Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 166

1.

Empirical Fluoroquinolones versus Broad-Spectrum Beta-Lactams for Gram-Negative Bloodstream Infections in the Absence of Antimicrobial Resistance Risk Factors.

Al-Hasan MN, Gould AP, Drennan C, Hill O, Justo JA, Kohn J, Brandon Bookstaver P.

J Glob Antimicrob Resist. 2019 Dec 27. pii: S2213-7165(19)30329-7. doi: 10.1016/j.jgar.2019.12.015. [Epub ahead of print]

PMID:
31887412
2.

Structural and Biochemical Investigations of the [4Fe-4S] Cluster-Containing Fumarate Hydratase from Leishmania major.

Feliciano PR, Drennan CL.

Biochemistry. 2019 Dec 10;58(49):5011-5021. doi: 10.1021/acs.biochem.9b00923. Epub 2019 Nov 27.

PMID:
31743022
3.

Assisted fertility - the legal and ethical issues.

Drennan C.

Med Leg J. 2019 Sep;87(3):113-120. doi: 10.1177/0025817219860959. Epub 2019 Aug 21. No abstract available.

PMID:
31433729
4.

Structural insight into metallocofactor maturation in carbon monoxide dehydrogenase.

Wittenborn EC, Cohen SE, Merrouch M, Léger C, Fourmond V, Dementin S, Drennan CL.

J Biol Chem. 2019 Aug 30;294(35):13017-13026. doi: 10.1074/jbc.RA119.009610. Epub 2019 Jul 11.

PMID:
31296570
5.

Solution structure and biochemical characterization of a spare part protein that restores activity to an oxygen-damaged glycyl radical enzyme.

Bowman SEJ, Backman LRF, Bjork RE, Andorfer MC, Yori S, Caruso A, Stultz CM, Drennan CL.

J Biol Inorg Chem. 2019 Sep;24(6):817-829. doi: 10.1007/s00775-019-01681-2. Epub 2019 Jun 27.

PMID:
31250200
6.

X-ray crystallography-based structural elucidation of enzyme-bound intermediates along the 1-deoxy-d-xylulose 5-phosphate synthase reaction coordinate.

Chen PY, DeColli AA, Freel Meyers CL, Drennan CL.

J Biol Chem. 2019 Aug 16;294(33):12405-12414. doi: 10.1074/jbc.RA119.009321. Epub 2019 Jun 25.

PMID:
31239351
7.

DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro.

Bian K, Lenz SAP, Tang Q, Chen F, Qi R, Jost M, Drennan CL, Essigmann JM, Wetmore SD, Li D.

Nucleic Acids Res. 2019 Jun 20;47(11):5522-5529. doi: 10.1093/nar/gkz395.

8.

A reverse TCA cycle 2-oxoacid:ferredoxin oxidoreductase that makes C-C bonds from CO2.

Chen PY, Li B, Drennan CL, Elliott SJ.

Joule. 2019 Feb 20;3(2):595-611. doi: 10.1016/j.joule.2018.12.006. Epub 2019 Jan 4.

PMID:
31080943
9.

A widely distributed diheme enzyme from Burkholderia that displays an atypically stable bis-Fe(IV) state.

Rizzolo K, Cohen SE, Weitz AC, López Muñoz MM, Hendrich MP, Drennan CL, Elliott SJ.

Nat Commun. 2019 Mar 7;10(1):1101. doi: 10.1038/s41467-019-09020-4.

10.

Crystal Structures of Fumarate Hydratases from Leishmania major in a Complex with Inhibitor 2-Thiomalate.

Feliciano PR, Drennan CL, Nonato MC.

ACS Chem Biol. 2019 Feb 15;14(2):266-275. doi: 10.1021/acschembio.8b00972. Epub 2019 Jan 24.

11.

Structure-Guided Identification of a Small Molecule That Inhibits Anaerobic Choline Metabolism by Human Gut Bacteria.

Orman M, Bodea S, Funk MA, Campo AM, Bollenbach M, Drennan CL, Balskus EP.

J Am Chem Soc. 2019 Jan 9;141(1):33-37. doi: 10.1021/jacs.8b04883. Epub 2018 Dec 17.

12.

Crystal structure of AdoMet radical enzyme 7-carboxy-7-deazaguanine synthase from Escherichia coli suggests how modifications near [4Fe-4S] cluster engender flavodoxin specificity.

Grell TAJ, Bell BN, Nguyen C, Dowling DP, Bruender NA, Bandarian V, Drennan CL.

Protein Sci. 2019 Jan;28(1):202-215. doi: 10.1002/pro.3529.

13.

Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer.

Vilimas T, Wang AQ, Patnaik S, Hughes EA, Singleton MD, Knotts Z, Li D, Frankowski K, Schlomer JJ, Guerin TM, Springer S, Drennan C, Dextras C, Wang C, Gilbert D, Southall N, Ferrer M, Huang S, Kozlov S, Marugan J, Xu X, Rudloff U.

Cancer Chemother Pharmacol. 2018 Dec;82(6):1067-1080. doi: 10.1007/s00280-018-3699-0. Epub 2018 Oct 10.

14.

Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase.

Wittenborn EC, Merrouch M, Ueda C, Fradale L, Léger C, Fourmond V, Pandelia ME, Dementin S, Drennan CL.

Elife. 2018 Oct 2;7. pii: e39451. doi: 10.7554/eLife.39451.

15.

Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase.

Grell TAJ, Kincannon WM, Bruender NA, Blaesi EJ, Krebs C, Bandarian V, Drennan CL.

J Biol Chem. 2018 Nov 9;293(45):17349-17361. doi: 10.1074/jbc.RA118.005369. Epub 2018 Sep 14.

16.

Metalloenzymes in natural product biosynthetic pathways.

Ryan KS, Drennan CL.

Nat Prod Rep. 2018 Jul 18;35(7):612-614. doi: 10.1039/c8np90023j. No abstract available.

PMID:
30009301
17.

A Rich Man, Poor Man Story of S-Adenosylmethionine and Cobalamin Revisited.

Bridwell-Rabb J, Grell TAJ, Drennan CL.

Annu Rev Biochem. 2018 Jun 20;87:555-584. doi: 10.1146/annurev-biochem-062917-012500. Review.

PMID:
29925255
18.

Isonitrile Formation by a Non-Heme Iron(II)-Dependent Oxidase/Decarboxylase.

Harris NC, Born DA, Cai W, Huang Y, Martin J, Khalaf R, Drennan CL, Zhang W.

Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9707-9710. doi: 10.1002/anie.201804307. Epub 2018 Jul 3.

19.

Biophysical Examination of the Calcium-Modulated Nickel-Binding Properties of Human Calprotectin Reveals Conformational Change in the EF-Hand Domains and His3Asp Site.

Nakashige TG, Bowman SEJ, Zygiel EM, Drennan CL, Nolan EM.

Biochemistry. 2018 Jul 17;57(28):4155-4164. doi: 10.1021/acs.biochem.8b00415. Epub 2018 Jun 26.

20.

Biochemical and Structural Characterization of a Schiff Base in the Radical-Mediated Biosynthesis of 4-Demethylwyosine by TYW1.

Grell TAJ, Young AP, Drennan CL, Bandarian V.

J Am Chem Soc. 2018 Jun 6;140(22):6842-6852. doi: 10.1021/jacs.8b01493. Epub 2018 May 24.

21.

Disruption of an oligomeric interface prevents allosteric inhibition of Escherichia coli class Ia ribonucleotide reductase.

Chen PY, Funk MA, Brignole EJ, Drennan CL.

J Biol Chem. 2018 Jun 29;293(26):10404-10412. doi: 10.1074/jbc.RA118.002569. Epub 2018 Apr 26.

22.

Binding site for coenzyme A revealed in the structure of pyruvate:ferredoxin oxidoreductase from Moorella thermoacetica.

Chen PY, Aman H, Can M, Ragsdale SW, Drennan CL.

Proc Natl Acad Sci U S A. 2018 Apr 10;115(15):3846-3851. doi: 10.1073/pnas.1722329115. Epub 2018 Mar 26.

23.

3.3-Å resolution cryo-EM structure of human ribonucleotide reductase with substrate and allosteric regulators bound.

Brignole EJ, Tsai KL, Chittuluru J, Li H, Aye Y, Penczek PA, Stubbe J, Drennan CL, Asturias F.

Elife. 2018 Feb 20;7. pii: e31502. doi: 10.7554/eLife.31502.

24.

Structural basis for methylphosphonate biosynthesis.

Born DA, Ulrich EC, Ju KS, Peck SC, van der Donk WA, Drennan CL.

Science. 2017 Dec 8;358(6368):1336-1339. doi: 10.1126/science.aao3435.

25.

New tricks for the glycyl radical enzyme family.

Backman LRF, Funk MA, Dawson CD, Drennan CL.

Crit Rev Biochem Mol Biol. 2017 Dec;52(6):674-695. doi: 10.1080/10409238.2017.1373741. Epub 2017 Sep 13. Review.

26.

Monovalent Cation Activation of the Radical SAM Enzyme Pyruvate Formate-Lyase Activating Enzyme.

Shisler KA, Hutcheson RU, Horitani M, Duschene KS, Crain AV, Byer AS, Shepard EM, Rasmussen A, Yang J, Broderick WE, Vey JL, Drennan CL, Hoffman BM, Broderick JB.

J Am Chem Soc. 2017 Aug 30;139(34):11803-11813. doi: 10.1021/jacs.7b04883. Epub 2017 Aug 22.

27.

A New Facet of Vitamin B12: Gene Regulation by Cobalamin-Based Photoreceptors.

Padmanabhan S, Jost M, Drennan CL, Elías-Arnanz M.

Annu Rev Biochem. 2017 Jun 20;86:485-514. doi: 10.1146/annurev-biochem-061516-044500. Review.

PMID:
28654327
28.

Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.

Cory SA, Van Vranken JG, Brignole EJ, Patra S, Winge DR, Drennan CL, Rutter J, Barondeau DP.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5325-E5334. doi: 10.1073/pnas.1702849114. Epub 2017 Jun 20.

29.

Nickel Sequestration by the Host-Defense Protein Human Calprotectin.

Nakashige TG, Zygiel EM, Drennan CL, Nolan EM.

J Am Chem Soc. 2017 Jul 5;139(26):8828-8836. doi: 10.1021/jacs.7b01212. Epub 2017 Jun 22.

30.

Documentation of 50% water conservation in a single process at a beef abattoir.

Drennan CL, DeOtte RE, Lawrence TE.

Meat Sci. 2017 Sep;131:183-186. doi: 10.1016/j.meatsci.2017.05.016. Epub 2017 May 17.

PMID:
28544978
31.

Glutamate 52-β at the α/β subunit interface of Escherichia coli class Ia ribonucleotide reductase is essential for conformational gating of radical transfer.

Lin Q, Parker MJ, Taguchi AT, Ravichandran K, Kim A, Kang G, Shao J, Drennan CL, Stubbe J.

J Biol Chem. 2017 Jun 2;292(22):9229-9239. doi: 10.1074/jbc.M117.783092. Epub 2017 Apr 4.

32.

A B12-dependent radical SAM enzyme involved in oxetanocin A biosynthesis.

Bridwell-Rabb J, Zhong A, Sun HG, Drennan CL, Liu HW.

Nature. 2017 Apr 20;544(7650):322-326. doi: 10.1038/nature21689. Epub 2017 Mar 27.

33.

Vitamin B12 in the spotlight again.

Bridwell-Rabb J, Drennan CL.

Curr Opin Chem Biol. 2017 Apr;37:63-70. doi: 10.1016/j.cbpa.2017.01.013. Epub 2017 Feb 3. Review.

34.

7-Carboxy-7-deazaguanine Synthase: A Radical S-Adenosyl-l-methionine Enzyme with Polar Tendencies.

Bruender NA, Grell TA, Dowling DP, McCarty RM, Drennan CL, Bandarian V.

J Am Chem Soc. 2017 Feb 8;139(5):1912-1920. doi: 10.1021/jacs.6b11381. Epub 2017 Jan 25.

35.

An HD domain phosphohydrolase active site tailored for oxetanocin-A biosynthesis.

Bridwell-Rabb J, Kang G, Zhong A, Liu HW, Drennan CL.

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):13750-13755. Epub 2016 Nov 14.

36.

Structural elements of an NRPS cyclization domain and its intermodule docking domain.

Dowling DP, Kung Y, Croft AK, Taghizadeh K, Kelly WL, Walsh CT, Drennan CL.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12432-12437. Epub 2016 Oct 17.

37.

Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase.

Bodea S, Funk MA, Balskus EP, Drennan CL.

Cell Chem Biol. 2016 Oct 20;23(10):1206-1216. doi: 10.1016/j.chembiol.2016.07.020. Epub 2016 Sep 24.

38.

Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus necator.

Wittenborn EC, Jost M, Wei Y, Stubbe J, Drennan CL.

J Biol Chem. 2016 Nov 25;291(48):25264-25277. Epub 2016 Oct 14.

39.

Molecular basis of cobalamin-dependent RNA modification.

Dowling DP, Miles ZD, Köhrer C, Maiocco SJ, Elliott SJ, Bandarian V, Drennan CL.

Nucleic Acids Res. 2016 Nov 16;44(20):9965-9976. Epub 2016 Sep 15.

40.

Crystal structure of an Fe-S cluster-containing fumarate hydratase enzyme from Leishmania major reveals a unique protein fold.

Feliciano PR, Drennan CL, Nonato MC.

Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9804-9. doi: 10.1073/pnas.1605031113. Epub 2016 Aug 15.

41.

Crystallographic snapshots of sulfur insertion by lipoyl synthase.

McLaughlin MI, Lanz ND, Goldman PJ, Lee KH, Booker SJ, Drennan CL.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):9446-50. doi: 10.1073/pnas.1602486113. Epub 2016 Aug 9.

42.

Creating the optimal workspace for hospital staff using human centred design.

Cawood T, Saunders E, Drennan C, Cross N, Nicholl D, Kenny A, Meates D, Laing R.

Intern Med J. 2016 Jul;46(7):840-5. doi: 10.1111/imj.13124.

PMID:
27405891
43.

A structural phylogeny for understanding 2-oxoacid oxidoreductase function.

Gibson MI, Chen PY, Drennan CL.

Curr Opin Struct Biol. 2016 Dec;41:54-61. doi: 10.1016/j.sbi.2016.05.011. Epub 2016 Jun 14. Review.

44.

Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example.

Oyala PH, Ravichandran KR, Funk MA, Stucky PA, Stich TA, Drennan CL, Britt RD, Stubbe J.

J Am Chem Soc. 2016 Jun 29;138(25):7951-64. doi: 10.1021/jacs.6b03605. Epub 2016 Jun 21.

45.

BIOCHEMISTRY. A radically unexpected mechanism.

Bridwell-Rabb J, Drennan CL.

Science. 2016 Mar 18;351(6279):1266-7. doi: 10.1126/science.aaf4942. No abstract available.

PMID:
26989237
46.

Metalloprotein Crystallography: More than a Structure.

Bowman SE, Bridwell-Rabb J, Drennan CL.

Acc Chem Res. 2016 Apr 19;49(4):695-702. doi: 10.1021/acs.accounts.5b00538. Epub 2016 Mar 15.

47.

Data publication with the structural biology data grid supports live analysis.

Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, Bonvin AM, Borek D, Brett TJ, Caflisch A, Chang CI, Chazin WJ, Corbett KD, Cosgrove MS, Crosson S, Dhe-Paganon S, Di Cera E, Drennan CL, Eck MJ, Eichman BF, Fan QR, Ferré-D'Amaré AR, Fromme JC, Garcia KC, Gaudet R, Gong P, Harrison SC, Heldwein EE, Jia Z, Keenan RJ, Kruse AC, Kvansakul M, McLellan JS, Modis Y, Nam Y, Otwinowski Z, Pai EF, Pereira PJ, Petosa C, Raman CS, Rapoport TA, Roll-Mecak A, Rosen MK, Rudenko G, Schlessinger J, Schwartz TU, Shamoo Y, Sondermann H, Tao YJ, Tolia NH, Tsodikov OV, Westover KD, Wu H, Foster I, Fraser JS, Maia FR, Gonen T, Kirchhausen T, Diederichs K, Crosas M, Sliz P.

Nat Commun. 2016 Mar 7;7:10882. doi: 10.1038/ncomms10882.

48.

Adaptive Response Enzyme AlkB Preferentially Repairs 1-Methylguanine and 3-Methylthymine Adducts in Double-Stranded DNA.

Chen F, Tang Q, Bian K, Humulock ZT, Yang X, Jost M, Drennan CL, Essigmann JM, Li D.

Chem Res Toxicol. 2016 Apr 18;29(4):687-93. doi: 10.1021/acs.chemrestox.5b00522. Epub 2016 Mar 15.

49.

Waltzing around cofactors.

Chen PY, Wittenborn EC, Drennan CL.

Elife. 2016 Feb 3;5:e13977. doi: 10.7554/eLife.13977.

50.

Molecular basis for allosteric specificity regulation in class Ia ribonucleotide reductase from Escherichia coli.

Zimanyi CM, Chen PY, Kang G, Funk MA, Drennan CL.

Elife. 2016 Jan 12;5:e07141. doi: 10.7554/eLife.07141.

Supplemental Content

Loading ...
Support Center