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Items: 22


Comparative Activities of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Enterobacteriaceae Isolates Producing Extended-Spectrum β-Lactamases from U.S. Hospitals.

Castanheira M, Doyle TB, Mendes RE, Sader HS.

Antimicrob Agents Chemother. 2019 Jun 24;63(7). pii: e00160-19. doi: 10.1128/AAC.00160-19. Print 2019 Jul.


Functional characterization of AC5 gain-of-function variants: Impact on the molecular basis of ADCY5-related dyskinesia.

Doyle TB, Hayes MP, Chen DH, Raskind WH, Watts VJ.

Biochem Pharmacol. 2019 May;163:169-177. doi: 10.1016/j.bcp.2019.02.005. Epub 2019 Feb 14.


Low Prevalence of Gram-Positive Isolates Showing Elevated Lefamulin MIC Results during the SENTRY Surveillance Program for 2015-2016 and Characterization of Resistance Mechanisms.

Mendes RE, Paukner S, Doyle TB, Gelone SP, Flamm RK, Sader HS.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02158-18. doi: 10.1128/AAC.02158-18. Print 2019 Apr.


Evaluation of the Revised Ceftaroline Disk Diffusion Breakpoints When Testing a Challenge Collection of Methicillin-Resistant Staphylococcus aureus Isolates.

Sader HS, Rhomberg PR, Doyle TB, Flamm RK, Mendes RE.

J Clin Microbiol. 2018 Nov 27;56(12). pii: e00777-18. doi: 10.1128/JCM.00777-18. Print 2018 Dec.


Structural basis for Na(+)-sensitivity in dopamine D2 and D3 receptors.

Michino M, Free RB, Doyle TB, Sibley DR, Shi L.

Chem Commun (Camb). 2015 May 21;51(41):8618-21. doi: 10.1039/c5cc02204e.


Dopamine receptor antagonists as new mode-of-action insecticide leads for control of Aedes and Culex mosquito vectors.

Nuss AB, Ejendal KF, Doyle TB, Meyer JM, Lang EG, Watts VJ, Hill CA.

PLoS Negl Trop Dis. 2015 Mar 20;9(3):e0003515. doi: 10.1371/journal.pntd.0003515. eCollection 2015 Mar.


Investigation of the binding and functional properties of extended length D3 dopamine receptor-selective antagonists.

Furman CA, Roof RA, Moritz AE, Miller BN, Doyle TB, Free RB, Banala AK, Paul NM, Kumar V, Sibley CD, Newman AH, Sibley DR.

Eur Neuropsychopharmacol. 2015 Sep;25(9):1448-61. doi: 10.1016/j.euroneuro.2014.11.013. Epub 2014 Nov 29.


Evaluation of AaDOP2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, Aedes aegypti.

Conley JM, Meyer JM, Nuss AB, Doyle TB, Savinov SN, Hill CA, Watts VJ.

J Pharmacol Exp Ther. 2015 Jan;352(1):53-60. doi: 10.1124/jpet.114.219717. Epub 2014 Oct 20.


(-)-Stepholidine is a potent pan-dopamine receptor antagonist of both G protein- and β-arrestin-mediated signaling.

Meade JA, Free RB, Miller NR, Chun LS, Doyle TB, Moritz AE, Conroy JL, Watts VJ, Sibley DR.

Psychopharmacology (Berl). 2015 Mar;232(5):917-30. doi: 10.1007/s00213-014-3726-8. Epub 2014 Sep 18.


Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor.

Free RB, Chun LS, Moritz AE, Miller BN, Doyle TB, Conroy JL, Padron A, Meade JA, Xiao J, Hu X, Dulcey AE, Han Y, Duan L, Titus S, Bryant-Genevier M, Barnaeva E, Ferrer M, Javitch JA, Beuming T, Shi L, Southall NT, Marugan JJ, Sibley DR.

Mol Pharmacol. 2014 Jul;86(1):96-105. doi: 10.1124/mol.113.090563. Epub 2014 Apr 22.


D1-D2 dopamine receptor synergy promotes calcium signaling via multiple mechanisms.

Chun LS, Free RB, Doyle TB, Huang XP, Rankin ML, Sibley DR.

Mol Pharmacol. 2013 Aug;84(2):190-200. doi: 10.1124/mol.113.085175. Epub 2013 May 16.


In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: studies of the mode of action in Staphylococcus aureus.

Robertson GT, Bonventre EJ, Doyle TB, Du Q, Duncan L, Morris TW, Roche ED, Yan D, Lynch AS.

Antimicrob Agents Chemother. 2008 Jul;52(7):2313-23. doi: 10.1128/AAC.01649-07. Epub 2008 Apr 28.


In vitro evaluation of CBR-2092, a novel rifamycin-quinolone hybrid antibiotic: microbiology profiling studies with staphylococci and streptococci.

Robertson GT, Bonventre EJ, Doyle TB, Du Q, Duncan L, Morris TW, Roche ED, Yan D, Lynch AS.

Antimicrob Agents Chemother. 2008 Jul;52(7):2324-34. doi: 10.1128/AAC.01651-07. Epub 2008 Apr 28.


A Novel indole compound that inhibits Pseudomonas aeruginosa growth by targeting MreB is a substrate for MexAB-OprM.

Robertson GT, Doyle TB, Du Q, Duncan L, Mdluli KE, Lynch AS.

J Bacteriol. 2007 Oct;189(19):6870-81. Epub 2007 Jul 20.


Further exploration of antimicrobial ketodihydronicotinic acid derivatives by multiple parallel syntheses.

Laursen JB, Nielsen J, Haack T, Pusuluri S, David S, Balakrishna R, Zeng Y, Ma Z, Doyle TB, Mitscher LA.

Comb Chem High Throughput Screen. 2006 Nov;9(9):663-81.


New C25 carbamate rifamycin derivatives are resistant to inactivation by ADP-ribosyl transferases.

Combrink KD, Denton DA, Harran S, Ma Z, Chapo K, Yan D, Bonventre E, Roche ED, Doyle TB, Robertson GT, Lynch AS.

Bioorg Med Chem Lett. 2007 Jan 15;17(2):522-6. Epub 2006 Oct 12.


The complex flagellar torque generator of Pseudomonas aeruginosa.

Doyle TB, Hawkins AC, McCarter LL.

J Bacteriol. 2004 Oct;186(19):6341-50.


Morphology-dependent intergranular behavior in high-Tc superconducting Y-Ba-Cu-O.

Doyle TB, Doyle RA.

Phys Rev B Condens Matter. 1993 Apr 1;47(13):8111-8118. No abstract available.


Periportal contrast enhancement on CT scans of the liver.

Hammerman AM, Kotner LM Jr, Doyle TB.

AJR Am J Roentgenol. 1991 Feb;156(2):313-5.


Appearance of adenosine triphosphate in the perfusate from working frog heart.

Doyle TB, Forrester T.

Pflugers Arch. 1985 Sep;405(1):80-2.


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