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Items: 1 to 50 of 54

1.

Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival.

Burrus CJ, McKinstry SU, Kim N, Ozlu MI, Santoki AV, Fang FY, Ma A, Karadeniz YB, Worthington AK, Dragatsis I, Zeitlin S, Yin HH, Eroglu C.

Cell Rep. 2020 Jan 21;30(3):642-657.e6. doi: 10.1016/j.celrep.2019.12.069.

PMID:
31968243
2.

Huntington's Disease Pathogenesis Is Modified In Vivo by Alfy/Wdfy3 and Selective Macroautophagy.

Fox LM, Kim K, Johnson CW, Chen S, Croce KR, Victor MB, Eenjes E, Bosco JR, Randolph LK, Dragatsis I, Dragich JM, Yoo AS, Yamamoto A.

Neuron. 2019 Dec 23. pii: S0896-6273(19)31045-1. doi: 10.1016/j.neuron.2019.12.003. [Epub ahead of print]

PMID:
31899071
3.

ATAT1-enriched vesicles promote microtubule acetylation via axonal transport.

Even A, Morelli G, Broix L, Scaramuzzino C, Turchetto S, Gladwyn-Ng I, Le Bail R, Shilian M, Freeman S, Magiera MM, Jijumon AS, Krusy N, Malgrange B, Brone B, Dietrich P, Dragatsis I, Janke C, Saudou F, Weil M, Nguyen L.

Sci Adv. 2019 Dec 18;5(12):eaax2705. doi: 10.1126/sciadv.aax2705. eCollection 2019 Dec.

4.

ELP1 Splicing Correction Reverses Proprioceptive Sensory Loss in Familial Dysautonomia.

Morini E, Gao D, Montgomery CM, Salani M, Mazzasette C, Krussig TA, Swain B, Dietrich P, Narasimhan J, Gabbeta V, Dakka A, Hedrick J, Zhao X, Weetall M, Naryshkin NA, Wojtkiewicz GG, Ko CP, Talkowski ME, Dragatsis I, Slaugenhaupt SA.

Am J Hum Genet. 2019 Apr 4;104(4):638-650. doi: 10.1016/j.ajhg.2019.02.009. Epub 2019 Mar 21.

5.

Lactobacillus plantarum prevents and mitigates alcohol-induced disruption of colonic epithelial tight junctions, endotoxemia, and liver damage by an EGF receptor-dependent mechanism.

Shukla PK, Meena AS, Manda B, Gomes-Solecki M, Dietrich P, Dragatsis I, Rao R.

FASEB J. 2018 Jun 18:fj201800351R. doi: 10.1096/fj.201800351R. [Epub ahead of print]

6.

Effect of early embryonic deletion of huntingtin from pyramidal neurons on the development and long-term survival of neurons in cerebral cortex and striatum.

Dragatsis I, Dietrich P, Ren H, Deng YP, Del Mar N, Wang HB, Johnson IM, Jones KR, Reiner A.

Neurobiol Dis. 2018 Mar;111:102-117. doi: 10.1016/j.nbd.2017.12.015. Epub 2017 Dec 21.

7.

Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis.

Dietrich P, Johnson IM, Alli S, Dragatsis I.

PLoS Genet. 2017 Jul 17;13(7):e1006846. doi: 10.1371/journal.pgen.1006846. eCollection 2017 Jul.

8.

Role of major and brain-specific Sgce isoforms in the pathogenesis of myoclonus-dystonia syndrome.

Xiao J, Vemula SR, Xue Y, Khan MM, Carlisle FA, Waite AJ, Blake DJ, Dragatsis I, Zhao Y, LeDoux MS.

Neurobiol Dis. 2017 Feb;98:52-65. doi: 10.1016/j.nbd.2016.11.003. Epub 2016 Nov 24.

9.

Familial Dysautonomia: Mechanisms and Models.

Dietrich P, Dragatsis I.

Genet Mol Biol. 2016 Oct-Dec;39(4):497-514. doi: 10.1590/1678-4685-GMB-2015-0335. Epub 2016 Aug 4.

10.

Sensory and autonomic deficits in a new humanized mouse model of familial dysautonomia.

Morini E, Dietrich P, Salani M, Downs HM, Wojtkiewicz GR, Alli S, Brenner A, Nilbratt M, LeClair JW, Oaklander AL, Slaugenhaupt SA, Dragatsis I.

Hum Mol Genet. 2016 Mar 15;25(6):1116-28. doi: 10.1093/hmg/ddv634. Epub 2016 Jan 13.

11.

Occludin deficiency promotes ethanol-induced disruption of colonic epithelial junctions, gut barrier dysfunction and liver damage in mice.

Mir H, Meena AS, Chaudhry KK, Shukla PK, Gangwar R, Manda B, Padala MK, Shen L, Turner JR, Dietrich P, Dragatsis I, Rao R.

Biochim Biophys Acta. 2016 Apr;1860(4):765-74. doi: 10.1016/j.bbagen.2015.12.013. Epub 2015 Dec 23.

12.

ALDH2 Deficiency Promotes Ethanol-Induced Gut Barrier Dysfunction and Fatty Liver in Mice.

Chaudhry KK, Samak G, Shukla PK, Mir H, Gangwar R, Manda B, Isse T, Kawamoto T, Salaspuro M, Kaihovaara P, Dietrich P, Dragatsis I, Nagy LE, Rao RK.

Alcohol Clin Exp Res. 2015 Aug;39(8):1465-75. doi: 10.1111/acer.12777. Epub 2015 Jul 14.

13.

HIF1α is necessary for exercise-induced neuroprotection while HIF2α is needed for dopaminergic neuron survival in the substantia nigra pars compacta.

Smeyne M, Sladen P, Jiao Y, Dragatsis I, Smeyne RJ.

Neuroscience. 2015 Jun 4;295:23-38. doi: 10.1016/j.neuroscience.2015.03.015. Epub 2015 Mar 19.

14.

Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits.

McKinstry SU, Karadeniz YB, Worthington AK, Hayrapetyan VY, Ozlu MI, Serafin-Molina K, Risher WC, Ustunkaya T, Dragatsis I, Zeitlin S, Yin HH, Eroglu C.

J Neurosci. 2014 Jul 9;34(28):9455-72. doi: 10.1523/JNEUROSCI.4699-13.2014.

15.

IKAP deficiency in an FD mouse model and in oligodendrocyte precursor cells results in downregulation of genes involved in oligodendrocyte differentiation and myelin formation.

Cheishvili D, Dietrich P, Maayan C, Even A, Weil M, Dragatsis I, Razin A.

PLoS One. 2014 Apr 23;9(4):e94612. doi: 10.1371/journal.pone.0094612. eCollection 2014.

16.

Cutting edge: Conditional MHC class II expression reveals a limited role for B cell antigen presentation in primary and secondary CD4 T cell responses.

Archambault AS, Carrero JA, Barnett LG, McGee NG, Sim J, Wright JO, Raabe T, Chen P, Ding H, Allenspach EJ, Dragatsis I, Laufer TM, Wu GF.

J Immunol. 2013 Jul 15;191(2):545-50. doi: 10.4049/jimmunol.1201598. Epub 2013 Jun 14.

17.

IKAP expression levels modulate disease severity in a mouse model of familial dysautonomia.

Dietrich P, Alli S, Shanmugasundaram R, Dragatsis I.

Hum Mol Genet. 2012 Dec 1;21(23):5078-90. doi: 10.1093/hmg/dds354. Epub 2012 Aug 24.

18.

Deletion of exon 20 of the Familial Dysautonomia gene Ikbkap in mice causes developmental delay, cardiovascular defects, and early embryonic lethality.

Dietrich P, Yue J, E S, Dragatsis I.

PLoS One. 2011;6(10):e27015. doi: 10.1371/journal.pone.0027015. Epub 2011 Oct 28.

19.

Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease.

Keryer G, Pineda JR, Liot G, Kim J, Dietrich P, Benstaali C, Smith K, Cordelières FP, Spassky N, Ferrante RJ, Dragatsis I, Saudou F.

J Clin Invest. 2011 Nov;121(11):4372-82. doi: 10.1172/JCI57552. Epub 2011 Oct 10.

20.

Genetics and neuropathology of Huntington's disease.

Reiner A, Dragatsis I, Dietrich P.

Int Rev Neurobiol. 2011;98:325-72. doi: 10.1016/B978-0-12-381328-2.00014-6. Review.

21.

Huntingtin is required for mitotic spindle orientation and mammalian neurogenesis.

Godin JD, Colombo K, Molina-Calavita M, Keryer G, Zala D, Charrin BC, Dietrich P, Volvert ML, Guillemot F, Dragatsis I, Bellaiche Y, Saudou F, Nguyen L, Humbert S.

Neuron. 2010 Aug 12;67(3):392-406. doi: 10.1016/j.neuron.2010.06.027.

22.

α8-integrins are required for hippocampal long-term potentiation but not for hippocampal-dependent learning.

Chan CS, Chen H, Bradley A, Dragatsis I, Rosenmund C, Davis RL.

Genes Brain Behav. 2010 Jun 1;9(4):402-10. doi: 10.1111/j.1601-183X.2010.00569.x. Epub 2010 Jan 30.

23.

Presenilins are essential for regulating neurotransmitter release.

Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, Shen J.

Nature. 2009 Jul 30;460(7255):632-6. doi: 10.1038/nature08177.

24.

The hormonal action of IGF1 in postnatal mouse growth.

Stratikopoulos E, Szabolcs M, Dragatsis I, Klinakis A, Efstratiadis A.

Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19378-83. doi: 10.1073/pnas.0809223105. Epub 2008 Nov 25.

25.

CAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse.

Dragatsis I, Goldowitz D, Del Mar N, Deng YP, Meade CA, Liu L, Sun Z, Dietrich P, Yue J, Reiner A.

Neurobiol Dis. 2009 Mar;33(3):315-30. doi: 10.1016/j.nbd.2008.10.009. Epub 2008 Nov 6.

26.

Congenital hydrocephalus associated with abnormal subcommissural organ in mice lacking huntingtin in Wnt1 cell lineages.

Dietrich P, Shanmugasundaram R, Shuyu E, Dragatsis I.

Hum Mol Genet. 2009 Jan 1;18(1):142-50. doi: 10.1093/hmg/ddn324. Epub 2008 Oct 6.

27.

Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts.

Zhang H, Das S, Li QZ, Dragatsis I, Repa J, Zeitlin S, Hajnóczky G, Bezprozvanny I.

BMC Neurosci. 2008 Apr 15;9:38. doi: 10.1186/1471-2202-9-38.

28.

A transgenic mouse class-III beta tubulin reporter using yellow fluorescent protein.

Liu L, Geisert EE, Frankfurter A, Spano AJ, Jiang CX, Yue J, Dragatsis I, Goldowitz D.

Genesis. 2007 Sep;45(9):560-9.

29.

Neuron-specific inactivation of the hypoxia inducible factor 1 alpha increases brain injury in a mouse model of transient focal cerebral ischemia.

Baranova O, Miranda LF, Pichiule P, Dragatsis I, Johnson RS, Chavez JC.

J Neurosci. 2007 Jun 6;27(23):6320-32.

30.

Huntingtin inhibits caspase-3 activation.

Zhang Y, Leavitt BR, van Raamsdonk JM, Dragatsis I, Goldowitz D, MacDonald ME, Hayden MR, Friedlander RM.

EMBO J. 2006 Dec 13;25(24):5896-906. Epub 2006 Nov 23.

31.

Neuronal deletion of Lepr elicits diabesity in mice without affecting cold tolerance or fertility.

McMinn JE, Liu SM, Liu H, Dragatsis I, Dietrich P, Ludwig T, Boozer CN, Chua SC Jr.

Am J Physiol Endocrinol Metab. 2005 Sep;289(3):E403-11. Epub 2005 May 3.

32.

Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage.

Helton R, Cui J, Scheel JR, Ellison JA, Ames C, Gibson C, Blouw B, Ouyang L, Dragatsis I, Zeitlin S, Johnson RS, Lipton SA, Barlow C.

J Neurosci. 2005 Apr 20;25(16):4099-107. Erratum in: J Neurosci. 2005 May 11;25(19):1 p following 4888.

33.
34.

An allelic series for the leptin receptor gene generated by CRE and FLP recombinase.

McMinn JE, Liu SM, Dragatsis I, Dietrich P, Ludwig T, Eiden S, Chua SC Jr.

Mamm Genome. 2004 Sep;15(9):677-85.

PMID:
15389315
35.

Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro.

Trushina E, Dyer RB, Badger JD 2nd, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Mandavilli BS, Van Houten B, Zeitlin S, McNiven M, Aebersold R, Hayden M, Parisi JE, Seeberg E, Dragatsis I, Doyle K, Bender A, Chacko C, McMurray CT.

Mol Cell Biol. 2004 Sep;24(18):8195-209.

36.

Transgenic rescue of insulin receptor-deficient mice.

Okamoto H, Nakae J, Kitamura T, Park BC, Dragatsis I, Accili D.

J Clin Invest. 2004 Jul;114(2):214-23.

37.

Wild-type huntingtin plays a role in brain development and neuronal survival.

Reiner A, Dragatsis I, Zeitlin S, Goldowitz D.

Mol Neurobiol. 2003 Dec;28(3):259-76. Review.

PMID:
14709789
38.

Presynaptic BDNF required for a presynaptic but not postsynaptic component of LTP at hippocampal CA1-CA3 synapses.

Zakharenko SS, Patterson SL, Dragatsis I, Zeitlin SO, Siegelbaum SA, Kandel ER, Morozov A.

Neuron. 2003 Sep 11;39(6):975-90.

39.

Insulin-like growth factor (IGF) signaling through type 1 IGF receptor plays an important role in remyelination.

Mason JL, Xuan S, Dragatsis I, Efstratiadis A, Goldman JE.

J Neurosci. 2003 Aug 20;23(20):7710-8.

40.

Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.

Menalled LB, Sison JD, Dragatsis I, Zeitlin S, Chesselet MF.

J Comp Neurol. 2003 Oct 6;465(1):11-26.

PMID:
12926013
41.

Proliferation and growth factor expression in abnormally enlarged placentas of mouse interspecific hybrids.

Zechner U, Hemberger M, Constância M, Orth A, Dragatsis I, Lüttges A, Hameister H, Fundele R.

Dev Dyn. 2002 Jun;224(2):125-34.

42.

Overgrowth of a mouse model of the Simpson-Golabi-Behmel syndrome is independent of IGF signaling.

Chiao E, Fisher P, Crisponi L, Deiana M, Dragatsis I, Schlessinger D, Pilia G, Efstratiadis A.

Dev Biol. 2002 Mar 1;243(1):185-206.

43.

Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice.

Reiner A, Del Mar N, Meade CA, Yang H, Dragatsis I, Zeitlin S, Goldowitz D.

J Neurosci. 2001 Oct 1;21(19):7608-19.

44.

A method for the generation of conditional gene repair mutations in mice.

Dragatsis I, Zeitlin S.

Nucleic Acids Res. 2001 Feb 1;29(3):E10.

45.

Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice.

Dragatsis I, Levine MS, Zeitlin S.

Nat Genet. 2000 Nov;26(3):300-6.

PMID:
11062468
46.

Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes.

Dietrich P, Dragatsis I, Xuan S, Zeitlin S, Efstratiadis A.

Mamm Genome. 2000 Mar;11(3):196-205.

PMID:
10723724
47.

CaMKIIalpha-Cre transgene expression and recombination patterns in the mouse brain.

Dragatsis I, Zeitlin S.

Genesis. 2000 Feb;26(2):133-5. No abstract available.

PMID:
10686608
48.

Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse.

Dragatsis I, Dietrich P, Zeitlin S.

Neurosci Lett. 2000 Mar 17;282(1-2):37-40.

PMID:
10713390
49.

Huntingtin is required for normal hematopoiesis.

Metzler M, Helgason CD, Dragatsis I, Zhang T, Gan L, Pineault N, Zeitlin SO, Humphries RK, Hayden MR.

Hum Mol Genet. 2000 Feb 12;9(3):387-94.

PMID:
10655548
50.

Mouse mutant embryos lacking huntingtin are rescued from lethality by wild-type extraembryonic tissues.

Dragatsis I, Efstratiadis A, Zeitlin S.

Development. 1998 Apr;125(8):1529-39.

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