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Items: 1 to 50 of 55

1.

Beneficial Effects of Human Anti-Interleukin-15 Antibody in Gluten-Sensitive Rhesus Macaques with Celiac Disease.

Sestak K, Dufour JP, Liu DX, Rout N, Alvarez X, Blanchard J, Faldas A, Laine DJ, Clarke AW, Doyle AG.

Front Immunol. 2018 Jul 11;9:1603. doi: 10.3389/fimmu.2018.01603. eCollection 2018.

2.

Correction to "Nickel-Catalyzed Enantioselective Reductive Cross-Coupling of Styrenyl Aziridines".

Woods BP, Orlandi M, Huang CD, Sigman MS, Doyle AG.

J Am Chem Soc. 2018 Jun 20;140(24):7744-7745. doi: 10.1021/jacs.8b05650. Epub 2018 Jun 11. No abstract available.

PMID:
29889505
3.

Deoxyfluorination with Sulfonyl Fluorides: Navigating Reaction Space with Machine Learning.

Nielsen MK, Ahneman DT, Riera O, Doyle AG.

J Am Chem Soc. 2018 Apr 18;140(15):5004-5008. doi: 10.1021/jacs.8b01523. Epub 2018 Apr 3.

PMID:
29584953
4.

Predicting reaction performance in C-N cross-coupling using machine learning.

Ahneman DT, Estrada JG, Lin S, Dreher SD, Doyle AG.

Science. 2018 Apr 13;360(6385):186-190. doi: 10.1126/science.aar5169. Epub 2018 Feb 15. Erratum in: Science. 2018 Apr 13;360(6385):.

PMID:
29449509
5.

An anti-TL1A antibody for the treatment of asthma and inflammatory bowel disease.

Clarke AW, Poulton L, Shim D, Mabon D, Butt D, Pollard M, Pande V, Husten J, Lyons J, Tian C, Doyle AG.

MAbs. 2018 May/Jun;10(4):664-677. doi: 10.1080/19420862.2018.1440164. Epub 2018 Mar 5.

6.

Long-Lived Charge-Transfer States of Nickel(II) Aryl Halide Complexes Facilitate Bimolecular Photoinduced Electron Transfer.

Shields BJ, Kudisch B, Scholes GD, Doyle AG.

J Am Chem Soc. 2018 Feb 28;140(8):3035-3039. doi: 10.1021/jacs.7b13281. Epub 2018 Feb 12.

PMID:
29400956
7.

Ni-Catalyzed Carbon-Carbon Bond-Forming Reductive Amination.

Heinz C, Lutz JP, Simmons EM, Miller MM, Ewing WR, Doyle AG.

J Am Chem Soc. 2018 Feb 14;140(6):2292-2300. doi: 10.1021/jacs.7b12212. Epub 2018 Feb 1.

PMID:
29341599
8.

Parameterization of phosphine ligands demonstrates enhancement of nickel catalysis via remote steric effects.

Wu K, Doyle AG.

Nat Chem. 2017 Aug;9(8):779-784. doi: 10.1038/nchem.2741. Epub 2017 Mar 6.

9.

Mild, Redox-Neutral Formylation of Aryl Chlorides through the Photocatalytic Generation of Chlorine Radicals.

Nielsen MK, Shields BJ, Liu J, Williams MJ, Zacuto MJ, Doyle AG.

Angew Chem Int Ed Engl. 2017 Jun 12;56(25):7191-7194. doi: 10.1002/anie.201702079. Epub 2017 May 23.

10.

Nickel-Catalyzed Enantioselective Reductive Cross-Coupling of Styrenyl Aziridines.

Woods BP, Orlandi M, Huang CY, Sigman MS, Doyle AG.

J Am Chem Soc. 2017 Apr 26;139(16):5688-5691. doi: 10.1021/jacs.7b03448. Epub 2017 Apr 13. Erratum in: J Am Chem Soc. 2018 Jun 20;140(24):7744-7745.

PMID:
28406622
11.

Dual Nickel- and Photoredox-Catalyzed Enantioselective Desymmetrization of Cyclic meso-Anhydrides.

Stache EE, Rovis T, Doyle AG.

Angew Chem Int Ed Engl. 2017 Mar 20;56(13):3679-3683. doi: 10.1002/anie.201700097. Epub 2017 Feb 23.

12.

Nickel-catalyzed enantioselective arylation of pyridine.

Lutz JP, Chau ST, Doyle AG.

Chem Sci. 2016 Jul 1;7(7):4105-4109. doi: 10.1039/c6sc00702c. Epub 2016 Mar 8.

13.

C-H functionalization of amines with aryl halides by nickel-photoredox catalysis.

Ahneman DT, Doyle AG.

Chem Sci. 2016 Dec 1;7(12):7002-7006. doi: 10.1039/C6SC02815B. Epub 2016 Jul 28.

14.

Direct C(sp3)-H Cross Coupling Enabled by Catalytic Generation of Chlorine Radicals.

Shields BJ, Doyle AG.

J Am Chem Soc. 2016 Oct 5;138(39):12719-12722. Epub 2016 Sep 21.

15.

Nucleophilic (Radio)Fluorination of α-Diazocarbonyl Compounds Enabled by Copper-Catalyzed H-F Insertion.

Gray EE, Nielsen MK, Choquette KA, Kalow JA, Graham TJ, Doyle AG.

J Am Chem Soc. 2016 Aug 31;138(34):10802-5. doi: 10.1021/jacs.6b06770. Epub 2016 Aug 17.

PMID:
27500313
16.

Direct Acylation of C(sp(3))-H Bonds Enabled by Nickel and Photoredox Catalysis.

Joe CL, Doyle AG.

Angew Chem Int Ed Engl. 2016 Mar 14;55(12):4040-3. doi: 10.1002/anie.201511438. Epub 2016 Feb 17.

17.

A phase I study of selumetinib (AZD6244/ARRY-142866), a MEK1/2 inhibitor, in combination with cetuximab in refractory solid tumors and KRAS mutant colorectal cancer.

Deming DA, Cavalcante LL, Lubner SJ, Mulkerin DL, LoConte NK, Eickhoff JC, Kolesar JM, Fioravanti S, Greten TF, Compton K, Doyle AG, Wilding G, Duffy A, Liu G.

Invest New Drugs. 2016 Apr;34(2):168-75. doi: 10.1007/s10637-015-0314-7. Epub 2015 Dec 14.

18.

Dialkyl Ether Formation by Nickel-Catalyzed Cross-Coupling of Acetals and Aryl Iodides.

Arendt KM, Doyle AG.

Angew Chem Int Ed Engl. 2015 Aug 17;54(34):9876-80. doi: 10.1002/anie.201503936. Epub 2015 Jul 15.

19.

PyFluor: A Low-Cost, Stable, and Selective Deoxyfluorination Reagent.

Nielsen MK, Ugaz CR, Li W, Doyle AG.

J Am Chem Soc. 2015 Aug 5;137(30):9571-4. doi: 10.1021/jacs.5b06307. Epub 2015 Jul 21.

20.

A modular, air-stable nickel precatalyst.

Shields JD, Gray EE, Doyle AG.

Org Lett. 2015 May 1;17(9):2166-9. doi: 10.1021/acs.orglett.5b00766. Epub 2015 Apr 17.

21.

Electron-deficient olefin ligands enable generation of quaternary carbons by Ni-catalyzed cross-coupling.

Huang CY, Doyle AG.

J Am Chem Soc. 2015 May 6;137(17):5638-41. doi: 10.1021/jacs.5b02503. Epub 2015 Apr 24.

PMID:
25879801
22.

Potent neutralizing anti-CD1d antibody reduces lung cytokine release in primate asthma model.

Nambiar J, Clarke AW, Shim D, Mabon D, Tian C, Windloch K, Buhmann C, Corazon B, Lindgren M, Pollard M, Domagala T, Poulton L, Doyle AG.

MAbs. 2015;7(3):638-50. doi: 10.1080/19420862.2015.1016693.

23.

Dual catalysis. Merging photoredox with nickel catalysis: coupling of α-carboxyl sp³-carbons with aryl halides.

Zuo Z, Ahneman DT, Chu L, Terrett JA, Doyle AG, MacMillan DW.

Science. 2014 Jul 25;345(6195):437-40. doi: 10.1126/science.1255525. Epub 2014 Jun 5.

24.

The chemistry of transition metals with three-membered ring heterocycles.

Huang CY, Doyle AG.

Chem Rev. 2014 Aug 27;114(16):8153-98. doi: 10.1021/cr500036t. Epub 2014 May 28. No abstract available.

PMID:
24869559
25.

Enantioselective radiosynthesis of positron emission tomography (PET) tracers containing [¹⁸F]fluorohydrins.

Graham TJ, Lambert RF, Ploessl K, Kung HF, Doyle AG.

J Am Chem Soc. 2014 Apr 9;136(14):5291-4. doi: 10.1021/ja5025645. Epub 2014 Mar 31.

PMID:
24628021
26.

Enantioselective, nickel-catalyzed Suzuki cross-coupling of quinolinium ions.

Shields JD, Ahneman DT, Graham TJ, Doyle AG.

Org Lett. 2014 Jan 3;16(1):142-5. doi: 10.1021/ol4031364. Epub 2013 Nov 26.

27.

Directed nickel-catalyzed negishi cross coupling of alkyl aziridines.

Nielsen DK, Huang CY, Doyle AG.

J Am Chem Soc. 2013 Sep 11;135(36):13605-9. doi: 10.1021/ja4076716. Epub 2013 Aug 30.

PMID:
23961769
28.

Palladium-catalyzed allylic C-H fluorination.

Braun MG, Doyle AG.

J Am Chem Soc. 2013 Sep 4;135(35):12990-3. doi: 10.1021/ja407223g. Epub 2013 Aug 20.

PMID:
23947740
29.

Nickel-catalyzed enantioselective arylation of pyridinium ions: harnessing an iminium ion activation mode.

Chau ST, Lutz JP, Wu K, Doyle AG.

Angew Chem Int Ed Engl. 2013 Aug 26;52(35):9153-6. doi: 10.1002/anie.201303994. Epub 2013 Jul 10. No abstract available.

30.
31.

Synthesis of β-fluoroamines by Lewis base catalyzed hydrofluorination of aziridines.

Kalow JA, Schmitt DE, Doyle AG.

J Org Chem. 2012 Apr 20;77(8):4177-83. doi: 10.1021/jo300433a. Epub 2012 Apr 10.

PMID:
22489747
32.

Nickel-catalyzed Negishi alkylations of styrenyl aziridines.

Huang CY, Doyle AG.

J Am Chem Soc. 2012 Jun 13;134(23):9541-4. doi: 10.1021/ja3013825. Epub 2012 Mar 16.

PMID:
22414150
33.

Nickel-catalyzed cross-coupling of chromene acetals and boronic acids.

Graham TJ, Doyle AG.

Org Lett. 2012 Mar 16;14(6):1616-9. doi: 10.1021/ol300364s. Epub 2012 Mar 2.

34.

Palladium-catalyzed regio- and enantioselective fluorination of acyclic allylic halides.

Katcher MH, Sha A, Doyle AG.

J Am Chem Soc. 2011 Oct 12;133(40):15902-5. doi: 10.1021/ja206960k. Epub 2011 Sep 19.

PMID:
21894884
35.

Mechanistic investigations of cooperative catalysis in the enantioselective fluorination of epoxides.

Kalow JA, Doyle AG.

J Am Chem Soc. 2011 Oct 12;133(40):16001-12. doi: 10.1021/ja207256s. Epub 2011 Sep 14.

PMID:
21863842
36.

Nickel-catalyzed cross-coupling of styrenyl epoxides with boronic acids.

Nielsen DK, Doyle AG.

Angew Chem Int Ed Engl. 2011 Jun 27;50(27):6056-9. doi: 10.1002/anie.201101191. Epub 2011 May 13. No abstract available.

PMID:
21574227
37.

Palladium-catalyzed asymmetric synthesis of allylic fluorides.

Katcher MH, Doyle AG.

J Am Chem Soc. 2010 Dec 15;132(49):17402-4. doi: 10.1021/ja109120n. Epub 2010 Nov 18.

PMID:
21087003
38.

Anti-TNFα domain antibody construct CEP-37247: Full antibody functionality at half the size.

Gay RD, Clarke AW, Elgundi Z, Domagala T, Simpson RJ, Le NB, Doyle AG, Jennings PA.

MAbs. 2010 Nov-Dec;2(6):625-38. Epub 2010 Nov 1.

39.

A novel class of anti-IL-12p40 antibodies: potent neutralization via inhibition of IL-12-IL-12Rβ2 and IL-23-IL-23R.

Clarke AW, Poulton L, Wai HY, Walker SA, Victor SD, Domagala T, Mraovic D, Butt D, Shewmaker N, Jennings P, Doyle AG.

MAbs. 2010 Sep-Oct;2(5):539-49. doi: 10.4161/mabs.2.5.13081. Epub 2010 Sep 1.

40.

Enantioselective ring opening of epoxides by fluoride anion promoted by a cooperative dual-catalyst system.

Kalow JA, Doyle AG.

J Am Chem Soc. 2010 Mar 17;132(10):3268-9. doi: 10.1021/ja100161d.

PMID:
20163118
41.

Enantioselective thiourea-catalyzed additions to oxocarbenium ions.

Reisman SE, Doyle AG, Jacobsen EN.

J Am Chem Soc. 2008 Jun 11;130(23):7198-9. doi: 10.1021/ja801514m. Epub 2008 May 14.

42.

Small-molecule H-bond donors in asymmetric catalysis.

Doyle AG, Jacobsen EN.

Chem Rev. 2007 Dec;107(12):5713-43. Review. No abstract available.

PMID:
18072808
43.

Enantioselective alkylation of acyclic alpha,alpha-disubstituted tributyltin enolates catalyzed by a {Cr(salen)} complex.

Doyle AG, Jacobsen EN.

Angew Chem Int Ed Engl. 2007;46(20):3701-5. No abstract available.

PMID:
17407117
44.

A review of advances in the use of the GnRH agonist deslorelin in control of reproduction.

Trigg TE, Doyle AG, Walsh JD, Swangchan-uthai T.

Theriogenology. 2006 Oct;66(6-7):1507-12. Epub 2006 Apr 5.

PMID:
16600356
46.

Use of a GnRH analogue implant to produce reversible long-term suppression of reproductive function in male and female domestic dogs.

Trigg TE, Wright PJ, Armour AF, Williamson PE, Junaidi A, Martin GB, Doyle AG, Walsh J.

J Reprod Fertil Suppl. 2001;57:255-61.

PMID:
11787159
47.

A synthetically useful, self-assembling MMO mimic system for catalytic alkene epoxidation with aqueous H2O2.

White MC, Doyle AG, Jacobsen EN.

J Am Chem Soc. 2001 Jul 25;123(29):7194-5. No abstract available.

PMID:
11459514
48.

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