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Items: 1 to 50 of 69

1.

A unique role for DNA (hydroxy)methylation in epigenetic regulation of human inhibitory neurons.

Kozlenkov A, Li J, Apontes P, Hurd YL, Byne WM, Koonin EV, Wegner M, Mukamel EA, Dracheva S.

Sci Adv. 2018 Sep 26;4(9):eaau6190. doi: 10.1126/sciadv.aau6190. eCollection 2018 Sep.

2.

Molecular windows into the human brain for psychiatric disorders.

Egervari G, Kozlenkov A, Dracheva S, Hurd YL.

Mol Psychiatry. 2019 May;24(5):653-673. doi: 10.1038/s41380-018-0125-2. Epub 2018 Jun 28. Review.

3.

Brain Cell Type Specific Gene Expression and Co-expression Network Architectures.

McKenzie AT, Wang M, Hauberg ME, Fullard JF, Kozlenkov A, Keenan A, Hurd YL, Dracheva S, Casaccia P, Roussos P, Zhang B.

Sci Rep. 2018 Jun 11;8(1):8868. doi: 10.1038/s41598-018-27293-5.

4.

A Novel Method for Rapid Molecular Subgrouping of Medulloblastoma.

Gómez S, Garrido-Garcia A, Garcia-Gerique L, Lemos I, Suñol M, de Torres C, Kulis M, Pérez-Jaume S, Carcaboso ÁM, Luu B, Kieran MW, Jabado N, Kozlenkov A, Dracheva S, Ramaswamy V, Hovestadt V, Johann P, Jones DTW, Pfister SM, Morales La Madrid A, Cruz O, Taylor MD, Martin-Subero JI, Mora J, Lavarino C.

Clin Cancer Res. 2018 Mar 15;24(6):1355-1363. doi: 10.1158/1078-0432.CCR-17-2243. Epub 2018 Jan 19.

5.

Antipsychotic-induced Hdac2 transcription via NF-κB leads to synaptic and cognitive side effects.

Ibi D, de la Fuente Revenga M, Kezunovic N, Muguruza C, Saunders JM, Gaitonde SA, Moreno JL, Ijaz MK, Santosh V, Kozlenkov A, Holloway T, Seto J, García-Bea A, Kurita M, Mosley GE, Jiang Y, Christoffel DJ, Callado LF, Russo SJ, Dracheva S, López-Giménez JF, Ge Y, Escalante CR, Meana JJ, Akbarian S, Huntley GW, González-Maeso J.

Nat Neurosci. 2017 Sep;20(9):1247-1259. doi: 10.1038/nn.4616. Epub 2017 Aug 7.

6.

DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age.

Kozlenkov A, Jaffe AE, Timashpolsky A, Apontes P, Rudchenko S, Barbu M, Byne W, Hurd YL, Horvath S, Dracheva S.

Genes (Basel). 2017 May 30;8(6). pii: E152. doi: 10.3390/genes8060152.

7.

Pericytes impair capillary blood flow and motor function after chronic spinal cord injury.

Li Y, Lucas-Osma AM, Black S, Bandet MV, Stephens MJ, Vavrek R, Sanelli L, Fenrich KK, Di Narzo AF, Dracheva S, Winship IR, Fouad K, Bennett DJ.

Nat Med. 2017 Jun;23(6):733-741. doi: 10.1038/nm.4331. Epub 2017 May 1.

8.

Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum.

Lu AT, Hannon E, Levine ME, Hao K, Crimmins EM, Lunnon K, Kozlenkov A, Mill J, Dracheva S, Horvath S.

Nat Commun. 2016 Feb 2;7:10561. doi: 10.1038/ncomms10561.

9.

NeuN+ neuronal nuclei in non-human primate prefrontal cortex and subcortical white matter after clozapine exposure.

Halene TB, Kozlenkov A, Jiang Y, Mitchell AC, Javidfar B, Dincer A, Park R, Wiseman J, Croxson PL, Giannaris EL, Hof PR, Roussos P, Dracheva S, Hemby SE, Akbarian S.

Schizophr Res. 2016 Feb;170(2-3):235-44. doi: 10.1016/j.schres.2015.12.016. Epub 2016 Jan 6.

10.

Substantial DNA methylation differences between two major neuronal subtypes in human brain.

Kozlenkov A, Wang M, Roussos P, Rudchenko S, Barbu M, Bibikova M, Klotzle B, Dwork AJ, Zhang B, Hurd YL, Koonin EV, Wegner M, Dracheva S.

Nucleic Acids Res. 2016 Apr 7;44(6):2593-612. doi: 10.1093/nar/gkv1304. Epub 2015 Nov 26.

11.

The PsychENCODE project.

PsychENCODE Consortium, Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, Weissman S, Sullivan PF, State MW, Weng Z, Peters MA, White KP, Gerstein MB, Amiri A, Armoskus C, Ashley-Koch AE, Bae T, Beckel-Mitchener A, Berman BP, Coetzee GA, Coppola G, Francoeur N, Fromer M, Gao R, Grennan K, Herstein J, Kavanagh DH, Ivanov NA, Jiang Y, Kitchen RR, Kozlenkov A, Kundakovic M, Li M, Li Z, Liu S, Mangravite LM, Mattei E, Markenscoff-Papadimitriou E, Navarro FC, North N, Omberg L, Panchision D, Parikshak N, Poschmann J, Price AJ, Purcaro M, Reddy TE, Roussos P, Schreiner S, Scuderi S, Sebra R, Shibata M, Shieh AW, Skarica M, Sun W, Swarup V, Thomas A, Tsuji J, van Bakel H, Wang D, Wang Y, Wang K, Werling DM, Willsey AJ, Witt H, Won H, Wong CC, Wray GA, Wu EY, Xu X, Yao L, Senthil G, Lehner T, Sklar P, Sestan N.

Nat Neurosci. 2015 Dec;18(12):1707-12. doi: 10.1038/nn.4156. Review. No abstract available.

12.

Decrease of mRNA Editing after Spinal Cord Injury is Caused by Down-regulation of ADAR2 that is Triggered by Inflammatory Response.

Di Narzo AF, Kozlenkov A, Ge Y, Zhang B, Sanelli L, May Z, Li Y, Fouad K, Cardozo C, Koonin EV, Bennett DJ, Dracheva S.

Sci Rep. 2015 Jul 30;5:12615. doi: 10.1038/srep12615.

13.

A unique gene expression signature associated with serotonin 2C receptor RNA editing in the prefrontal cortex and altered in suicide.

Di Narzo AF, Kozlenkov A, Roussos P, Hao K, Hurd Y, Lewis DA, Sibille E, Siever LJ, Koonin E, Dracheva S.

Hum Mol Genet. 2014 Sep 15;23(18):4801-13. doi: 10.1093/hmg/ddu195. Epub 2014 Apr 29.

14.

Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites.

Kozlenkov A, Roussos P, Timashpolsky A, Barbu M, Rudchenko S, Bibikova M, Klotzle B, Byne W, Lyddon R, Di Narzo AF, Hurd YL, Koonin EV, Dracheva S.

Nucleic Acids Res. 2014 Jan;42(1):109-27. doi: 10.1093/nar/gkt838. Epub 2013 Sep 20.

15.

Dependencies among editing sites in serotonin 2C receptor mRNA.

Carmel L, Koonin EV, Dracheva S.

PLoS Comput Biol. 2012;8(9):e1002663. doi: 10.1371/journal.pcbi.1002663. Epub 2012 Sep 6.

16.

Ionotropic glutamate receptor mRNA editing in the prefrontal cortex: no alterations in schizophrenia or bipolar disorder.

Lyddon R, Navarrett S, Dracheva S.

J Psychiatry Neurosci. 2012 Jul;37(4):267-72. doi: 10.1503/jpn.110107.

17.

Serotonin 2c receptor RNA editing in major depression and suicide.

Lyddon R, Dwork AJ, Keddache M, Siever LJ, Dracheva S.

World J Biol Psychiatry. 2013 Dec;14(8):590-601. doi: 10.3109/15622975.2011.630406. Epub 2012 Mar 9.

18.

PubChem's BioAssay Database.

Wang Y, Xiao J, Suzek TO, Zhang J, Wang J, Zhou Z, Han L, Karapetyan K, Dracheva S, Shoemaker BA, Bolton E, Gindulyte A, Bryant SH.

Nucleic Acids Res. 2012 Jan;40(Database issue):D400-12. doi: 10.1093/nar/gkr1132. Epub 2011 Dec 2.

19.

Alterations of serotonin 2C and 2A receptors in response to T10 spinal cord transection in rats.

Navarrett S, Collier L, Cardozo C, Dracheva S.

Neurosci Lett. 2012 Jan 6;506(1):74-8. doi: 10.1016/j.neulet.2011.10.052. Epub 2011 Oct 28.

PMID:
22056918
20.

No link of serotonin 2C receptor editing to serotonin transporter genotype.

Lyddon R, Cuppen E, Haroutunian V, Siever LJ, Dracheva S.

Neuroreport. 2010 Dec 8;21(17):1080-4. doi: 10.1097/WNR.0b013e32834052f0.

PMID:
20948451
21.

Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease.

De Gasperi R, Sosa MA, Dracheva S, Elder GA.

Mol Neurodegener. 2010 Sep 23;5:38. doi: 10.1186/1750-1326-5-38.

22.

Gene expression abnormalities and oligodendrocyte deficits in the internal capsule in schizophrenia.

Kerns D, Vong GS, Barley K, Dracheva S, Katsel P, Casaccia P, Haroutunian V, Byne W.

Schizophr Res. 2010 Jul;120(1-3):150-8. doi: 10.1016/j.schres.2010.04.012. Epub 2010 May 23.

PMID:
20580881
23.

An overview of the PubChem BioAssay resource.

Wang Y, Bolton E, Dracheva S, Karapetyan K, Shoemaker BA, Suzek TO, Wang J, Xiao J, Zhang J, Bryant SH.

Nucleic Acids Res. 2010 Jan;38(Database issue):D255-66. doi: 10.1093/nar/gkp965. Epub 2009 Nov 19.

24.

Fear conditioning induces distinct patterns of gene expression in lateral amygdala.

Lamprecht R, Dracheva S, Assoun S, LeDoux JE.

Genes Brain Behav. 2009 Nov;8(8):735-43. doi: 10.1111/j.1601-183X.2009.00515.x. Epub 2009 Jun 23.

25.

Editing of serotonin 2C receptor mRNA in the prefrontal cortex characterizes high-novelty locomotor response behavioral trait.

Dracheva S, Lyddon R, Barley K, Marcus SM, Hurd YL, Byne WM.

Neuropsychopharmacology. 2009 Sep;34(10):2237-51. doi: 10.1038/npp.2009.51. Epub 2009 Jun 3.

26.

Subcortical oligodendrocyte- and astrocyte-associated gene expression in subjects with schizophrenia, major depression and bipolar disorder.

Barley K, Dracheva S, Byne W.

Schizophr Res. 2009 Jul;112(1-3):54-64. doi: 10.1016/j.schres.2009.04.019. Epub 2009 May 17.

PMID:
19447584
27.

TaqMan-based, real-time quantitative polymerase chain reaction method for RNA editing analysis.

Wong K, Lyddon R, Dracheva S.

Anal Biochem. 2009 Jul 15;390(2):173-80. doi: 10.1016/j.ab.2009.04.011. Epub 2009 Apr 14.

PMID:
19371717
28.

Ionotropic glutamate receptor mRNA expression in the human thalamus: absence of change in schizophrenia.

Dracheva S, Byne W, Chin B, Haroutunian V.

Brain Res. 2008 Jun 12;1214:23-34. doi: 10.1016/j.brainres.2008.03.039. Epub 2008 Apr 1.

29.

Altered serotonin 2C receptor RNA splicing in suicide: association with editing.

Dracheva S, Chin B, Haroutunian V.

Neuroreport. 2008 Feb 12;19(3):379-82. doi: 10.1097/WNR.0b013e3282f556d2.

PMID:
18303585
30.

Schizophrenia and sex associated differences in the expression of neuronal and oligodendrocyte-specific genes in individual thalamic nuclei.

Byne W, Dracheva S, Chin B, Schmeidler JM, Davis KL, Haroutunian V.

Schizophr Res. 2008 Jan;98(1-3):118-28. Epub 2007 Oct 29.

31.

Increased serotonin 2C receptor mRNA editing: a possible risk factor for suicide.

Dracheva S, Patel N, Woo DA, Marcus SM, Siever LJ, Haroutunian V.

Mol Psychiatry. 2008 Nov;13(11):1001-10. Epub 2007 Sep 11.

PMID:
17848916
32.

Variations in oligodendrocyte-related gene expression across multiple cortical regions: implications for the pathophysiology of schizophrenia.

Haroutunian V, Katsel P, Dracheva S, Stewart DG, Davis KL.

Int J Neuropsychopharmacol. 2007 Aug;10(4):565-73. Epub 2007 Feb 12.

PMID:
17291370
33.
34.

Characterization of KIAA0513, a novel signaling molecule that interacts with modulators of neuroplasticity, apoptosis, and the cytoskeleton.

Lauriat TL, Dracheva S, Kremerskothen J, Duning K, Haroutunian V, Buxbaum JD, Hyde TM, Kleinman JE, McInnes LA.

Brain Res. 2006 Nov 22;1121(1):1-11. Epub 2006 Sep 29.

PMID:
17010949
35.

Quantitative analysis of glutamate transporter mRNA expression in prefrontal and primary visual cortex in normal and schizophrenic brain.

Lauriat TL, Dracheva S, Chin B, Schmeidler J, McInnes LA, Haroutunian V.

Neuroscience. 2006 Feb;137(3):843-51. Epub 2005 Nov 16.

PMID:
16297566
36.

A QTL resource and comparison tool for pigs: PigQTLDB.

Hu ZL, Dracheva S, Jang W, Maglott D, Bastiaansen J, Rothschild MF, Reecy JM.

Mamm Genome. 2005 Oct;16(10):792-800. Epub 2005 Oct 29.

PMID:
16261421
37.

Myelin-associated mRNA and protein expression deficits in the anterior cingulate cortex and hippocampus in elderly schizophrenia patients.

Dracheva S, Davis KL, Chin B, Woo DA, Schmeidler J, Haroutunian V.

Neurobiol Dis. 2006 Mar;21(3):531-40. Epub 2005 Oct 5.

PMID:
16213148
38.

mRNA expression of AMPA receptors and AMPA receptor binding proteins in the cerebral cortex of elderly schizophrenics.

Dracheva S, McGurk SR, Haroutunian V.

J Neurosci Res. 2005 Mar 15;79(6):868-78.

PMID:
15696539
39.

Allelic expression of APOE in human brain: effects of epsilon status and promoter haplotypes.

Bray NJ, Jehu L, Moskvina V, Buxbaum JD, Dracheva S, Haroutunian V, Williams J, Buckland PR, Owen MJ, O'Donovan MC.

Hum Mol Genet. 2004 Nov 15;13(22):2885-92. Epub 2004 Sep 22.

PMID:
15385439
40.

Abnormalities in the dopamine system in schizophrenia may lie in altered levels of dopamine receptor-interacting proteins.

Bai J, He F, Novikova SI, Undie AS, Dracheva S, Haroutunian V, Lidow MS.

Biol Psychiatry. 2004 Sep 15;56(6):427-40.

PMID:
15364041
41.

GAD67 and GAD65 mRNA and protein expression in cerebrocortical regions of elderly patients with schizophrenia.

Dracheva S, Elhakem SL, McGurk SR, Davis KL, Haroutunian V.

J Neurosci Res. 2004 May 15;76(4):581-92.

PMID:
15114630
42.

RNA editing and alternative splicing of human serotonin 2C receptor in schizophrenia.

Dracheva S, Elhakem SL, Marcus SM, Siever LJ, McGurk SR, Haroutunian V.

J Neurochem. 2003 Dec;87(6):1402-12.

43.

Purple membrane lipid control of bacteriorhodopsin conformational flexibility and photocycle activity.

Hendler RW, Barnett SM, Dracheva S, Bose S, Levin IW.

Eur J Biochem. 2003 May;270(9):1920-5.

44.
45.

Modulation of multiple experimental arthritis models by collagen-induced arthritis quantitative trait loci isolated in congenic rat lines: different effects of non-major histocompatibility complex quantitative trait loci in males and females.

Remmers EF, Joe B, Griffiths MM, Dobbins DE, Dracheva SV, Hashiramoto A, Furuya T, Salstrom JL, Wang J, Gulko PS, Cannon GW, Wilder RL.

Arthritis Rheum. 2002 Aug;46(8):2225-34.

46.

D1 dopamine receptor regulation of microtubule-associated protein-2 phosphorylation in developing cerebral cortical neurons.

Song ZM, Undie AS, Koh PO, Fang YY, Zhang L, Dracheva S, Sealfon SC, Lidow MS.

J Neurosci. 2002 Jul 15;22(14):6092-105.

47.

Importance of lipids for bacteriorhodopsin structure, photocycle, and function.

Hendler RW, Dracheva S.

Biochemistry (Mosc). 2001 Nov;66(11):1311-4. Review.

48.

N-methyl-D-aspartic acid receptor expression in the dorsolateral prefrontal cortex of elderly patients with schizophrenia.

Dracheva S, Marras SA, Elhakem SL, Kramer FR, Davis KL, Haroutunian V.

Am J Psychiatry. 2001 Sep;158(9):1400-10. Erratum in: Am J Psychiatry 2001 Dec;158(12):2107.

PMID:
11532724
49.

Locomotor behavior of dopamine D1 receptor transgenic/D2 receptor deficient hybrid mice.

Dracheva S, Haroutunian V.

Brain Res. 2001 Jun 29;905(1-2):142-51.

PMID:
11423089
50.

Genetic dissection of collagen-induced arthritis in Chromosome 10 quantitative trait locus speed congenic rats: evidence for more than one regulatory locus and sex influences.

Joe B, Remmers EF, Dobbins DE, Salstrom JL, Furuya T, Dracheva S, Gulko PS, Cannon GW, Griffiths MM, Wilder RL.

Immunogenetics. 2000 Sep;51(11):930-44.

PMID:
11003387

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