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Items: 26


MARK2/Par1b kinase present at centrosomes and retraction fibres corrects spindle off-centring induced by actin disassembly.

Hart M, Zulkipli I, Shrestha RL, Dang D, Conti D, Gul P, Kujawiak I, Draviam VM.

Open Biol. 2019 Jun 28;9(6):180263. doi: 10.1098/rsob.180263. Epub 2019 Jun 26.


Spindle rotation in human cells is reliant on a MARK2-mediated equatorial spindle-centering mechanism.

Zulkipli I, Clark J, Hart M, Shrestha RL, Gul P, Dang D, Kasichiwin T, Kujawiak I, Sastry N, Draviam VM.

J Cell Biol. 2018 Sep 3;217(9):3057-3070. doi: 10.1083/jcb.201804166. Epub 2018 Jun 25.


Aurora-B kinase pathway controls the lateral to end-on conversion of kinetochore-microtubule attachments in human cells.

Shrestha RL, Conti D, Tamura N, Braun D, Ramalingam RA, Cieslinski K, Ries J, Draviam VM.

Nat Commun. 2017 Jul 28;8(1):150. doi: 10.1038/s41467-017-00209-z.


Editorial: Quantitative Biology: Dynamics of Living Systems.

Hiroi N, Draviam VM, Funahashi A.

Front Physiol. 2016 Jun 2;7:196. doi: 10.3389/fphys.2016.00196. eCollection 2016. No abstract available.


A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning Predictions.

Iorio F, Shrestha RL, Levin N, Boilot V, Garnett MJ, Saez-Rodriguez J, Draviam VM.

PLoS One. 2015 Oct 9;10(10):e0139446. doi: 10.1371/journal.pone.0139446. eCollection 2015.


Modeling of Noisy Spindle Dynamics Reveals Separable Contributions to Achieving Correct Orientation.

Corrigan AM, Shrestha R, Draviam VM, Donald AM.

Biophys J. 2015 Oct 6;109(7):1398-409. doi: 10.1016/j.bpj.2015.08.014.


High-speed microscopy with an electrically tunable lens to image the dynamics of in vivo molecular complexes.

Nakai Y, Ozeki M, Hiraiwa T, Tanimoto R, Funahashi A, Hiroi N, Taniguchi A, Nonaka S, Boilot V, Shrestha R, Clark J, Tamura N, Draviam VM, Oku H.

Rev Sci Instrum. 2015 Jan;86(1):013707. doi: 10.1063/1.4905330.


A proteomic study of mitotic phase-specific interactors of EB1 reveals a role for SXIP-mediated protein interactions in anaphase onset.

Tamura N, Simon JE, Nayak A, Shenoy R, Hiroi N, Boilot V, Funahashi A, Draviam VM.

Biol Open. 2015 Jan 16;4(2):155-69. doi: 10.1242/bio.201410413.


DNA repair. PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair.

Ochi T, Blackford AN, Coates J, Jhujh S, Mehmood S, Tamura N, Travers J, Wu Q, Draviam VM, Robinson CV, Blundell TL, Jackson SP.

Science. 2015 Jan 9;347(6218):185-188. doi: 10.1126/science.1261971.


Need for multi-scale systems to identify spindle orientation regulators relevant to tissue disorganization in solid cancers.

Chin HM, Nandra K, Clark J, Draviam VM.

Front Physiol. 2014 Jul 25;5:278. doi: 10.3389/fphys.2014.00278. eCollection 2014. No abstract available.


TAO1 kinase maintains chromosomal stability by facilitating proper congression of chromosomes.

Shrestha RL, Tamura N, Fries A, Levin N, Clark J, Draviam VM.

Open Biol. 2014 Jun;4(6):130108. doi: 10.1098/rsob.130108.


Automated tracking of mitotic spindle pole positions shows that LGN is required for spindle rotation but not orientation maintenance.

Corrigan AM, Shrestha RL, Zulkipli I, Hiroi N, Liu Y, Tamura N, Yang B, Patel J, Funahashi A, Donald A, Draviam VM.

Cell Cycle. 2013 Aug 15;12(16):2643-55. doi: 10.4161/cc.25671. Epub 2013 Jul 16.


Lateral to end-on conversion of chromosome-microtubule attachment requires kinesins CENP-E and MCAK.

Shrestha RL, Draviam VM.

Curr Biol. 2013 Aug 19;23(16):1514-26. doi: 10.1016/j.cub.2013.06.040. Epub 2013 Jul 25. Erratum in: Curr Biol. 2013 Dec 2;23(23):2440-1.


Meeting report of the International Workshop on Quantitative Biology 2012: mesoscopic and microscopic worlds meet.

Draviam VM, Funahashi A, Hiroi N, Kimura A, Kobayashi TJ.

Front Physiol. 2013 Jan 11;3:479. doi: 10.3389/fphys.2012.00479. eCollection 2012. No abstract available.


Microtubule plus-ends within a mitotic cell are 'moving platforms' with anchoring, signalling and force-coupling roles.

Tamura N, Draviam VM.

Open Biol. 2012 Nov;2(11):120132. doi: 10.1098/rsob.120132. Review.


Roles for the conserved spc105p/kre28p complex in kinetochore-microtubule binding and the spindle assembly checkpoint.

Pagliuca C, Draviam VM, Marco E, Sorger PK, De Wulf P.

PLoS One. 2009 Oct 28;4(10):e7640. doi: 10.1371/journal.pone.0007640.


Studying chromosome instability in the mouse.

Foijer F, Draviam VM, Sorger PK.

Biochim Biophys Acta. 2008 Sep;1786(1):73-82. doi: 10.1016/j.bbcan.2008.07.004. Epub 2008 Jul 26. Review.


Anaphase initiation is regulated by antagonistic ubiquitination and deubiquitination activities.

Stegmeier F, Rape M, Draviam VM, Nalepa G, Sowa ME, Ang XL, McDonald ER 3rd, Li MZ, Hannon GJ, Sorger PK, Kirschner MW, Harper JW, Elledge SJ.

Nature. 2007 Apr 19;446(7138):876-81.


A functional genomic screen identifies a role for TAO1 kinase in spindle-checkpoint signalling.

Draviam VM, Stegmeier F, Nalepa G, Sowa ME, Chen J, Liang A, Hannon GJ, Sorger PK, Harper JW, Elledge SJ.

Nat Cell Biol. 2007 May;9(5):556-64. Epub 2007 Apr 8.


Hsp90 is required to localise cyclin B and Msps/ch-TOG to the mitotic spindle in Drosophila and humans.

Basto R, Gergely F, Draviam VM, Ohkura H, Liley K, Raff JW.

J Cell Sci. 2007 Apr 1;120(Pt 7):1278-87.


The human kinetochore proteins Nnf1R and Mcm21R are required for accurate chromosome segregation.

McAinsh AD, Meraldi P, Draviam VM, Toso A, Sorger PK.

EMBO J. 2006 Sep 6;25(17):4033-49. Epub 2006 Aug 24. Erratum in: EMBO J. 2009 May 6;28(9):1374.


Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells.

Draviam VM, Shapiro I, Aldridge B, Sorger PK.

EMBO J. 2006 Jun 21;25(12):2814-27. Epub 2006 Jun 8.


Timing and checkpoints in the regulation of mitotic progression.

Meraldi P, Draviam VM, Sorger PK.

Dev Cell. 2004 Jul;7(1):45-60.


Chromosome segregation and genomic stability.

Draviam VM, Xie S, Sorger PK.

Curr Opin Genet Dev. 2004 Apr;14(2):120-5. Review.


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