Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 35

1.

Excellence in Industrial Organic Synthesis 2019: The Past, Present, and Future.

Ragan JA, Dreher SD.

J Org Chem. 2019 Apr 19;84(8):4577-4579. doi: 10.1021/acs.joc.9b00847. No abstract available.

PMID:
30999757
2.

The importance of synthetic chemistry in the pharmaceutical industry.

Campos KR, Coleman PJ, Alvarez JC, Dreher SD, Garbaccio RM, Terrett NK, Tillyer RD, Truppo MD, Parmee ER.

Science. 2019 Jan 18;363(6424). pii: eaat0805. doi: 10.1126/science.aat0805. Review.

PMID:
30655413
3.

Response to Comment on "Predicting reaction performance in C-N cross-coupling using machine learning".

Estrada JG, Ahneman DT, Sheridan RP, Dreher SD, Doyle AG.

Science. 2018 Nov 16;362(6416). pii: eaat8763. doi: 10.1126/science.aat8763.

PMID:
30442777
4.

Mapping the dark space of chemical reactions with extended nanomole synthesis and MALDI-TOF MS.

Lin S, Dikler S, Blincoe WD, Ferguson RD, Sheridan RP, Peng Z, Conway DV, Zawatzky K, Wang H, Cernak T, Davies IW, DiRocco DA, Sheng H, Welch CJ, Dreher SD.

Science. 2018 Aug 10;361(6402). pii: eaar6236. doi: 10.1126/science.aar6236. Epub 2018 May 24.

PMID:
29794218
5.

Predicting reaction performance in C-N cross-coupling using machine learning.

Ahneman DT, Estrada JG, Lin S, Dreher SD, Doyle AG.

Science. 2018 Apr 13;360(6385):186-190. doi: 10.1126/science.aar5169. Epub 2018 Feb 15. Erratum in: Science. 2018 Apr 13;360(6385):.

PMID:
29449509
6.

The Evolution of Chemical High-Throughput Experimentation To Address Challenging Problems in Pharmaceutical Synthesis.

Krska SW, DiRocco DA, Dreher SD, Shevlin M.

Acc Chem Res. 2017 Dec 19;50(12):2976-2985. doi: 10.1021/acs.accounts.7b00428. Epub 2017 Nov 27.

PMID:
29172435
7.

Palladium-Catalyzed Enantioselective Arylation of Aryl Sulfenate Anions: A Combined Experimental and Computational Study.

Jia T, Zhang M, McCollom SP, Bellomo A, Montel S, Mao J, Dreher SD, Welch CJ, Regalado EL, Williamson RT, Manor BC, Tomson NC, Walsh PJ.

J Am Chem Soc. 2017 Jun 21;139(24):8337-8345. doi: 10.1021/jacs.7b03623. Epub 2017 Jun 7.

PMID:
28537724
8.

Microscale High-Throughput Experimentation as an Enabling Technology in Drug Discovery: Application in the Discovery of (Piperidinyl)pyridinyl-1H-benzimidazole Diacylglycerol Acyltransferase 1 Inhibitors.

Cernak T, Gesmundo NJ, Dykstra K, Yu Y, Wu Z, Shi ZC, Vachal P, Sperbeck D, He S, Murphy BA, Sonatore L, Williams S, Madeira M, Verras A, Reiter M, Lee CH, Cuff J, Sherer EC, Kuethe J, Goble S, Perrotto N, Pinto S, Shen DM, Nargund R, Balkovec J, DeVita RJ, Dreher SD.

J Med Chem. 2017 May 11;60(9):3594-3605. doi: 10.1021/acs.jmedchem.6b01543. Epub 2017 Mar 2.

PMID:
28252959
9.

Synthesis of Complex Druglike Molecules by the Use of Highly Functionalized Bench-Stable Organozinc Reagents.

Greshock TJ, Moore KP, McClain RT, Bellomo A, Chung CK, Dreher SD, Kutchukian PS, Peng Z, Davies IW, Vachal P, Ellwart M, Manolikakes SM, Knochel P, Nantermet PG.

Angew Chem Int Ed Engl. 2016 Oct 24;55(44):13714-13718. doi: 10.1002/anie.201604652. Epub 2016 Sep 30.

PMID:
27690172
10.

Aryl amination using ligand-free Ni(II) salts and photoredox catalysis.

Corcoran EB, Pirnot MT, Lin S, Dreher SD, DiRocco DA, Davies IW, Buchwald SL, MacMillan DW.

Science. 2016 Jul 15;353(6296):279-83. doi: 10.1126/science.aag0209. Epub 2016 Jun 23.

11.

Chemistry informer libraries: a chemoinformatics enabled approach to evaluate and advance synthetic methods.

Kutchukian PS, Dropinski JF, Dykstra KD, Li B, DiRocco DA, Streckfuss EC, Campeau LC, Cernak T, Vachal P, Davies IW, Krska SW, Dreher SD.

Chem Sci. 2016 Apr 21;7(4):2604-2613. doi: 10.1039/c5sc04751j. Epub 2016 Jan 26.

12.

Palladium-Catalyzed Asymmetric Allylic Alkylations with Toluene Derivatives as Pronucleophiles.

Mao J, Zhang J, Jiang H, Bellomo A, Zhang M, Gao Z, Dreher SD, Walsh PJ.

Angew Chem Int Ed Engl. 2016 Feb 12;55(7):2526-30. doi: 10.1002/anie.201509917. Epub 2016 Jan 12.

13.

P2Et Phosphazene: A Mild, Functional Group Tolerant Base for Soluble, Room Temperature Pd-Catalyzed C-N, C-O, and C-C Cross-Coupling Reactions.

Buitrago Santanilla A, Christensen M, Campeau LC, Davies IW, Dreher SD.

Org Lett. 2015 Jul 2;17(13):3370-3. doi: 10.1021/acs.orglett.5b01648. Epub 2015 Jun 22.

PMID:
26099020
14.

Organic chemistry. Nanomole-scale high-throughput chemistry for the synthesis of complex molecules.

Buitrago Santanilla A, Regalado EL, Pereira T, Shevlin M, Bateman K, Campeau LC, Schneeweis J, Berritt S, Shi ZC, Nantermet P, Liu Y, Helmy R, Welch CJ, Vachal P, Davies IW, Cernak T, Dreher SD.

Science. 2015 Jan 2;347(6217):49-53. doi: 10.1126/science.1259203. Epub 2014 Nov 20.

15.

NiXantphos: a deprotonatable ligand for room-temperature palladium-catalyzed cross-couplings of aryl chlorides.

Zhang J, Bellomo A, Trongsiriwat N, Jia T, Carroll PJ, Dreher SD, Tudge MT, Yin H, Robinson JR, Schelter EJ, Walsh PJ.

J Am Chem Soc. 2014 Apr 30;136(17):6276-87. doi: 10.1021/ja411855d. Epub 2014 Apr 21.

16.

Development of a practical, asymmetric synthesis of the hepatitis C virus protease inhibitor MK-5172.

Kuethe J, Zhong YL, Yasuda N, Beutner G, Linn K, Kim M, Marcune B, Dreher SD, Humphrey G, Pei T.

Org Lett. 2013 Aug 16;15(16):4174-7. doi: 10.1021/ol401864t. Epub 2013 Aug 6.

PMID:
23919347
17.

Palladium-catalyzed direct arylation of methyl sulfoxides with aryl halides.

Jia T, Bellomo A, Baina KE, Dreher SD, Walsh PJ.

J Am Chem Soc. 2013 Mar 13;135(10):3740-3. doi: 10.1021/ja4009776. Epub 2013 Feb 27.

PMID:
23419158
18.

Asymmetric cross-coupling of aryl triflates to the benzylic position of benzylamines.

McGrew GI, Stanciu C, Zhang J, Carroll PJ, Dreher SD, Walsh PJ.

Angew Chem Int Ed Engl. 2012 Nov 12;51(46):11510-3. doi: 10.1002/anie.201201874. Epub 2012 Oct 4. No abstract available.

PMID:
23037512
19.

Palladium-catalyzed C(sp3)-H arylation of diarylmethanes at room temperature: synthesis of triarylmethanes via deprotonative-cross-coupling processes.

Zhang J, Bellomo A, Creamer AD, Dreher SD, Walsh PJ.

J Am Chem Soc. 2012 Aug 22;134(33):13765-72. doi: 10.1021/ja3047816. Epub 2012 Aug 7.

PMID:
22816972
20.

Scope of the palladium-catalyzed aryl borylation utilizing bis-boronic acid.

Molander GA, Trice SL, Kennedy SM, Dreher SD, Tudge MT.

J Am Chem Soc. 2012 Jul 18;134(28):11667-73. doi: 10.1021/ja303181m. Epub 2012 Jul 6.

21.

Rapid and efficient access to secondary arylmethylamines.

Fleury-Brégeot N, Raushel J, Sandrock DL, Dreher SD, Molander GA.

Chemistry. 2012 Jul 27;18(31):9564-70. doi: 10.1002/chem.201200831. Epub 2012 Jul 5.

22.

Rapid catalyst identification for the synthesis of the pyrimidinone core of HIV integrase inhibitors.

Bellomo A, Celebi-Olcum N, Bu X, Rivera N, Ruck RT, Welch CJ, Houk KN, Dreher SD.

Angew Chem Int Ed Engl. 2012 Jul 9;51(28):6912-5. doi: 10.1002/anie.201201720. Epub 2012 Jun 11.

PMID:
22689502
23.

Efficient palladium-catalyzed cross-coupling of highly acidic substrates, nitroacetates.

Metz AE, Berritt S, Dreher SD, Kozlowski MC.

Org Lett. 2012 Feb 3;14(3):760-3. doi: 10.1021/ol203303b. Epub 2012 Jan 20.

24.

Palladium-catalyzed allylic substitution with (η6-arene-CH2Z)Cr(CO)(3)-based nucleophiles.

Zhang J, Stanciu C, Wang B, Hussain MM, Da CS, Carroll PJ, Dreher SD, Walsh PJ.

J Am Chem Soc. 2011 Dec 21;133(50):20552-60. doi: 10.1021/ja208935u. Epub 2011 Nov 29.

25.

Palladium-catalyzed, direct boronic acid synthesis from aryl chlorides: a simplified route to diverse boronate ester derivatives.

Molander GA, Trice SL, Dreher SD.

J Am Chem Soc. 2010 Dec 22;132(50):17701-3. doi: 10.1021/ja1089759. Epub 2010 Nov 24.

26.

Nickel-catalyzed cross-coupling of potassium aryl- and heteroaryltrifluoroborates with unactivated alkyl halides.

Molander GA, Argintaru OA, Aron I, Dreher SD.

Org Lett. 2010 Dec 17;12(24):5783-5. doi: 10.1021/ol102717x. Epub 2010 Nov 19.

27.

Stereospecific cross-coupling of secondary alkyl β-trifluoroboratoamides.

Sandrock DL, Jean-Gérard L, Chen CY, Dreher SD, Molander GA.

J Am Chem Soc. 2010 Dec 8;132(48):17108-10. doi: 10.1021/ja108949w. Epub 2010 Nov 15.

28.

Suzuki-Miyaura cross-coupling reactions of primary alkyltrifluoroborates with aryl chlorides.

Dreher SD, Lim SE, Sandrock DL, Molander GA.

J Org Chem. 2009 May 15;74(10):3626-31. doi: 10.1021/jo900152n.

29.

Copper-facilitated Suzuki reactions: application to 2-heterocyclic boronates.

Deng JZ, Paone DV, Ginnetti AT, Kurihara H, Dreher SD, Weissman SA, Stauffer SR, Burgey CS.

Org Lett. 2009 Jan 15;11(2):345-7. doi: 10.1021/ol802556f.

PMID:
19093828
30.

Efficient cross-coupling of secondary alkyltrifluoroborates with aryl chlorides--reaction discovery using parallel microscale experimentation.

Dreher SD, Dormer PG, Sandrock DL, Molander GA.

J Am Chem Soc. 2008 Jul 23;130(29):9257-9. doi: 10.1021/ja8031423. Epub 2008 Jun 27.

31.

Asymmetric hydrogenation of N-sulfonylated-alpha-dehydroamino acids: toward the synthesis of an anthrax lethal factor inhibitor.

Shultz CS, Dreher SD, Ikemoto N, Williams JM, Grabowski EJ, Krska SW, Sun Y, Dormer PG, Dimichele L.

Org Lett. 2005 Aug 4;7(16):3405-8.

PMID:
16048303
32.

Highly diastereoselective heterogeneously catalyzed hydrogenation of enamines for the synthesis of chiral beta-amino acid derivatives.

Ikemoto N, Tellers DM, Dreher SD, Liu J, Huang A, Rivera NR, Njolito E, Hsiao Y, McWilliams JC, Williams JM, Armstrong JD 3rd, Sun Y, Mathre DJ, Grabowski EJ, Tillyer RD.

J Am Chem Soc. 2004 Mar 17;126(10):3048-9.

PMID:
15012124
33.

Easy Synthesis of Functionalized Hetero[7]helicenes.

Dreher SD, Weix DJ, Katz TJ.

J Org Chem. 1999 May 14;64(10):3671-3678.

PMID:
11674496
34.

Formal total synthesis of mycoticin A.

Dreher SD, Leighton JL.

J Am Chem Soc. 2001 Jan 17;123(2):341-2. No abstract available.

PMID:
11456525
35.

Yb(OTf)(3)-Catalyzed oxymercuration of homoallylic alcohol-derived hemiacetals and hemiketals.

Dreher SD, Hornberger KR, Sarraf ST, Leighton JL.

Org Lett. 2000 Oct 5;2(20):3197-9.

PMID:
11009380

Supplemental Content

Loading ...
Support Center