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Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate.

Feliciano PR, Drennan CL, Nonato MC.

ACS Chem Biol. 2019 Feb 15;14(2):266-275. doi: 10.1021/acschembio.8b00972. Epub 2019 Jan 24.


Structure-Guided Identification of a Small Molecule That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria.

Orman M, Bodea S, Funk MA, Campo AM, Bollenbach M, Drennan CL, Balskus EP.

J Am Chem Soc. 2018 Dec 17. doi: 10.1021/jacs.8b04883. [Epub ahead of print]


Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity.

Grell TAJ, Bell BN, Nguyen C, Dowling DP, Bruender NA, Bandarian V, Drennan CL.

Protein Sci. 2019 Jan;28(1):202-215. doi: 10.1002/pro.3529.


Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase.

Wittenborn EC, Merrouch M, Ueda C, Fradale L, Léger C, Fourmond V, Pandelia ME, Dementin S, Drennan CL.

Elife. 2018 Oct 2;7. pii: e39451. doi: 10.7554/eLife.39451.


Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase.

Grell TAJ, Kincannon WM, Bruender NA, Blaesi EJ, Krebs C, Bandarian V, Drennan CL.

J Biol Chem. 2018 Nov 9;293(45):17349-17361. doi: 10.1074/jbc.RA118.005369. Epub 2018 Sep 14.


Metalloenzymes in natural product biosynthetic pathways.

Ryan KS, Drennan CL.

Nat Prod Rep. 2018 Jul 18;35(7):612-614. doi: 10.1039/c8np90023j. No abstract available.


A Rich Man, Poor Man Story of S-Adenosylmethionine and Cobalamin Revisited.

Bridwell-Rabb J, Grell TAJ, Drennan CL.

Annu Rev Biochem. 2018 Jun 20;87:555-584. doi: 10.1146/annurev-biochem-062917-012500.


Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase.

Harris NC, Born DA, Cai W, Huang Y, Martin J, Khalaf R, Drennan CL, Zhang W.

Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9707-9710. doi: 10.1002/anie.201804307. Epub 2018 Jul 3.


Biophysical Examination of the Calcium-Modulated Nickel-Binding Properties of Human Calprotectin Reveals Conformational Change in the EF-Hand Domains and His3Asp Site.

Nakashige TG, Bowman SEJ, Zygiel EM, Drennan CL, Nolan EM.

Biochemistry. 2018 Jul 17;57(28):4155-4164. doi: 10.1021/acs.biochem.8b00415. Epub 2018 Jun 26.


Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1.

Grell TAJ, Young AP, Drennan CL, Bandarian V.

J Am Chem Soc. 2018 Jun 6;140(22):6842-6852. doi: 10.1021/jacs.8b01493. Epub 2018 May 24.


Disruption of an oligomeric interface prevents allosteric inhibition of Escherichia coli class Ia ribonucleotide reductase.

Chen PY, Funk MA, Brignole EJ, Drennan CL.

J Biol Chem. 2018 Jun 29;293(26):10404-10412. doi: 10.1074/jbc.RA118.002569. Epub 2018 Apr 26.


Binding site for coenzyme A revealed in the structure of pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica.

Chen PY, Aman H, Can M, Ragsdale SW, Drennan CL.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3846-3851. doi: 10.1073/pnas.1722329115. Epub 2018 Mar 26.


3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.

Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F.

Elife. 2018 Feb 20;7. pii: e31502. doi: 10.7554/eLife.31502.


Structural basis for methylphosphonate biosynthesis.

Born DA, Ulrich EC, Ju KS, Peck SC, van der Donk WA, Drennan CL.

Science. 2017 Dec 8;358(6368):1336-1339. doi: 10.1126/science.aao3435.


New tricks for the glycyl radical enzyme family.

Backman LRF, Funk MA, Dawson CD, Drennan CL.

Crit Rev Biochem Mol Biol. 2017 Dec;52(6):674-695. doi: 10.1080/10409238.2017.1373741. Epub 2017 Sep 13. Review.


Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme.

Shisler KA, Hutcheson RU, Horitani M, Duschene KS, Crain AV, Byer AS, Shepard EM, Rasmussen A, Yang J, Broderick WE, Vey JL, Drennan CL, Hoffman BM, Broderick JB.

J Am Chem Soc. 2017 Aug 30;139(34):11803-11813. doi: 10.1021/jacs.7b04883. Epub 2017 Aug 22.


A New Facet of Vitamin B12: Gene Regulation by Cobalamin-Based Photoreceptors.

Padmanabhan S, Jost M, Drennan CL, Elías-Arnanz M.

Annu Rev Biochem. 2017 Jun 20;86:485-514. doi: 10.1146/annurev-biochem-061516-044500. Review.


Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.

Cory SA, Van Vranken JG, Brignole EJ, Patra S, Winge DR, Drennan CL, Rutter J, Barondeau DP.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5325-E5334. doi: 10.1073/pnas.1702849114. Epub 2017 Jun 20.


Nickel Sequestration by the Host-Defense Protein Human Calprotectin.

Nakashige TG, Zygiel EM, Drennan CL, Nolan EM.

J Am Chem Soc. 2017 Jul 5;139(26):8828-8836. doi: 10.1021/jacs.7b01212. Epub 2017 Jun 22.


Documentation of 50% water conservation in a single process at a beef abattoir.

Drennan CL, DeOtte RE, Lawrence TE.

Meat Sci. 2017 Sep;131:183-186. doi: 10.1016/j.meatsci.2017.05.016. Epub 2017 May 17.


Glutamate 52-β at the α/β subunit interface of Escherichia coli class Ia ribonucleotide reductase is essential for conformational gating of radical transfer.

Lin Q, Parker MJ, Taguchi AT, Ravichandran K, Kim A, Kang G, Shao J, Drennan CL, Stubbe J.

J Biol Chem. 2017 Jun 2;292(22):9229-9239. doi: 10.1074/jbc.M117.783092. Epub 2017 Apr 4.


A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis.

Bridwell-Rabb J, Zhong A, Sun HG, Drennan CL, Liu HW.

Nature. 2017 Apr 20;544(7650):322-326. doi: 10.1038/nature21689. Epub 2017 Mar 27.


Vitamin B12 in the spotlight again.

Bridwell-Rabb J, Drennan CL.

Curr Opin Chem Biol. 2017 Apr;37:63-70. doi: 10.1016/j.cbpa.2017.01.013. Epub 2017 Feb 3. Review.


7-Carboxy-7-deazaguanine Synthase: A Radical S-Adenosyl-l-methionine Enzyme with Polar Tendencies.

Bruender NA, Grell TA, Dowling DP, McCarty RM, Drennan CL, Bandarian V.

J Am Chem Soc. 2017 Feb 8;139(5):1912-1920. doi: 10.1021/jacs.6b11381. Epub 2017 Jan 25.


An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis.

Bridwell-Rabb J, Kang G, Zhong A, Liu HW, Drennan CL.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13750-13755. Epub 2016 Nov 14.


Structural elements of an NRPS cyclization domain and its intermodule docking domain.

Dowling DP, Kung Y, Croft AK, Taghizadeh K, Kelly WL, Walsh CT, Drennan CL.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12432-12437. Epub 2016 Oct 17.


Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase.

Bodea S, Funk MA, Balskus EP, Drennan CL.

Cell Chem Biol. 2016 Oct 20;23(10):1206-1216. doi: 10.1016/j.chembiol.2016.07.020. Epub 2016 Sep 24.


Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator.

Wittenborn EC, Jost M, Wei Y, Stubbe J, Drennan CL.

J Biol Chem. 2016 Nov 25;291(48):25264-25277. Epub 2016 Oct 14.


Molecular basis of cobalamin-dependent RNA modification.

Dowling DP, Miles ZD, Köhrer C, Maiocco SJ, Elliott SJ, Bandarian V, Drennan CL.

Nucleic Acids Res. 2016 Nov 16;44(20):9965-9976. Epub 2016 Sep 15.


Crystal structure of an Fe-S cluster-containing fumarate hydratase enzyme from Leishmania major reveals a unique protein fold.

Feliciano PR, Drennan CL, Nonato MC.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9804-9. doi: 10.1073/pnas.1605031113. Epub 2016 Aug 15.


Crystallographic snapshots of sulfur insertion by lipoyl synthase.

McLaughlin MI, Lanz ND, Goldman PJ, Lee KH, Booker SJ, Drennan CL.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9446-50. doi: 10.1073/pnas.1602486113. Epub 2016 Aug 9.


A structural phylogeny for understanding 2-oxoacid oxidoreductase function.

Gibson MI, Chen PY, Drennan CL.

Curr Opin Struct Biol. 2016 Dec;41:54-61. doi: 10.1016/ Epub 2016 Jun 14. Review.


Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example.

Oyala PH, Ravichandran KR, Funk MA, Stucky PA, Stich TA, Drennan CL, Britt RD, Stubbe J.

J Am Chem Soc. 2016 Jun 29;138(25):7951-64. doi: 10.1021/jacs.6b03605. Epub 2016 Jun 21.


BIOCHEMISTRY. A radically unexpected mechanism.

Bridwell-Rabb J, Drennan CL.

Science. 2016 Mar 18;351(6279):1266-7. doi: 10.1126/science.aaf4942. No abstract available.


Metalloprotein Crystallography: More than a Structure.

Bowman SE, Bridwell-Rabb J, Drennan CL.

Acc Chem Res. 2016 Apr 19;49(4):695-702. doi: 10.1021/acs.accounts.5b00538. Epub 2016 Mar 15.


Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.


Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA.

Chen F, Tang Q, Bian K, Humulock ZT, Yang X, Jost M, Drennan CL, Essigmann JM, Li D.

Chem Res Toxicol. 2016 Apr 18;29(4):687-93. doi: 10.1021/acs.chemrestox.5b00522. Epub 2016 Mar 15.


Waltzing around cofactors.

Chen PY, Wittenborn EC, Drennan CL.

Elife. 2016 Feb 3;5:e13977. doi: 10.7554/eLife.13977.


Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli.

Zimanyi CM, Chen PY, Kang G, Funk MA, Drennan CL.

Elife. 2016 Jan 12;5:e07141. doi: 10.7554/eLife.07141.


Allosteric Inhibition of Human Ribonucleotide Reductase by dATP Entails the Stabilization of a Hexamer.

Ando N, Li H, Brignole EJ, Thompson S, McLaughlin MI, Page JE, Asturias FJ, Stubbe J, Drennan CL.

Biochemistry. 2016 Jan 19;55(2):373-81. doi: 10.1021/acs.biochem.5b01207. Epub 2016 Jan 4.


One-carbon chemistry of oxalate oxidoreductase captured by X-ray crystallography.

Gibson MI, Chen PY, Johnson AC, Pierce E, Can M, Ragsdale SW, Drennan CL.

Proc Natl Acad Sci U S A. 2016 Jan 12;113(2):320-5. doi: 10.1073/pnas.1518537113. Epub 2015 Dec 28.


Radical-mediated ring contraction in the biosynthesis of 7-deazapurines.

Bandarian V, Drennan CL.

Curr Opin Struct Biol. 2015 Dec;35:116-24. doi: 10.1016/ Epub 2015 Nov 28. Review.


Structural basis for gene regulation by a B12-dependent photoreceptor.

Jost M, Fernández-Zapata J, Polanco MC, Ortiz-Guerrero JM, Chen PY, Kang G, Padmanabhan S, Elías-Arnanz M, Drennan CL.

Nature. 2015 Oct 22;526(7574):536-41. doi: 10.1038/nature14950. Epub 2015 Sep 28.


Structural Basis for Substrate Specificity in Adenosylcobalamin-dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases.

Jost M, Born DA, Cracan V, Banerjee R, Drennan CL.

J Biol Chem. 2015 Nov 6;290(45):26882-98. doi: 10.1074/jbc.M115.676890. Epub 2015 Aug 28.


Substrate-bound structures of benzylsuccinate synthase reveal how toluene is activated in anaerobic hydrocarbon degradation.

Funk MA, Marsh EN, Drennan CL.

J Biol Chem. 2015 Sep 11;290(37):22398-408. doi: 10.1074/jbc.M115.670737. Epub 2015 Jul 29.


The Structure of an Oxalate Oxidoreductase Provides Insight into Microbial 2-Oxoacid Metabolism.

Gibson MI, Brignole EJ, Pierce E, Can M, Ragsdale SW, Drennan CL.

Biochemistry. 2015 Jul 7;54(26):4112-20. doi: 10.1021/acs.biochem.5b00521. Epub 2015 Jun 24.


The Transcription Factor CarH Safeguards Use of Adenosylcobalamin as a Light Sensor by Altering the Photolysis Products.

Jost M, Simpson JH, Drennan CL.

Biochemistry. 2015 Jun 2;54(21):3231-4. doi: 10.1021/acs.biochem.5b00416. Epub 2015 May 19.


An epitope tag alters phosphoglycerate dehydrogenase structure and impairs ability to support cell proliferation.

Mattaini KR, Brignole EJ, Kini M, Davidson SM, Fiske BP, Drennan CL, Vander Heiden MG.

Cancer Metab. 2015 Apr 29;3:5. doi: 10.1186/s40170-015-0131-7. eCollection 2015.


Rheostat re-wired: alternative hypotheses for the control of thioredoxin reduction potentials.

Bewley KD, Dey M, Bjork RE, Mitra S, Chobot SE, Drennan CL, Elliott SJ.

PLoS One. 2015 Apr 13;10(4):e0122466. doi: 10.1371/journal.pone.0122466. eCollection 2015.


Next-generation sequencing reveals the biological significance of the N(2),3-ethenoguanine lesion in vivo.

Chang SC, Fedeles BI, Wu J, Delaney JC, Li D, Zhao L, Christov PP, Yau E, Singh V, Jost M, Drennan CL, Marnett LJ, Rizzo CJ, Levine SS, Guengerich FP, Essigmann JM.

Nucleic Acids Res. 2015 Jun 23;43(11):5489-500. doi: 10.1093/nar/gkv243. Epub 2015 Apr 2.

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