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The benefit of immediate compared with deferred antiretroviral therapy on CD4+ cell count recovery in early HIV infection.

Sharma S, Schlusser KE, de la Torre P, Tambussi G, Draenert R, Pinto AN, Metcalf JA, Neaton JD, Laeyendecker O; INSIGHT START Study Group.

AIDS. 2019 Jul 1;33(8):1335-1344. doi: 10.1097/QAD.0000000000002219.



Seybold U, Stubbe H, Draenert R, Bogner JR.

MMW Fortschr Med. 2018 May;160(10):37-40. doi: 10.1007/s15006-018-0580-3. Review. German. No abstract available.


[Atypical pneumonia - important facts for the general practitioner].

Draenert R, Jung J, Seybold U, Bogner J.

MMW Fortschr Med. 2018 May;160(10):41-44. doi: 10.1007/s15006-018-0581-2. Review. German. No abstract available.


Treatment Intensification in HIV-Infected Patients Is Associated With Reduced Frequencies of Regulatory T Cells.

Grützner EM, Hoffmann T, Wolf E, Gersbacher E, Neizert A, Stirner R, Pauli R, Ulmer A, Brust J, Bogner JR, Jaeger H, Draenert R.

Front Immunol. 2018 Apr 30;9:811. doi: 10.3389/fimmu.2018.00811. eCollection 2018.


Comparison of Self-report to Biomarkers of Recent HIV Infection: Findings from the START Trial.

Schlusser KE, Sharma S, de la Torre P, Tambussi G, Draenert R, Pinto AN, Metcalf JA, German D, Neaton JD, Laeyendecker O; INSIGHT START Study Group.

AIDS Behav. 2018 Jul;22(7):2277-2283. doi: 10.1007/s10461-018-2048-y.


T cells with low CD2 levels express reduced restriction factors and are preferentially infected in therapy naïve chronic HIV-1 patients.

Bolduan S, Koppensteiner H, Businger R, Rebensburg S, Kunze C, Brack-Werner R, Draenert R, Schindler M.

J Int AIDS Soc. 2017 Sep 19;20(1):21865. doi: 10.7448/IAS.20.1.21865.


Gag-protease coevolution analyses define novel structural surfaces in the HIV-1 matrix and capsid involved in resistance to Protease Inhibitors.

Codoñer FM, Peña R, Blanch-Lombarte O, Jimenez-Moyano E, Pino M, Vollbrecht T, Clotet B, Martinez-Picado J, Draenert R, Prado JG.

Sci Rep. 2017 Jun 16;7(1):3717. doi: 10.1038/s41598-017-03260-4.


Case report of three consecutive lues maligna infections in an HIV-infected patient.

Sammet S, Draenert R.

Int J STD AIDS. 2017 Apr;28(5):523-525. doi: 10.1177/0956462416674102. Epub 2016 Oct 10.


Measles, mumps, rubella and VZV: importance of serological testing of vaccine-preventable diseases in young adults living with HIV in Germany.

Schwarze-Zander C, Draenert R, Lehmann C, Stecher M, Boesecke C, Sammet S, Wasmuth JC, Seybold U, Gillor D, Wieland U, Kümmerle T, Strassburg CP, Mankertz A, Eis-Hübinger AM, Jäger G, Fätkenheuer G, Bogner JR, Rockstroh JK, Vehreschild JJ.

Epidemiol Infect. 2017 Jan;145(2):236-244. Epub 2016 Oct 26.


[Antibiotics in the general practice].

Bogner J, Draenert R, Seybold U.

MMW Fortschr Med. 2016 Jun 23;158(12):56-61; quiz 62-3. doi: 10.1007/s15006-016-7661-y. Review. German. No abstract available.


Kinetics of human myeloid-derived suppressor cells after blood draw.

Grützner E, Stirner R, Arenz L, Athanasoulia AP, Schrödl K, Berking C, Bogner JR, Draenert R.

J Transl Med. 2016 Jan 6;14:2. doi: 10.1186/s12967-015-0755-y.


T cells are functionally not impaired in AML: increased PD-1 expression is only seen at time of relapse and correlates with a shift towards the memory T cell compartment.

Schnorfeil FM, Lichtenegger FS, Emmerig K, Schlueter M, Neitz JS, Draenert R, Hiddemann W, Subklewe M.

J Hematol Oncol. 2015 Jul 30;8:93. doi: 10.1186/s13045-015-0189-2.


Novel antibiotics: are we still in the pre-post-antibiotic era?

Draenert R, Seybold U, Grützner E, Bogner JR.

Infection. 2015 Apr;43(2):145-51. doi: 10.1007/s15010-015-0749-y. Epub 2015 Feb 21. Review.


Selective inhibitors of the FK506-binding protein 51 by induced fit.

Gaali S, Kirschner A, Cuboni S, Hartmann J, Kozany C, Balsevich G, Namendorf C, Fernandez-Vizarra P, Sippel C, Zannas AS, Draenert R, Binder EB, Almeida OF, Rühter G, Uhr M, Schmidt MV, Touma C, Bracher A, Hausch F.

Nat Chem Biol. 2015 Jan;11(1):33-7. doi: 10.1038/nchembio.1699. Epub 2014 Dec 1.


Cell exhaustion in HIV-1 infection: role of suppressor cells.

Seddiki N, Brezar V, Draenert R.

Curr Opin HIV AIDS. 2014 Sep;9(5):452-8. doi: 10.1097/COH.0000000000000087. Review.


Mapping of optimal CD8 T cell epitopes.

Roider J, Vollbrecht T, Draenert R.

Methods Mol Biol. 2014;1169:97-106. doi: 10.1007/978-1-4939-0882-0_10.


Lack of significant elevation of myeloid-derived suppressor cells in peripheral blood of chronically hepatitis C virus-infected individuals.

Nonnenmann J, Stirner R, Roider J, Jung MC, Schrödl K, Bogner JR, Draenert R.

J Virol. 2014 Jul;88(13):7678-82. doi: 10.1128/JVI.00113-14. Epub 2014 Apr 16.


Comparison of experimental fine-mapping to in silico prediction results of HIV-1 epitopes reveals ongoing need for mapping experiments.

Roider J, Meissner T, Kraut F, Vollbrecht T, Stirner R, Bogner JR, Draenert R.

Immunology. 2014 Oct;143(2):193-201. doi: 10.1111/imm.12301.


Severe non-specific immune reconstitution inflammatory syndrome (IRIS) presenting with graft-versus-host disease-like colitis.

Reu S, Neumann J, Draenert R.

Infection. 2014 Jun;42(3):599-600. doi: 10.1007/s15010-014-0585-5. Epub 2014 Jan 28. No abstract available.


Adaptation of CD8 T cell responses to changing HIV-1 sequences in a cohort of HIV-1 infected individuals not selected for a certain HLA allele.

Roider J, Kalteis AL, Vollbrecht T, Gloning L, Stirner R, Henrich N, Bogner JR, Draenert R.

PLoS One. 2013 Dec 3;8(12):e80045. doi: 10.1371/journal.pone.0080045. eCollection 2013.


Sexual and reproductive health services for people living with HIV/AIDS in Germany: are we up to the challenge?

Mueller MC, Walentiny C, Seybold U, Nöstlinger C, Platteau T, Borms R, Draenert R, Bogner JR.

Infection. 2013 Aug;41(4):761-8. doi: 10.1007/s15010-013-0499-7. Epub 2013 Jul 10.


A new cytokine release assay: a simple approach to monitor the immune status of HIV-infected patients.

Kaufmann I, Draenert R, Gruber M, Feuerecker M, Roider J, Choukèr A.

Infection. 2013 Jun;41(3):687-90. doi: 10.1007/s15010-013-0445-8. Epub 2013 Mar 28.


Virus immune evasion: new mechanism and implications in disease outcome.

Draenert R, Frater J, Prado JG.

Adv Virol. 2012;2012:490549. doi: 10.1155/2012/490549. Epub 2012 Sep 24. No abstract available.


Chronic progressive HIV-1 infection is associated with elevated levels of myeloid-derived suppressor cells.

Vollbrecht T, Stirner R, Tufman A, Roider J, Huber RM, Bogner JR, Lechner A, Bourquin C, Draenert R.

AIDS. 2012 Jul 31;26(12):F31-7. doi: 10.1097/QAD.0b013e328354b43f.


Control of M184V HIV-1 mutants by CD8 T-cell responses.

Vollbrecht T, Eberle J, Roider J, Bühler S, Stirner R, Henrich N, Seybold U, Bogner JR, Draenert R.

Med Microbiol Immunol. 2012 May;201(2):201-11. doi: 10.1007/s00430-011-0222-1. Epub 2011 Dec 27.


[Calculated antibiotic therapy].

Seybold U, Draenert R, Bogner JR.

MMW Fortschr Med. 2011 May 12;153(19):45-8; quiz 49. Review. German. No abstract available.


Nef-specific CD45RA+ CD8+ T cells secreting MIP-1beta but not IFN-gamma are associated with nonprogressive HIV-1 infection.

Dembek CJ, Kutscher S, Heltai S, Allgayer S, Biswas P, Ghezzi S, Vicenzi E, Hoffmann D, Reitmeir P, Tambussi G, Bogner JR, Lusso P, Stellbrink HJ, Santagostino E, Vollbrecht T, Goebel FD, Protzer U, Draenert R, Tinelli M, Poli G, Erfle V, Malnati M, Cosma A.

AIDS Res Ther. 2010 Jul 2;7:20. doi: 10.1186/1742-6405-7-20.


Impact of changes in antigen level on CD38/PD-1 co-expression on HIV-specific CD8 T cells in chronic, untreated HIV-1 infection.

Vollbrecht T, Brackmann H, Henrich N, Roeling J, Seybold U, Bogner JR, Goebel FD, Draenert R.

J Med Virol. 2010 Mar;82(3):358-70. doi: 10.1002/jmv.21723.


[New antibiotics: small or big advances?].

Draenert R, Bogner JR.

Internist (Berl). 2009 Oct;50(10):1282, 1284-8. doi: 10.1007/s00108-009-2483-y. Review. German.


Prevalence and risk factors of nasal colonization with Staphylococcus aureus - association with HIV infection in older patients.

Seybold U, Supthut-Schroder B, Draenert R, Hogardt M, Bogner JR.

Scand J Infect Dis. 2009;41(1):63-6. doi: 10.1080/00365540802460000.


Decreased CXCR3+ CD8 T cells in advanced human immunodeficiency virus infection suggest that a homing defect contributes to cytotoxic T-lymphocyte dysfunction.

Brainard DM, Tager AM, Misdraji J, Frahm N, Lichterfeld M, Draenert R, Brander C, Walker BD, Luster AD.

J Virol. 2007 Aug;81(16):8439-50. Epub 2007 Jun 6.


Fully differentiated HIV-1 specific CD8+ T effector cells are more frequently detectable in controlled than in progressive HIV-1 infection.

Addo MM, Draenert R, Rathod A, Verrill CL, Davis BT, Gandhi RT, Robbins GK, Basgoz NO, Stone DR, Cohen DE, Johnston MN, Flynn T, Wurcel AG, Rosenberg ES, Altfeld M, Walker BD.

PLoS One. 2007 Mar 28;2(3):e321.


HIV-specific CD8 T cells express low levels of IL-7Ralpha: implications for HIV-specific T cell memory.

Wherry EJ, Day CL, Draenert R, Miller JD, Kiepiela P, Woodberry T, Brander C, Addo M, Klenerman P, Ahmed R, Walker BD.

Virology. 2006 Sep 30;353(2):366-73. Epub 2006 Jul 24.


HIV-associated renal diseases and highly active antiretroviral therapy-induced nephropathy.

Röling J, Schmid H, Fischereder M, Draenert R, Goebel FD.

Clin Infect Dis. 2006 May 15;42(10):1488-95. Epub 2006 Apr 11. Review.


Constraints on HIV-1 evolution and immunodominance revealed in monozygotic adult twins infected with the same virus.

Draenert R, Allen TM, Liu Y, Wrin T, Chappey C, Verrill CL, Sirera G, Eldridge RL, Lahaie MP, Ruiz L, Clotet B, Petropoulos CJ, Walker BD, Martinez-Picado J.

J Exp Med. 2006 Mar 20;203(3):529-39. Epub 2006 Mar 13.


Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire.

Meyer-Olson D, Brady KW, Bartman MT, O'Sullivan KM, Simons BC, Conrad JA, Duncan CB, Lorey S, Siddique A, Draenert R, Addo M, Altfeld M, Rosenberg E, Allen TM, Walker BD, Kalams SA.

Blood. 2006 Mar 15;107(6):2373-83. Epub 2005 Dec 1.


Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution.

Allen TM, Altfeld M, Geer SC, Kalife ET, Moore C, O'sullivan KM, Desouza I, Feeney ME, Eldridge RL, Maier EL, Kaufmann DE, Lahaie MP, Reyor L, Tanzi G, Johnston MN, Brander C, Draenert R, Rockstroh JK, Jessen H, Rosenberg ES, Mallal SA, Walker BD.

J Virol. 2005 Nov;79(21):13239-49.


[Options in HIV therapy: present and future].

Röling J, Draenert R, Goebel FD.

Internist (Berl). 2005 Aug;46(8):892-4, 896-8. Review. German.


HIV-1 viral escape in infancy followed by emergence of a variant-specific CTL response.

Feeney ME, Tang Y, Pfafferott K, Roosevelt KA, Draenert R, Trocha A, Yu XG, Verrill C, Allen T, Moore C, Mallal S, Burchett S, McIntosh K, Pelton SI, St John MA, Hazra R, Klenerman P, Altfeld M, Walker BD, Goulder PJ.

J Immunol. 2005 Jun 15;174(12):7524-30.


Infected cat-bite wound treated successfully with moxifloxacin after failure of parenteral cefuroxime and ciprofloxacin.

Draenert R, Kunzelmann M, Roggenkamp A, Hellers J, Bogner JR.

Eur J Clin Microbiol Infect Dis. 2005 Apr;24(4):288-90. No abstract available.


Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA.

Leslie A, Kavanagh D, Honeyborne I, Pfafferott K, Edwards C, Pillay T, Hilton L, Thobakgale C, Ramduth D, Draenert R, Le Gall S, Luzzi G, Edwards A, Brander C, Sewell AK, Moore S, Mullins J, Moore C, Mallal S, Bhardwaj N, Yusim K, Phillips R, Klenerman P, Korber B, Kiepiela P, Walker B, Goulder P.

J Exp Med. 2005 Mar 21;201(6):891-902.


The magnitude and breadth of hepatitis C virus-specific CD8+ T cells depend on absolute CD4+ T-cell count in individuals coinfected with HIV-1.

Kim AY, Lauer GM, Ouchi K, Addo MM, Lucas M, Schulze Zur Wiesch J, Timm J, Boczanowski M, Duncan JE, Wurcel AG, Casson D, Chung RT, Draenert R, Klenerman P, Walker BD.

Blood. 2005 Feb 1;105(3):1170-8. Epub 2004 Sep 30.


What's new in HIV/AIDS. Protective immunity in HIV infection: where do we stand?

Draenert R, Goebel FD.

Infection. 2004 Aug;32(4):250-2. Review.


Heat shock protein-mediated cross-presentation of exogenous HIV antigen on HLA class I and class II.

SenGupta D, Norris PJ, Suscovich TJ, Hassan-Zahraee M, Moffett HF, Trocha A, Draenert R, Goulder PJ, Binder RJ, Levey DL, Walker BD, Srivastava PK, Brander C.

J Immunol. 2004 Aug 1;173(3):1987-93.


Immune selection for altered antigen processing leads to cytotoxic T lymphocyte escape in chronic HIV-1 infection.

Draenert R, Le Gall S, Pfafferott KJ, Leslie AJ, Chetty P, Brander C, Holmes EC, Chang SC, Feeney ME, Addo MM, Ruiz L, Ramduth D, Jeena P, Altfeld M, Thomas S, Tang Y, Verrill CL, Dixon C, Prado JG, Kiepiela P, Martinez-Picado J, Walker BD, Goulder PJ.

J Exp Med. 2004 Apr 5;199(7):905-15.


Impact of intrapeptide epitope location on CD8 T cell recognition: implications for design of overlapping peptide panels.

Draenert R, Brander C, Yu XG, Altfeld M, Verrill CL, Feeney ME, Walker BD, Goulder PJ.

AIDS. 2004 Apr 9;18(6):871-6.


HIV-1 specific CD8+ T cells with an effector phenotype and control of viral replication.

Hess C, Altfeld M, Thomas SY, Addo MM, Rosenberg ES, Allen TM, Draenert R, Eldrige RL, van Lunzen J, Stellbrink HJ, Walker BD, Luster AD.

Lancet. 2004 Mar 13;363(9412):863-6.


Consistent cytotoxic-T-lymphocyte targeting of immunodominant regions in human immunodeficiency virus across multiple ethnicities.

Frahm N, Korber BT, Adams CM, Szinger JJ, Draenert R, Addo MM, Feeney ME, Yusim K, Sango K, Brown NV, SenGupta D, Piechocka-Trocha A, Simonis T, Marincola FM, Wurcel AG, Stone DR, Russell CJ, Adolf P, Cohen D, Roach T, StJohn A, Khatri A, Davis K, Mullins J, Goulder PJ, Walker BD, Brander C.

J Virol. 2004 Mar;78(5):2187-200.


HIV evolution: CTL escape mutation and reversion after transmission.

Leslie AJ, Pfafferott KJ, Chetty P, Draenert R, Addo MM, Feeney M, Tang Y, Holmes EC, Allen T, Prado JG, Altfeld M, Brander C, Dixon C, Ramduth D, Jeena P, Thomas SA, St John A, Roach TA, Kupfer B, Luzzi G, Edwards A, Taylor G, Lyall H, Tudor-Williams G, Novelli V, Martinez-Picado J, Kiepiela P, Walker BD, Goulder PJ.

Nat Med. 2004 Mar;10(3):282-9. Epub 2004 Feb 8.


Persistent recognition of autologous virus by high-avidity CD8 T cells in chronic, progressive human immunodeficiency virus type 1 infection.

Draenert R, Verrill CL, Tang Y, Allen TM, Wurcel AG, Boczanowski M, Lechner A, Kim AY, Suscovich T, Brown NV, Addo MM, Walker BD.

J Virol. 2004 Jan;78(2):630-41.

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