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Items: 36

1.

A clinical drug-drug interaction study to evaluate the effect of a proton-pump inhibitor, a combined P-glycoprotein/cytochrome 450 enzyme (CYP)3A4 inhibitor, and a CYP2C9 inhibitor on the pharmacokinetics of vismodegib.

Malhi V, Colburn D, Williams SJ, Hop CE, Dresser MJ, Chandra P, Graham RA.

Cancer Chemother Pharmacol. 2016 Jul;78(1):41-9. doi: 10.1007/s00280-016-3020-z. Epub 2016 May 6.

2.

Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans.

Takahashi RH, Choo EF, Ma S, Wong S, Halladay J, Deng Y, Rooney I, Gates M, Hop CE, Khojasteh SC, Dresser MJ, Musib L.

Drug Metab Dispos. 2016 Jan;44(1):28-39. doi: 10.1124/dmd.115.066282. Epub 2015 Oct 8.

PMID:
26451002
3.

Best practices for the use of itraconazole as a replacement for ketoconazole in drug-drug interaction studies.

Liu L, Bello A, Dresser MJ, Heald D, Komjathy SF, O'Mara E, Rogge M, Stoch SA, Robertson SM.

J Clin Pharmacol. 2016 Feb;56(2):143-51. doi: 10.1002/jcph.562. Epub 2015 Jul 29. Review.

PMID:
26044116
4.

The use of betaine HCl to enhance dasatinib absorption in healthy volunteers with rabeprazole-induced hypochlorhydria.

Yago MR, Frymoyer A, Benet LZ, Smelick GS, Frassetto LA, Ding X, Dean B, Salphati L, Budha N, Jin JY, Dresser MJ, Ware JA.

AAPS J. 2014 Nov;16(6):1358-65. doi: 10.1208/s12248-014-9673-9. Epub 2014 Oct 2.

5.

Impact of food and the proton pump inhibitor rabeprazole on the pharmacokinetics of GDC-0941 in healthy volunteers: bench to bedside investigation of pH-dependent solubility.

Ware JA, Dalziel G, Jin JY, Pellett JD, Smelick GS, West DA, Salphati L, Ding X, Sutton R, Fridyland J, Dresser MJ, Morrisson G, Holden SN.

Mol Pharm. 2013 Nov 4;10(11):4074-81. doi: 10.1021/mp4005595. Epub 2013 Oct 24.

PMID:
24099279
6.

Prevalence of acid-reducing agents (ARA) in cancer populations and ARA drug-drug interaction potential for molecular targeted agents in clinical development.

Smelick GS, Heffron TP, Chu L, Dean B, West DA, Duvall SL, Lum BL, Budha N, Holden SN, Benet LZ, Frymoyer A, Dresser MJ, Ware JA.

Mol Pharm. 2013 Nov 4;10(11):4055-62. doi: 10.1021/mp400403s. Epub 2013 Oct 24.

PMID:
24044612
7.

Absolute bioavailability and effect of formulation change, food, or elevated pH with rabeprazole on cobimetinib absorption in healthy subjects.

Musib L, Choo E, Deng Y, Eppler S, Rooney I, Chan IT, Dresser MJ.

Mol Pharm. 2013 Nov 4;10(11):4046-54. doi: 10.1021/mp400383x. Epub 2013 Sep 30.

PMID:
24010577
8.

Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria.

Yago MR, Frymoyer AR, Smelick GS, Frassetto LA, Budha NR, Dresser MJ, Ware JA, Benet LZ.

Mol Pharm. 2013 Nov 4;10(11):4032-7. doi: 10.1021/mp4003738. Epub 2013 Sep 10.

9.

A physiologically based pharmacokinetic (PBPK) approach to evaluate pharmacokinetics in patients with cancer.

Cheeti S, Budha NR, Rajan S, Dresser MJ, Jin JY.

Biopharm Drug Dispos. 2013 Apr;34(3):141-54. doi: 10.1002/bdd.1830. Epub 2013 Feb 26.

PMID:
23225350
10.

Daily dosing of vismodegib to steady state does not prolong the QTc interval in healthy volunteers.

Graham RA, Chang I, Jin JY, Wang B, Dufek MB, Ayache JA, Ezzet F, Zerivitz K, Low JA, Dresser MJ.

J Cardiovasc Pharmacol. 2013 Jan;61(1):83-9. doi: 10.1097/FJC.0b013e3182793ac9.

PMID:
23107871
11.

Drug absorption interactions between oral targeted anticancer agents and PPIs: is pH-dependent solubility the Achilles heel of targeted therapy?

Budha NR, Frymoyer A, Smelick GS, Jin JY, Yago MR, Dresser MJ, Holden SN, Benet LZ, Ware JA.

Clin Pharmacol Ther. 2012 Aug;92(2):203-13. doi: 10.1038/clpt.2012.73. Epub 2012 Jun 27. Review.

PMID:
22739140
12.

Single and multiple dose intravenous and oral pharmacokinetics of the hedgehog pathway inhibitor vismodegib in healthy female subjects.

Graham RA, Hop CE, Borin MT, Lum BL, Colburn D, Chang I, Shin YG, Malhi V, Low JA, Dresser MJ.

Br J Clin Pharmacol. 2012 Nov;74(5):788-96. doi: 10.1111/j.1365-2125.2012.04281.x.

13.

A guide to rational dosing of monoclonal antibodies.

Bai S, Jorga K, Xin Y, Jin D, Zheng Y, Damico-Beyer LA, Gupta M, Tang M, Allison DE, Lu D, Zhang Y, Joshi A, Dresser MJ.

Clin Pharmacokinet. 2012 Feb 1;51(2):119-35. doi: 10.2165/11596370-000000000-00000.

PMID:
22257150
14.

Pharmacokinetics of dapoxetine, a new treatment for premature ejaculation: Impact of age and effects of a high-fat meal.

Dresser MJ, Kang D, Staehr P, Gidwani S, Guo C, Mulhall JP, Modi NB.

J Clin Pharmacol. 2006 Sep;46(9):1023-9.

PMID:
16920897
15.

Single- and multiple-dose pharmacokinetics of dapoxetine hydrochloride, a novel agent for the treatment of premature ejaculation.

Modi NB, Dresser MJ, Simon M, Lin D, Desai D, Gupta S.

J Clin Pharmacol. 2006 Mar;46(3):301-9.

PMID:
16490806
16.

Dapoxetine, a novel treatment for premature ejaculation, does not have pharmacokinetic interactions with phosphodiesterase-5 inhibitors.

Dresser MJ, Desai D, Gidwani S, Seftel AD, Modi NB.

Int J Impot Res. 2006 Jan-Feb;18(1):104-10.

PMID:
16307008
17.

Interactions of n-tetraalkylammonium compounds and biguanides with a human renal organic cation transporter (hOCT2).

Dresser MJ, Xiao G, Leabman MK, Gray AT, Giacomini KM.

Pharm Res. 2002 Aug;19(8):1244-7. No abstract available.

PMID:
12240953
18.

Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT.

Gerstin KM, Dresser MJ, Giacomini KM.

Am J Physiol Renal Physiol. 2002 Aug;283(2):F344-9.

19.

The potency of new muscle relaxants on recombinant muscle-type acetylcholine receptors.

Paul M, Kindler CH, Fokt RM, Dresser MJ, Dipp NC, Yost CS.

Anesth Analg. 2002 Mar;94(3):597-603; table of contents.

PMID:
11867382
20.
21.

Arginine 454 and lysine 370 are essential for the anion specificity of the organic anion transporter, rOAT3.

Feng B, Dresser MJ, Shu Y, Johns SJ, Giacomini KM.

Biochemistry. 2001 May 8;40(18):5511-20.

PMID:
11331016
22.

Transporters involved in the elimination of drugs in the kidney: organic anion transporters and organic cation transporters.

Dresser MJ, Leabman MK, Giacomini KM.

J Pharm Sci. 2001 Apr;90(4):397-421. Review.

PMID:
11170032
23.

Molecular cloning of a Na+-dependent nucleoside transporter from rabbit intestine.

Gerstin KM, Dresser MJ, Wang J, Giacomini KM.

Pharm Res. 2000 Aug;17(8):906-10.

PMID:
11028933
24.

Electrophysiological analysis of the substrate selectivity of a sodium-coupled nucleoside transporter (rCNT1) expressed in Xenopus laevis oocytes.

Dresser MJ, Gerstin KM, Gray AT, Loo DD, Giacomini KM.

Drug Metab Dispos. 2000 Sep;28(9):1135-40.

PMID:
10950861
25.

Molecular and functional characteristics of cloned human organic cation transporters.

Dresser MJ, Zhang L, Giacomini KM.

Pharm Biotechnol. 1999;12:441-69. Review. No abstract available.

PMID:
10742984
26.

Kinetic and selectivity differences between rodent, rabbit, and human organic cation transporters (OCT1).

Dresser MJ, Gray AT, Giacomini KM.

J Pharmacol Exp Ther. 2000 Mar;292(3):1146-52.

PMID:
10688634
27.

The interaction of n-tetraalkylammonium compounds with a human organic cation transporter, hOCT1.

Zhang L, Gorset W, Dresser MJ, Giacomini KM.

J Pharmacol Exp Ther. 1999 Mar;288(3):1192-8.

PMID:
10027858
28.

Biochemical Characterization and Crystallographic Structure of an Escherichia coli Protein from the Phosphotriesterase Gene Family.

Buchbinder JL, Stephenson RC, Dresser MJ, Pitera JW, Scanlan TS, Fletterick RJ.

Biochemistry. 1998 Jul 28;37(30):10860. No abstract available.

PMID:
9692977
29.

Biochemical characterization and crystallographic structure of an Escherichia coli protein from the phosphotriesterase gene family.

Buchbinder JL, Stephenson RC, Dresser MJ, Pitera JW, Scanlan TS, Fletterick RJ.

Biochemistry. 1998 Apr 14;37(15):5096-106. Erratum in: Biochemistry 1998 Jul 28;37(30):10860.

PMID:
9548740
30.

Molecular cloning and functional expression of a rabbit renal organic cation transporter.

Terashita S, Dresser MJ, Zhang L, Gray AT, Yost SC, Giacomini KM.

Biochim Biophys Acta. 1998 Feb 2;1369(1):1-6.

31.

Na(+)-dependent purine nucleoside transporter from human kidney: cloning and functional characterization.

Wang J, Su SF, Dresser MJ, Schaner ME, Washington CB, Giacomini KM.

Am J Physiol. 1997 Dec;273(6):F1058-65. doi: 10.1152/ajprenal.1997.273.6.F1058.

PMID:
9435697
32.

Cloning and functional characterization of a rat renal organic cation transporter isoform (rOCT1A).

Zhang L, Dresser MJ, Chun JK, Babbitt PC, Giacomini KM.

J Biol Chem. 1997 Jun 27;272(26):16548-54.

33.

Cloning and functional expression of a human liver organic cation transporter.

Zhang L, Dresser MJ, Gray AT, Yost SC, Terashita S, Giacomini KM.

Mol Pharmacol. 1997 Jun;51(6):913-21.

PMID:
9187257
34.

Direct observation of chemical bond dynamics on surfaces.

Yates JT Jr, Alvey MD, Dresser MJ, Henderson MA, Kiskinova M, Ramsier RD, Szabó A.

Science. 1992 Mar 13;255(5050):1397-403.

PMID:
17801228
35.

Identification of a metastable particle produced by electron-stimulated desorption: CO on W(100).

Sandstrom DR, Dresser MJ, Dong WD.

Phys Rev B Condens Matter. 1986 Oct 15;34(8):5125-5129. No abstract available.

PMID:
9940337
36.

Metastable angular distributions from electron-stimulated desorption.

Alvey MD, Dresser MJ, Yates JT Jr.

Phys Rev Lett. 1986 Jan 27;56(4):367-370. No abstract available.

PMID:
10033169

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