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Antimicrob Agents Chemother. 2011 Oct;55(10):4912-4. doi: 10.1128/AAC.00341-11. Epub 2011 Aug 1.

First description of an RND-type multidrug efflux pump in Achromobacter xylosoxidans, AxyABM.

Author information

1
Department of Bacteriology, University Hospital of Dijon, BP 37013, 21070 Dijon Cedex, France.

Abstract

Achromobacter xylosoxidans is an emerging pathogen in cystic fibrosis patients. The multidrug resistance of these bacteria remains poorly understood. We have characterized in a clinical strain the first resistance-nodulation-cell division (RND)-type multidrug efflux pump in this species: AxyABM. The inactivation of the transporter component axyB gene led to decreased MICs of cephalosporins (except cefepime), aztreonam, nalidixic acid, fluoroquinolones, and chloramphenicol.

PMID:
21807978
PMCID:
PMC3186983
DOI:
10.1128/AAC.00341-11
[Indexed for MEDLINE]
Free PMC Article

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