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Loneliness in healthy young adults predicts inflammatory responsiveness to a mild immune challenge in vivo.

Balter LJT, Raymond JE, Aldred S, Drayson MT, Veldhuijzen van Zanten JJCS, Higgs S, Bosch JA.

Brain Behav Immun. 2019 Aug 30. pii: S0889-1591(19)30317-4. doi: 10.1016/j.bbi.2019.08.196. [Epub ahead of print]


Selective effects of acute low-grade inflammation on human visual attention.

Balter LJ, Bosch JA, Aldred S, Drayson MT, Veldhuijzen van Zanten JJ, Higgs S, Raymond JE, Mazaheri A.

Neuroimage. 2019 Aug 12;202:116098. doi: 10.1016/j.neuroimage.2019.116098. [Epub ahead of print]


Excluding myeloma diagnosis using revised thresholds for serum free light chain ratios and M-protein levels.

Heaney JLJ, Richter A, Bowcock S, Pratt G, Child JA, Jackson G, Morgan G, Turesson I, Drayson MT.

Haematologica. 2019 Aug 8. pii: haematol.2019.224360. doi: 10.3324/haematol.2019.224360. [Epub ahead of print]


Unplanned admissions for patients with myeloma in the UK: Low frequency but high costs.

Kolovos S, Nador G, Kishore B, Streetly M, Rabin NK, Chantry AD, Yong K, Ashcroft J, Bowcock S, Drayson MT, Ramasamy K, Prieto-Alhambra D, Cooper C, Javaid MK, Pinedo-Villanueva R.

J Bone Oncol. 2019 Jun 7;17:100243. doi: 10.1016/j.jbo.2019.100243. eCollection 2019 Aug.


Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients.

Jones JR, Weinhold N, Ashby C, Walker BA, Wardell C, Pawlyn C, Rasche L, Melchor L, Cairns DA, Gregory WM, Johnson D, Begum DB, Ellis S, Sherborne AL, Cook G, Kaiser MF, Drayson MT, Owen RG, Jackson GH, Davies FE, Greaves M, Morgan GJ; NCRI Haemato-Oncology CSG.

Haematologica. 2019 Jul;104(7):1440-1450. doi: 10.3324/haematol.2018.202200. Epub 2019 Feb 7.


The impact of cytogenetics on duration of response and overall survival in patients with relapsed multiple myeloma (long-term follow-up results from BSBMT/UKMF Myeloma X Relapse [Intensive]): a randomised, open-label, phase 3 trial.

Cook G, Royle KL, O'Connor S, Cairns DA, Ashcroft AJ, Williams CD, Hockaday A, Cavenagh JD, Snowden JA, Ademokun D, Tholouli E, Andrews VE, Jenner M, Parrish C, Yong K, Cavet J, Hunter H, Bird JM, Pratt G, Drayson MT, Brown JM, Morris TCM; National Cancer Research Institute Haemato-oncology Clinical Studies Group.

Br J Haematol. 2019 May;185(3):450-467. doi: 10.1111/bjh.15782. Epub 2019 Feb 6.


Lenalidomide maintenance versus observation for patients with newly diagnosed multiple myeloma (Myeloma XI): a multicentre, open-label, randomised, phase 3 trial.

Jackson GH, Davies FE, Pawlyn C, Cairns DA, Striha A, Collett C, Hockaday A, Jones JR, Kishore B, Garg M, Williams CD, Karunanithi K, Lindsay J, Jenner MW, Cook G, Russell NH, Kaiser MF, Drayson MT, Owen RG, Gregory WM, Morgan GJ; UK NCRI Haemato-oncology Clinical Studies Group.

Lancet Oncol. 2019 Jan;20(1):57-73. doi: 10.1016/S1470-2045(18)30687-9. Epub 2018 Dec 14.


Subclonal TP53 copy number is associated with prognosis in multiple myeloma.

Shah V, Johnson DC, Sherborne AL, Ellis S, Aldridge FM, Howard-Reeves J, Begum F, Price A, Kendall J, Chiecchio L, Savola S, Jenner MW, Drayson MT, Owen RG, Gregory WM, Morgan GJ, Davies FE, Houlston RS, Cook G, Cairns DA, Jackson G, Kaiser MF; National Cancer Research Institute Haematology Clinical Studies Group.

Blood. 2018 Dec 6;132(23):2465-2469. doi: 10.1182/blood-2018-06-857250. Epub 2018 Oct 29.


Successful Renal Outcome in Membranoproliferative Glomerulonephritis Following Treatment of the Underlying Subtle Clone: A Case Report.

Rana R, Cockwell P, Vydianath B, Cook M, Pratt G, Drayson MT, Pinney JH.

Mayo Clin Proc Innov Qual Outcomes. 2018 Jun 5;2(3):297-302. doi: 10.1016/j.mayocpiqo.2018.04.003. eCollection 2018 Sep.


Humoral immunity in late-onset Pre-eclampsia and linkage with angiogenic and inflammatory markers.

Sarween N, Drayson MT, Hodson J, Knox EM, Plant T, Day CJ, Lipkin GW.

Am J Reprod Immunol. 2018 Nov;80(5):e13041. doi: 10.1111/aji.13041. Epub 2018 Aug 31.


Serum free light chain levels and renal function at diagnosis in patients with multiple myeloma.

Yadav P, Cockwell P, Cook M, Pinney J, Giles H, Aung YS, Cairns D, Owen RG, Davies FE, Jackson GH, Child JA, Morgan GJ, Drayson MT.

BMC Nephrol. 2018 Jul 13;19(1):178. doi: 10.1186/s12882-018-0962-x.


Quality of life during and following sequential treatment of previously untreated patients with multiple myeloma: findings of the Medical Research Council Myeloma IX randomised study.

Royle KL, Gregory WM, Cairns DA, Bell SE, Cook G, Owen RG, Drayson MT, Davies FE, Jackson GH, Morgan GJ, Child JA.

Br J Haematol. 2018 Sep;182(6):816-829. doi: 10.1111/bjh.15459. Epub 2018 Jul 9.


Characterisation of immunoparesis in newly diagnosed myeloma and its impact on progression-free and overall survival in both old and recent myeloma trials.

Heaney JLJ, Campbell JP, Iqbal G, Cairns D, Richter A, Child JA, Gregory W, Jackson G, Kaiser M, Owen R, Davies F, Morgan G, Dunn J, Drayson MT.

Leukemia. 2018 Aug;32(8):1727-1738. doi: 10.1038/s41375-018-0163-4. Epub 2018 Jun 20.


Low-grade inflammation decreases emotion recognition - Evidence from the vaccination model of inflammation.

Balter LJT, Hulsken S, Aldred S, Drayson MT, Higgs S, Veldhuijzen van Zanten JJCS, Raymond JE, Bosch JA.

Brain Behav Immun. 2018 Oct;73:216-221. doi: 10.1016/j.bbi.2018.05.006. Epub 2018 May 6.


The role of ixazomib as an augmented conditioning therapy in salvage autologous stem cell transplant (ASCT) and as a post-ASCT consolidation and maintenance strategy in patients with relapsed multiple myeloma (ACCoRd [UK-MRA Myeloma XII] trial): study protocol for a Phase III randomised controlled trial.

Striha A, Ashcroft AJ, Hockaday A, Cairns DA, Boardman K, Jacques G, Williams C, Snowden JA, Garg M, Cavenagh J, Yong K, Drayson MT, Owen R, Cook M, Cook G.

Trials. 2018 Mar 7;19(1):169. doi: 10.1186/s13063-018-2524-8.


Response comparison of multiple myeloma and monoclonal gammopathy of undetermined significance to the same anti-myeloma therapy: a retrospective cohort study.

Campbell JP, Heaney JLJ, Pandya S, Afzal Z, Kaiser M, Owen R, Child JA, Cairns DA, Gregory W, Morgan GJ, Jackson GH, Bunce CM, Drayson MT.

Lancet Haematol. 2017 Dec;4(12):e584-e594. doi: 10.1016/S2352-3026(17)30209-0. Epub 2017 Nov 13.


Multiple myeloma can be accurately diagnosed in acute kidney injury patients using a rapid serum free light chain test.

Heaney JLJ, Campbell JP, Yadav P, Griffin AE, Shemar M, Pinney JH, Drayson MT.

BMC Nephrol. 2017 Jul 20;18(1):247. doi: 10.1186/s12882-017-0661-z.


Active multiple myeloma suppresses and typically eliminates coexisting MGUS.

Campbell JP, Heaney JLJ, Pandya S, Afzal Z, Kaiser M, Owen R, Child JA, Gregory W, Morgan GJ, Jackson GH, Bunce CM, Drayson MT.

Br J Cancer. 2017 Sep 5;117(6):835-839. doi: 10.1038/bjc.2017.229. Epub 2017 Jul 20.


Increased fracture risk in plasma cell dyscrasias is associated with poorer overall survival.

McIlroy G, Mytton J, Evison F, Yadav P, Drayson MT, Cook M, Pratt G, Cockwell P, Pinney JH.

Br J Haematol. 2017 Oct;179(1):61-65. doi: 10.1111/bjh.14815. Epub 2017 Jun 27.


Prediction of outcome in newly diagnosed myeloma: a meta-analysis of the molecular profiles of 1905 trial patients.

Shah V, Sherborne AL, Walker BA, Johnson DC, Boyle EM, Ellis S, Begum DB, Proszek PZ, Jones JR, Pawlyn C, Savola S, Jenner MW, Drayson MT, Owen RG, Houlston RS, Cairns DA, Gregory WM, Cook G, Davies FE, Jackson GH, Morgan GJ, Kaiser MF.

Leukemia. 2018 Jan;32(1):102-110. doi: 10.1038/leu.2017.179. Epub 2017 Jun 6.


Diagnosis and monitoring for light chain only and oligosecretory myeloma using serum free light chain tests.

Heaney JLJ, Campbell JP, Griffin AE, Birtwistle J, Shemar M, Child JA, Gregory WM, Cairns DA, Morgan G, Jackson G, Drayson MT.

Br J Haematol. 2017 Jul;178(2):220-230. doi: 10.1111/bjh.14753. Epub 2017 Jun 1.


Probing the action of a novel anti-leukaemic drug therapy at the single cell level using modern vibrational spectroscopy techniques.

Denbigh JL, Perez-Guaita D, Vernooij RR, Tobin MJ, Bambery KR, Xu Y, Southam AD, Khanim FL, Drayson MT, Lockyer NP, Goodacre R, Wood BR.

Sci Rep. 2017 Jun 1;7(1):2649. doi: 10.1038/s41598-017-02069-5.


Cytokine Profiles in Malawian Children Presenting with Uncomplicated Malaria, Severe Malarial Anemia, and Cerebral Malaria.

Mandala WL, Msefula CL, Gondwe EN, Drayson MT, Molyneux ME, MacLennan CA.

Clin Vaccine Immunol. 2017 Apr 5;24(4). pii: e00533-16. doi: 10.1128/CVI.00533-16. Print 2017 Apr.


Second malignancies in the context of lenalidomide treatment: an analysis of 2732 myeloma patients enrolled to the Myeloma XI trial.

Jones JR, Cairns DA, Gregory WM, Collett C, Pawlyn C, Sigsworth R, Striha A, Henderson R, Kaiser MF, Jenner M, Cook G, Russell NH, Williams C, Pratt G, Kishore B, Lindsay J, Drayson MT, Davies FE, Boyd KD, Owen RG, Jackson GH, Morgan GJ.

Blood Cancer J. 2016 Dec 9;6(12):e506. doi: 10.1038/bcj.2016.114.


The utility of saliva for the assessment of anti-pneumococcal antibodies: investigation of saliva as a marker of antibody status in serum.

Heaney JLJ, Phillips AC, Carroll D, Drayson MT.

Biomarkers. 2018 Mar;23(2):115-122. doi: 10.1080/1354750X.2016.1265009. Epub 2016 Dec 12.


The Spectrum and Clinical Impact of Epigenetic Modifier Mutations in Myeloma.

Pawlyn C, Kaiser MF, Heuck C, Melchor L, Wardell CP, Murison A, Chavan SS, Johnson DC, Begum DB, Dahir NM, Proszek PZ, Cairns DA, Boyle EM, Jones JR, Cook G, Drayson MT, Owen RG, Gregory WM, Jackson GH, Barlogie B, Davies FE, Walker BA, Morgan GJ.

Clin Cancer Res. 2016 Dec 1;22(23):5783-5794. Epub 2016 May 27.


A population-based study of the impact of dialysis on mortality in multiple myeloma.

Evison F, Sangha J, Yadav P, Aung YS, Sharif A, Pinney JA, Drayson MT, Cook M, Cockwell P.

Br J Haematol. 2018 Feb;180(4):588-591. doi: 10.1111/bjh.14394. Epub 2016 Oct 21. No abstract available.


Corrigendum to 'Morning vaccination enhances antibody response over afternoon vaccination: A cluster-randomised trial' [Vaccine 34 (2016) 2679-2685].

Long JE, Drayson MT, Taylor AE, Toellner KM, Lord JM, Phillips AC.

Vaccine. 2016 Sep 14;34(40):4842. doi: 10.1016/j.vaccine.2016.08.031. Epub 2016 Aug 16. No abstract available.


Development of a rapid and quantitative lateral flow assay for the simultaneous measurement of serum κ and λ immunoglobulin free light chains (FLC): inception of a new near-patient FLC screening tool.

Campbell JP, Heaney JL, Shemar M, Baldwin D, Griffin AE, Oldridge E, Goodall M, Afzal Z, Plant T, Cobbold M, Jefferis R, Jacobs JF, Hand C, Drayson MT.

Clin Chem Lab Med. 2017 Mar 1;55(3):424-434. doi: 10.1515/cclm-2016-0194.


The effect of salvage autologous stem-cell transplantation on overall survival in patients with relapsed multiple myeloma (final results from BSBMT/UKMF Myeloma X Relapse [Intensive]): a randomised, open-label, phase 3 trial.

Cook G, Ashcroft AJ, Cairns DA, Williams CD, Brown JM, Cavenagh JD, Snowden JA, Parrish C, Yong K, Cavet J, Hunter H, Bird JM, Pratt G, Chown S, Heartin E, O'Connor S, Drayson MT, Hockaday A, Morris TC; National Cancer Research Institute Haemato-oncology Clinical Studies Group.

Lancet Haematol. 2016 Jul;3(7):e340-51. doi: 10.1016/S2352-3026(16)30049-7.


Inhibition of Histone Deacetylase 6 Reveals a Potent Immunosuppressant Effect in Models of Transplantation.

Ellis JD, Neil DA, Inston NG, Jenkinson E, Drayson MT, Hampson P, Shuttleworth SJ, Ready AR, Cobbold M.

Transplantation. 2016 Aug;100(8):1667-74. doi: 10.1097/TP.0000000000001208.


Cytokine Profiles during Invasive Nontyphoidal Salmonella Disease Predict Outcome in African Children.

Gilchrist JJ, Heath JN, Msefula CL, Gondwe EN, Naranbhai V, Mandala W, MacLennan JM, Molyneux EM, Graham SM, Drayson MT, Molyneux ME, MacLennan CA.

Clin Vaccine Immunol. 2016 Jul 5;23(7):601-9. doi: 10.1128/CVI.00128-16. Print 2016 Jul.


Brief Report: Immunization of HIV-Infected Adults in the UK With Haemophilus influenzae b/Meningococcal C Glycoconjugate and Pneumococcal Polysaccharide Vaccines.

MacLennan CA, Richter A, Hodson J, Faustini S, Birtwistle J, Whitelegg A, Chigiga J, Singo M, Walker-Haywood J, Mulugeta B, Masuka S, Mainey C, Plant T, Drayson MT, Manavi K.

J Acquir Immune Defic Syndr. 2016 Nov 1;73(3):287-293.


Morning vaccination enhances antibody response over afternoon vaccination: A cluster-randomised trial.

Long JE, Drayson MT, Taylor AE, Toellner KM, Lord JM, Phillips AC.

Vaccine. 2016 May 23;34(24):2679-85. doi: 10.1016/j.vaccine.2016.04.032. Epub 2016 Apr 26. Erratum in: Vaccine. 2016 Sep 14;34(40):4842.


Monocyte activation and cytokine production in Malawian children presenting with P. falciparum malaria.

Mandala WL, Msefula CL, Gondwe EN, Drayson MT, Molyneux ME, MacLennan CA.

Parasite Immunol. 2016 May;38(5):317-25. doi: 10.1111/pim.12319.


Serum tryptase concentration and progression to end-stage renal disease.

Jesky MD, Stringer SJ, Fenton A, Ng KP, Yadav P, Ndumbo M, McCann K, Plant T, Dasgupta I, Harding SJ, Drayson MT, Redegeld F, Ferro CJ, Cockwell P.

Eur J Clin Invest. 2016 May;46(5):460-74. doi: 10.1111/eci.12622. Epub 2016 Apr 15.


Serum free light chains are reduced in endurance trained older adults: Evidence that exercise training may reduce basal inflammation in older adults.

Heaney JL, Phillips AC, Drayson MT, Campbell JP.

Exp Gerontol. 2016 May;77:69-75. doi: 10.1016/j.exger.2016.02.011. Epub 2016 Feb 26.


Salivary immunoglobulin free light chains: reference ranges and responses to exercise in young and older adults.

Heaney JL, Gleeson M, Phillips AC, Taylor IM, Drayson MT, Goodall M, He CS, Svendsen IS, Killer SC, Campbell JP.

Exerc Immunol Rev. 2016;22:28-41.


Salivary Immunoglobulin A Secretion Rate Is Negatively Associated with Cancer Mortality: The West of Scotland Twenty-07 Study.

Phillips AC, Carroll D, Drayson MT, Der G.

PLoS One. 2015 Dec 23;10(12):e0145083. doi: 10.1371/journal.pone.0145083. eCollection 2015.


Lymphocyte Perturbations in Malawian Children with Severe and Uncomplicated Malaria.

Mandala WL, Msefula CL, Gondwe EN, Gilchrist JJ, Graham SM, Pensulo P, Mwimaniwa G, Banda M, Taylor TE, Molyneux EE, Drayson MT, Ward SA, Molyneux ME, MacLennan CA.

Clin Vaccine Immunol. 2015 Nov 18;23(2):95-103. doi: 10.1128/CVI.00564-15.


Minimal residual disease following autologous stem cell transplant in myeloma: impact on outcome is independent of induction regimen.

de Tute RM, Rawstron AC, Gregory WM, Child JA, Davies FE, Bell SE, Cook G, Szubert AJ, Drayson MT, Jackson GH, Morgan GJ, Owen RG.

Haematologica. 2016 Feb;101(2):e69-71. doi: 10.3324/haematol.2015.128215. Epub 2015 Oct 15. No abstract available.


Salivary Functional Antibody Secretion Is Reduced in Older Adults: A Potential Mechanism of Increased Susceptibility to Bacterial Infection in the Elderly.

Heaney JL, Phillips AC, Carroll D, Drayson MT.

J Gerontol A Biol Sci Med Sci. 2015 Dec;70(12):1578-85. doi: 10.1093/gerona/glv085. Epub 2015 Aug 31.


Mutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.

Walker BA, Boyle EM, Wardell CP, Murison A, Begum DB, Dahir NM, Proszek PZ, Johnson DC, Kaiser MF, Melchor L, Aronson LI, Scales M, Pawlyn C, Mirabella F, Jones JR, Brioli A, Mikulasova A, Cairns DA, Gregory WM, Quartilho A, Drayson MT, Russell N, Cook G, Jackson GH, Leleu X, Davies FE, Morgan GJ.

J Clin Oncol. 2015 Nov 20;33(33):3911-20. doi: 10.1200/JCO.2014.59.1503. Epub 2015 Aug 17.


Patients with multiple myeloma have excellent long-term outcomes after recovery from dialysis-dependent acute kidney injury.

Yadav P, Hutchison CA, Basnayake K, Stringer S, Jesky M, Fifer L, Snell K, Pinney J, Drayson MT, Cook M, Cockwell P.

Eur J Haematol. 2016 Jun;96(6):610-7. doi: 10.1111/ejh.12644. Epub 2015 Sep 16.


Drug Redeployment to Kill Leukemia and Lymphoma Cells by Disrupting SCD1-Mediated Synthesis of Monounsaturated Fatty Acids.

Southam AD, Khanim FL, Hayden RE, Constantinou JK, Koczula KM, Michell RH, Viant MR, Drayson MT, Bunce CM.

Cancer Res. 2015 Jun 15;75(12):2530-40. doi: 10.1158/0008-5472.CAN-15-0202. Epub 2015 May 5.


Poor functional antibody responses are present in nearly all patients with chronic lymphocytic leukaemia, irrespective of total IgG concentration, and are associated with increased risk of infection.

Parry HM, Birtwistle J, Whitelegg A, Hudson C, McSkeane T, Hazlewood P, Mudongo N, Pratt G, Moss P, Drayson MT, Murray J, Richter AG.

Br J Haematol. 2015 Dec;171(5):887-90. doi: 10.1111/bjh.13455. Epub 2015 Apr 28. No abstract available.


APOBEC family mutational signatures are associated with poor prognosis translocations in multiple myeloma.

Walker BA, Wardell CP, Murison A, Boyle EM, Begum DB, Dahir NM, Proszek PZ, Melchor L, Pawlyn C, Kaiser MF, Johnson DC, Qiang YW, Jones JR, Cairns DA, Gregory WM, Owen RG, Cook G, Drayson MT, Jackson GH, Davies FE, Morgan GJ.

Nat Commun. 2015 Apr 23;6:6997. doi: 10.1038/ncomms7997.


Minimal residual disease in myeloma by flow cytometry: independent prediction of survival benefit per log reduction.

Rawstron AC, Gregory WM, de Tute RM, Davies FE, Bell SE, Drayson MT, Cook G, Jackson GH, Morgan GJ, Child JA, Owen RG.

Blood. 2015 Mar 19;125(12):1932-5. doi: 10.1182/blood-2014-07-590166. Epub 2015 Feb 2.


Negative affectivity predicts decreased pain tolerance during low-grade inflammation in healthy women.

Lacourt TE, Houtveen JH, Veldhuijzen van Zanten JJ, Bosch JA, Drayson MT, Van Doornen LJ.

Brain Behav Immun. 2015 Feb;44:32-6. doi: 10.1016/j.bbi.2014.10.003. Epub 2014 Oct 14.


Coexistent hyperdiploidy does not abrogate poor prognosis in myeloma with adverse cytogenetics and may precede IGH translocations.

Pawlyn C, Melchor L, Murison A, Wardell CP, Brioli A, Boyle EM, Kaiser MF, Walker BA, Begum DB, Dahir NB, Proszek P, Gregory WM, Drayson MT, Jackson GH, Ross FM, Davies FE, Morgan GJ.

Blood. 2015 Jan 29;125(5):831-40. doi: 10.1182/blood-2014-07-584268. Epub 2014 Nov 26.

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