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Items: 35


Versatile and robust genome editing with Streptococcus thermophilus CRISPR1-Cas9.

Agudelo D, Carter S, Velimirovic M, Duringer A, Rivest JF, Levesque S, Loehr J, Mouchiroud M, Cyr D, Waters PJ, Laplante M, Moineau S, Goulet A, Doyon Y.

Genome Res. 2020 Jan;30(1):107-117. doi: 10.1101/gr.255414.119. Epub 2020 Jan 3.


Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6.

Fuchsbauer O, Swuec P, Zimberger C, Amigues B, Levesque S, Agudelo D, Duringer A, Chaves-Sanjuan A, Spinelli S, Rousseau GM, Velimirovic M, Bolognesi M, Roussel A, Cambillau C, Moineau S, Doyon Y, Goulet A.

Mol Cell. 2019 Dec 19;76(6):922-937.e7. doi: 10.1016/j.molcel.2019.09.012. Epub 2019 Oct 8.


Widespread anti-CRISPR proteins in virulent bacteriophages inhibit a range of Cas9 proteins.

Hynes AP, Rousseau GM, Agudelo D, Goulet A, Amigues B, Loehr J, Romero DA, Fremaux C, Horvath P, Doyon Y, Cambillau C, Moineau S.

Nat Commun. 2018 Jul 25;9(1):2919. doi: 10.1038/s41467-018-05092-w.


Gene Therapy in Tyrosinemia: Potential and Pitfalls.

Carter S, Doyon Y.

Adv Exp Med Biol. 2017;959:231-243. doi: 10.1007/978-3-319-55780-9_21. Review.


Marker-free coselection for CRISPR-driven genome editing in human cells.

Agudelo D, Duringer A, Bozoyan L, Huard CC, Carter S, Loehr J, Synodinou D, Drouin M, Salsman J, Dellaire G, Laganière J, Doyon Y.

Nat Methods. 2017 Jun;14(6):615-620. doi: 10.1038/nmeth.4265. Epub 2017 Apr 17.


Preparation and Analysis of Native Chromatin-Modifying Complexes.

Doyon Y, Côté J.

Methods Enzymol. 2016;573:303-18. doi: 10.1016/bs.mie.2016.01.017. Epub 2016 Mar 16.


The TIP60 Complex Regulates Bivalent Chromatin Recognition by 53BP1 through Direct H4K20me Binding and H2AK15 Acetylation.

Jacquet K, Fradet-Turcotte A, Avvakumov N, Lambert JP, Roques C, Pandita RK, Paquet E, Herst P, Gingras AC, Pandita TK, Legube G, Doyon Y, Durocher D, Côté J.

Mol Cell. 2016 May 5;62(3):409-421. doi: 10.1016/j.molcel.2016.03.031.


A Scalable Genome-Editing-Based Approach for Mapping Multiprotein Complexes in Human Cells.

Dalvai M, Loehr J, Jacquet K, Huard CC, Roques C, Herst P, Côté J, Doyon Y.

Cell Rep. 2015 Oct 20;13(3):621-633. doi: 10.1016/j.celrep.2015.09.009. Epub 2015 Oct 8.


In vivo genome editing of the albumin locus as a platform for protein replacement therapy.

Sharma R, Anguela XM, Doyon Y, Wechsler T, DeKelver RC, Sproul S, Paschon DE, Miller JC, Davidson RJ, Shivak D, Zhou S, Rieders J, Gregory PD, Holmes MC, Rebar EJ, High KA.

Blood. 2015 Oct 8;126(15):1777-84. doi: 10.1182/blood-2014-12-615492. Epub 2015 Aug 21.


IL-1α Gene Deletion Protects Oligodendrocytes after Spinal Cord Injury through Upregulation of the Survival Factor Tox3.

Bastien D, Bellver Landete V, Lessard M, Vallières N, Champagne M, Takashima A, Tremblay MÈ, Doyon Y, Lacroix S.

J Neurosci. 2015 Jul 29;35(30):10715-30. doi: 10.1523/JNEUROSCI.0498-15.2015.


Robust ZFN-mediated genome editing in adult hemophilic mice.

Anguela XM, Sharma R, Doyon Y, Miller JC, Li H, Haurigot V, Rohde ME, Wong SY, Davidson RJ, Zhou S, Gregory PD, Holmes MC, High KA.

Blood. 2013 Nov 7;122(19):3283-7. doi: 10.1182/blood-2013-04-497354. Epub 2013 Oct 1.


Cancer translocations in human cells induced by zinc finger and TALE nucleases.

Piganeau M, Ghezraoui H, De Cian A, Guittat L, Tomishima M, Perrouault L, René O, Katibah GE, Zhang L, Holmes MC, Doyon Y, Concordet JP, Giovannangeli C, Jasin M, Brunet E.

Genome Res. 2013 Jul;23(7):1182-93. doi: 10.1101/gr.147314.112. Epub 2013 Apr 8.


Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme.

Wang J, Friedman G, Doyon Y, Wang NS, Li CJ, Miller JC, Hua KL, Yan JJ, Babiarz JE, Gregory PD, Holmes MC.

Genome Res. 2012 Jul;22(7):1316-26. doi: 10.1101/gr.122879.111. Epub 2012 Mar 20.


Conserved molecular interactions within the HBO1 acetyltransferase complexes regulate cell proliferation.

Avvakumov N, Lalonde ME, Saksouk N, Paquet E, Glass KC, Landry AJ, Doyon Y, Cayrou C, Robitaille GA, Richard DE, Yang XJ, Kutateladze TG, Côté J.

Mol Cell Biol. 2012 Feb;32(3):689-703. doi: 10.1128/MCB.06455-11. Epub 2011 Dec 5.


Inducing high rates of targeted mutagenesis in zebrafish using zinc finger nucleases (ZFNs).

McCammon JM, Doyon Y, Amacher SL.

Methods Mol Biol. 2011;770:505-27. doi: 10.1007/978-1-61779-210-6_20.


In vivo genome editing restores haemostasis in a mouse model of haemophilia.

Li H, Haurigot V, Doyon Y, Li T, Wong SY, Bhagwat AS, Malani N, Anguela XM, Sharma R, Ivanciu L, Murphy SL, Finn JD, Khazi FR, Zhou S, Paschon DE, Rebar EJ, Bushman FD, Gregory PD, Holmes MC, High KA.

Nature. 2011 Jun 26;475(7355):217-21. doi: 10.1038/nature10177.


Efficient targeted gene disruption in the soma and germ line of the frog Xenopus tropicalis using engineered zinc-finger nucleases.

Young JJ, Cherone JM, Doyon Y, Ankoudinova I, Faraji FM, Lee AH, Ngo C, Guschin DY, Paschon DE, Miller JC, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Harland RM, Zeitler B.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):7052-7. doi: 10.1073/pnas.1102030108. Epub 2011 Apr 6.


Rapid and efficient clathrin-mediated endocytosis revealed in genome-edited mammalian cells.

Doyon JB, Zeitler B, Cheng J, Cheng AT, Cherone JM, Santiago Y, Lee AH, Vo TD, Doyon Y, Miller JC, Paschon DE, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Drubin DG.

Nat Cell Biol. 2011 Mar;13(3):331-7. doi: 10.1038/ncb2175. Epub 2011 Feb 6.


Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures.

Doyon Y, Vo TD, Mendel MC, Greenberg SG, Wang J, Xia DF, Miller JC, Urnov FD, Gregory PD, Holmes MC.

Nat Methods. 2011 Jan;8(1):74-9. doi: 10.1038/nmeth.1539. Epub 2010 Dec 5.


Transient cold shock enhances zinc-finger nuclease-mediated gene disruption.

Doyon Y, Choi VM, Xia DF, Vo TD, Gregory PD, Holmes MC.

Nat Methods. 2010 Jun;7(6):459-60. doi: 10.1038/nmeth.1456. Epub 2010 May 2.


Precise genome modification in the crop species Zea mays using zinc-finger nucleases.

Shukla VK, Doyon Y, Miller JC, DeKelver RC, Moehle EA, Worden SE, Mitchell JC, Arnold NL, Gopalan S, Meng X, Choi VM, Rock JM, Wu YY, Katibah GE, Zhifang G, McCaskill D, Simpson MA, Blakeslee B, Greenwalt SA, Butler HJ, Hinkley SJ, Zhang L, Rebar EJ, Gregory PD, Urnov FD.

Nature. 2009 May 21;459(7245):437-41. doi: 10.1038/nature07992. Epub 2009 Apr 29.


HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail.

Saksouk N, Avvakumov N, Champagne KS, Hung T, Doyon Y, Cayrou C, Paquet E, Ullah M, Landry AJ, Côté V, Yang XJ, Gozani O, Kutateladze TG, Côté J.

Mol Cell. 2009 Jan 30;33(2):257-65. doi: 10.1016/j.molcel.2009.01.007.


Targeted transgene integration in plant cells using designed zinc finger nucleases.

Cai CQ, Doyon Y, Ainley WM, Miller JC, Dekelver RC, Moehle EA, Rock JM, Lee YL, Garrison R, Schulenberg L, Blue R, Worden A, Baker L, Faraji F, Zhang L, Holmes MC, Rebar EJ, Collingwood TN, Rubin-Wilson B, Gregory PD, Urnov FD, Petolino JF.

Plant Mol Biol. 2009 Apr;69(6):699-709. doi: 10.1007/s11103-008-9449-7. Epub 2008 Dec 27.


Molecular architecture of quartet MOZ/MORF histone acetyltransferase complexes.

Ullah M, Pelletier N, Xiao L, Zhao SP, Wang K, Degerny C, Tahmasebi S, Cayrou C, Doyon Y, Goh SL, Champagne N, Côté J, Yang XJ.

Mol Cell Biol. 2008 Nov;28(22):6828-43. doi: 10.1128/MCB.01297-08. Epub 2008 Sep 15. Erratum in: Mol Cell Biol. 2009 Feb;29(3):942.


Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases.

Doyon Y, McCammon JM, Miller JC, Faraji F, Ngo C, Katibah GE, Amora R, Hocking TD, Zhang L, Rebar EJ, Gregory PD, Urnov FD, Amacher SL.

Nat Biotechnol. 2008 Jun;26(6):702-8. doi: 10.1038/nbt1409. Epub 2008 May 25.


Eaf1 is the platform for NuA4 molecular assembly that evolutionarily links chromatin acetylation to ATP-dependent exchange of histone H2A variants.

Auger A, Galarneau L, Altaf M, Nourani A, Doyon Y, Utley RT, Cronier D, Allard S, Côté J.

Mol Cell Biol. 2008 Apr;28(7):2257-70. doi: 10.1128/MCB.01755-07. Epub 2008 Jan 22.


[Mystification and cleverness of tumor suppressors in nuclear functions].

Cayrou C, Doyon Y, Landry AJ, Côté V, Côté J.

Med Sci (Paris). 2006 Nov;22(11):919-21. French. No abstract available.


ING tumor suppressor proteins are critical regulators of chromatin acetylation required for genome expression and perpetuation.

Doyon Y, Cayrou C, Ullah M, Landry AJ, Côté V, Selleck W, Lane WS, Tan S, Yang XJ, Côté J.

Mol Cell. 2006 Jan 6;21(1):51-64.


The highly conserved and multifunctional NuA4 HAT complex.

Doyon Y, Côté J.

Curr Opin Genet Dev. 2004 Apr;14(2):147-54. Review.


Identification and analysis of native HAT complexes.

McMahon SJ, Doyon Y, Côté J, Grant PA.

Methods Enzymol. 2004;377:154-67. No abstract available.


Structural and functional conservation of the NuA4 histone acetyltransferase complex from yeast to humans.

Doyon Y, Selleck W, Lane WS, Tan S, Côté J.

Mol Cell Biol. 2004 Mar;24(5):1884-96.


Effect of C-domain N-glycosylation and deletion on rat pancreatic alpha-amylase secretion and activity.

Doyon Y, Home W, Daull P, LeBel D.

Biochem J. 2002 Feb 15;362(Pt 1):259-64.


Role of an ING1 growth regulator in transcriptional activation and targeted histone acetylation by the NuA4 complex.

Nourani A, Doyon Y, Utley RT, Allard S, Lane WS, Côté J.

Mol Cell Biol. 2001 Nov;21(22):7629-40.


Compressed work-week: psychophysiological and physiological repercussions.

Volle M, Brisson GR, Pérusse M, Tanaka M, Doyon Y.

Ergonomics. 1979 Sep;22(9):1001-10. No abstract available.


[Group psychotherapy of preadolescents presenting behavior problems of neurotic origin].

Chabot F, Doyon Y.

Vie Med Can Fr. 1973;2(2):115-7. French. No abstract available.


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