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Pathologic Fibroblasts in Idiopathic Subglottic Stenosis Amplify Local Inflammatory Signals.

Morrison RJ, Katsantonis NG, Motz KM, Hillel AT, Garrett CG, Netterville JL, Wootten CT, Majka SM, Blackwell TS, Drake WP, Gelbard A.

Otolaryngol Head Neck Surg. 2019 Jan;160(1):107-115. doi: 10.1177/0194599818803584. Epub 2018 Oct 16.


PD-1 up-regulation on CD4+ T cells promotes pulmonary fibrosis through STAT3-mediated IL-17A and TGF-β1 production.

Celada LJ, Kropski JA, Herazo-Maya JD, Luo W, Creecy A, Abad AT, Chioma OS, Lee G, Hassell NE, Shaginurova GI, Wang Y, Johnson JE, Kerrigan A, Mason WR, Baughman RP, Ayers GD, Bernard GR, Culver DA, Montgomery CG, Maher TM, Molyneaux PL, Noth I, Mutsaers SE, Prele CM, Peebles RS Jr, Newcomb DC, Kaminski N, Blackwell TS, Van Kaer L, Drake WP.

Sci Transl Med. 2018 Sep 26;10(460). pii: eaar8356. doi: 10.1126/scitranslmed.aar8356.


Local and Systemic CD4+ T Cell Exhaustion Reverses with Clinical Resolution of Pulmonary Sarcoidosis.

Hawkins C, Shaginurova G, Shelton DA, Herazo-Maya JD, Oswald-Richter KA, Rotsinger JE, Young A, Celada LJ, Kaminski N, Sevin C, Drake WP.

J Immunol Res. 2017;2017:3642832. doi: 10.1155/2017/3642832. Epub 2017 Nov 6.


Safety Analysis of Autologous Stem Cell Therapy in a Variety of Degenerative Diseases and Injuries Using the Stromal Vascular Fraction.

Comella K, Parlo M, Daly R, Depasquale V, Edgerton E, Mallory P, Schmidt R, Drake WP.

J Clin Med Res. 2017 Nov;9(11):935-942. doi: 10.14740/jocmr3187w. Epub 2017 Oct 2.


Role of Microbial Agents in Pulmonary Fibrosis

Chioma OS, Drake WP.

Yale J Biol Med. 2017 Jun 23;90(2):219-227. eCollection 2017 Jun. Review.


Idiopathic subglottic stenosis is associated with activation of the inflammatory IL-17A/IL-23 axis.

Gelbard A, Katsantonis NG, Mizuta M, Newcomb D, Rotsinger J, Rousseau B, Daniero JJ, Edell ES, Ekbom DC, Kasperbauer JL, Hillel AT, Yang L, Garrett CG, Netterville JL, Wootten CT, Francis DO, Stratton C, Jenkins K, McGregor TL, Gaddy JA, Blackwell TS, Drake WP.

Laryngoscope. 2016 Nov;126(11):E356-E361. doi: 10.1002/lary.26098. Epub 2016 Jun 14.


Programmed Death-1 Inhibition of Phosphatidylinositol 3-Kinase/AKT/Mechanistic Target of Rapamycin Signaling Impairs Sarcoidosis CD4+ T Cell Proliferation.

Celada LJ, Rotsinger JE, Young A, Shaginurova G, Shelton D, Hawkins C, Drake WP.

Am J Respir Cell Mol Biol. 2017 Jan;56(1):74-82. doi: 10.1165/rcmb.2016-0037OC.


Molecular analysis of idiopathic subglottic stenosis for Mycobacterium species.

Gelbard A, Katsantonis NG, Mizuta M, Newcomb D, Rotsinger J, Rousseau B, Daniero JJ, Edell ES, Ekbom DC, Kasperbauer JL, Hillel AT, Yang L, Garrett CG, Netterville JL, Wootten CT, Francis DO, Stratton C, Jenkins K, McGregor TL, Gaddy JA, Blackwell TS, Drake WP.

Laryngoscope. 2017 Jan;127(1):179-185. doi: 10.1002/lary.26097. Epub 2016 Jun 14.


Molecular Analysis of Sarcoidosis Granulomas Reveals Antimicrobial Targets.

Rotsinger JE, Celada LJ, Polosukhin VV, Atkinson JB, Drake WP.

Am J Respir Cell Mol Biol. 2016 Jul;55(1):128-34. doi: 10.1165/rcmb.2015-0212OC.


The Etiologic Role of Infectious Antigens in Sarcoidosis Pathogenesis.

Celada LJ, Hawkins C, Drake WP.

Clin Chest Med. 2015 Dec;36(4):561-8. doi: 10.1016/j.ccm.2015.08.001. Epub 2015 Sep 19. Review.


Solving the Conundrum: Immunogenetics of Sarcoidosis.

Kaminski N, Drake WP.

Am J Respir Crit Care Med. 2015 Sep 15;192(6):652-4. doi: 10.1164/rccm.201506-1235ED. No abstract available.


Resolution of chronic ocular sarcoidosis with antimycobacterial therapy.

Richmond BW, Richter K, King LE, Drake WP.

Case Rep Intern Med. 2014;1(2). pii: 5042.


Targeting CD4(+) T cells for the treatment of sarcoidosis: a promising strategy?

Celada LJ, Drake WP.

Immunotherapy. 2015;7(1):57-66. doi: 10.2217/imt.14.103. Review.


Association of HLA-DRB1 with Sarcoidosis Susceptibility and Progression in African Americans.

Levin AM, Adrianto I, Datta I, Iannuzzi MC, Trudeau S, Li J, Drake WP, Montgomery CG, Rybicki BA.

Am J Respir Cell Mol Biol. 2015 Aug;53(2):206-16. doi: 10.1165/rcmb.2014-0227OC.


A pilot study of the noninvasive assessment of the lung microbiota as a potential tool for the early diagnosis of ventilator-associated pneumonia.

May AK, Brady JS, Romano-Keeler J, Drake WP, Norris PR, Jenkins JM, Isaacs RJ, Boczko EM.

Chest. 2015 Jun;147(6):1494-1502. doi: 10.1378/chest.14-1687.


Blockade of the programmed death-1 pathway restores sarcoidosis CD4(+) T-cell proliferative capacity.

Braun NA, Celada LJ, Herazo-Maya JD, Abraham S, Shaginurova G, Sevin CM, Grutters J, Culver DA, Dworski R, Sheller J, Massion PP, Polosukhin VV, Johnson JE, Kaminski N, Wilkes DS, Oswald-Richter KA, Drake WP.

Am J Respir Crit Care Med. 2014 Sep 1;190(5):560-71. doi: 10.1164/rccm.201401-0188OC.


Effects of broad-spectrum antimycobacterial therapy on chronic pulmonary sarcoidosis.

Drake WP, Richmond BW, Oswald-Richter K, Yu C, Isom JM, Worrell JA, Shipley GR.

Sarcoidosis Vasc Diffuse Lung Dis. 2013 Nov 25;30(3):201-11.


Oral antimycobacterial therapy in chronic cutaneous sarcoidosis: a randomized, single-masked, placebo-controlled study.

Drake WP, Oswald-Richter K, Richmond BW, Isom J, Burke VE, Algood H, Braun N, Taylor T, Pandit KV, Aboud C, Yu C, Kaminski N, Boyd AS, King LE.

JAMA Dermatol. 2013 Sep;149(9):1040-9. doi: 10.1001/jamadermatol.2013.4646.


Reversal of global CD4+ subset dysfunction is associated with spontaneous clinical resolution of pulmonary sarcoidosis.

Oswald-Richter KA, Richmond BW, Braun NA, Isom J, Abraham S, Taylor TR, Drake JM, Culver DA, Wilkes DS, Drake WP.

J Immunol. 2013 Jun 1;190(11):5446-53. doi: 10.4049/jimmunol.1202891. Epub 2013 Apr 29.


Sarcoidosis Th17 cells are ESAT-6 antigen specific but demonstrate reduced IFN-γ expression.

Richmond BW, Ploetze K, Isom J, Chambers-Harris I, Braun NA, Taylor T, Abraham S, Mageto Y, Culver DA, Oswald-Richter KA, Drake WP.

J Clin Immunol. 2013 Feb;33(2):446-55. doi: 10.1007/s10875-012-9817-6. Epub 2012 Oct 18.


Dual analysis for mycobacteria and propionibacteria in sarcoidosis BAL.

Oswald-Richter KA, Beachboard DC, Seeley EH, Abraham S, Shepherd BE, Jenkins CA, Culver DA, Caprioli RM, Drake WP.

J Clin Immunol. 2012 Oct;32(5):1129-40. doi: 10.1007/s10875-012-9700-5. Epub 2012 May 3.


Where next for gene expression profiling? So much promise.

Noth I, Gibson KF, Drake WP.

Am J Respir Crit Care Med. 2011 Nov 15;184(10):1102-3. doi: 10.1164/rccm.201109-1612ED. No abstract available.


Enzyme-linked immunospot assay (ELISPOT): Quantification of Th-1 cellular immune responses against microbial antigens.

Chambers IR, Cone TR, Oswald-Richter K, Drake WP.

J Vis Exp. 2010 Nov 23;(45). pii: 2221. doi: 10.3791/2221.


The etiologic role of infectious antigens in sarcoidosis pathogenesis.

Oswald-Richter KA, Drake WP.

Semin Respir Crit Care Med. 2010 Aug;31(4):375-9. doi: 10.1055/s-0030-1262205. Epub 2010 Jul 27.


Vitamin D, innate immunity, and sarcoidosis granulomatous inflammation: insights from mycobacterial research.

Richmond BW, Drake WP.

Curr Opin Pulm Med. 2010 Sep;16(5):461-4. doi: 10.1097/MCP.0b013e32833af7e8. Review.


Development of a sarcoidosis murine lung granuloma model using Mycobacterium superoxide dismutase A peptide.

Swaisgood CM, Oswald-Richter K, Moeller SD, Klemenc JM, Ruple LM, Farver CF, Drake JM, Culver DA, Drake WP.

Am J Respir Cell Mol Biol. 2011 Feb;44(2):166-74. doi: 10.1165/rcmb.2009-0350OC. Epub 2010 Mar 26.


Cellular responses to mycobacterial antigens are present in bronchoalveolar lavage fluid used in the diagnosis of sarcoidosis.

Oswald-Richter KA, Culver DA, Hawkins C, Hajizadeh R, Abraham S, Shepherd BE, Jenkins CA, Judson MA, Drake WP.

Infect Immun. 2009 Sep;77(9):3740-8. doi: 10.1128/IAI.00142-09. Epub 2009 Jul 13.


Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101.

Oswald-Richter K, Sato H, Hajizadeh R, Shepherd BE, Sidney J, Sette A, Newman LS, Drake WP.

J Clin Immunol. 2010 Jan;30(1):157-66. doi: 10.1007/s10875-009-9311-y. Epub 2009 Jun 18.


When a commensal becomes a pathogen.

Drake WP.

Sarcoidosis Vasc Diffuse Lung Dis. 2008 Sep;25(1):10-1. No abstract available.


Superoxide dismutase A antigens derived from molecular analysis of sarcoidosis granulomas elicit systemic Th-1 immune responses.

Allen SS, Evans W, Carlisle J, Hajizadeh R, Nadaf M, Shepherd BE, Pride DT, Johnson JE, Drake WP.

Respir Res. 2008 Apr 25;9:36. doi: 10.1186/1465-9921-9-36.


Mycobacterium tuberculosis Antigen 85A induces Th-1 immune responses in systemic sarcoidosis.

Hajizadeh R, Sato H, Carlisle J, Nadaf MT, Evans W, Shepherd BE, Miller RF, Kalams SA, Drake WP.

J Clin Immunol. 2007 Jul;27(4):445-54. Epub 2007 Mar 15.


Cellular recognition of Mycobacterium tuberculosis ESAT-6 and KatG peptides in systemic sarcoidosis.

Drake WP, Dhason MS, Nadaf M, Shepherd BE, Vadivelu S, Hajizadeh R, Newman LS, Kalams SA.

Infect Immun. 2007 Jan;75(1):527-30. Epub 2006 Nov 6.


Mycobacterial antigens may be important in sarcoidosis pathogenesis.

Drake WP, Newman LS.

Curr Opin Pulm Med. 2006 Sep;12(5):359-63. Review.


Molecular analysis of sarcoidosis tissues for mycobacterium species DNA.

Drake WP, Pei Z, Pride DT, Collins RD, Cover TL, Blaser MJ.

Emerg Infect Dis. 2002 Nov;8(11):1334-41.


Alteration of cellular ribonucleases associated with murine oncogenic virus infection.

Drake WP, Frazier LM, Sidle D, Mardiney MR Jr.

Biomedicine. 1978 Jan-Feb;28(1):24-8.


Application of laser cytometry to the analysis of immunologically induced in vitro lymphocyte responsiveness.

Ruckdeschel JC, Doukas JG, Drake WP, Mardiney MR Jr.

Transplantation. 1977 May;23(5):396-403.


A proper sequence for the treatment of B16 melanoma: chemotherapy, surgery, and immunotherapy.

Pendergrast WJ Jr, Drake WP, Mardiney MR Jr.

J Natl Cancer Inst. 1976 Sep;57(3):539-44.


The age-dependent efficacy of polyadenylic-polyuridylic acid therapy upon the development of spontaneous leukemia in AKR mice.

Drake WP, Pendergrast WJ Jr, Kramer RE, Mardiney MR Jr.

Cancer Res. 1976 Mar;36(3):1172-5.


The kinetics of the interaction of heterologous anti-tumor serum and heterologous complement in non-tumor bearing mice.

Drake WP, Roberts GC, Pendergrast WJ, Mardiney MR Jr.

Biomedicine. 1975 Nov;22(6):502-8.


The dependence of successful immunotherapy on adequate tumor burden as shown by the treatment of AKR leukemia with poly A-poly U.

Pendergrast WJ Jr, Drake WP, Mardiney MR Jr.

J Natl Cancer Inst. 1975 Nov;55(5):1223-5.


Abnormal profile of human nucleolytic activity as a test for cancer.

Drake WP, Schmukler M, Pendergrast WJ Jr, Davis AS, Lichtenfeld JL, Mardiney MR Jr.

J Natl Cancer Inst. 1975 Nov;55(5):1055-9.


Enhancement of spontaneous C3H/HeJ mammary tumorigenesis by long-term polyadenylic-polyuridylic acid therapy.

Drake WP, Pendergrast WJ Jr, Kramer RE, Mardiney MR Jr.

Cancer Res. 1975 Nov;35(11 Pt 1):3051-3.


A white blood cell RNase assay for the possible monitoring of malignancy.

Drake WP, Pokorney DR, Ruckdeschel JC, Levy CC, Mardiney MR Jr.

J Natl Cancer Inst. 1975 Jun;54(6):1475-8.


Elevated ribonuclease activity in the thymus and white blood cells of genetically cancer prone mice.

Drake WP, Pokorney DR, Chipman S, Levy CC, Mardiney MR Jr.

J Exp Med. 1975 Apr 1;141(4):918-23.


Complement-mediated alteration of antibody specificity in vivo.

Drake WP, Mardiney MR Jr.

J Immunol. 1975 Mar;114(3):1052-7.


Alterations in ribonuclease activities in the plasma, spleen, and thymus of tumor-bearing mice.

Drake WP, Kopyta LP, Levy CC, Mardiney MR Jr.

Cancer Res. 1975 Feb;35(2):322-4.


In vivo abrogation of serum C3 and C5 by administration of cobra venom factor and heterologous anti-C3.

Drake WP, Pokorney DR, Mardiney MR Jr.

J Immunol Methods. 1974 Dec;6(1-2):61-72. No abstract available.


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