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Items: 1 to 50 of 64

1.

Nrf2 controls iron homeostasis in haemochromatosis and thalassaemia via Bmp6 and hepcidin.

Lim PJ, Duarte TL, Arezes J, Garcia-Santos D, Hamdi A, Pasricha SR, Armitage AE, Mehta H, Wideman S, Santos AG, Santos-Gonçalves A, Morovat A, Hughes JR, Soilleux E, Wang CY, Bayer AL, Klenerman P, Willberg CB, Hartley RC, Murphy MP, Babitt JL, Ponka P, Porto G, Drakesmith H.

Nat Metab. 2019 May;1(5):519-531. doi: 10.1038/s42255-019-0063-6. Epub 2019 May 13.

PMID:
31276102
2.

Respiratory infections drive hepcidin-mediated blockade of iron absorption leading to iron deficiency anemia in African children.

Prentice AM, Bah A, Jallow MW, Jallow AT, Sanyang S, Sise EA, Ceesay K, Danso E, Armitage AE, Pasricha SR, Drakesmith H, Wathuo M, Kessler N, Cerami C, Wegmüller R.

Sci Adv. 2019 Mar 27;5(3):eaav9020. doi: 10.1126/sciadv.aav9020. eCollection 2019 Mar.

3.

Author Correction: The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays.

Tanner R, O'Shea MK, White AD, Müller J, Harrington-Kandt R, Matsumiya M, Dennis MJ, Parizotto EA, Harris S, Stylianou E, Naranbhai V, Bettencourt P, Drakesmith H, Sharpe S, Fletcher HA, McShane H.

Sci Rep. 2019 Apr 3;9(1):5596. doi: 10.1038/s41598-019-41387-8.

4.

Rapid growth is a dominant predictor of hepcidin suppression and declining ferritin in Gambian infants.

Armitage AE, Agbla SC, Betts M, Sise EA, Jallow MW, Sambou E, Darboe B, Worwui A, Weinstock GM, Antonio M, Pasricha SR, Prentice AM, Drakesmith H, Darboe MK, Kwambana-Adams BA.

Haematologica. 2019 Aug;104(8):1542-1553. doi: 10.3324/haematol.2018.210146. Epub 2019 Feb 7.

5.

Antiviral activity of bone morphogenetic proteins and activins.

Eddowes LA, Al-Hourani K, Ramamurthy N, Frankish J, Baddock HT, Sandor C, Ryan JD, Fusco DN, Arezes J, Giannoulatou E, Boninsegna S, Chevaliez S, Owens BMJ, Sun CC, Fabris P, Giordani MT, Martines D, Vukicevic S, Crowe J, Lin HY, Rehwinkel J, McHugh PJ, Binder M, Babitt JL, Chung RT, Lawless MW, Armitage AE, Webber C, Klenerman P, Drakesmith H.

Nat Microbiol. 2019 Feb;4(2):339-351. doi: 10.1038/s41564-018-0301-9. Epub 2018 Dec 3.

6.

Hemoglobinopathies in the Fetal Position.

Pasricha SR, Drakesmith H.

N Engl J Med. 2018 Oct 25;379(17):1675-1677. doi: 10.1056/NEJMcibr1809628. No abstract available.

PMID:
30354961
7.

Intravenous Irons: From Basic Science to Clinical Practice.

Bhandari S, Pereira DIA, Chappell HF, Drakesmith H.

Pharmaceuticals (Basel). 2018 Aug 27;11(3). pii: E82. doi: 10.3390/ph11030082. Review.

8.

Erythroferrone inhibits the induction of hepcidin by BMP6.

Arezes J, Foy N, McHugh K, Sawant A, Quinkert D, Terraube V, Brinth A, Tam M, LaVallie ER, Taylor S, Armitage AE, Pasricha SR, Cunningham O, Lambert M, Draper SJ, Jasuja R, Drakesmith H.

Blood. 2018 Oct 4;132(14):1473-1477. doi: 10.1182/blood-2018-06-857995. Epub 2018 Aug 10.

9.

Reducing anaemia in low income countries: control of infection is essential.

Pasricha SR, Armitage AE, Prentice AM, Drakesmith H.

BMJ. 2018 Aug 1;362:k3165. doi: 10.1136/bmj.k3165. No abstract available.

10.

Decreased Hepcidin Levels Are Associated with Low Steady-state Hemoglobin in Children With Sickle Cell Disease in Tanzania.

Lee N, Makani J, Tluway F, Makubi A, Armitage AE, Pasricha SR, Drakesmith H, Prentice AM, Cox SE.

EBioMedicine. 2018 Aug;34:158-164. doi: 10.1016/j.ebiom.2018.07.024. Epub 2018 Jul 25.

11.

Serum hepcidin potentially identifies iron deficiency in survivors of critical illness at the time of hospital discharge.

Shah A, Wray K, James T, Shine B, Morovat R, Stanworth S, McKechnie S, Kirkbride R, Griffith DM, Walsh TS, Drakesmith H, Roy N.

Br J Haematol. 2019 Jan;184(2):279-281. doi: 10.1111/bjh.15067. Epub 2018 Jan 24. No abstract available.

PMID:
29363744
12.

Hepcidin deficiency and iron deficiency do not alter tuberculosis susceptibility in a murine M.tb infection model.

Harrington-Kandt R, Stylianou E, Eddowes LA, Lim PJ, Stockdale L, Pinpathomrat N, Bull N, Pasricha J, Ulaszewska M, Beglov Y, Vaulont S, Drakesmith H, McShane H.

PLoS One. 2018 Jan 11;13(1):e0191038. doi: 10.1371/journal.pone.0191038. eCollection 2018.

13.

Role of Activins in Hepcidin Regulation during Malaria.

Spottiswoode N, Armitage AE, Williams AR, Fyfe AJ, Biswas S, Hodgson SH, Llewellyn D, Choudhary P, Draper SJ, Duffy PE, Drakesmith H.

Infect Immun. 2017 Nov 17;85(12). pii: e00191-17. doi: 10.1128/IAI.00191-17. Print 2017 Dec.

14.

Hepcidin is regulated by promoter-associated histone acetylation and HDAC3.

Pasricha SR, Lim PJ, Duarte TL, Casu C, Oosterhuis D, Mleczko-Sanecka K, Suciu M, Da Silva AR, Al-Hourani K, Arezes J, McHugh K, Gooding S, Frost JN, Wray K, Santos A, Porto G, Repapi E, Gray N, Draper SJ, Ashley N, Soilleux E, Olinga P, Muckenthaler MU, Hughes JR, Rivella S, Milne TA, Armitage AE, Drakesmith H.

Nat Commun. 2017 Sep 1;8(1):403. doi: 10.1038/s41467-017-00500-z.

15.

Improving iron supplements: cooking with GOS.

Drakesmith H, Allen SJ.

Gut. 2017 Nov;66(11):1881-1882. doi: 10.1136/gutjnl-2017-314593. Epub 2017 Aug 3. No abstract available.

PMID:
28774884
16.

Hepatic iron is the major determinant of serum ferritin in NAFLD patients.

Ryan JD, Armitage AE, Cobbold JF, Banerjee R, Borsani O, Dongiovanni P, Neubauer S, Morovat R, Wang LM, Pasricha SR, Fargion S, Collier J, Barnes E, Drakesmith H, Valenti L, Pavlides M.

Liver Int. 2018 Jan;38(1):164-173. doi: 10.1111/liv.13513. Epub 2017 Jul 29.

PMID:
28679028
17.

Serum Hepcidin Concentrations Decline during Pregnancy and May Identify Iron Deficiency: Analysis of a Longitudinal Pregnancy Cohort in The Gambia.

Bah A, Pasricha SR, Jallow MW, Sise EA, Wegmuller R, Armitage AE, Drakesmith H, Moore SE, Prentice AM.

J Nutr. 2017 Jun;147(6):1131-1137. doi: 10.3945/jn.116.245373. Epub 2017 Apr 19.

18.

Short-Term versus Long-Term Blood Storage.

Ryan JD, Drakesmith H.

N Engl J Med. 2017 Mar 16;376(11):1092. doi: 10.1056/NEJMc1700464. No abstract available.

PMID:
28301108
19.

The influence of haemoglobin and iron on in vitro mycobacterial growth inhibition assays.

Tanner R, O'Shea MK, White AD, Müller J, Harrington-Kandt R, Matsumiya M, Dennis MJ, Parizotto EA, Harris S, Stylianou E, Naranbhai V, Bettencourt P, Drakesmith H, Sharpe S, Fletcher HA, McShane H.

Sci Rep. 2017 Mar 3;7:43478. doi: 10.1038/srep43478. Erratum in: Sci Rep. 2019 Apr 3;9(1):5596.

20.

Hepcidin detects iron deficiency in Sri Lankan adolescents with a high burden of hemoglobinopathy: A diagnostic test accuracy study.

Wray K, Allen A, Evans E, Fisher C, Premawardhena A, Perera L, Rodrigo R, Goonathilaka G, Ramees L, Webster C, Armitage AE, Prentice AM, Weatherall DJ, Drakesmith H, Pasricha SR.

Am J Hematol. 2017 Feb;92(2):196-203. doi: 10.1002/ajh.24617.

21.

Induced Disruption of the Iron-Regulatory Hormone Hepcidin Inhibits Acute Inflammatory Hypoferraemia.

Armitage AE, Lim PJ, Frost JN, Pasricha SR, Soilleux EJ, Evans E, Morovat A, Santos A, Diaz R, Biggs D, Davies B, Gileadi U, Robbins PA, Lakhal-Littleton S, Drakesmith H.

J Innate Immun. 2016;8(5):517-28. doi: 10.1159/000447713. Epub 2016 Jul 16.

22.

Cord Blood Hepcidin: Cross-Sectional Correlates and Associations with Anemia, Malaria, and Mortality in a Tanzanian Birth Cohort Study.

Brickley EB, Spottiswoode N, Kabyemela E, Morrison R, Kurtis JD, Wood AM, Drakesmith H, Fried M, Duffy PE.

Am J Trop Med Hyg. 2016 Oct 5;95(4):817-826. Epub 2016 Jun 27.

23.

Toward Worldwide Hepcidin Assay Harmonization: Identification of a Commutable Secondary Reference Material.

van der Vorm LN, Hendriks JC, Laarakkers CM, Klaver S, Armitage AE, Bamberg A, Geurts-Moespot AJ, Girelli D, Herkert M, Itkonen O, Konrad RJ, Tomosugi N, Westerman M, Bansal SS, Campostrini N, Drakesmith H, Fillet M, Olbina G, Pasricha SR, Pitts KR, Sloan JH, Tagliaro F, Weykamp CW, Swinkels DW.

Clin Chem. 2016 Jul;62(7):993-1001. doi: 10.1373/clinchem.2016.256768. Epub 2016 May 12.

24.

Regulation of Hepcidin by Erythropoiesis: The Story So Far.

Pasricha SR, McHugh K, Drakesmith H.

Annu Rev Nutr. 2016 Jul 17;36:417-34. doi: 10.1146/annurev-nutr-071715-050731. Epub 2016 May 4. Review.

PMID:
27146013
25.

Iron Deficiency Anemia: Problems in Diagnosis and Prevention at the Population Level.

Pasricha SR, Drakesmith H.

Hematol Oncol Clin North Am. 2016 Apr;30(2):309-25. doi: 10.1016/j.hoc.2015.11.003. Review.

PMID:
27040956
26.

Next-Generation Biomarkers for Iron Status.

Drakesmith H.

Nestle Nutr Inst Workshop Ser. 2016;84:59-69. doi: 10.1159/000436955. Epub 2016 Jan 14.

PMID:
26764474
27.

From one Nobel Prize (P. Ehrlich) to another (Tu Youyou): 100 years of chemotherapy of infectious diseases.

Cabantchik ZI, Drakesmith H.

Clin Microbiol Infect. 2016 Mar;22(3):213-4. doi: 10.1016/j.cmi.2015.11.011. Epub 2015 Dec 7. No abstract available.

28.

Malaria and Age Variably but Critically Control Hepcidin Throughout Childhood in Kenya.

Atkinson SH, Uyoga SM, Armitage AE, Khandwala S, Mugyenyi CK, Bejon P, Marsh K, Beeson JG, Prentice AM, Drakesmith H, Williams TN.

EBioMedicine. 2015 Aug 8;2(10):1478-86. doi: 10.1016/j.ebiom.2015.08.016. eCollection 2015 Oct.

29.

Ironing out Ferroportin.

Drakesmith H, Nemeth E, Ganz T.

Cell Metab. 2015 Nov 3;22(5):777-87. doi: 10.1016/j.cmet.2015.09.006. Epub 2015 Oct 1. Review.

30.

Rapidly Escalating Hepcidin and Associated Serum Iron Starvation Are Features of the Acute Response to Typhoid Infection in Humans.

Darton TC, Blohmke CJ, Giannoulatou E, Waddington CS, Jones C, Sturges P, Webster C, Drakesmith H, Pollard AJ, Armitage AE.

PLoS Negl Trop Dis. 2015 Sep 22;9(9):e0004029. doi: 10.1371/journal.pntd.0004029. eCollection 2015 Sep.

31.

A cross-sectional study of the prevalence and associations of iron deficiency in a cohort of patients with chronic obstructive pulmonary disease.

Nickol AH, Frise MC, Cheng HY, McGahey A, McFadyen BM, Harris-Wright T, Bart NK, Curtis MK, Khandwala S, O'Neill DP, Pollard KA, Hardinge FM, Rahman NM, Armitage AE, Dorrington KL, Drakesmith H, Ratcliffe PJ, Robbins PA.

BMJ Open. 2015 Jul 6;5(7):e007911. doi: 10.1136/bmjopen-2015-007911.

32.

Elevated Hepcidin Is Part of a Complex Relation That Links Mortality with Iron Homeostasis and Anemia in Men and Women with HIV Infection.

Minchella PA, Armitage AE, Darboe B, Jallow MW, Drakesmith H, Jaye A, Prentice AM, McDermid JM.

J Nutr. 2015 Jun;145(6):1194-201. doi: 10.3945/jn.114.203158. Epub 2015 Apr 22.

33.

Hepcidin is suppressed by erythropoiesis in hemoglobin E β-thalassemia and β-thalassemia trait.

Jones E, Pasricha SR, Allen A, Evans P, Fisher CA, Wray K, Premawardhena A, Bandara D, Perera A, Webster C, Sturges P, Olivieri NF, St Pierre T, Armitage AE, Porter JB, Weatherall DJ, Drakesmith H.

Blood. 2015 Jan 29;125(5):873-80. doi: 10.1182/blood-2014-10-606491. Epub 2014 Dec 17.

34.

Genetics. The battle for iron.

Armitage AE, Drakesmith H.

Science. 2014 Dec 12;346(6215):1299-300. doi: 10.1126/science.aaa2468. No abstract available.

PMID:
25504706
35.

Elevated hepcidin at HIV diagnosis is associated with incident tuberculosis in a retrospective cohort study.

Minchella PA, Armitage AE, Darboe B, Jallow MW, Drakesmith H, Jaye A, Prentice AM, McDermid JM.

Int J Tuberc Lung Dis. 2014 Nov;18(11):1337-9. doi: 10.5588/ijtld.14.0143.

PMID:
25299867
36.

Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infections.

Armitage AE, Stacey AR, Giannoulatou E, Marshall E, Sturges P, Chatha K, Smith NM, Huang X, Xu X, Pasricha SR, Li N, Wu H, Webster C, Prentice AM, Pellegrino P, Williams I, Norris PJ, Drakesmith H, Borrow P.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12187-92. doi: 10.1073/pnas.1402351111. Epub 2014 Aug 4.

37.

Iron, anemia and hepcidin in malaria.

Spottiswoode N, Duffy PE, Drakesmith H.

Front Pharmacol. 2014 May 30;5:125. doi: 10.3389/fphar.2014.00125. eCollection 2014. Review.

38.

Intravenous iron and vertical HIV transmission: any connection?

Thompson F, Ghanem M, Conway K, de Ruiter A, Taylor GP, Drakesmith H, Lyall H.

AIDS. 2014 May 15;28(8):1245-6. doi: 10.1097/QAD.0000000000000220. No abstract available.

PMID:
24871353
39.

Expression of the iron hormone hepcidin distinguishes different types of anemia in African children.

Pasricha SR, Atkinson SH, Armitage AE, Khandwala S, Veenemans J, Cox SE, Eddowes LA, Hayes T, Doherty CP, Demir AY, Tijhaar E, Verhoef H, Prentice AM, Drakesmith H.

Sci Transl Med. 2014 May 7;6(235):235re3. doi: 10.1126/scitranslmed.3008249.

40.

Combinatorial effects of malaria season, iron deficiency, and inflammation determine plasma hepcidin concentration in African children.

Atkinson SH, Armitage AE, Khandwala S, Mwangi TW, Uyoga S, Bejon PA, Williams TN, Prentice AM, Drakesmith H.

Blood. 2014 May 22;123(21):3221-9. doi: 10.1182/blood-2013-10-533000. Epub 2014 Mar 4.

41.

Control of iron deficiency anemia in low- and middle-income countries.

Pasricha SR, Drakesmith H, Black J, Hipgrave D, Biggs BA.

Blood. 2013 Apr 4;121(14):2607-17. doi: 10.1182/blood-2012-09-453522. Epub 2013 Jan 25. Review.

42.

Hepcidin and the iron-infection axis.

Drakesmith H, Prentice AM.

Science. 2012 Nov 9;338(6108):768-72. doi: 10.1126/science.1224577. Review.

PMID:
23139325
43.

Implications of malaria on iron deficiency control strategies.

Spottiswoode N, Fried M, Drakesmith H, Duffy PE.

Adv Nutr. 2012 Jul 1;3(4):570-8. doi: 10.3945/an.111.001156.

44.

Hepcidin is the major predictor of erythrocyte iron incorporation in anemic African children.

Prentice AM, Doherty CP, Abrams SA, Cox SE, Atkinson SH, Verhoef H, Armitage AE, Drakesmith H.

Blood. 2012 Feb 23;119(8):1922-8. doi: 10.1182/blood-2011-11-391219. Epub 2012 Jan 6.

45.

Superinfection in malaria: Plasmodium shows its iron will.

Portugal S, Drakesmith H, Mota MM.

EMBO Rep. 2011 Dec 1;12(12):1233-42. doi: 10.1038/embor.2011.213. Review.

46.

Hepcidin regulation by innate immune and infectious stimuli.

Armitage AE, Eddowes LA, Gileadi U, Cole S, Spottiswoode N, Selvakumar TA, Ho LP, Townsend AR, Drakesmith H.

Blood. 2011 Oct 13;118(15):4129-39. doi: 10.1182/blood-2011-04-351957. Epub 2011 Aug 26.

47.

Host-mediated regulation of superinfection in malaria.

Portugal S, Carret C, Recker M, Armitage AE, Gonçalves LA, Epiphanio S, Sullivan D, Roy C, Newbold CI, Drakesmith H, Mota MM.

Nat Med. 2011 Jun;17(6):732-7. doi: 10.1038/nm.2368. Epub 2011 May 15.

48.

Plasmodium falciparum infected erythrocytes induce hepcidin (HAMP) mRNA synthesis by peripheral blood mononuclear cells.

Armitage AE, Pinches R, Eddowes LA, Newbold CI, Drakesmith H.

Br J Haematol. 2009 Dec;147(5):769-71. doi: 10.1111/j.1365-2141.2009.07880.x. Epub 2009 Aug 31. No abstract available.

PMID:
19747361
49.

In vitro binding of HFE to the cation-independent mannose-6 phosphate receptor.

Schimanski LM, Drakesmith H, Sweetland E, Bastin J, Rezgui D, Edelmann M, Kessler B, Merryweather-Clarke AT, Robson KJ, Townsend AR.

Blood Cells Mol Dis. 2009 Sep-Oct;43(2):180-93. doi: 10.1016/j.bcmd.2009.03.010. Epub 2009 May 31.

PMID:
19487139
50.

Reflecting on a quarter century of HIV research.

Armitage AE, McMichael AJ, Drakesmith H.

Nat Immunol. 2008 Aug;9(8):823-6. doi: 10.1038/ni0808-823. No abstract available.

PMID:
18645585

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