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Items: 1 to 50 of 179

1.

Targeting the terminase: An important step forward in the treatment and prophylaxis of human cytomegalovirus infections.

Gentry BG, Bogner E, Drach JC.

Antiviral Res. 2019 Jan;161:116-124. doi: 10.1016/j.antiviral.2018.11.005. Epub 2018 Nov 23. Review.

PMID:
30472161
2.

Tetrahalogenated benzimidazole D-ribonucleosides are active against rat cytomegalovirus.

Dittmer A, Woskobojnik I, Adfeldt R, Drach JC, Townsend LB, Voigt S, Bogner E.

Antiviral Res. 2017 Jan;137:102-107. doi: 10.1016/j.antiviral.2016.11.012. Epub 2016 Nov 18.

PMID:
27871886
3.

Human cytomegalovirus resistance to deoxyribosylindole nucleosides maps to a transversion mutation in the terminase subunit-encoding gene UL89.

Gentry BG, Phan Q, Hall ED, Breitenbach JM, Borysko KZ, Kamil JP, Townsend LB, Drach JC.

Antimicrob Agents Chemother. 2015 Jan;59(1):226-32. doi: 10.1128/AAC.03686-14. Epub 2014 Oct 27.

4.

Metabolism of cyclopropavir and ganciclovir in human cytomegalovirus-infected cells.

Gentry BG, Drach JC.

Antimicrob Agents Chemother. 2014;58(4):2329-33. doi: 10.1128/AAC.02311-13. Epub 2014 Feb 10.

5.

Resistance of human cytomegalovirus to cyclopropavir maps to a base pair deletion in the open reading frame of UL97.

Gentry BG, Vollmer LE, Hall ED, Borysko KZ, Zemlicka J, Kamil JP, Drach JC.

Antimicrob Agents Chemother. 2013 Sep;57(9):4343-8. doi: 10.1128/AAC.00214-13. Epub 2013 Jul 1.

6.

Synthesis and antiviral activity of 6-deoxycyclopropavir, a new prodrug of cyclopropavir.

Li C, Quenelle DC, Prichard MN, Drach JC, Zemlicka J.

Bioorg Med Chem. 2012 Apr 15;20(8):2669-74. doi: 10.1016/j.bmc.2012.02.031. Epub 2012 Feb 20.

7.

Tyrosine-based 1-(S)-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) prodrugs: synthesis, stability, antiviral activity, and in vivo transport studies.

Zakharova VM, Serpi M, Krylov IS, Peterson LW, Breitenbach JM, Borysko KZ, Drach JC, Collins M, Hilfinger JM, Kashemirov BA, McKenna CE.

J Med Chem. 2011 Aug 25;54(16):5680-93. doi: 10.1021/jm2001426. Epub 2011 Aug 3.

8.

Synthesis, transport and antiviral activity of Ala-Ser and Val-Ser prodrugs of cidofovir.

Peterson LW, Kim JS, Kijek P, Mitchell S, Hilfinger J, Breitenbach J, Borysko K, Drach JC, Kashemirov BA, McKenna CE.

Bioorg Med Chem Lett. 2011 Jul 1;21(13):4045-9. doi: 10.1016/j.bmcl.2011.04.126. Epub 2011 May 3.

9.

Benzimidazole analogs inhibit human herpesvirus 6.

Prichard MN, Frederick SL, Daily S, Borysko KZ, Townsend LB, Drach JC, Kern ER.

Antimicrob Agents Chemother. 2011 May;55(5):2442-5. doi: 10.1128/AAC.01523-10. Epub 2011 Feb 7.

10.

Phosphorylation of antiviral and endogenous nucleotides to di- and triphosphates by guanosine monophosphate kinase.

Gentry BG, Gentry SN, Jackson TL, Zemlicka J, Drach JC.

Biochem Pharmacol. 2011 Jan 1;81(1):43-9. doi: 10.1016/j.bcp.2010.09.005. Epub 2010 Sep 22.

PMID:
20846508
11.

Stereoselective phosphorylation of cyclopropavir by pUL97 and competitive inhibition by maribavir.

Gentry BG, Kamil JP, Coen DM, Zemlicka J, Drach JC.

Antimicrob Agents Chemother. 2010 Aug;54(8):3093-8. doi: 10.1128/AAC.00468-10. Epub 2010 Jun 14.

12.

Synthesis and enantioselectivity of cyclopropavir phosphates for cellular GMP kinase.

Li C, Gentry BG, Drach JC, Zemlicka J.

Nucleosides Nucleotides Nucleic Acids. 2009 Sep;28(9):795-808. doi: 10.1080/15257770903172720.

PMID:
20183619
13.

Inhibition of human immunodeficiency virus type 1 by triciribine involves the accessory protein nef.

Ptak RG, Gentry BG, Hartman TL, Watson KM, Osterling MC, Buckheit RW Jr, Townsend LB, Drach JC.

Antimicrob Agents Chemother. 2010 Apr;54(4):1512-9. doi: 10.1128/AAC.01443-09. Epub 2010 Jan 19.

14.

L-valine ester of cyclopropavir: a new antiviral prodrug.

Wu Z, Drach JC, Prichard MN, Yanachkova M, Yanachkov I, Bowlin TL, Zemlicka J.

Antivir Chem Chemother. 2009 Sep 25;20(1):37-46. doi: 10.3851/IMP782.

15.

Susceptibilities of human cytomegalovirus clinical isolates and other herpesviruses to new acetylated, tetrahalogenated benzimidazole D-ribonucleosides.

Hwang JS, Schilf R, Drach JC, Townsend LB, Bogner E.

Antimicrob Agents Chemother. 2009 Dec;53(12):5095-101. doi: 10.1128/AAC.00809-09. Epub 2009 Sep 28.

16.

Phosphonate analogues of cyclopropavir phosphates and their E-isomers. Synthesis and antiviral activity.

Mhaske SB, Ksebati B, Prichard MN, Drach JC, Zemlicka J.

Bioorg Med Chem. 2009 Jun 1;17(11):3892-9. doi: 10.1016/j.bmc.2009.04.020. Epub 2009 Apr 17.

18.

Design and synthesis of vidarabine prodrugs as antiviral agents.

Shen W, Kim JS, Kish PE, Zhang J, Mitchell S, Gentry BG, Breitenbach JM, Drach JC, Hilfinger J.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):792-6. doi: 10.1016/j.bmcl.2008.12.031. Epub 2008 Dec 10.

19.

Design and synthesis of 1-(beta-D-ribofuranosyl)imidazo[4,5-c]pyrazoles as 5:5 bicyclic analogs of purine nucleosides.

Chien TC, Drach JC, Townsend LB.

Nucleic Acids Symp Ser (Oxf). 2008;(52):593-4. doi: 10.1093/nass/nrn300.

PMID:
18776519
20.

Serine peptide phosphoester prodrugs of cyclic cidofovir: synthesis, transport, and antiviral activity.

Eriksson U, Peterson LW, Kashemirov BA, Hilfinger JM, Drach JC, Borysko KZ, Breitenbach JM, Kim JS, Mitchell S, Kijek P, McKenna CE.

Mol Pharm. 2008 Jul-Aug;5(4):598-609. doi: 10.1021/mp8000099. Epub 2008 May 16.

21.

Fluorinated methylenecyclopropane analogues of nucleosides. Synthesis and antiviral activity of (Z)- and (E)-9-{[(2-fluoromethyl-2-hydroxymethyl)-cyclopropylidene]methyl}adenine and -guanine.

Li C, Prichard MN, Korba BE, Drach JC, Zemlicka J.

Bioorg Med Chem. 2008 Mar 1;16(5):2148-55. Epub 2007 Dec 5. Erratum in: Bioorg Med Chem. 2009 Jan 1;17(1):427.

22.

Identification of acetylated, tetrahalogenated benzimidazole D-ribonucleosides with enhanced activity against human cytomegalovirus.

Hwang JS, Kregler O, Schilf R, Bannert N, Drach JC, Townsend LB, Bogner E.

J Virol. 2007 Nov;81(21):11604-11. Epub 2007 Aug 29.

24.

Synthesis and biological activation of an ethylene glycol-linked amino acid conjugate of cyclic cidofovir.

Eriksson U, Hilfinger JM, Kim JS, Mitchell S, Kijek P, Borysko KZ, Breitenbach JM, Drach JC, Kashemirov BA, McKenna CE.

Bioorg Med Chem Lett. 2007 Feb 1;17(3):583-6. Epub 2006 Nov 10.

25.

9-{[3-fluoro-2-(hydroxymethyl)cyclopropylidene]methyl}adenines and -guanines. Synthesis and antiviral activity of all stereoisomers1.

Zhou S, Kern ER, Gullen E, Cheng YC, Drach JC, Tamiya S, Mitsuya H, Zemlicka J.

J Med Chem. 2006 Oct 5;49(20):6120-8.

26.

Vanadium complex of 2-(2'-Pyridyl)-4,5-dicyanoimidazole showing spermicidal and cytotoxic properties.

Less GB, Ockwig NW, Rasmussen PG, Smith GD, Keller LM, Drach JC.

Inorg Chem. 2006 Sep 4;45(18):7105-10.

PMID:
16933910
27.

Human cytomegalovirus UL27 is not required for viral replication in human tissue implanted in SCID mice.

Prichard MN, Quenelle DC, Bidanset DJ, Komazin G, Chou S, Drach JC, Kern ER.

Virol J. 2006 Mar 29;3:18.

28.

N-methylpurine DNA glycosylase and 8-oxoguanine dna glycosylase metabolize the antiviral nucleoside 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole.

Lorenzi PL, Landowski CP, Brancale A, Song X, Townsend LB, Drach JC, Amidon GL.

Drug Metab Dispos. 2006 Jun;34(6):1070-7. Epub 2006 Mar 24.

PMID:
16565170
29.
30.

Synthesis of 3-aminoimidazo[4,5-c]pyrazole nucleoside via the N-N bond formation strategy as a [5:5] fused analog of adenosine.

Chien TC, Berry DA, Drach JC, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1971-96.

PMID:
16438060
31.

Phosphoralaninate pronucleotides of pyrimidine methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.

Ambrose A, Zemlicka J, Kern ER, Drach JC, Gullen E, Cheng YC.

Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1763-74.

PMID:
16438046
32.

Synthesis and antiviral activity of some 2-substituted 3-formyl- and 3-cyano-5,6-dichloroindole nucleosides.

Williams JD, Drach JC, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1613-26.

PMID:
16438038
33.

Design, synthesis, and antiviral evaluation of some polyhalogenated indole C-nucleosides.

Chen JJ, Wei Y, Williams JD, Drach JC, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2005;24(10-12):1417-37.

PMID:
16438026
35.

Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides.

Qin X, Chen X, Wang K, Polin L, Kern ER, Drach JC, Gullen E, Cheng YC, Zemlicka J.

Bioorg Med Chem. 2006 Feb 15;14(4):1247-54. Epub 2005 Oct 18.

PMID:
16242337
37.

Amino acid ester prodrugs of 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole enhance metabolic stability in vitro and in vivo.

Lorenzi PL, Landowski CP, Song X, Borysko KZ, Breitenbach JM, Kim JS, Hilfinger JM, Townsend LB, Drach JC, Amidon GL.

J Pharmacol Exp Ther. 2005 Aug;314(2):883-90. Epub 2005 May 18.

PMID:
15901797
38.

Amino acid ester prodrugs of the antiviral agent 2-bromo-5,6-dichloro-1-(beta-D-ribofuranosyl)benzimidazole as potential substrates of hPEPT1 transporter.

Song X, Vig BS, Lorenzi PL, Drach JC, Townsend LB, Amidon GL.

J Med Chem. 2005 Feb 24;48(4):1274-7.

PMID:
15715497
39.

Nucleotides and pronucleotides of 2,2-bis(hydroxymethyl)methylenecyclopropane analogues of purine nucleosides: synthesis and antiviral activity.

Yan Z, Kern ER, Gullen E, Cheng YC, Drach JC, Zemlicka J.

J Med Chem. 2005 Jan 13;48(1):91-9.

PMID:
15634003
40.

(Z)- and (E)-[2-Fluoro-2-(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines, a new class of methylenecyclopropane analogues of nucleosides: synthesis and antiviral activity.

Zhou S, Kern ER, Gullen E, Cheng YC, Drach JC, Matsumi S, Mitsuya H, Zemlicka J.

J Med Chem. 2004 Dec 30;47(27):6964-72.

PMID:
15615545
41.

Synthesis, antiviral activity, and mode of action of some 3-substituted 2,5,6-trichloroindole 2'- and 5'-deoxyribonucleosides.

Williams JD, Ptak RG, Drach JC, Townsend LB.

J Med Chem. 2004 Nov 4;47(23):5773-82.

PMID:
15509176
42.

Synthesis and antiviral activity of 3-formyl- and 3-cyano-2,5,6-trichloroindole nucleoside derivatives.

Williams JD, Chen JJ, Drach JC, Townsend LB.

J Med Chem. 2004 Nov 4;47(23):5766-72.

PMID:
15509175
43.

Design, synthesis, and antiviral activity of certain 3-substituted 2,5,6-trichloroindole nucleosides.

Williams JD, Chen JJ, Drach JC, Townsend LB.

J Med Chem. 2004 Nov 4;47(23):5753-65.

PMID:
15509174
44.
45.

Inhibition of human cytomegalovirus replication by benzimidazole nucleosides involves three distinct mechanisms.

Evers DL, Komazin G, Ptak RG, Shin D, Emmer BT, Townsend LB, Drach JC.

Antimicrob Agents Chemother. 2004 Oct;48(10):3918-27.

46.

Synthesis and antiviral evaluation of some novel tricyclic pyrazolo[3,4-b]indole nucleosides.

Williams JD, Drach JC, Townsend LB.

Nucleosides Nucleotides Nucleic Acids. 2004 May;23(5):805-12.

PMID:
15281368
47.

Rhesus cytomegalovirus is similar to human cytomegalovirus in susceptibility to benzimidazole nucleosides.

North TW, Sequar G, Townsend LB, Drach JC, Barry PA.

Antimicrob Agents Chemother. 2004 Jul;48(7):2760-5.

48.

Activities of benzimidazole D- and L-ribonucleosides in animal models of cytomegalovirus infections.

Kern ER, Hartline CB, Rybak RJ, Drach JC, Townsend LB, Biron KK, Bidanset DJ.

Antimicrob Agents Chemother. 2004 May;48(5):1749-55.

49.

Mechanism of action of the ribopyranoside benzimidazole GW275175X against human cytomegalovirus.

Underwood MR, Ferris RG, Selleseth DW, Davis MG, Drach JC, Townsend LB, Biron KK, Boyd FL.

Antimicrob Agents Chemother. 2004 May;48(5):1647-51.

50.

Synthesis and antiviral activity of (Z)- and (E)-2,2-[bis(hydroxymethyl)cyclopropylidene]methylpurines and -pyrimidines: second-generation methylenecyclopropane analogues of nucleosides.

Zhou S, Breitenbach JM, Borysko KZ, Drach JC, Kern ER, Gullen E, Cheng YC, Zemlicka J.

J Med Chem. 2004 Jan 29;47(3):566-75.

PMID:
14736238

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