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Items: 1 to 50 of 103

1.

High-throughput screens for agonists of bone morphogenetic protein (BMP) signaling identify potent benzoxazole compounds.

Bradford STJ, Ranghini EJ, Grimley E, Lee PH, Dressler GR.

J Biol Chem. 2019 Jan 2. pii: jbc.RA118.006817. doi: 10.1074/jbc.RA118.006817. [Epub ahead of print]

2.

Expression Profiling of Fibroblasts in Chronic and Acute Disease Models Reveals Novel Pathways in Kidney Fibrosis.

Higashi AY, Aronow BJ, Dressler GR.

J Am Soc Nephrol. 2019 Jan;30(1):80-94. doi: 10.1681/ASN.2018060644. Epub 2018 Dec 13.

PMID:
30545984
3.

HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis.

Sun Y, Zhou B, Mao F, Xu J, Miao H, Zou Z, Phuc Khoa LT, Jang Y, Cai S, Witkin M, Koche R, Ge K, Dressler GR, Levine RL, Armstrong SA, Dou Y, Hess JL.

Cancer Cell. 2018 Oct 8;34(4):643-658.e5. doi: 10.1016/j.ccell.2018.08.018. Epub 2018 Sep 27.

PMID:
30270123
4.

Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation.

Ihermann-Hella A, Hirashima T, Kupari J, Kurtzeborn K, Li H, Kwon HN, Cebrian C, Soofi A, Dapkunas A, Miinalainen I, Dressler GR, Matsuda M, Kuure S.

Stem Cell Reports. 2018 Oct 9;11(4):912-928. doi: 10.1016/j.stemcr.2018.08.012. Epub 2018 Sep 13.

5.

Are Pax proteins potential therapeutic targets in kidney disease and cancer?

Grimley E, Dressler GR.

Kidney Int. 2018 Aug;94(2):259-267. doi: 10.1016/j.kint.2018.01.025. Epub 2018 Apr 21. Review.

PMID:
29685496
6.

From Otic Induction to Hair Cell Production: Pax2EGFP Cell Line Illuminates Key Stages of Development in Mouse Inner Ear Organoid Model.

Schaefer SA, Higashi AY, Loomis B, Schrepfer T, Wan G, Corfas G, Dressler GR, Duncan RK.

Stem Cells Dev. 2018 Feb 15;27(4):237-251. doi: 10.1089/scd.2017.0142. Epub 2018 Jan 29.

7.

The kielin/chordin-like protein (KCP) attenuates high-fat diet-induced obesity and metabolic syndrome in mice.

Soofi A, Wolf KI, Emont MP, Qi N, Martinez-Santibanez G, Grimley E, Ostwani W, Dressler GR.

J Biol Chem. 2017 Jun 2;292(22):9051-9062. doi: 10.1074/jbc.M116.771428. Epub 2017 Apr 19.

8.

Inhibition of Pax2 Transcription Activation with a Small Molecule that Targets the DNA Binding Domain.

Grimley E, Liao C, Ranghini EJ, Nikolovska-Coleska Z, Dressler GR.

ACS Chem Biol. 2017 Mar 17;12(3):724-734. doi: 10.1021/acschembio.6b00782. Epub 2017 Jan 24.

9.

The kielin/chordin-like protein KCP attenuates nonalcoholic fatty liver disease in mice.

Soofi A, Wolf KI, Ranghini EJ, Amin MA, Dressler GR.

Am J Physiol Gastrointest Liver Physiol. 2016 Oct 1;311(4):G587-G598. doi: 10.1152/ajpgi.00165.2016. Epub 2016 Aug 11.

10.

The Groucho-associated phosphatase PPM1B displaces Pax transactivation domain interacting protein (PTIP) to switch the transcription factor Pax2 from a transcriptional activator to a repressor.

Abraham S, Paknikar R, Bhumbra S, Luan D, Garg R, Dressler GR, Patel SR.

J Biol Chem. 2015 Mar 13;290(11):7185-94. doi: 10.1074/jbc.M114.607424. Epub 2015 Jan 28.

11.

Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms.

Ranghini EJ, Dressler GR.

Dev Biol. 2015 Mar 15;399(2):296-305. doi: 10.1016/j.ydbio.2015.01.005. Epub 2015 Jan 21.

12.

Epigenetics in kidney development and renal disease.

Dressler GR, Patel SR.

Transl Res. 2015 Jan;165(1):166-76. doi: 10.1016/j.trsl.2014.04.007. Epub 2014 Jun 4. Review.

13.

Crumbs3 is essential for proper epithelial development and viability.

Whiteman EL, Fan S, Harder JL, Walton KD, Liu CJ, Soofi A, Fogg VC, Hershenson MB, Dressler GR, Deutsch GH, Gumucio DL, Margolis B.

Mol Cell Biol. 2014 Jan;34(1):43-56. doi: 10.1128/MCB.00999-13. Epub 2013 Oct 28.

14.

The Groucho protein Grg4 suppresses Smad7 to activate BMP signaling.

Zhang P, Dressler GR.

Biochem Biophys Res Commun. 2013 Oct 25;440(3):454-9. doi: 10.1016/j.bbrc.2013.09.128. Epub 2013 Oct 5.

15.

The genetics and epigenetics of kidney development.

Patel SR, Dressler GR.

Semin Nephrol. 2013 Jul;33(4):314-26. doi: 10.1016/j.semnephrol.2013.05.004. Review.

16.

Mechanisms of gene activation and repression by Pax proteins in the developing kidney.

Patel SR, Ranghini E, Dressler GR.

Pediatr Nephrol. 2014 Apr;29(4):589-95. doi: 10.1007/s00467-013-2603-8. Epub 2013 Sep 1. Review.

17.

Kielin/chordin-like protein attenuates both acute and chronic renal injury.

Soofi A, Zhang P, Dressler GR.

J Am Soc Nephrol. 2013 May;24(6):897-905. doi: 10.1681/ASN.2012070759. Epub 2013 Mar 28.

18.

Arrested spermatogenesis and evidence for DNA damage in PTIP mutant testes.

Schwab KR, Smith GD, Dressler GR.

Dev Biol. 2013 Jan 1;373(1):64-71. doi: 10.1016/j.ydbio.2012.10.006. Epub 2012 Oct 12.

19.

A polyglutamine expansion disease protein sequesters PTIP to attenuate DNA repair and increase genomic instability.

Xiao H, Yu Z, Wu Y, Nan J, Merry DE, Sekiguchi JM, Ferguson DO, Lieberman AP, Dressler GR.

Hum Mol Genet. 2012 Oct 1;21(19):4225-36. doi: 10.1093/hmg/dds246. Epub 2012 Jun 26.

20.

Activation of Wnt11 by transforming growth factor-β drives mesenchymal gene expression through non-canonical Wnt protein signaling in renal epithelial cells.

Zhang P, Cai Y, Soofi A, Dressler GR.

J Biol Chem. 2012 Jun 15;287(25):21290-302. doi: 10.1074/jbc.M112.357202. Epub 2012 May 3.

21.

Two novel EGFP insertion alleles reveal unique aspects of Pax2 function in embryonic and adult kidneys.

Soofi A, Levitan I, Dressler GR.

Dev Biol. 2012 May 1;365(1):241-50. doi: 10.1016/j.ydbio.2012.02.032. Epub 2012 Mar 3.

22.

Epigenetic mechanisms of Groucho/Grg/TLE mediated transcriptional repression.

Patel SR, Bhumbra SS, Paknikar RS, Dressler GR.

Mol Cell. 2012 Jan 27;45(2):185-95. doi: 10.1016/j.molcel.2011.11.007. Epub 2011 Dec 8.

23.

Polarity and renal cystogenesis.

Dressler GR.

J Am Soc Nephrol. 2012 Jan;23(1):4-5. doi: 10.1681/ASN.2011111121. Epub 2011 Dec 8. No abstract available.

24.

Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes.

Stein AB, Jones TA, Herron TJ, Patel SR, Day SM, Noujaim SF, Milstein ML, Klos M, Furspan PB, Jalife J, Dressler GR.

J Clin Invest. 2011 Jul;121(7):2641-50. doi: 10.1172/JCI44641. Epub 2011 Jun 6.

25.

The role of Pax2 in mouse prostate development.

Xu B, Hariharan A, Rakshit S, Dressler GR, Wellik DM.

Prostate. 2012 Feb 1;72(2):217-24. doi: 10.1002/pros.21424. Epub 2011 May 18.

26.

Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus.

Schwab KR, Patel SR, Dressler GR.

Mol Cell Biol. 2011 Apr;31(7):1503-11. doi: 10.1128/MCB.00990-10. Epub 2011 Jan 31.

27.

Patterning and early cell lineage decisions in the developing kidney: the role of Pax genes.

Dressler GR.

Pediatr Nephrol. 2011 Sep;26(9):1387-94. doi: 10.1007/s00467-010-1749-x. Epub 2011 Jan 11. Review.

28.

Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.

Lefevre GM, Patel SR, Kim D, Tessarollo L, Dressler GR.

PLoS Genet. 2010 Oct 28;6(10):e1001142. doi: 10.1371/journal.pgen.1001142.

29.

PTIP promotes chromatin changes critical for immunoglobulin class switch recombination.

Daniel JA, Santos MA, Wang Z, Zang C, Schwab KR, Jankovic M, Filsuf D, Chen HT, Gazumyan A, Yamane A, Cho YW, Sun HW, Ge K, Peng W, Nussenzweig MC, Casellas R, Dressler GR, Zhao K, Nussenzweig A.

Science. 2010 Aug 20;329(5994):917-23. doi: 10.1126/science.1187942. Epub 2010 Jul 29.

30.

Joint loss of PAX2 and PTEN expression in endometrial precancers and cancer.

Monte NM, Webster KA, Neuberg D, Dressler GR, Mutter GL.

Cancer Res. 2010 Aug 1;70(15):6225-32. doi: 10.1158/0008-5472.CAN-10-0149. Epub 2010 Jul 14.

31.

Turning the page on epigenetic bookmarks.

Dressler GR.

Dev Cell. 2010 Jan 19;18(1):4-5. doi: 10.1016/j.devcel.2010.01.004.

32.

Advances in early kidney specification, development and patterning.

Dressler GR.

Development. 2009 Dec;136(23):3863-74. doi: 10.1242/dev.034876. Review.

33.
34.

The role of PTIP in maintaining embryonic stem cell pluripotency.

Kim D, Patel SR, Xiao H, Dressler GR.

Stem Cells. 2009 Jul;27(7):1516-23. doi: 10.1002/stem.79.

35.

Drosophila ptip is essential for anterior/posterior patterning in development and interacts with the PcG and trxG pathways.

Fang M, Ren H, Liu J, Cadigan KM, Patel SR, Dressler GR.

Development. 2009 Jun;136(11):1929-38. doi: 10.1242/dev.026559.

36.

PTIP regulates 53BP1 and SMC1 at the DNA damage sites.

Wu J, Prindle MJ, Dressler GR, Yu X.

J Biol Chem. 2009 Jul 3;284(27):18078-84. doi: 10.1074/jbc.M109.002527. Epub 2009 May 4.

37.

Epigenetics, development, and the kidney.

Dressler GR.

J Am Soc Nephrol. 2008 Nov;19(11):2060-7. doi: 10.1681/ASN.2008010119. Epub 2008 Aug 20. Review.

38.

Another niche for Notch.

Dressler GR.

Kidney Int. 2008 Jun;73(11):1207-9. doi: 10.1038/ki.2008.39.

39.
40.

The development of the bladder trigone, the center of the anti-reflux mechanism.

Viana R, Batourina E, Huang H, Dressler GR, Kobayashi A, Behringer RR, Shapiro E, Hensle T, Lambert S, Mendelsohn C.

Development. 2007 Oct;134(20):3763-9. Epub 2007 Sep 19.

41.

A Hox-Eya-Pax complex regulates early kidney developmental gene expression.

Gong KQ, Yallowitz AR, Sun H, Dressler GR, Wellik DM.

Mol Cell Biol. 2007 Nov;27(21):7661-8. Epub 2007 Sep 4.

42.

PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney.

Kim D, Dressler GR.

Dev Biol. 2007 Jul 15;307(2):290-9. Epub 2007 May 8.

43.

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K.

J Biol Chem. 2007 Jul 13;282(28):20395-406. Epub 2007 May 11.

44.

Pax transactivation-domain interacting protein is required for urine concentration and osmotolerance in collecting duct epithelia.

Kim D, Wang M, Cai Q, Brooks H, Dressler GR.

J Am Soc Nephrol. 2007 May;18(5):1458-65. Epub 2007 Apr 11.

45.

Regulation of c-Ret in the developing kidney is responsive to Pax2 gene dosage.

Clarke JC, Patel SR, Raymond RM Jr, Andrew S, Robinson BG, Dressler GR, Brophy PD.

Hum Mol Genet. 2006 Dec 1;15(23):3420-8. Epub 2006 Oct 17.

PMID:
17047028
46.

Six2 is required for suppression of nephrogenesis and progenitor renewal in the developing kidney.

Self M, Lagutin OV, Bowling B, Hendrix J, Cai Y, Dressler GR, Oliver G.

EMBO J. 2006 Nov 1;25(21):5214-28. Epub 2006 Oct 12.

47.

The cellular basis of kidney development.

Dressler GR.

Annu Rev Cell Dev Biol. 2006;22:509-29. Review.

PMID:
16822174
48.
49.

Proposed changes to biomedical funding.

Dressler GR.

Science. 2005 Nov 25;310(5752):1279. No abstract available.

PMID:
16311319
50.

Nephrogenic factors promote differentiation of mouse embryonic stem cells into renal epithelia.

Kim D, Dressler GR.

J Am Soc Nephrol. 2005 Dec;16(12):3527-34. Epub 2005 Nov 2.

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