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Antibody-Drug Conjugates Targeting the Urokinase Receptor (uPAR) as a Possible Treatment of Aggressive Breast Cancer.

Harel ET, Drake PM, Barfield RM, Lui I, Farr-Jones S, Van't Veer L, Gartner ZJ, Green EM, Lourenço AL, Cheng Y, Hann BC, Rabuka D, Craik CS.

Antibodies (Basel). 2019 Nov 5;8(4). pii: E54. doi: 10.3390/antib8040054.


An overlooked placode: Recharacterizing the papillae in the embryonic eye of reptilia.

Drake PM, Jourdeuil K, Franz-Odendaal TA.

Dev Dyn. 2019 Oct 30. doi: 10.1002/dvdy.128. [Epub ahead of print]


A Case Study to Identify the Drug Conjugation Site of a Site-Specific Antibody-Drug-Conjugate Using Middle-Down Mass Spectrometry.

Hernandez-Alba O, Houel S, Hessmann S, Erb S, Rabuka D, Huguet R, Josephs J, Beck A, Drake PM, Cianférani S.

J Am Soc Mass Spectrom. 2019 Nov;30(11):2419-2429. doi: 10.1007/s13361-019-02296-2. Epub 2019 Aug 19.


Maytansine-bearing antibody-drug conjugates induce in vitro hallmarks of immunogenic cell death selectively in antigen-positive target cells.

Bauzon M, Drake PM, Barfield RM, Cornali BM, Rupniewski I, Rabuka D.

Oncoimmunology. 2019 Jan 22;8(4):e1565859. doi: 10.1080/2162402X.2019.1565859. eCollection 2019.


Antibody-drug conjugate library prepared by scanning insertion of the aldehyde tag into IgG1 constant regions.

Huang BCB, Kim YC, Bañas S, Barfield RM, Drake PM, Rupniewski I, Haskins WE, Rabuka D.

MAbs. 2018 Nov-Dec;10(8):1182-1189. doi: 10.1080/19420862.2018.1512327. Epub 2018 Sep 25.


A Potential Role for MMPs during the Formation of Non-Neurogenic Placodes.

Drake PM, Franz-Odendaal TA.

J Dev Biol. 2018 Jul 26;6(3). pii: E20. doi: 10.3390/jdb6030020. Review.


CAT-02-106, a Site-Specifically Conjugated Anti-CD22 Antibody Bearing an MDR1-Resistant Maytansine Payload Yields Excellent Efficacy and Safety in Preclinical Models.

Drake PM, Carlson A, McFarland JM, Bañas S, Barfield RM, Zmolek W, Kim YC, Huang BCB, Kudirka R, Rabuka D.

Mol Cancer Ther. 2018 Jan;17(1):161-168. doi: 10.1158/1535-7163.MCT-17-0776. Epub 2017 Nov 15.


Recent Developments in ADC Technology: Preclinical Studies Signal Future Clinical Trends.

Drake PM, Rabuka D.

BioDrugs. 2017 Dec;31(6):521-531. doi: 10.1007/s40259-017-0254-1. Review.


Murine IL-4Δ2 splice variant down-regulates IL-4 activities independently of IL-4Rα binding and STAT-6 phosphorylation.

Diogo GR, Sparrow A, Paul MJ, Copland A, Hart PJ, Stelter S, van Dolleweerd C, Drake PMW, Macallan DC, Reljic R.

Cytokine. 2017 Nov;99:154-162. doi: 10.1016/j.cyto.2017.09.007. Epub 2017 Sep 13.


Insights from native mass spectrometry approaches for top- and middle- level characterization of site-specific antibody-drug conjugates.

Botzanowski T, Erb S, Hernandez-Alba O, Ehkirch A, Colas O, Wagner-Rousset E, Rabuka D, Beck A, Drake PM, Cianférani S.

MAbs. 2017 Jul;9(5):801-811. doi: 10.1080/19420862.2017.1316914. Epub 2017 Apr 13.


Site-Specific Tandem Knoevenagel Condensation-Michael Addition To Generate Antibody-Drug Conjugates.

Kudirka RA, Barfield RM, McFarland JM, Drake PM, Carlson A, Bañas S, Zmolek W, Garofalo AW, Rabuka D.

ACS Med Chem Lett. 2016 Aug 30;7(11):994-998. eCollection 2016 Nov 10.


A simple LC/MRM-MS-based method to quantify free linker-payload in antibody-drug conjugate preparations.

Zmolek W, Bañas S, Barfield RM, Rabuka D, Drake PM.

J Chromatogr B Analyt Technol Biomed Life Sci. 2016 Oct 1;1032:144-148. doi: 10.1016/j.jchromb.2016.05.055. Epub 2016 Jun 1.


Recombinant biologic products versus nutraceuticals from plants - a regulatory choice?

Drake PM, Szeto TH, Paul MJ, Teh AY, Ma JK.

Br J Clin Pharmacol. 2017 Jan;83(1):82-87. doi: 10.1111/bcp.13041. Epub 2016 Jul 28. Review.


Generating aldehyde-tagged antibodies with high titers and high formylglycine yields by supplementing culture media with copper(II).

York D, Baker J, Holder PG, Jones LC, Drake PM, Barfield RM, Bleck GT, Rabuka D.

BMC Biotechnol. 2016 Feb 24;16:23. doi: 10.1186/s12896-016-0254-0.


Rhizosecretion improves the production of Cyanovirin-N in Nicotiana tabacum through simplified downstream processing.

Madeira LM, Szeto TH, Ma JK, Drake PMW.

Biotechnol J. 2016 Jul;11(7):910-919. doi: 10.1002/biot.201500371. Epub 2016 Mar 9.


An emerging playbook for antibody-drug conjugates: lessons from the laboratory and clinic suggest a strategy for improving efficacy and safety.

Drake PM, Rabuka D.

Curr Opin Chem Biol. 2015 Oct;28:174-80. doi: 10.1016/j.cbpa.2015.08.005. Epub 2015 Sep 2. Review.


High-yield production of a human monoclonal IgG by rhizosecretion in hydroponic tobacco cultures.

Madeira LM, Szeto TH, Henquet M, Raven N, Runions J, Huddleston J, Garrard I, Drake PM, Ma JK.

Plant Biotechnol J. 2016 Feb;14(2):615-24. doi: 10.1111/pbi.12407. Epub 2015 Jun 3.


Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion.

Holder PG, Jones LC, Drake PM, Barfield RM, Bañas S, de Hart GW, Baker J, Rabuka D.

J Biol Chem. 2015 Jun 19;290(25):15730-45. doi: 10.1074/jbc.M115.652669. Epub 2015 Apr 30.


Generating site-specifically modified proteins via a versatile and stable nucleophilic carbon ligation.

Kudirka R, Barfield RM, McFarland J, Albers AE, de Hart GW, Drake PM, Holder PG, Banas S, Jones LC, Garofalo AW, Rabuka D.

Chem Biol. 2015 Feb 19;22(2):293-8. doi: 10.1016/j.chembiol.2014.11.019. Epub 2015 Jan 22.


A Randomized-Controlled Trial of the Effects of Online Training on Implementation Fidelity.

Drake PM, Firpo-Triplett R, Glassman JR, Ong SL, Unti L.

Am J Sex Educ. 2015;10(4):351-376. Epub 2015 Dec 11. No abstract available.


Characterization of a plant-produced recombinant human secretory IgA with broad neutralizing activity against HIV.

Paul M, Reljic R, Klein K, Drake PM, van Dolleweerd C, Pabst M, Windwarder M, Arcalis E, Stoger E, Altmann F, Cosgrove C, Bartolf A, Baden S, Ma JK.

MAbs. 2014;6(6):1585-97. doi: 10.4161/mabs.36336.


Urine, peritoneal fluid and omental fat proteomes of reproductive age women: Endometriosis-related changes and associations with endocrine disrupting chemicals.

Williams KE, Miroshnychenko O, Johansen EB, Niles RK, Sundaram R, Kannan K, Albertolle M, Zhou Y, Prasad N, Drake PM, Giudice LC, Hall SC, Witkowska HE, Buck Louis GM, Fisher SJ.

J Proteomics. 2015 Jan 15;113:194-205. doi: 10.1016/j.jprot.2014.09.015. Epub 2014 Oct 13.


Exploring the effects of linker composition on site-specifically modified antibody-drug conjugates.

Albers AE, Garofalo AW, Drake PM, Kudirka R, de Hart GW, Barfield RM, Baker J, Banas S, Rabuka D.

Eur J Med Chem. 2014 Dec 17;88:3-9. doi: 10.1016/j.ejmech.2014.08.062. Epub 2014 Aug 23.


Exploring the world of human development and reproduction.

Red-Horse K, Drake PM, Fisher S.

Int J Dev Biol. 2014;58(2-4):87-93. doi: 10.1387/ijdb.140063kr.


Aldehyde tag coupled with HIPS chemistry enables the production of ADCs conjugated site-specifically to different antibody regions with distinct in vivo efficacy and PK outcomes.

Drake PM, Albers AE, Baker J, Banas S, Barfield RM, Bhat AS, de Hart GW, Garofalo AW, Holder P, Jones LC, Kudirka R, McFarland J, Zmolek W, Rabuka D.

Bioconjug Chem. 2014 Jul 16;25(7):1331-41. doi: 10.1021/bc500189z. Epub 2014 Jun 23.


Variation and quantification among a target set of phosphopeptides in human plasma by multiple reaction monitoring and SWATH-MS2 data-independent acquisition.

Zawadzka AM, Schilling B, Held JM, Sahu AK, Cusack MP, Drake PM, Fisher SJ, Gibson BW.

Electrophoresis. 2014 Dec;35(24):3487-97. doi: 10.1002/elps.201400167. Epub 2014 Jul 10.


Plant-derived recombinant immune complexes as self-adjuvanting TB immunogens for mucosal boosting of BCG.

Pepponi I, Diogo GR, Stylianou E, van Dolleweerd CJ, Drake PM, Paul MJ, Sibley L, Ma JK, Reljic R.

Plant Biotechnol J. 2014 Sep;12(7):840-50. doi: 10.1111/pbi.12185. Epub 2014 Mar 13.


Reversal of gene dysregulation in cultured cytotrophoblasts reveals possible causes of preeclampsia.

Zhou Y, Gormley MJ, Hunkapiller NM, Kapidzic M, Stolyarov Y, Feng V, Nishida M, Drake PM, Bianco K, Wang F, McMaster MT, Fisher SJ.

J Clin Invest. 2013 Jul;123(7):2862-72. doi: 10.1172/JCI66966. Epub 2013 Jun 24. Erratum in: J Clin Invest. 2013 Oct 1;123(10):4541.


Transformation of Althaea officinalis L. by Agrobacterium rhizogenes for the production of transgenic roots expressing the anti-HIV microbicide cyanovirin-N.

Drake PM, de Moraes Madeira L, Szeto TH, Ma JK.

Transgenic Res. 2013 Dec;22(6):1225-9. doi: 10.1007/s11248-013-9730-7. Epub 2013 Jul 13.


Hydrazino-Pictet-Spengler ligation as a biocompatible method for the generation of stable protein conjugates.

Agarwal P, Kudirka R, Albers AE, Barfield RM, de Hart GW, Drake PM, Jones LC, Rabuka D.

Bioconjug Chem. 2013 Jun 19;24(6):846-51. doi: 10.1021/bc400042a. Epub 2013 Jun 3.


Immune-complex mimics as a molecular platform for adjuvant-free vaccine delivery.

Pepponi I, Stylianou E, van Dolleweerd C, Diogo GR, Paul MJ, Drake PM, Ma JK, Reljic R.

PLoS One. 2013 Apr 23;8(4):e60855. doi: 10.1371/journal.pone.0060855. Print 2013.


Polysialic acid enhances the migration and invasion of human cytotrophoblasts.

Hromatka BS, Drake PM, Kapidzic M, Stolp H, Goldfien GA, Shih IeM, Fisher SJ.

Glycobiology. 2013 May;23(5):593-602. doi: 10.1093/glycob/cws162. Epub 2012 Dec 3.


Lectin chromatography/mass spectrometry discovery workflow identifies putative biomarkers of aggressive breast cancers.

Drake PM, Schilling B, Niles RK, Prakobphol A, Li B, Jung K, Cho W, Braten M, Inerowicz HD, Williams K, Albertolle M, Held JM, Iacovides D, Sorensen DJ, Griffith OL, Johansen E, Zawadzka AM, Cusack MP, Allen S, Gormley M, Hall SC, Witkowska HE, Gray JW, Regnier F, Gibson BW, Fisher SJ.

J Proteome Res. 2012 Apr 6;11(4):2508-20. doi: 10.1021/pr201206w. Epub 2012 Mar 13.


Antibody degradation in tobacco plants: a predominantly apoplastic process.

Hehle VK, Paul MJ, Drake PM, Ma JK, van Dolleweerd CJ.

BMC Biotechnol. 2011 Dec 30;11:128. doi: 10.1186/1472-6750-11-128.


Molecular Pharming: future targets and aspirations.

Paul M, van Dolleweerd C, Drake PM, Reljic R, Thangaraj H, Barbi T, Stylianou E, Pepponi I, Both L, Hehle V, Madeira L, Inchakalody V, Ho S, Guerra T, Ma JK.

Hum Vaccin. 2011 Mar;7(3):375-82. Epub 2011 Mar 1. Review.


Expression and plasma membrane localization of the mammalian B-cell receptor complex in transgenic Nicotiana tabacum.

Barbi T, Irons SL, Pepponi I, Hawes C, Ma JK, Drake PM.

Plant Biotechnol J. 2011 May;9(4):455-65. doi: 10.1111/j.1467-7652.2010.00566.x. Epub 2010 Sep 22.


A lectin affinity workflow targeting glycosite-specific, cancer-related carbohydrate structures in trypsin-digested human plasma.

Drake PM, Schilling B, Niles RK, Braten M, Johansen E, Liu H, Lerch M, Sorensen DJ, Li B, Allen S, Hall SC, Witkowska HE, Regnier FE, Gibson BW, Fisher SJ.

Anal Biochem. 2011 Jan 1;408(1):71-85. doi: 10.1016/j.ab.2010.08.010. Epub 2010 Aug 10.


Generation of transgenic plants expressing plasma membrane-bound antibodies to the environmental pollutant microcystin-LR.

Barbi T, Drake PM, Drever M, van Dolleweerd CJ, Porter AR, Ma JK.

Transgenic Res. 2011 Jun;20(3):701-7. doi: 10.1007/s11248-010-9431-4. Epub 2010 Jul 30.


Molecular farming, patents and access to medicines.

Drake PM, Thangaraj H.

Expert Rev Vaccines. 2010 Aug;9(8):811-9. doi: 10.1586/erv.10.72. Review.


Sweetening the pot: adding glycosylation to the biomarker discovery equation.

Drake PM, Cho W, Li B, Prakobphol A, Johansen E, Anderson NL, Regnier FE, Gibson BW, Fisher SJ.

Clin Chem. 2010 Feb;56(2):223-36. doi: 10.1373/clinchem.2009.136333. Epub 2009 Dec 3. Review.


Generation of transgenic plants expressing antibodies to the environmental pollutant microcystin-LR.

Drake PM, Barbi T, Drever MR, van Dolleweerd CJ, Porter AJ, Ma JK.

FASEB J. 2010 Mar;24(3):882-90. doi: 10.1096/fj.09-140848. Epub 2009 Oct 19.


A lectin HPLC method to enrich selectively-glycosylated peptides from complex biological samples.

Johansen E, Schilling B, Lerch M, Niles RK, Liu H, Li B, Allen S, Hall SC, Witkowska HE, Regnier FE, Gibson BW, Fisher SJ, Drake PM.

J Vis Exp. 2009 Oct 1;(32). pii: 1398. doi: 10.3791/1398.


Optimisation of contained Nicotiana tabacum cultivation for the production of recombinant protein pharmaceuticals.

Colgan R, Atkinson CJ, Paul M, Hassan S, Drake PM, Sexton AL, Santa-Cruz S, James D, Hamp K, Gutteridge C, Ma JK.

Transgenic Res. 2010 Apr;19(2):241-56. doi: 10.1007/s11248-009-9303-y. Epub 2009 Jul 9.


Polysialic acid governs T-cell development by regulating progenitor access to the thymus.

Drake PM, Stock CM, Nathan JK, Gip P, Golden KP, Weinhold B, Gerardy-Schahn R, Bertozzi CR.

Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):11995-2000. doi: 10.1073/pnas.0905188106. Epub 2009 Jul 8.


IDPicker 2.0: Improved protein assembly with high discrimination peptide identification filtering.

Ma ZQ, Dasari S, Chambers MC, Litton MD, Sobecki SM, Zimmerman LJ, Halvey PJ, Schilling B, Drake PM, Gibson BW, Tabb DL.

J Proteome Res. 2009 Aug;8(8):3872-81. doi: 10.1021/pr900360j.


Development of rhizosecretion as a production system for recombinant proteins from hydroponic cultivated tobacco.

Drake PM, Barbi T, Sexton A, McGowan E, Stadlmann J, Navarre C, Paul MJ, Ma JK.

FASEB J. 2009 Oct;23(10):3581-9. doi: 10.1096/fj.09-131771. Epub 2009 May 26.


Polysialic acid, a glycan with highly restricted expression, is found on human and murine leukocytes and modulates immune responses.

Drake PM, Nathan JK, Stock CM, Chang PV, Muench MO, Nakata D, Reader JR, Gip P, Golden KP, Weinhold B, Gerardy-Schahn R, Troy FA 2nd, Bertozzi CR.

J Immunol. 2008 Nov 15;181(10):6850-8.


Genetically modified plants and human health.

Key S, Ma JK, Drake PM.

J R Soc Med. 2008 Jun;101(6):290-8. doi: 10.1258/jrsm.2008.070372. Review.


HIV-1 p24-immunoglobulin fusion molecule: a new strategy for plant-based protein production.

Obregon P, Chargelegue D, Drake PM, Prada A, Nuttall J, Frigerio L, Ma JK.

Plant Biotechnol J. 2006 Mar;4(2):195-207.


Transgenic plant production of Cyanovirin-N, an HIV microbicide.

Sexton A, Drake PM, Mahmood N, Harman SJ, Shattock RJ, Ma JK.

FASEB J. 2006 Feb;20(2):356-8. Epub 2005 Dec 14.


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