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Items: 7

1.

The enhanced immunopharmacology of VIB4920, a novel Tn3 fusion protein and CD40L antagonist, and assessment of its safety profile in cynomolgus monkeys.

Nicholson SM, Casey KA, Gunsior M, Drabic S, Iverson W, Cook H, Scott S, O'Day T, Karanth S, Dixit R, Ryan PC.

Br J Pharmacol. 2020 Mar;177(5):1061-1076. doi: 10.1111/bph.14897. Epub 2020 Feb 3.

PMID:
31648370
2.

A CD40L-targeting protein reduces autoantibodies and improves disease activity in patients with autoimmunity.

Karnell JL, Albulescu M, Drabic S, Wang L, Moate R, Baca M, Oganesyan V, Gunsior M, Thisted T, Yan L, Li J, Xiong X, Eck SC, de Los Reyes M, Yusuf I, Streicher K, Müller-Ladner U, Howe D, Ettinger R, Herbst R, Drappa J.

Sci Transl Med. 2019 Apr 24;11(489). pii: eaar6584. doi: 10.1126/scitranslmed.aar6584.

PMID:
31019027
3.

Fibronectin type III domains engineered to bind CD40L: cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of two complexes.

Oganesyan V, Ferguson A, Grinberg L, Wang L, Phipps S, Chacko B, Drabic S, Thisted T, Baca M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Sep;69(Pt 9):1045-8. doi: 10.1107/S1744309113022847. Epub 2013 Aug 21.

4.

Toll-like receptor 9-dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE.

Tian J, Avalos AM, Mao SY, Chen B, Senthil K, Wu H, Parroche P, Drabic S, Golenbock D, Sirois C, Hua J, An LL, Audoly L, La Rosa G, Bierhaus A, Naworth P, Marshak-Rothstein A, Crow MK, Fitzgerald KA, Latz E, Kiener PA, Coyle AJ.

Nat Immunol. 2007 May;8(5):487-96. Epub 2007 Apr 8. Erratum in: Nat Immunol. 2007 Jul;8(7):780.

PMID:
17417641
5.

Identification and structure-activity relationships of a new series of Melanocortin-4 receptor antagonists.

Vos TJ, Balani S, Blackburn C, Chau RW, Danca MD, Drabic SV, Farrer CA, Patane MA, Stroud SG, Yowe DL, Claiborne CF.

Bioorg Med Chem Lett. 2006 Apr 15;16(8):2302-5. Epub 2006 Feb 3.

PMID:
16458508
6.

Synthesis and biological evaluation of imidazole-based small molecule antagonists of the melanocortin 4 receptor (MC4-R).

Marsilje TH, Roses JB, Calderwood EF, Stroud SG, Forsyth NE, Blackburn C, Yowe DL, Miao W, Drabic SV, Bohane MD, Daniels JS, Li P, Wu L, Patane MA, Claiborne CF.

Bioorg Med Chem Lett. 2004 Jul 16;14(14):3721-5.

PMID:
15203150
7.

Identification of 2-[2-[2-(5-bromo-2- methoxyphenyl)-ethyl]-3-fluorophenyl]-4,5-dihydro-1H-imidazole (ML00253764), a small molecule melanocortin 4 receptor antagonist that effectively reduces tumor-induced weight loss in a mouse model.

Vos TJ, Caracoti A, Che JL, Dai M, Farrer CA, Forsyth NE, Drabic SV, Horlick RA, Lamppu D, Yowe DL, Balani S, Li P, Zeng H, Joseph IB, Rodriguez LE, Maguire MP, Patane MA, Claiborne CF.

J Med Chem. 2004 Mar 25;47(7):1602-4.

PMID:
15027849

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