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Items: 1 to 50 of 80

1.

Improved Case Manager Satisfaction by Stratification of Case Load.

Doyle ML, Jenkins BD, Dreyer AM.

Prof Case Manag. 2018 Mar/Apr;23(2):95-98. doi: 10.1097/NCM.0000000000000278. No abstract available.

PMID:
29381677
2.

Development of a Model Protein Interaction Pair as a Benchmarking Tool for the Quantitative Analysis of 2-Site Protein-Protein Interactions.

Yamniuk AP, Newitt JA, Doyle ML, Arisaka F, Giannetti AM, Hensley P, Myszka DG, Schwarz FP, Thomson JA, Eisenstein E.

J Biomol Tech. 2015 Dec;26(4):125-41. doi: 10.7171/jbt.15-2604-001. Epub 2015 Oct 29.

3.

The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex.

Ramamurthy V, Yamniuk AP, Lawrence EJ, Yong W, Schneeweis LA, Cheng L, Murdock M, Corbett MJ, Doyle ML, Sheriff S.

Acta Crystallogr F Struct Biol Commun. 2015 Oct;71(Pt 10):1273-81. doi: 10.1107/S2053230X15016416. Epub 2015 Sep 23.

4.

Impact of substrate feed patterns on solids reduction by the Cannibal process.

Khanthongthip P, Novak JT, Doyle ML.

Water Environ Res. 2015 Mar;87(3):274-80.

PMID:
25842539
5.

Hydrogen/deuterium exchange mass spectrometry applied to IL-23 interaction characteristics: potential impact for therapeutics.

Iacob RE, Krystek SR, Huang RY, Wei H, Tao L, Lin Z, Morin PE, Doyle ML, Tymiak AA, Engen JR, Chen G.

Expert Rev Proteomics. 2015 Apr;12(2):159-69. doi: 10.1586/14789450.2015.1018897. Epub 2015 Feb 24. Review.

6.

The influence of adnectin binding on the extracellular domain of epidermal growth factor receptor.

Iacob RE, Chen G, Ahn J, Houel S, Wei H, Mo J, Tao L, Cohen D, Xie D, Lin Z, Morin PE, Doyle ML, Tymiak AA, Engen JR.

J Am Soc Mass Spectrom. 2014 Dec;25(12):2093-102. doi: 10.1007/s13361-014-0973-1. Epub 2014 Sep 16.

7.

Application of a kosmotrope-based solubility assay to multiple protein therapeutic classes indicates broad use as a high-throughput screen for protein therapeutic aggregation propensity.

Yamniuk AP, Ditto N, Patel M, Dai J, Sejwal P, Stetsko P, Doyle ML.

J Pharm Sci. 2013 Aug;102(8):2424-39. doi: 10.1002/jps.23618. Epub 2013 May 27.

PMID:
23712759
8.

The role of anaerobic sludge recycle in improving anaerobic digester performance.

Young MN, Krajmalnik-Brown R, Liu W, Doyle ML, Rittmann BE.

Bioresour Technol. 2013 Jan;128:731-7. doi: 10.1016/j.biortech.2012.11.079. Epub 2012 Nov 28.

PMID:
23265819
9.

ABRF-MIRG benchmark study: molecular interactions in a three-component system.

Yamniuk AP, Edavettal SC, Bergqvist S, Yadav SP, Doyle ML, Calabrese K, Parsons JF, Eisenstein E.

J Biomol Tech. 2012 Sep;23(3):101-14. doi: 10.7171/jbt.12-2303-003.

10.

MIRG Survey 2011: snapshot of rapidly evolving label-free technologies used for characterizing molecular interactions.

Yadav SP, Bergqvist S, Doyle ML, Neubert TA, Yamniuk AP.

J Biomol Tech. 2012 Sep;23(3):94-100. doi: 10.7171/jbt.12-2303-002.

11.

Reversible and pH-dependent weak drug-excipient binding does not affect oral bioavailability of high dose drugs.

Narang AS, Yamniuk AP, Zhang L, Comezoglu SN, Bindra DS, Varia S, Doyle ML, Badawy S.

J Pharm Pharmacol. 2012 Apr;64(4):553-65. doi: 10.1111/j.2042-7158.2011.01435.x. Epub 2012 Jan 13.

PMID:
22420661
12.

A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor.

Emanuel SL, Engle LJ, Chao G, Zhu RR, Cao C, Lin Z, Yamniuk AP, Hosbach J, Brown J, Fitzpatrick E, Gokemeijer J, Morin P, Morse BA, Carvajal IM, Fabrizio D, Wright MC, Das Gupta R, Gosselin M, Cataldo D, Ryseck RP, Doyle ML, Wong TW, Camphausen RT, Cload ST, Marsh HN, Gottardis MM, Furfine ES.

MAbs. 2011 Jan-Feb;3(1):38-48. Epub 2011 Jan 1.

13.

Structural mass spectrometry in protein therapeutics discovery.

Kim YJ, Doyle ML.

Anal Chem. 2010 Sep 1;82(17):7083-9. doi: 10.1021/ac101575d.

PMID:
20698501
14.

Ghrelin is dispensable for embryonic pancreatic islet development and differentiation.

Hill JT, Mastracci TL, Vinton C, Doyle ML, Anderson KR, Loomis ZL, Schrunk JM, Minic AD, Prabakar KR, Pugliese A, Sun Y, Smith RG, Sussel L.

Regul Pept. 2009 Oct 9;157(1-3):51-6. doi: 10.1016/j.regpep.2009.02.013. Epub 2009 Mar 5.

15.

Titration microcalorimetry.

Doyle ML.

Curr Protoc Protein Sci. 2001 May;Chapter 20:Unit20.4. doi: 10.1002/0471140864.ps2004s18.

PMID:
18429159
16.

Time-resolved limited proteolysis of mitogen-activated protein kinase-activated protein kinase-2 determined by LC/MS only.

Tao L, Kiefer SE, Xie D, Bryson JW, Hefta SA, Doyle ML.

J Am Soc Mass Spectrom. 2008 Jun;19(6):841-54. doi: 10.1016/j.jasms.2008.02.014. Epub 2008 Mar 18.

17.

Development and testing of a chemical mechanism for atmospheric photochemical transformations of 1,3-butadiene.

Sexton KG, Doyle ML, Jeffries HE, Ebersviller S.

Chem Biol Interact. 2007 Mar 20;166(1-3):156-62. Epub 2007 Jan 10.

PMID:
17328875
18.

Molecular basis for increased susceptibility of isolates with atazanavir resistance-conferring substitution I50L to other protease inhibitors.

Yanchunas J Jr, Langley DR, Tao L, Rose RE, Friborg J, Colonno RJ, Doyle ML.

Antimicrob Agents Chemother. 2005 Sep;49(9):3825-32.

19.

Structural and functional characterization of CFE88: evidence that a conserved and essential bacterial protein is a methyltransferase.

Constantine KL, Krystek SR, Healy MD, Doyle ML, Siemers NO, Thanassi J, Yan N, Xie D, Goldfarb V, Yanchunas J, Tao L, Dougherty BA, Farmer BT 2nd.

Protein Sci. 2005 Jun;14(6):1472-84.

20.

Decrypting the biochemical function of an essential gene from Streptococcus pneumoniae using ThermoFluor technology.

Carver TE, Bordeau B, Cummings MD, Petrella EC, Pucci MJ, Zawadzke LE, Dougherty BA, Tredup JA, Bryson JW, Yanchunas J Jr, Doyle ML, Witmer MR, Nelen MI, DesJarlais RL, Jaeger EP, Devine H, Asel ED, Springer BA, Bone R, Salemme FR, Todd MJ.

J Biol Chem. 2005 Mar 25;280(12):11704-12. Epub 2005 Jan 5.

21.

Worker training for new threats: a proposed framework.

Mitchell CS, Doyle ML, Moran JB, Lippy B, Hughes JT Jr, Lum M, Agnew J.

Am J Ind Med. 2004 Nov;46(5):423-31.

PMID:
15490470
22.

The ABRF-MIRG'02 study: assembly state, thermodynamic, and kinetic analysis of an enzyme/inhibitor interaction.

Myszka DG, Abdiche YN, Arisaka F, Byron O, Eisenstein E, Hensley P, Thomson JA, Lombardo CR, Schwarz F, Stafford W, Doyle ML.

J Biomol Tech. 2003 Dec;14(4):247-69.

23.

Selective binding and oligomerization of the murine granulocyte colony-stimulating factor receptor by a low molecular weight, nonpeptidyl ligand.

Doyle ML, Tian SS, Miller SG, Kessler L, Baker AE, Brigham-Burke MR, Dillon SB, Duffy KJ, Keenan RM, Lehr R, Rosen J, Schneeweis LA, Trill J, Young PR, Luengo JI, Lamb P.

J Biol Chem. 2003 Mar 14;278(11):9426-34. Epub 2003 Jan 10.

24.

HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.

Kwong PD, Doyle ML, Casper DJ, Cicala C, Leavitt SA, Majeed S, Steenbeke TD, Venturi M, Chaiken I, Fung M, Katinger H, Parren PW, Robinson J, Van Ryk D, Wang L, Burton DR, Freire E, Wyatt R, Sodroski J, Hendrickson WA, Arthos J.

Nature. 2002 Dec 12;420(6916):678-82.

PMID:
12478295
25.

Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein.

Xiang SH, Kwong PD, Gupta R, Rizzuto CD, Casper DJ, Wyatt R, Wang L, Hendrickson WA, Doyle ML, Sodroski J.

J Virol. 2002 Oct;76(19):9888-99.

26.

Steady-state kinetic characterization of substrates and metal-ion specificities of the full-length and N-terminally truncated recombinant human methionine aminopeptidases (type 2).

Yang G, Kirkpatrick RB, Ho T, Zhang GF, Liang PH, Johanson KO, Casper DJ, Doyle ML, Marino JP Jr, Thompson SK, Chen W, Tew DG, Meek TD.

Biochemistry. 2001 Sep 4;40(35):10645-54.

PMID:
11524009
27.

Identification, substrate specificity, and inhibition of the Streptococcus pneumoniae beta-ketoacyl-acyl carrier protein synthase III (FabH).

Khandekar SS, Gentry DR, Van Aller GS, Warren P, Xiang H, Silverman C, Doyle ML, Chambers PA, Konstantinidis AK, Brandt M, Daines RA, Lonsdale JT.

J Biol Chem. 2001 Aug 10;276(32):30024-30. Epub 2001 May 24.

28.

Subunit-subunit interactions in trimeric arginase. Generation of active monomers by mutation of a single amino acid.

Lavulo LT, Sossong TM Jr, Brigham-Burke MR, Doyle ML, Cox JD, Christianson DW, Ash DE.

J Biol Chem. 2001 Apr 27;276(17):14242-8. Epub 2001 Jan 24.

29.

Modification of the Fc region of a primatized IgG antibody to human CD4 retains its ability to modulate CD4 receptors but does not deplete CD4(+) T cells in chimpanzees.

Newman R, Hariharan K, Reff M, Anderson DR, Braslawsky G, Santoro D, Hanna N, Bugelski PJ, Brigham-Burke M, Crysler C, Gagnon RC, Dal Monte P, Doyle ML, Hensley PC, Reddy MP, Sweet RW, Truneh A.

Clin Immunol. 2001 Feb;98(2):164-74.

PMID:
11161972
30.
31.

Measurement of protein interaction bioenergetics: application to structural variants of anti-sCD4 antibody.

Doyle ML, Brigham-Burke M, Blackburn MN, Brooks IS, Smith TM, Newman R, Reff M, Stafford WF 3rd, Sweet RW, Truneh A, Hensley P, O'Shannessy DJ.

Methods Enzymol. 2000;323:207-30.

PMID:
10944754
32.

Evaluating energetics of erythropoietin ligand binding to homodimerized receptor extracellular domains.

Hensley P, Doyle ML, Myszka DG, Woody RW, Brigham-Burke MR, Erickson-Miller CL, Griffin CA, Jones CS, McNulty DE, O'Brien SP, Amegadzie BY, MacKenzie L, Ryan MD, Young PR.

Methods Enzymol. 2000;323:177-207. No abstract available.

PMID:
10944753
33.

Energetics of the HIV gp120-CD4 binding reaction.

Myszka DG, Sweet RW, Hensley P, Brigham-Burke M, Kwong PD, Hendrickson WA, Wyatt R, Sodroski J, Doyle ML.

Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):9026-31.

34.

Rational design of femtomolar inhibitors of isoleucyl tRNA synthetase from a binding model for pseudomonic acid-A.

Brown MJ, Mensah LM, Doyle ML, Broom NJ, Osbourne N, Forrest AK, Richardson CM, O'Hanlon PJ, Pope AJ.

Biochemistry. 2000 May 23;39(20):6003-11.

PMID:
10821672
35.

Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor.

Truneh A, Sharma S, Silverman C, Khandekar S, Reddy MP, Deen KC, McLaughlin MM, Srinivasula SM, Livi GP, Marshall LA, Alnemri ES, Williams WV, Doyle ML.

J Biol Chem. 2000 Jul 28;275(30):23319-25.

36.

Identification and initial characterization of four novel members of the interleukin-1 family.

Kumar S, McDonnell PC, Lehr R, Tierney L, Tzimas MN, Griswold DE, Capper EA, Tal-Singer R, Wells GI, Doyle ML, Young PR.

J Biol Chem. 2000 Apr 7;275(14):10308-14.

37.

Expression, purification, and crystallization of the Escherichia coli selenomethionyl beta-ketoacyl-acyl carrier protein synthase III.

Khandekar SS, Konstantinidis AK, Silverman C, Janson CA, McNulty DE, Nwagwu S, Van Aller GS, Doyle ML, Kane JF, Qiu X, Lonsdale J.

Biochem Biophys Res Commun. 2000 Apr 2;270(1):100-7.

PMID:
10733911
38.

Elimination of Fc receptor-dependent effector functions of a modified IgG4 monoclonal antibody to human CD4.

Reddy MP, Kinney CA, Chaikin MA, Payne A, Fishman-Lobell J, Tsui P, Dal Monte PR, Doyle ML, Brigham-Burke MR, Anderson D, Reff M, Newman R, Hanna N, Sweet RW, Truneh A.

J Immunol. 2000 Feb 15;164(4):1925-33.

39.

A direct comparison of the activities of two humanized respiratory syncytial virus monoclonal antibodies: MEDI-493 and RSHZl9.

Johnson S, Griego SD, Pfarr DS, Doyle ML, Woods R, Carlin D, Prince GA, Koenig S, Young JF, Dillon SB.

J Infect Dis. 1999 Jul;180(1):35-40.

PMID:
10353858
40.

Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase.

Herberg FW, Doyle ML, Cox S, Taylor SS.

Biochemistry. 1999 May 11;38(19):6352-60.

PMID:
10320366
41.

Structural and functional properties of human hemoglobins reassembled after synthesis in Escherichia coli.

Hui HL, Kavanaugh JS, Doyle ML, Wierzba A, Rogers PH, Arnone A, Holt JM, Ackers GK, Noble RW.

Biochemistry. 1999 Jan 19;38(3):1040-9.

PMID:
9894000
42.
43.

Interpreting kinetic rate constants from optical biosensor data recorded on a decaying surface.

Joss L, Morton TA, Doyle ML, Myszka DG.

Anal Biochem. 1998 Aug 1;261(2):203-10.

PMID:
9716423
44.

Site-directed mutagenesis probing the catalytic role of arginines 165 and 166 of human cytomegalovirus protease.

Liang PH, Brun KA, Feild JA, O'Donnell K, Doyle ML, Green SM, Baker AE, Blackburn MN, Abdel-Meguid SS.

Biochemistry. 1998 Apr 28;37(17):5923-9.

PMID:
9558326
45.

Thermodynamic studies on the equilibrium properties of a series of recombinant betaW37 hemoglobin mutants.

Kiger L, Klinger AL, Kwiatkowski LD, De Young A, Doyle ML, Holt JM, Noble RW, Ackers GK.

Biochemistry. 1998 Mar 31;37(13):4336-45.

PMID:
9521754
46.

Monomeric isomers of human interleukin 5 show that 1:1 receptor recruitment is sufficient for function.

Li J, Cook R, Doyle ML, Hensley P, McNulty DE, Chaiken I.

Proc Natl Acad Sci U S A. 1997 Jun 24;94(13):6694-9.

47.

Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site.

Young PR, McLaughlin MM, Kumar S, Kassis S, Doyle ML, McNulty D, Gallagher TF, Fisher S, McDonnell PC, Carr SA, Huddleston MJ, Seibel G, Porter TG, Livi GP, Adams JL, Lee JC.

J Biol Chem. 1997 May 2;272(18):12116-21.

48.
49.

Kinetic analysis of a protein antigen-antibody interaction limited by mass transport on an optical biosensor.

Myszka DG, Morton TA, Doyle ML, Chaiken IM.

Biophys Chem. 1997 Feb 28;64(1-3):127-37.

PMID:
9127943
50.

Characterization of binding interactions by isothermal titration calorimetry.

Doyle ML.

Curr Opin Biotechnol. 1997 Feb 1;8(1):31-5.

PMID:
9013658

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