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Items: 1 to 50 of 146

1.

Bacterial Lipid II Analogs: Novel In Vitro Substrates for Mammalian Oligosaccharyl Diphosphodolichol Diphosphatase (DLODP) Activities.

Massarweh A, Bosco M, Chantret I, Léger T, Jamal L, Roper DI, Dowson CG, Busca P, Bouhss A, Gravier-Pelletier C, Moore SEH.

Molecules. 2019 Jun 6;24(11). pii: E2135. doi: 10.3390/molecules24112135.

2.

Profiling interactions of vaborbactam with metallo-β-lactamases.

Langley GW, Cain R, Tyrrell JM, Hinchliffe P, Calvopiña K, Tooke CL, Widlake E, Dowson CG, Spencer J, Walsh TR, Schofield CJ, Brem J.

Bioorg Med Chem Lett. 2019 Aug 1;29(15):1981-1984. doi: 10.1016/j.bmcl.2019.05.031. Epub 2019 May 17.

3.

Evaluation of a library of FDA-approved drugs for their ability to potentiate antibiotics against multidrug resistant Gram-negative pathogens.

Hind CK, Dowson CG, Sutton JM, Jackson T, Clifford M, Garner RC, Czaplewski L.

Antimicrob Agents Chemother. 2019 Jun 3. pii: AAC.00769-19. doi: 10.1128/AAC.00769-19. [Epub ahead of print]

4.

Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.

Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N.

J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.

5.

Structural studies suggest aggregation as one of the modes of action for teixobactin.

Öster C, Walkowiak GP, Hughes DE, Spoering AL, Peoples AJ, Catherwood AC, Tod JA, Lloyd AJ, Herrmann T, Lewis K, Dowson CG, Lewandowski JR.

Chem Sci. 2018 Sep 20;9(47):8850-8859. doi: 10.1039/c8sc03655a. eCollection 2018 Dec 21.

6.

Meeting the discovery challenge of drug-resistant infections: progress and focusing resources.

Dougan G, Dowson C, Overington J; Next Generation Antibiotic Discovery Symposium Participants.

Drug Discov Today. 2019 Feb;24(2):452-461. doi: 10.1016/j.drudis.2018.11.015. Epub 2018 Nov 23. Review.

PMID:
30476550
7.

Biguanide Iridium(III) Complexes with Potent Antimicrobial Activity.

Chen F, Moat J, McFeely D, Clarkson G, Hands-Portman IJ, Furner-Pardoe JP, Harrison F, Dowson CG, Sadler PJ.

J Med Chem. 2018 Aug 23;61(16):7330-7344. doi: 10.1021/acs.jmedchem.8b00906. Epub 2018 Aug 2.

8.

The role of the jaw subdomain of peptidoglycan glycosyltransferases for lipid II polymerization.

Punekar AS, Samsudin F, Lloyd AJ, Dowson CG, Scott DJ, Khalid S, Roper DI.

Cell Surf. 2018 Jun;2:54-66. doi: 10.1016/j.tcsw.2018.06.002.

9.

Touching proteins with virtual bare hands : Visualizing protein-drug complexes and their dynamics in self-made virtual reality using gaming hardware.

Ratamero EM, Bellini D, Dowson CG, Römer RA.

J Comput Aided Mol Des. 2018 Jun;32(6):703-709. doi: 10.1007/s10822-018-0123-0. Epub 2018 Jun 7.

10.

In silico identification, synthesis and biological evaluation of novel tetrazole inhibitors of MurB.

Hrast M, Jukič M, Patin D, Tod J, Dowson CG, Roper DI, Barreteau H, Gobec S.

Chem Biol Drug Des. 2018 Jun;91(6):1101-1112. doi: 10.1111/cbdd.13172. Epub 2018 Feb 12.

PMID:
29363274
11.

Inhibition of D-Ala:D-Ala ligase through a phosphorylated form of the antibiotic D-cycloserine.

Batson S, de Chiara C, Majce V, Lloyd AJ, Gobec S, Rea D, Fülöp V, Thoroughgood CW, Simmons KJ, Dowson CG, Fishwick CWG, de Carvalho LPS, Roper DI.

Nat Commun. 2017 Dec 5;8(1):1939. doi: 10.1038/s41467-017-02118-7.

12.

In vitro characterization of the antivirulence target of Gram-positive pathogens, peptidoglycan O-acetyltransferase A (OatA).

Sychantha D, Jones CS, Little DJ, Moynihan PJ, Robinson H, Galley NF, Roper DI, Dowson CG, Howell PL, Clarke AJ.

PLoS Pathog. 2017 Oct 27;13(10):e1006667. doi: 10.1371/journal.ppat.1006667. eCollection 2017 Oct.

13.

Sequence Control as a Powerful Tool for Improving the Selectivity of Antimicrobial Polymers.

Kuroki A, Sangwan P, Qu Y, Peltier R, Sanchez-Cano C, Moat J, Dowson CG, Williams EGL, Locock KES, Hartlieb M, Perrier S.

ACS Appl Mater Interfaces. 2017 Nov 22;9(46):40117-40126. doi: 10.1021/acsami.7b14996. Epub 2017 Nov 9.

PMID:
29068226
14.

Combatting AMR: photoactivatable ruthenium(ii)-isoniazid complex exhibits rapid selective antimycobacterial activity.

Smith NA, Zhang P, Greenough SE, Horbury MD, Clarkson GJ, McFeely D, Habtemariam A, Salassa L, Stavros VG, Dowson CG, Sadler PJ.

Chem Sci. 2017 Jan 1;8(1):395-404. doi: 10.1039/c6sc03028a. Epub 2016 Aug 30.

15.

Sansanmycin natural product analogues as potent and selective anti-mycobacterials that inhibit lipid I biosynthesis.

Tran AT, Watson EE, Pujari V, Conroy T, Dowman LJ, Giltrap AM, Pang A, Wong WR, Linington RG, Mahapatra S, Saunders J, Charman SA, West NP, Bugg TD, Tod J, Dowson CG, Roper DI, Crick DC, Britton WJ, Payne RJ.

Nat Commun. 2017 Mar 1;8:14414. doi: 10.1038/ncomms14414.

16.

Innate Immunity in Systemic Sclerosis.

Dowson C, Simpson N, Duffy L, O'Reilly S.

Curr Rheumatol Rep. 2017 Jan;19(1):2. doi: 10.1007/s11926-017-0630-3. Review.

PMID:
28116578
17.

Diaryltriazenes as antibacterial agents against methicillin resistant Staphylococcus aureus (MRSA) and Mycobacterium smegmatis.

Vajs J, Proud C, Brozovic A, Gazvoda M, Lloyd A, Roper DI, Osmak M, Košmrlj J, Dowson CG.

Eur J Med Chem. 2017 Feb 15;127:223-234. doi: 10.1016/j.ejmech.2016.12.060. Epub 2016 Dec 31.

PMID:
28063354
18.

Concordance in diabetic foot ulceration: a cross-sectional study of agreement between wound swabbing and tissue sampling in infected ulcers.

Nelson EA, Wright-Hughes A, Brown S, Lipsky BA, Backhouse M, Bhogal M, Ndosi M, Reynolds C, Sykes G, Dowson C, Edmonds M, Vowden P, Jude EB, Dickie T, Nixon J.

Health Technol Assess. 2016 Nov;20(82):1-176.

19.

DNA methylation in fibrosis.

Dowson C, O'Reilly S.

Eur J Cell Biol. 2016 Sep;95(9):323-30. doi: 10.1016/j.ejcb.2016.06.003. Epub 2016 Jun 14. Review.

PMID:
27346523
20.

Whole-Genome Sequence of Corynebacterium pseudotuberculosis 262 Biovar equi Isolated from Cow Milk.

Araújo CL, Dias LM, Veras AA, Alves JT, Cavalcante AL, Dowson CG, Azevedo V, Ramos RT, Silva A, Carneiro AR.

Genome Announc. 2016 Mar 24;4(2). pii: e00176-16. doi: 10.1128/genomeA.00176-16.

21.

Reconstruction of diaminopimelic acid biosynthesis allows characterisation of Mycobacterium tuberculosis N-succinyl-L,L-diaminopimelic acid desuccinylase.

Usha V, Lloyd AJ, Roper DI, Dowson CG, Kozlov G, Gehring K, Chauhan S, Imam HT, Blindauer CA, Besra GS.

Sci Rep. 2016 Mar 15;6:23191. doi: 10.1038/srep23191.

22.

Carbohydrate scaffolds as glycosyltransferase inhibitors with in vivo antibacterial activity.

Zuegg J, Muldoon C, Adamson G, McKeveney D, Le Thanh G, Premraj R, Becker B, Cheng M, Elliott AG, Huang JX, Butler MS, Bajaj M, Seifert J, Singh L, Galley NF, Roper DI, Lloyd AJ, Dowson CG, Cheng TJ, Cheng WC, Demon D, Meyer E, Meutermans W, Cooper MA.

Nat Commun. 2015 Jul 21;6:7719. doi: 10.1038/ncomms8719.

23.

Patient experience and satisfaction with Onabotulinumtoxin A for refractory overactive bladder.

Malde S, Dowson C, Fraser O, Watkins J, Khan MS, Dasgupta P, Sahai A.

BJU Int. 2015 Sep;116(3):443-9. doi: 10.1111/bju.13025. Epub 2015 Apr 16.

24.

Validation of the bladder control self-assessment questionnaire (B-SAQ) in men.

Sahai A, Dowson C, Cortes E, Seth J, Watkins J, Khan MS, Dasgupta P, Cardozo L, Chapple C, De Ridder D, Wagg A, Kelleher C.

BJU Int. 2014 May;113(5):783-8. doi: 10.1111/bju.12521.

25.

An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation.

Spruit MA, Singh SJ, Garvey C, ZuWallack R, Nici L, Rochester C, Hill K, Holland AE, Lareau SC, Man WD, Pitta F, Sewell L, Raskin J, Bourbeau J, Crouch R, Franssen FM, Casaburi R, Vercoulen JH, Vogiatzis I, Gosselink R, Clini EM, Effing TW, Maltais F, van der Palen J, Troosters T, Janssen DJ, Collins E, Garcia-Aymerich J, Brooks D, Fahy BF, Puhan MA, Hoogendoorn M, Garrod R, Schols AM, Carlin B, Benzo R, Meek P, Morgan M, Rutten-van Mölken MP, Ries AL, Make B, Goldstein RS, Dowson CA, Brozek JL, Donner CF, Wouters EF; ATS/ERS Task Force on Pulmonary Rehabilitation.

Am J Respir Crit Care Med. 2013 Oct 15;188(8):e13-64. doi: 10.1164/rccm.201309-1634ST. Erratum in: Am J Respir Crit Care Med. 2014 Jun 15;189(12):1570.

PMID:
24127811
26.

Specificity determinants for lysine incorporation in Staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex.

Ruane KM, Lloyd AJ, Fülöp V, Dowson CG, Barreteau H, Boniface A, Dementin S, Blanot D, Mengin-Lecreulx D, Gobec S, Dessen A, Roper DI.

J Biol Chem. 2013 Nov 15;288(46):33439-48. doi: 10.1074/jbc.M113.508135. Epub 2013 Sep 24.

27.

Adenosine tetraphosphoadenosine drives a continuous ATP-release assay for aminoacyl-tRNA synthetases and other adenylate-forming enzymes.

Lloyd AJ, Potter NJ, Fishwick CW, Roper DI, Dowson CG.

ACS Chem Biol. 2013 Oct 18;8(10):2157-63. doi: 10.1021/cb400248f. Epub 2013 Aug 13.

28.

Key role for efflux in the preservative susceptibility and adaptive resistance of Burkholderia cepacia complex bacteria.

Rushton L, Sass A, Baldwin A, Dowson CG, Donoghue D, Mahenthiralingam E.

Antimicrob Agents Chemother. 2013 Jul;57(7):2972-80. doi: 10.1128/AAC.00140-13. Epub 2013 Apr 15.

29.

Botulinum toxin-A for the treatment of overactive bladder: UK contributions.

Seth JH, Dowson C, Khan MS, Panicker JN, Fowler CJ, Dasgupta P, Sahai A.

J Clin Urol. 2013 Mar;6(2):77-83.

30.

Oxidation of tertiary amine-derivatized surfaces to control protein adhesion.

Dobrzanska DA, Cooper AL, Dowson CG, Evans SD, Fox DJ, Johnson BR, Biggs CI, Randev RK, Stec HM, Taylor PC, Marsh A.

Langmuir. 2013 Mar 5;29(9):2961-70. doi: 10.1021/la4003719. Epub 2013 Feb 22.

PMID:
23402628
31.

Whole-genome sequence of Corynebacterium pseudotuberculosis strain Cp162, isolated from camel.

Hassan SS, Schneider MP, Ramos RT, Carneiro AR, Ranieri A, Guimarães LC, Ali A, Bakhtiar SM, Pereira Ude P, dos Santos AR, Soares Sde C, Dorella F, Pinto AC, Ribeiro D, Barbosa MS, Almeida S, Abreu V, Aburjaile F, Fiaux K, Barbosa E, Diniz C, Rocha FS, Saxena R, Tiwari S, Zambare V, Ghosh P, Pacheco LG, Dowson CG, Kumar A, Barh D, Miyoshi A, Azevedo V, Silva A.

J Bacteriol. 2012 Oct;194(20):5718-9.

32.

A Role for Sigma Factor σ(E) in Corynebacterium pseudotuberculosis Resistance to Nitric Oxide/Peroxide Stress.

Pacheco LG, Castro TL, Carvalho RD, Moraes PM, Dorella FA, Carvalho NB, Slade SE, Scrivens JH, Feelisch M, Meyer R, Miyoshi A, Oliveira SC, Dowson CG, Azevedo V.

Front Microbiol. 2012 Apr 3;3:126. doi: 10.3389/fmicb.2012.00126. eCollection 2012.

33.

Repeated botulinum toxin type A injections for refractory overactive bladder: medium-term outcomes, safety profile, and discontinuation rates.

Dowson C, Watkins J, Khan MS, Dasgupta P, Sahai A.

Eur Urol. 2012 Apr;61(4):834-9. doi: 10.1016/j.eururo.2011.12.011. Epub 2011 Dec 13.

PMID:
22204745
34.

Multilocus sequence types of invasive Corynebacterium diphtheriae isolated in the Rio de Janeiro urban area, Brazil.

Viguetti SZ, Pacheco LG, Santos LS, Soares SC, Bolt F, Baldwin A, Dowson CG, Rosso ML, Guiso N, Miyoshi A, Hirata R Jr, Mattos-Guaraldi AL, Azevedo V.

Epidemiol Infect. 2012 Apr;140(4):617-20. doi: 10.1017/S0950268811000963. Epub 2011 Jun 14.

PMID:
21669023
35.

The safety and efficacy of botulinum toxin-A in the management of bladder oversensitivity: a randomised double-blind placebo-controlled trial.

Dowson C, Sahai A, Watkins J, Dasgupta P, Khan MS.

Int J Clin Pract. 2011 Jun;65(6):698-704. doi: 10.1111/j.1742-1241.2011.02663.x.

PMID:
21564444
36.

A novel multilocus sequence typing scheme for the opportunistic pathogen Propionibacterium acnes and characterization of type I cell surface-associated antigens.

McDowell A, Gao A, Barnard E, Fink C, Murray PI, Dowson CG, Nagy I, Lambert PA, Patrick S.

Microbiology. 2011 Jul;157(Pt 7):1990-2003. doi: 10.1099/mic.0.049676-0. Epub 2011 Apr 21.

PMID:
21511767
37.

A combined approach for comparative exoproteome analysis of Corynebacterium pseudotuberculosis.

Pacheco LG, Slade SE, Seyffert N, Santos AR, Castro TL, Silva WM, Santos AV, Santos SG, Farias LM, Carvalho MA, Pimenta AM, Meyer R, Silva A, Scrivens JH, Oliveira SC, Miyoshi A, Dowson CG, Azevedo V.

BMC Microbiol. 2011 Jan 17;11(1):12. doi: 10.1186/1471-2180-11-12.

38.

Bacterial cell wall assembly: still an attractive antibacterial target.

Bugg TD, Braddick D, Dowson CG, Roper DI.

Trends Biotechnol. 2011 Apr;29(4):167-73. doi: 10.1016/j.tibtech.2010.12.006. Epub 2011 Jan 12. Review.

PMID:
21232809
39.

Repeat botulinum toxin-A injections for treatment of adult detrusor overactivity.

Dowson C, Khan MS, Dasgupta P, Sahai A.

Nat Rev Urol. 2010 Dec;7(12):661-7. doi: 10.1038/nrurol.2010.187. Review.

PMID:
21139642
40.

Infection with transmissible strains of Pseudomonas aeruginosa and clinical outcomes in adults with cystic fibrosis.

Aaron SD, Vandemheen KL, Ramotar K, Giesbrecht-Lewis T, Tullis E, Freitag A, Paterson N, Jackson M, Lougheed MD, Dowson C, Kumar V, Ferris W, Chan F, Doucette S, Fergusson D.

JAMA. 2010 Nov 17;304(19):2145-53. doi: 10.1001/jama.2010.1665.

PMID:
21081727
41.

Multilocus sequence typing identifies evidence for recombination and two distinct lineages of Corynebacterium diphtheriae.

Bolt F, Cassiday P, Tondella ML, Dezoysa A, Efstratiou A, Sing A, Zasada A, Bernard K, Guiso N, Badell E, Rosso ML, Baldwin A, Dowson C.

J Clin Microbiol. 2010 Nov;48(11):4177-85. doi: 10.1128/JCM.00274-10. Epub 2010 Sep 15.

42.

Indistinguishability and identifiability of kinetic models for the MurC reaction in peptidoglycan biosynthesis.

Hattersley JG, Pérez-Velázquez J, Chappell MJ, Bearup D, Roper D, Dowson C, Bugg T, Evans ND.

Comput Methods Programs Biomed. 2011 Nov;104(2):70-80. doi: 10.1016/j.cmpb.2010.07.009. Epub 2010 Sep 1.

PMID:
20813422
43.

Novel Corynebacterium diphtheriae in domestic cats.

Hall AJ, Cassiday PK, Bernard KA, Bolt F, Steigerwalt AG, Bixler D, Pawloski LC, Whitney AM, Iwaki M, Baldwin A, Dowson CG, Komiya T, Takahashi M, Hinrikson HP, Tondella ML.

Emerg Infect Dis. 2010 Apr;16(4):688-91. doi: 10.3201/eid1604.091107.

44.

Impact of panic disorder upon self-management educational goals in chronic obstructive pulmonary disease?

Dowson CA, Kuijer RG, Town IG, Mulder RT.

Chron Respir Dis. 2010;7(2):83-90. doi: 10.1177/1479972310365363. Epub 2010 Mar 18.

PMID:
20299537
45.

Repeated injections of botulinum toxin-A for idiopathic detrusor overactivity.

Sahai A, Dowson C, Khan MS, Dasgupta P; GKT Botulinum Study Group.

Urology. 2010 Mar;75(3):552-8. doi: 10.1016/j.urology.2009.05.097. Epub 2009 Dec 29.

PMID:
20035984
46.

VenUS II: a randomised controlled trial of larval therapy in the management of leg ulcers.

Dumville JC, Worthy G, Soares MO, Bland JM, Cullum N, Dowson C, Iglesias C, McCaughan D, Mitchell JL, Nelson EA, Torgerson DJ; VenUS II team.

Health Technol Assess. 2009 Nov;13(55):1-182, iii-iv. doi: 10.3310/hta13550.

47.

Oxidative stress of Burkholderia cenocepacia induces insertion sequence-mediated genomic rearrangements that interfere with macrorestriction-based genotyping.

Drevinek P, Baldwin A, Lindenburg L, Joshi LT, Marchbank A, Vosahlikova S, Dowson CG, Mahenthiralingam E.

J Clin Microbiol. 2010 Jan;48(1):34-40. doi: 10.1128/JCM.01433-09. Epub 2009 Nov 4.

48.

Multilocus sequence typing of Cronobacter sakazakii and Cronobacter malonaticus reveals stable clonal structures with clinical significance which do not correlate with biotypes.

Baldwin A, Loughlin M, Caubilla-Barron J, Kucerova E, Manning G, Dowson C, Forsythe S.

BMC Microbiol. 2009 Oct 23;9:223. doi: 10.1186/1471-2180-9-223.

49.

Cross-sectional and longitudinal multilocus sequence typing of pseudomonas aeruginosa in cystic fibrosis sputum samples.

Waine DJ, Honeybourne D, Smith EG, Whitehouse JL, Dowson CG.

J Clin Microbiol. 2009 Nov;47(11):3444-8. doi: 10.1128/JCM.00459-09. Epub 2009 Aug 26.

50.

Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis.

Holden MT, Hauser H, Sanders M, Ngo TH, Cherevach I, Cronin A, Goodhead I, Mungall K, Quail MA, Price C, Rabbinowitsch E, Sharp S, Croucher NJ, Chieu TB, Mai NT, Diep TS, Chinh NT, Kehoe M, Leigh JA, Ward PN, Dowson CG, Whatmore AM, Chanter N, Iversen P, Gottschalk M, Slater JD, Smith HE, Spratt BG, Xu J, Ye C, Bentley S, Barrell BG, Schultsz C, Maskell DJ, Parkhill J.

PLoS One. 2009 Jul 15;4(7):e6072. doi: 10.1371/journal.pone.0006072.

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