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Items: 9


Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects.

Corbet C, Bastien E, Draoui N, Doix B, Mignion L, Jordan BF, Marchand A, Vanherck JC, Chaltin P, Schakman O, Becker HM, Riant O, Feron O.

Nat Commun. 2018 Mar 23;9(1):1208. doi: 10.1038/s41467-018-03525-0.


Angiogenesis revisited from a metabolic perspective: role and therapeutic implications of endothelial cell metabolism.

Draoui N, de Zeeuw P, Carmeliet P.

Open Biol. 2017 Dec;7(12). pii: 170219. doi: 10.1098/rsob.170219. Review.


Endothelial cell metabolism: an update anno 2017.

Teuwen LA, Draoui N, Dubois C, Carmeliet P.

Curr Opin Hematol. 2017 May;24(3):240-247. doi: 10.1097/MOH.0000000000000335. Review.


A new ER-specific photosensitizer unravels (1)O2-driven protein oxidation and inhibition of deubiquitinases as a generic mechanism for cancer PDT.

Pinto A, Mace Y, Drouet F, Bony E, Boidot R, Draoui N, Lobysheva I, Corbet C, Polet F, Martherus R, Deraedt Q, Rodríguez J, Lamy C, Schicke O, Delvaux D, Louis C, Kiss R, Kriegsheim AV, Dessy C, Elias B, Quetin-Leclercq J, Riant O, Feron O.

Oncogene. 2016 Jul 28;35(30):3976-85. doi: 10.1038/onc.2015.474. Epub 2015 Dec 21.


Vitamin E-based micelles enhance the anticancer activity of doxorubicin.

Danhier F, Kouhé TT, Duhem N, Ucakar B, Staub A, Draoui N, Feron O, Préat V.

Int J Pharm. 2014 Dec 10;476(1-2):9-15. doi: 10.1016/j.ijpharm.2014.09.028. Epub 2014 Sep 22.


The SIRT1/HIF2α axis drives reductive glutamine metabolism under chronic acidosis and alters tumor response to therapy.

Corbet C, Draoui N, Polet F, Pinto A, Drozak X, Riant O, Feron O.

Cancer Res. 2014 Oct 1;74(19):5507-19. doi: 10.1158/0008-5472.CAN-14-0705. Epub 2014 Aug 1.


Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux.

Draoui N, Schicke O, Seront E, Bouzin C, Sonveaux P, Riant O, Feron O.

Mol Cancer Ther. 2014 Jun;13(6):1410-8. doi: 10.1158/1535-7163.MCT-13-0653. Epub 2014 Mar 26.


Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells.

Draoui N, Schicke O, Fernandes A, Drozak X, Nahra F, Dumont A, Douxfils J, Hermans E, Dogné JM, Corbau R, Marchand A, Chaltin P, Sonveaux P, Feron O, Riant O.

Bioorg Med Chem. 2013 Nov 15;21(22):7107-17. doi: 10.1016/j.bmc.2013.09.010. Epub 2013 Sep 13.


Lactate shuttles at a glance: from physiological paradigms to anti-cancer treatments.

Draoui N, Feron O.

Dis Model Mech. 2011 Nov;4(6):727-32. doi: 10.1242/dmm.007724. Review.

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