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Items: 1 to 50 of 105

1.

Structure-Guided Enhancement of Selectivity of Chemical Probe Inhibitors Targeting Bacterial Seryl-tRNA Synthetase.

Cain R, Salimraj R, Punekar AS, Bellini D, Fishwick CWG, Czaplewski L, Scott DJ, Harris G, Dowson CG, Lloyd AJ, Roper DI.

J Med Chem. 2019 Nov 14;62(21):9703-9717. doi: 10.1021/acs.jmedchem.9b01131. Epub 2019 Nov 5.

PMID:
31626547
2.
3.

The Molecular Basis of Antibiotic Action and Resistance.

Maxwell A, Dowson CG, Spencer J.

J Mol Biol. 2019 Aug 23;431(18):3367-3369. doi: 10.1016/j.jmb.2019.06.018. Epub 2019 Jun 29. No abstract available.

PMID:
31265828
4.

Bacterial Lipid II Analogs: Novel In Vitro Substrates for Mammalian Oligosaccharyl Diphosphodolichol Diphosphatase (DLODP) Activities.

Massarweh A, Bosco M, Chantret I, Léger T, Jamal L, Roper DI, Dowson CG, Busca P, Bouhss A, Gravier-Pelletier C, Moore SEH.

Molecules. 2019 Jun 6;24(11). pii: E2135. doi: 10.3390/molecules24112135.

5.

Profiling interactions of vaborbactam with metallo-β-lactamases.

Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J.

Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17.

6.

Evaluation of a Library of FDA-Approved Drugs for Their Ability To Potentiate Antibiotics against Multidrug-Resistant Gram-Negative Pathogens.

Hind CK, Dowson CG, Sutton JM, Jackson T, Clifford M, Garner RC, Czaplewski L.

Antimicrob Agents Chemother. 2019 Jul 25;63(8). pii: e00769-19. doi: 10.1128/AAC.00769-19. Print 2019 Aug.

7.

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.

Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N.

J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.

8.

Structural studies suggest aggregation as one of the modes of action for teixobactin.

Öster C, Walkowiak GP, Hughes DE, Spoering AL, Peoples AJ, Catherwood AC, Tod JA, Lloyd AJ, Herrmann T, Lewis K, Dowson CG, Lewandowski JR.

Chem Sci. 2018 Sep 20;9(47):8850-8859. doi: 10.1039/c8sc03655a. eCollection 2018 Dec 21.

9.

Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity.

Chen F, Moat J, McFeely D, Clarkson G, Hands-Portman IJ, Furner-Pardoe JP, Harrison F, Dowson CG, Sadler PJ.

J Med Chem. 2018 Aug 23;61(16):7330-7344. doi: 10.1021/acs.jmedchem.8b00906. Epub 2018 Aug 2.

10.

The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization.

Punekar AS, Samsudin F, Lloyd AJ, Dowson CG, Scott DJ, Khalid S, Roper DI.

Cell Surf. 2018 Jun;2:54-66. doi: 10.1016/j.tcsw.2018.06.002.

11.

Touching proteins with virtual bare hands : Visualizing protein-drug complexes and their dynamics in self-made virtual reality using gaming hardware.

Ratamero EM, Bellini D, Dowson CG, Römer RA.

J Comput Aided Mol Des. 2018 Jun;32(6):703-709. doi: 10.1007/s10822-018-0123-0. Epub 2018 Jun 7.

12.

In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB.

Hrast M, Jukič M, Patin D, Tod J, Dowson CG, Roper DI, Barreteau H, Gobec S.

Chem Biol Drug Des. 2018 Jun;91(6):1101-1112. doi: 10.1111/cbdd.13172. Epub 2018 Feb 12.

PMID:
29363274
13.

Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.

Batson S, de Chiara C, Majce V, Lloyd AJ, Gobec S, Rea D, Fülöp V, Thoroughgood CW, Simmons KJ, Dowson CG, Fishwick CWG, de Carvalho LPS, Roper DI.

Nat Commun. 2017 Dec 5;8(1):1939. doi: 10.1038/s41467-017-02118-7.

14.

In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA).

Sychantha D, Jones CS, Little DJ, Moynihan PJ, Robinson H, Galley NF, Roper DI, Dowson CG, Howell PL, Clarke AJ.

PLoS Pathog. 2017 Oct 27;13(10):e1006667. doi: 10.1371/journal.ppat.1006667. eCollection 2017 Oct.

15.

Sequence Control as a Powerful Tool for Improving the Selectivity of Antimicrobial Polymers.

Kuroki A, Sangwan P, Qu Y, Peltier R, Sanchez-Cano C, Moat J, Dowson CG, Williams EGL, Locock KES, Hartlieb M, Perrier S.

ACS Appl Mater Interfaces. 2017 Nov 22;9(46):40117-40126. doi: 10.1021/acsami.7b14996. Epub 2017 Nov 9.

PMID:
29068226
16.

Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity.

Smith NA, Zhang P, Greenough SE, Horbury MD, Clarkson GJ, McFeely D, Habtemariam A, Salassa L, Stavros VG, Dowson CG, Sadler PJ.

Chem Sci. 2017 Jan 1;8(1):395-404. doi: 10.1039/c6sc03028a. Epub 2016 Aug 30.

17.

Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis.

Tran AT, Watson EE, Pujari V, Conroy T, Dowman LJ, Giltrap AM, Pang A, Wong WR, Linington RG, Mahapatra S, Saunders J, Charman SA, West NP, Bugg TD, Tod J, Dowson CG, Roper DI, Crick DC, Britton WJ, Payne RJ.

Nat Commun. 2017 Mar 1;8:14414. doi: 10.1038/ncomms14414.

18.

Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis.

Vajs J, Proud C, Brozovic A, Gazvoda M, Lloyd A, Roper DI, Osmak M, Košmrlj J, Dowson CG.

Eur J Med Chem. 2017 Feb 15;127:223-234. doi: 10.1016/j.ejmech.2016.12.060. Epub 2016 Dec 31.

PMID:
28063354
19.

Whole-Genome Sequence of Corynebacterium pseudotuberculosis 262 Biovar equi Isolated from Cow Milk.

Araújo CL, Dias LM, Veras AA, Alves JT, Cavalcante AL, Dowson CG, Azevedo V, Ramos RT, Silva A, Carneiro AR.

Genome Announc. 2016 Mar 24;4(2). pii: e00176-16. doi: 10.1128/genomeA.00176-16.

20.

Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase.

Usha V, Lloyd AJ, Roper DI, Dowson CG, Kozlov G, Gehring K, Chauhan S, Imam HT, Blindauer CA, Besra GS.

Sci Rep. 2016 Mar 15;6:23191. doi: 10.1038/srep23191.

21.

Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity.

Zuegg J, Muldoon C, Adamson G, McKeveney D, Le Thanh G, Premraj R, Becker B, Cheng M, Elliott AG, Huang JX, Butler MS, Bajaj M, Seifert J, Singh L, Galley NF, Roper DI, Lloyd AJ, Dowson CG, Cheng TJ, Cheng WC, Demon D, Meyer E, Meutermans W, Cooper MA.

Nat Commun. 2015 Jul 21;6:7719. doi: 10.1038/ncomms8719.

22.

Specificity determinants for lysine incorporation in Staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex.

Ruane KM, Lloyd AJ, Fülöp V, Dowson CG, Barreteau H, Boniface A, Dementin S, Blanot D, Mengin-Lecreulx D, Gobec S, Dessen A, Roper DI.

J Biol Chem. 2013 Nov 15;288(46):33439-48. doi: 10.1074/jbc.M113.508135. Epub 2013 Sep 24.

23.

Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes.

Lloyd AJ, Potter NJ, Fishwick CW, Roper DI, Dowson CG.

ACS Chem Biol. 2013 Oct 18;8(10):2157-63. doi: 10.1021/cb400248f. Epub 2013 Aug 13.

24.

Key role for efflux in the preservative susceptibility and adaptive resistance of Burkholderia cepacia complex bacteria.

Rushton L, Sass A, Baldwin A, Dowson CG, Donoghue D, Mahenthiralingam E.

Antimicrob Agents Chemother. 2013 Jul;57(7):2972-80. doi: 10.1128/AAC.00140-13. Epub 2013 Apr 15.

25.

Oxidation of tertiary amine-derivatized surfaces to control protein adhesion.

Dobrzanska DA, Cooper AL, Dowson CG, Evans SD, Fox DJ, Johnson BR, Biggs CI, Randev RK, Stec HM, Taylor PC, Marsh A.

Langmuir. 2013 Mar 5;29(9):2961-70. doi: 10.1021/la4003719. Epub 2013 Feb 22.

PMID:
23402628
26.

Whole-genome sequence of Corynebacterium pseudotuberculosis strain Cp162, isolated from camel.

Hassan SS, Schneider MP, Ramos RT, Carneiro AR, Ranieri A, Guimarães LC, Ali A, Bakhtiar SM, Pereira Ude P, dos Santos AR, Soares Sde C, Dorella F, Pinto AC, Ribeiro D, Barbosa MS, Almeida S, Abreu V, Aburjaile F, Fiaux K, Barbosa E, Diniz C, Rocha FS, Saxena R, Tiwari S, Zambare V, Ghosh P, Pacheco LG, Dowson CG, Kumar A, Barh D, Miyoshi A, Azevedo V, Silva A.

J Bacteriol. 2012 Oct;194(20):5718-9.

27.

A Role for Sigma Factor σ(E) in Corynebacterium pseudotuberculosis Resistance to Nitric Oxide/Peroxide Stress.

Pacheco LG, Castro TL, Carvalho RD, Moraes PM, Dorella FA, Carvalho NB, Slade SE, Scrivens JH, Feelisch M, Meyer R, Miyoshi A, Oliveira SC, Dowson CG, Azevedo V.

Front Microbiol. 2012 Apr 3;3:126. doi: 10.3389/fmicb.2012.00126. eCollection 2012.

28.

Multilocus sequence types of invasive Corynebacterium diphtheriae isolated in the Rio de Janeiro urban area, Brazil.

Viguetti SZ, Pacheco LG, Santos LS, Soares SC, Bolt F, Baldwin A, Dowson CG, Rosso ML, Guiso N, Miyoshi A, Hirata R Jr, Mattos-Guaraldi AL, Azevedo V.

Epidemiol Infect. 2012 Apr;140(4):617-20. doi: 10.1017/S0950268811000963. Epub 2011 Jun 14.

PMID:
21669023
29.

A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens.

McDowell A, Gao A, Barnard E, Fink C, Murray PI, Dowson CG, Nagy I, Lambert PA, Patrick S.

Microbiology. 2011 Jul;157(Pt 7):1990-2003. doi: 10.1099/mic.0.049676-0. Epub 2011 Apr 21.

PMID:
21511767
30.

A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis.

Pacheco LG, Slade SE, Seyffert N, Santos AR, Castro TL, Silva WM, Santos AV, Santos SG, Farias LM, Carvalho MA, Pimenta AM, Meyer R, Silva A, Scrivens JH, Oliveira SC, Miyoshi A, Dowson CG, Azevedo V.

BMC Microbiol. 2011 Jan 17;11(1):12. doi: 10.1186/1471-2180-11-12.

31.

Bacterial cell wall assembly: still an attractive antibacterial target.

Bugg TD, Braddick D, Dowson CG, Roper DI.

Trends Biotechnol. 2011 Apr;29(4):167-73. doi: 10.1016/j.tibtech.2010.12.006. Epub 2011 Jan 12. Review.

PMID:
21232809
32.

Novel Corynebacterium diphtheriae in domestic cats.

Hall AJ, Cassiday PK, Bernard KA, Bolt F, Steigerwalt AG, Bixler D, Pawloski LC, Whitney AM, Iwaki M, Baldwin A, Dowson CG, Komiya T, Takahashi M, Hinrikson HP, Tondella ML.

Emerg Infect Dis. 2010 Apr;16(4):688-91. doi: 10.3201/eid1604.091107.

33.

Oxidative stress of Burkholderia cenocepacia induces insertion sequence-mediated genomic rearrangements that interfere with macrorestriction-based genotyping.

Drevinek P, Baldwin A, Lindenburg L, Joshi LT, Marchbank A, Vosahlikova S, Dowson CG, Mahenthiralingam E.

J Clin Microbiol. 2010 Jan;48(1):34-40. doi: 10.1128/JCM.01433-09. Epub 2009 Nov 4.

34.

Cross-sectional and longitudinal multilocus sequence typing of pseudomonas aeruginosa in cystic fibrosis sputum samples.

Waine DJ, Honeybourne D, Smith EG, Whitehouse JL, Dowson CG.

J Clin Microbiol. 2009 Nov;47(11):3444-8. doi: 10.1128/JCM.00459-09. Epub 2009 Aug 26.

35.

Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.

Holden MT, Hauser H, Sanders M, Ngo TH, Cherevach I, Cronin A, Goodhead I, Mungall K, Quail MA, Price C, Rabbinowitsch E, Sharp S, Croucher NJ, Chieu TB, Mai NT, Diep TS, Chinh NT, Kehoe M, Leigh JA, Ward PN, Dowson CG, Whatmore AM, Chanter N, Iversen P, Gottschalk M, Slater JD, Smith HE, Spratt BG, Xu J, Ye C, Bentley S, Barrell BG, Schultsz C, Maskell DJ, Parkhill J.

PLoS One. 2009 Jul 15;4(7):e6072. doi: 10.1371/journal.pone.0006072.

36.

Expanded multilocus sequence typing for burkholderia species.

Spilker T, Baldwin A, Bumford A, Dowson CG, Mahenthiralingam E, LiPuma JJ.

J Clin Microbiol. 2009 Aug;47(8):2607-10. doi: 10.1128/JCM.00770-09. Epub 2009 Jun 3.

37.

Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors.

Cressina E, Lloyd AJ, De Pascale G, James Mok B, Caddick S, Roper DI, Dowson CG, Bugg TD.

Bioorg Med Chem. 2009 May 1;17(9):3443-55. doi: 10.1016/j.bmc.2009.03.028. Epub 2009 Mar 21.

PMID:
19356937
38.

Mutational analysis of the substrate specificity of Escherichia coli penicillin binding protein 4.

Clarke TB, Kawai F, Park SY, Tame JR, Dowson CG, Roper DI.

Biochemistry. 2009 Mar 31;48(12):2675-83. doi: 10.1021/bi801993x.

PMID:
19209901
39.

Evidence for niche adaptation in the genome of the bovine pathogen Streptococcus uberis.

Ward PN, Holden MT, Leigh JA, Lennard N, Bignell A, Barron A, Clark L, Quail MA, Woodward J, Barrell BG, Egan SA, Field TR, Maskell D, Kehoe M, Dowson CG, Chanter N, Whatmore AM, Bentley SD, Parkhill J.

BMC Genomics. 2009 Jan 28;10:54. doi: 10.1186/1471-2164-10-54.

40.

Biocide susceptibility of the Burkholderia cepacia complex.

Rose H, Baldwin A, Dowson CG, Mahenthiralingam E.

J Antimicrob Chemother. 2009 Mar;63(3):502-10. doi: 10.1093/jac/dkn540. Epub 2009 Jan 18.

41.

Kinetic characterization of lipid II-Ala:alanyl-tRNA ligase (MurN) from Streptococcus pneumoniae using semisynthetic aminoacyl-lipid II substrates.

De Pascale G, Lloyd AJ, Schouten JA, Gilbey AM, Roper DI, Dowson CG, Bugg TD.

J Biol Chem. 2008 Dec 12;283(50):34571-9. doi: 10.1074/jbc.M805807200. Epub 2008 Oct 8.

42.

Association between hypermutator phenotype, clinical variables, mucoid phenotype, and antimicrobial resistance in Pseudomonas aeruginosa.

Waine DJ, Honeybourne D, Smith EG, Whitehouse JL, Dowson CG.

J Clin Microbiol. 2008 Oct;46(10):3491-3. doi: 10.1128/JCM.00357-08. Epub 2008 Aug 6.

43.

The use of microarray technology for the analysis of Streptococcus pneumoniae.

McCluskey J, Dowson CG, Mitchell TJ.

Comp Funct Genomics. 2002;3(4):366-8. doi: 10.1002/cfg.190.

44.

Diversity of the parB and repA genes of the Burkholderia cepacia complex and their utility for rapid identification of Burkholderia cenocepacia.

Drevinek P, Baldwin A, Dowson CG, Mahenthiralingam E.

BMC Microbiol. 2008 Mar 7;8:44. doi: 10.1186/1471-2180-8-44.

45.

Burkholderia cepacia complex bacteria: opportunistic pathogens with important natural biology.

Mahenthiralingam E, Baldwin A, Dowson CG.

J Appl Microbiol. 2008 Jun;104(6):1539-51. doi: 10.1111/j.1365-2672.2007.03706.x. Epub 2008 Jan 24. Review.

46.

Characterization of tRNA-dependent peptide bond formation by MurM in the synthesis of Streptococcus pneumoniae peptidoglycan.

Lloyd AJ, Gilbey AM, Blewett AM, De Pascale G, El Zoeiby A, Levesque RC, Catherwood AC, Tomasz A, Bugg TD, Roper DI, Dowson CG.

J Biol Chem. 2008 Mar 7;283(10):6402-17. Epub 2007 Dec 12.

47.

Elucidating global epidemiology of Burkholderia multivorans in cases of cystic fibrosis by multilocus sequence typing.

Baldwin A, Mahenthiralingam E, Drevinek P, Pope C, Waine DJ, Henry DA, Speert DP, Carter P, Vandamme P, LiPuma JJ, Dowson CG.

J Clin Microbiol. 2008 Jan;46(1):290-5. Epub 2007 Nov 21.

48.

Nod1 signaling overcomes resistance of S. pneumoniae to opsonophagocytic killing.

Lysenko ES, Clarke TB, Shchepetov M, Ratner AJ, Roper DI, Dowson CG, Weiser JN.

PLoS Pathog. 2007 Aug 24;3(8):e118.

49.

Environmental Burkholderia cepacia complex isolates in human infections.

Baldwin A, Mahenthiralingam E, Drevinek P, Vandamme P, Govan JR, Waine DJ, LiPuma JJ, Chiarini L, Dalmastri C, Henry DA, Speert DP, Honeybourne D, Maiden MC, Dowson CG.

Emerg Infect Dis. 2007 Mar;13(3):458-61.

50.

Adenosine phosphonate inhibitors of lipid II: alanyl tRNA ligase MurM from Streptococcus pneumoniae.

Cressina E, Lloyd AJ, De Pascale G, Roper DI, Dowson CG, Bugg TD.

Bioorg Med Chem Lett. 2007 Aug 15;17(16):4654-6. Epub 2007 May 25.

PMID:
17548193

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