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Items: 1 to 50 of 251

1.

Porphyromonas gingivalis in Alzheimer's disease brains: Evidence for disease causation and treatment with small-molecule inhibitors.

Dominy SS, Lynch C, Ermini F, Benedyk M, Marczyk A, Konradi A, Nguyen M, Haditsch U, Raha D, Griffin C, Holsinger LJ, Arastu-Kapur S, Kaba S, Lee A, Ryder MI, Potempa B, Mydel P, Hellvard A, Adamowicz K, Hasturk H, Walker GD, Reynolds EC, Faull RLM, Curtis MA, Dragunow M, Potempa J.

Sci Adv. 2019 Jan 23;5(1):eaau3333. doi: 10.1126/sciadv.aau3333. eCollection 2019 Jan.

2.

Cerebellar degeneration correlates with motor symptoms in Huntington disease.

Singh-Bains MK, Mehrabi NF, Sehji T, Austria MDR, Tan AYS, Tippett LJ, Dragunow M, Waldvogel HJ, Faull RLM.

Ann Neurol. 2019 Jan 11. doi: 10.1002/ana.25413. [Epub ahead of print]

PMID:
30635944
3.

PU.1 regulates Alzheimer's disease-associated genes in primary human microglia.

Rustenhoven J, Smith AM, Smyth LC, Jansson D, Scotter EL, Swanson MEV, Aalderink M, Coppieters N, Narayan P, Handley R, Overall C, Park TIH, Schweder P, Heppner P, Curtis MA, Faull RLM, Dragunow M.

Mol Neurodegener. 2018 Aug 20;13(1):44. doi: 10.1186/s13024-018-0277-1.

4.

Markers for human brain pericytes and smooth muscle cells.

Smyth LCD, Rustenhoven J, Scotter EL, Schweder P, Faull RLM, Park TIH, Dragunow M.

J Chem Neuroanat. 2018 Oct;92:48-60. doi: 10.1016/j.jchemneu.2018.06.001. Epub 2018 Jun 7.

PMID:
29885791
5.

Unique and shared inflammatory profiles of human brain endothelia and pericytes.

Smyth LCD, Rustenhoven J, Park TI, Schweder P, Jansson D, Heppner PA, O'Carroll SJ, Mee EW, Faull RLM, Curtis M, Dragunow M.

J Neuroinflammation. 2018 May 11;15(1):138. doi: 10.1186/s12974-018-1167-8.

6.

Modelling physiological and pathological conditions to study pericyte biology in brain function and dysfunction.

Rustenhoven J, Smyth LC, Jansson D, Schweder P, Aalderink M, Scotter EL, Mee EW, Faull RLM, Park TI, Dragunow M.

BMC Neurosci. 2018 Feb 22;19(1):6. doi: 10.1186/s12868-018-0405-4.

7.

Motor neuron disease mortality rates in New Zealand 1992-2013.

Cao MC, Chancellor A, Charleston A, Dragunow M, Scotter EL.

Amyotroph Lateral Scler Frontotemporal Degener. 2018 May;19(3-4):285-293. doi: 10.1080/21678421.2018.1432660. Epub 2018 Jan 30.

PMID:
29382218
8.

Alzheimer's Disease and Histone Code Alterations.

Narayan P, Dragunow M.

Adv Exp Med Biol. 2017;978:321-336. doi: 10.1007/978-3-319-53889-1_17. Review.

PMID:
28523554
9.

Insulin promotes cell migration by regulating PSA-NCAM.

Monzo HJ, Coppieters N, Park TIH, Dieriks BV, Faull RLM, Dragunow M, Curtis MA.

Exp Cell Res. 2017 Jun 1;355(1):26-39. doi: 10.1016/j.yexcr.2017.03.029. Epub 2017 Mar 21.

PMID:
28341445
10.

α-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain pericytes from Parkinson's disease patients.

Dieriks BV, Park TI, Fourie C, Faull RL, Dragunow M, Curtis MA.

Sci Rep. 2017 Feb 23;7:42984. doi: 10.1038/srep42984.

11.

Brain Pericytes As Mediators of Neuroinflammation.

Rustenhoven J, Jansson D, Smyth LC, Dragunow M.

Trends Pharmacol Sci. 2017 Mar;38(3):291-304. doi: 10.1016/j.tips.2016.12.001. Epub 2016 Dec 22. Review.

PMID:
28017362
12.

Complement peptide C3a stimulates neural plasticity after experimental brain ischaemia.

Stokowska A, Atkins AL, Morán J, Pekny T, Bulmer L, Pascoe MC, Barnum SR, Wetsel RA, Nilsson JA, Dragunow M, Pekna M.

Brain. 2017 Feb;140(2):353-369. doi: 10.1093/brain/aww314. Epub 2016 Dec 12.

PMID:
27956400
13.

Interferon-γ blocks signalling through PDGFRβ in human brain pericytes.

Jansson D, Scotter EL, Rustenhoven J, Coppieters N, Smyth LC, Oldfield RL, Bergin PS, Mee EW, Graham ES, Faull RL, Dragunow M.

J Neuroinflammation. 2016 Sep 21;13(1):249.

14.

C9ORF72 and UBQLN2 mutations are causes of amyotrophic lateral sclerosis in New Zealand: a genetic and pathologic study using banked human brain tissue.

Scotter EL, Smyth L, Bailey JAWT, Wong CH, de Majo M, Vance CA, Synek BJ, Turner C, Pereira J, Charleston A, Waldvogel HJ, Curtis MA, Dragunow M, Shaw CE, Smith BN, Faull RLM.

Neurobiol Aging. 2017 Jan;49:214.e1-214.e5. doi: 10.1016/j.neurobiolaging.2016.06.019. Epub 2016 Jul 5.

PMID:
27480424
15.

Metabolite mapping reveals severe widespread perturbation of multiple metabolic processes in Huntington's disease human brain.

Patassini S, Begley P, Xu J, Church SJ, Reid SJ, Kim EH, Curtis MA, Dragunow M, Waldvogel HJ, Snell RG, Unwin RD, Faull RL, Cooper GJ.

Biochim Biophys Acta. 2016 Sep;1862(9):1650-62. doi: 10.1016/j.bbadis.2016.06.002. Epub 2016 Jun 4.

16.

Cultured pericytes from human brain show phenotypic and functional differences associated with differential CD90 expression.

Park TI, Feisst V, Brooks AE, Rustenhoven J, Monzo HJ, Feng SX, Mee EW, Bergin PS, Oldfield R, Graham ES, Curtis MA, Faull RL, Dunbar PR, Dragunow M.

Sci Rep. 2016 May 24;6:26587. doi: 10.1038/srep26587.

17.

TGF-beta1 regulates human brain pericyte inflammatory processes involved in neurovasculature function.

Rustenhoven J, Aalderink M, Scotter EL, Oldfield RL, Bergin PS, Mee EW, Graham ES, Faull RL, Curtis MA, Park TI, Dragunow M.

J Neuroinflammation. 2016 Feb 11;13:37. doi: 10.1186/s12974-016-0503-0.

18.

Isolation of highly enriched primary human microglia for functional studies.

Rustenhoven J, Park TI, Schweder P, Scotter J, Correia J, Smith AM, Gibbons HM, Oldfield RL, Bergin PS, Mee EW, Faull RL, Curtis MA, Scott Graham E, Dragunow M.

Sci Rep. 2016 Jan 18;6:19371. doi: 10.1038/srep19371.

19.

Erratum to: Studying Human Brain Inflammation in Leptomeningeal and Choroid Plexus Explant Cultures.

Dragunow M, Feng S, Rustenhoven J, Curtis M, Faull R.

Neurochem Res. 2016 Apr;41(4):943. doi: 10.1007/s11064-015-1822-8. No abstract available.

PMID:
26755168
20.

Erratum to: A role for human brain pericytes in neuroinflammation.

Jansson D, Rustenhoven J, Feng S, Hurley D, Oldfield RL, Bergin PS, Mee EW, Faull RL, Dragunow M.

J Neuroinflammation. 2015 Nov 19;12:213. doi: 10.1186/s12974-015-0430-5. No abstract available.

21.

Identification of elevated urea as a severe, ubiquitous metabolic defect in the brain of patients with Huntington's disease.

Patassini S, Begley P, Reid SJ, Xu J, Church SJ, Curtis M, Dragunow M, Waldvogel HJ, Unwin RD, Snell RG, Faull RL, Cooper GJ.

Biochem Biophys Res Commun. 2015 Dec 4-11;468(1-2):161-6. doi: 10.1016/j.bbrc.2015.10.140. Epub 2015 Oct 30.

PMID:
26522227
22.

String Vessel Formation is Increased in the Brain of Parkinson Disease.

Yang P, Pavlovic D, Waldvogel H, Dragunow M, Synek B, Turner C, Faull R, Guan J.

J Parkinsons Dis. 2015;5(4):821-36. doi: 10.3233/JPD-140454.

PMID:
26444086
23.

Studying Human Brain Inflammation in Leptomeningeal and Choroid Plexus Explant Cultures.

Dragunow M, Feng S, Rustenhoven J, Curtis M, Faull R.

Neurochem Res. 2016 Mar;41(3):579-88. doi: 10.1007/s11064-015-1682-2. Epub 2015 Aug 5. Erratum in: Neurochem Res. 2016 Apr;41(4):943.

PMID:
26243439
24.

Glucocorticoid-Induced Preterm Birth and Neonatal Hyperglycemia Alter Ovine β-Cell Development.

Bansal A, Bloomfield FH, Connor KL, Dragunow M, Thorstensen EB, Oliver MH, Sloboda DM, Harding JE, Alsweiler JM.

Endocrinology. 2015 Oct;156(10):3763-76. doi: 10.1210/en.2015-1095. Epub 2015 Jul 23.

PMID:
26204462
25.

An anti-inflammatory role for C/EBPδ in human brain pericytes.

Rustenhoven J, Scotter EL, Jansson D, Kho DT, Oldfield RL, Bergin PS, Mee EW, Faull RL, Curtis MA, Graham SE, Park TI, Dragunow M.

Sci Rep. 2015 Jul 13;5:12132. doi: 10.1038/srep12132.

26.

Disrupted vasculature and blood-brain barrier in Huntington disease.

Waldvogel HJ, Dragunow M, Faull RL.

Ann Neurol. 2015 Aug;78(2):158-9. doi: 10.1002/ana.24445. Epub 2015 Jul 1. No abstract available.

PMID:
26018216
27.

Assessing fibrinogen extravasation into Alzheimer's disease brain using high-content screening of brain tissue microarrays.

Narayan PJ, Kim SL, Lill C, Feng S, Faull RL, Curtis MA, Dragunow M.

J Neurosci Methods. 2015 May 30;247:41-9. doi: 10.1016/j.jneumeth.2015.03.017. Epub 2015 Mar 23.

PMID:
25813427
28.

Hypothermic neuroprotection is associated with recovery of spectral edge frequency after asphyxia in preterm fetal sheep.

Wassink G, Barrett RD, Davidson JO, Bennet L, Galinsky R, Dragunow M, Gunn AJ.

Stroke. 2015 Feb;46(2):585-7. doi: 10.1161/STROKEAHA.114.008484. Epub 2015 Jan 13.

PMID:
25586829
29.

Increased acetyl and total histone levels in post-mortem Alzheimer's disease brain.

Narayan PJ, Lill C, Faull R, Curtis MA, Dragunow M.

Neurobiol Dis. 2015 Feb;74:281-94. doi: 10.1016/j.nbd.2014.11.023. Epub 2014 Dec 5.

PMID:
25484284
30.

Adenosine kinase, glutamine synthetase and EAAT2 as gene therapy targets for temporal lobe epilepsy.

Young D, Fong DM, Lawlor PA, Wu A, Mouravlev A, McRae M, Glass M, Dragunow M, During MJ.

Gene Ther. 2014 Dec;21(12):1029-40. doi: 10.1038/gt.2014.82. Epub 2014 Sep 18.

31.

A role for human brain pericytes in neuroinflammation.

Jansson D, Rustenhoven J, Feng S, Hurley D, Oldfield RL, Bergin PS, Mee EW, Faull RL, Dragunow M.

J Neuroinflammation. 2014 Jun 11;11:104. doi: 10.1186/1742-2094-11-104. Erratum in: J Neuroinflammation. 2015;12:213.

32.

Response to Watkins and Hutchinson.

Smith AM, Dragunow M.

Trends Neurosci. 2014 Apr;37(4):190. doi: 10.1016/j.tins.2014.02.005. Epub 2014 Mar 11. No abstract available.

PMID:
24630097
33.

The human side of microglia.

Smith AM, Dragunow M.

Trends Neurosci. 2014 Mar;37(3):125-35. doi: 10.1016/j.tins.2013.12.001. Epub 2014 Jan 2. Review.

PMID:
24388427
34.

Global changes in DNA methylation and hydroxymethylation in Alzheimer's disease human brain.

Coppieters N, Dieriks BV, Lill C, Faull RL, Curtis MA, Dragunow M.

Neurobiol Aging. 2014 Jun;35(6):1334-44. doi: 10.1016/j.neurobiolaging.2013.11.031. Epub 2013 Dec 4.

PMID:
24387984
35.

Adult human glia, pericytes and meningeal fibroblasts respond similarly to IFNy but not to TGFβ1 or M-CSF.

Smith AM, Graham ES, Feng SX, Oldfield RL, Bergin PM, Mee EW, Faull RL, Curtis MA, Dragunow M.

PLoS One. 2013 Dec 5;8(12):e80463. doi: 10.1371/journal.pone.0080463. eCollection 2013.

36.

M1 muscarinic receptor activation mediates cell death in M1-HEK293 cells.

Graham ES, Woo KK, Aalderink M, Fry S, Greenwood JM, Glass M, Dragunow M.

PLoS One. 2013 Sep 2;8(9):e72011. doi: 10.1371/journal.pone.0072011. eCollection 2013.

37.

Identifying neural progenitor cells in the adult human brain.

Park TI, Waldvogel HJ, Montgomery JM, Mee EW, Bergin PS, Faull RL, Dragunow M, Curtis MA.

Methods Mol Biol. 2013;1059:195-225. doi: 10.1007/978-1-62703-574-3_17.

PMID:
23934845
38.

M-CSF increases proliferation and phagocytosis while modulating receptor and transcription factor expression in adult human microglia.

Smith AM, Gibbons HM, Oldfield RL, Bergin PM, Mee EW, Curtis MA, Faull RL, Dragunow M.

J Neuroinflammation. 2013 Jul 17;10:85. doi: 10.1186/1742-2094-10-85.

39.

Insulin and IGF1 modulate turnover of polysialylated neural cell adhesion molecule (PSA-NCAM) in a process involving specific extracellular matrix components.

Monzo HJ, Park TI, Dieriks BV, Jansson D, Faull RL, Dragunow M, Curtis MA.

J Neurochem. 2013 Sep;126(6):758-70. doi: 10.1111/jnc.12363. Epub 2013 Aug 5.

40.

Isolation and culture of adult human microglia within mixed glial cultures for functional experimentation and high-content analysis.

Smith AM, Gibbons HM, Lill C, Faull RL, Dragunow M.

Methods Mol Biol. 2013;1041:41-51. doi: 10.1007/978-1-62703-520-0_6.

PMID:
23813368
41.

Receptor for complement peptide C3a: a therapeutic target for neonatal hypoxic-ischemic brain injury.

Järlestedt K, Rousset CI, Ståhlberg A, Sourkova H, Atkins AL, Thornton C, Barnum SR, Wetsel RA, Dragunow M, Pekny M, Mallard C, Hagberg H, Pekna M.

FASEB J. 2013 Sep;27(9):3797-804. doi: 10.1096/fj.13-230011. Epub 2013 Jun 4.

PMID:
23737250
42.

The cell injury device: a high-throughput platform for traumatic brain injury research.

Jowers CT, Taberner AJ, Dragunow M, Anderson IA.

J Neurosci Methods. 2013 Aug 15;218(1):1-8. doi: 10.1016/j.jneumeth.2013.04.020. Epub 2013 May 6.

PMID:
23660525
43.

The transcription factor PU.1 is critical for viability and function of human brain microglia.

Smith AM, Gibbons HM, Oldfield RL, Bergin PM, Mee EW, Faull RL, Dragunow M.

Glia. 2013 Jun;61(6):929-42. doi: 10.1002/glia.22486. Epub 2013 Mar 9.

PMID:
23483680
44.

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules.

Vance C, Scotter EL, Nishimura AL, Troakes C, Mitchell JC, Kathe C, Urwin H, Manser C, Miller CC, Hortobágyi T, Dragunow M, Rogelj B, Shaw CE.

Hum Mol Genet. 2013 Jul 1;22(13):2676-88. doi: 10.1093/hmg/ddt117. Epub 2013 Mar 7.

45.

Meningeal and choroid plexus cells--novel drug targets for CNS disorders.

Dragunow M.

Brain Res. 2013 Mar 21;1501:32-55. doi: 10.1016/j.brainres.2013.01.013. Epub 2013 Jan 14. Review.

PMID:
23328079
46.

Requirements for NADPH oxidase and myeloperoxidase in neutrophil extracellular trap formation differ depending on the stimulus.

Parker H, Dragunow M, Hampton MB, Kettle AJ, Winterbourn CC.

J Leukoc Biol. 2012 Oct;92(4):841-9. doi: 10.1189/jlb.1211601. Epub 2012 Jul 16.

PMID:
22802447
47.

Adult human brain neural progenitor cells (NPCs) and fibroblast-like cells have similar properties in vitro but only NPCs differentiate into neurons.

Park TI, Monzo H, Mee EW, Bergin PS, Teoh HH, Montgomery JM, Faull RL, Curtis MA, Dragunow M.

PLoS One. 2012;7(6):e37742. doi: 10.1371/journal.pone.0037742. Epub 2012 Jun 4.

48.

A method for generating high-yield enriched neuronal cultures from P19 embryonal carcinoma cells.

Monzo HJ, Park TIH, Montgomery JM, Faull RLM, Dragunow M, Curtis MA.

J Neurosci Methods. 2012 Feb 15;204(1):87-103. doi: 10.1016/j.jneumeth.2011.11.008. Epub 2011 Nov 11.

PMID:
22101194
49.

No change in progenitor cell proliferation in the hippocampus in Huntington's disease.

Low VF, Dragunow M, Tippett LJ, Faull RL, Curtis MA.

Neuroscience. 2011 Dec 29;199:577-88. doi: 10.1016/j.neuroscience.2011.09.010. Epub 2011 Sep 14.

PMID:
21946006
50.

Epigenetics in Alzheimer's disease: a focus on DNA modifications.

Coppieters N, Dragunow M.

Curr Pharm Des. 2011;17(31):3398-412. Review.

PMID:
21902668

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