafrate AJ, Engelman JA.

Sci Transl Med. 2012 Feb 8;4(120):120ra17. doi: 10.1126/scitranslmed.3003316. Epub 2012 Jan 25.

38.

Reported adverse events in young women following quadrivalent human papillomavirus vaccination.

Naleway AL, Gold R, Drew L, Riedlinger K, Henninger ML, Gee J.

J Womens Health (Larchmt). 2012 Apr;21(4):425-32. doi: 10.1089/jwh.2011.2895. Epub 2012 Jan 9.

PMID:
22229713
39.

Food for thought: linking caloric intake to behavior via sirtuin activity.

Drew LJ, Hen R.

Cell. 2011 Dec 23;147(7):1436-7. doi: 10.1016/j.cell.2011.11.052.

40.

Fear erasure in mice requires synergy between antidepressant drugs and extinction training.

Karpova NN, Pickenhagen A, Lindholm J, Tiraboschi E, Kulesskaya N, Agústsdóttir A, Antila H, Popova D, Akamine Y, Bahi A, Sullivan R, Hen R, Drew LJ, Castrén E.

Science. 2011 Dec 23;334(6063):1731-4. doi: 10.1126/science.1214592. Erratum in: Science. 2012 Feb 10;335(6069):657. Bahi, Amine [added].

41.

Altered axonal targeting and short-term plasticity in the hippocampus of Disc1 mutant mice.

Kvajo M, McKellar H, Drew LJ, Lepagnol-Bestel AM, Xiao L, Levy RJ, Blazeski R, Arguello PA, Lacefield CO, Mason CA, Simonneau M, O'Donnell JM, MacDermott AB, Karayiorgou M, Gogos JA.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):E1349-58. doi: 10.1073/pnas.1114113108. Epub 2011 Nov 2.

42.

Similar secondary stroke prevention and medication persistence rates among rural and urban patients.

Rodriguez D, Cox M, Zimmer LO, Olson DM, Goldstein LB, Drew L, Peterson ED, Bushnell CD; AVAIL Investigators.

J Rural Health. 2011 Winter;27(4):401-8. doi: 10.1111/j.1748-0361.2010.00352.x. Epub 2011 Jan 4.

PMID:
21967384
43.

Depleted parental psychological resources as mediators of the association of income with adherence and metabolic control.

Drew LM, Berg C, King P, Verdant C, Griffith K, Butler J, Wiebe DJ.

J Fam Psychol. 2011 Oct;25(5):751-8. doi: 10.1037/a0025259.

44.

Wheezing lower respiratory disease and vaccination of premature infants.

Mullooly JP, Schuler R, Mesa J, Drew L, DeStefano F; VSD team.

Vaccine. 2011 Oct 13;29(44):7611-7. doi: 10.1016/j.vaccine.2011.08.022. Epub 2011 Aug 27.

PMID:
21875634
45.

Should the clozapine protocol be obeyed?

Drew L.

Aust N Z J Psychiatry. 2011 Sep;45(9):790. doi: 10.3109/00048674.2011.587398. Epub 2011 Jun 13. No abstract available.

PMID:
21668297
46.

Evidence for altered hippocampal function in a mouse model of the human 22q11.2 microdeletion.

Drew LJ, Stark KL, Fénelon K, Karayiorgou M, Macdermott AB, Gogos JA.

Mol Cell Neurosci. 2011 Aug;47(4):293-305. doi: 10.1016/j.mcn.2011.05.008. Epub 2011 May 24.

47.

Sodium channel mechanosensitivity: pay a-tension to voltage sensor movement.

Drew LJ.

J Physiol. 2011 Mar 1;589(Pt 5):1003-4. doi: 10.1113/jphysiol.2011.205880. No abstract available.

48.

Deficiency of Dgcr8, a gene disrupted by the 22q11.2 microdeletion, results in altered short-term plasticity in the prefrontal cortex.

Fénelon K, Mukai J, Xu B, Hsu PK, Drew LJ, Karayiorgou M, Fischbach GD, Macdermott AB, Gogos JA.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4447-52. doi: 10.1073/pnas.1101219108. Epub 2011 Feb 28.

49.

3-amido-4-anilinocinnolines as a novel class of CSF-1R inhibitor.

Scott DA, Dakin LA, Del Valle DJ, Diebold RB, Drew L, Gero TW, Ogoe CA, Omer CA, Repik G, Thakur K, Ye Q, Zheng X.

Bioorg Med Chem Lett. 2011 Mar 1;21(5):1382-4. doi: 10.1016/j.bmcl.2011.01.033. Epub 2011 Jan 14.

PMID:
21295474
50.

Elective withdrawal from clozapine.

Drew LR.

Aust N Z J Psychiatry. 2011 Mar;45(3):264. doi: 10.3109/00048674.2010.514855. Epub 2011 Jan 27. No abstract available.

PMID:
21271752

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