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Nexin-Dynein regulatory complex component DRC7 but not FBXL13 is required for sperm flagellum formation and male fertility in mice.
Morohoshi A, Miyata H, Shimada K, Nozawa K, Matsumura T, Yanase R, Shiba K, Inaba K, Ikawa M. Morohoshi A, et al. PLoS Genet. 2020 Jan 21;16(1):e1008585. doi: 10.1371/journal.pgen.1008585. eCollection 2020 Jan. PLoS Genet. 2020. PMID: 31961863 Free PMC article.
Further, TCTE1 has been shown to interact with FBXL13 (DRC6) and DRC7; however, functional roles of FBXL13 and DRC7 in mammals have not been elucidated. ...Further, other N-DRC components fail to incorporate into the flagellum without DRC7. These results indi …
Further, TCTE1 has been shown to interact with FBXL13 (DRC6) and DRC7; however, functional roles of FBXL13 and DRC7 in mammals …
A Comprehensive Genetic Study of Microtubule-Associated Gene Clusters for Male Infertility in a Taiwanese Cohort.
Chan CC, Yen TH, Tseng HC, Mai B, Ho PK, Chou JL, Wu GJ, Huang YC. Chan CC, et al. Int J Mol Sci. 2023 Oct 19;24(20):15363. doi: 10.3390/ijms242015363. Int J Mol Sci. 2023. PMID: 37895049 Free PMC article.
Our analysis revealed five distinct affected genes covering seven SNPs based on the targeted NGS panel and WES data: SPATA16 (rs16846616, 1515442, 1515441), CFTR (rs213950), KIF6 (rs2273063), STPG2 (r2903150), and DRC7 (rs3809611). Infertile men have a higher mutation rate …
Our analysis revealed five distinct affected genes covering seven SNPs based on the targeted NGS panel and WES data: SPATA16 (rs16846616, 15 …
Mutations of METTL3 predict response to neoadjuvant chemotherapy in muscle-invasive bladder cancer.
Yang Z, Shen Z, Jin D, Zhang N, Wang Y, Lei W, Zhang Z, Chen H, Naz F, Xu L, Wang L, Wang S, Su X, Yu C, Li C. Yang Z, et al. J Clin Transl Res. 2021 Jun 5;7(3):386-413. eCollection 2021 Jun 26. J Clin Transl Res. 2021. PMID: 34239995 Free PMC article.
RESULTS: In the discovery cohort, the mutation frequencies of TP53, MED16, DRC7, CEND1, ATAD5, SETD8, and PIK3CA were significantly higher in 13 MIBC patients. ...
RESULTS: In the discovery cohort, the mutation frequencies of TP53, MED16, DRC7, CEND1, ATAD5, SETD8, and PIK3CA were significantly h …
Scaffold subunits support associated subunit assembly in the Chlamydomonas ciliary nexin-dynein regulatory complex.
Gui L, Song K, Tritschler D, Bower R, Yan S, Dai A, Augspurger K, Sakizadeh J, Grzemska M, Ni T, Porter ME, Nicastro D. Gui L, et al. Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23152-23162. doi: 10.1073/pnas.1910960116. Epub 2019 Oct 28. Proc Natl Acad Sci U S A. 2019. PMID: 31659045 Free PMC article.
Here, using cryo-electron tomography, we have compared the structure of Chlamydomonas wild-type flagella to that of strains with specific DRC subunit deletions or rescued strains with tagged DRC subunits. Our results show that DRC7 is a central linker subunit that helps co …
Here, using cryo-electron tomography, we have compared the structure of Chlamydomonas wild-type flagella to that of strains with specific DR …
Effects of Tcte1 knockout on energy chain transportation and spermatogenesis: implications for male infertility.
Olszewska M, Malcher A, Stokowy T, Pollock N, Berman AJ, Budkiewicz S, Kamieniczna M, Jackowiak H, Suszynska-Zajczyk J, Jedrzejczak P, Yatsenko AN, Kurpisz M. Olszewska M, et al. Hum Reprod Open. 2024 Apr 4;2024(2):hoae020. doi: 10.1093/hropen/hoae020. eCollection 2024. Hum Reprod Open. 2024. PMID: 38650655 Free PMC article.
The nexin-dynein regulatory complex (N-DRC) coordinates the dynein arm activity and is built from the DRC1-DRC7 proteins. DRC5 (TCTE1), one of the N-DRC elements, has already been reported as a candidate for abnormal sperm flagella beating; however, only in a restricted ma …
The nexin-dynein regulatory complex (N-DRC) coordinates the dynein arm activity and is built from the DRC1-DRC7 proteins. DRC5 (TCTE1 …