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An assessment of risk compensation and spillover behavioural adaptions associated with the use of vaccines in animal disease management.

Enticott G, Maye D, Naylor R, Brunton L, Downs SH, Donnelly CA.

Vaccine. 2020 Jan 29;38(5):1065-1075. doi: 10.1016/j.vaccine.2019.11.037. Epub 2019 Dec 6.


Exploring the Risk Posed by Animals with an Inconclusive Reaction to the Bovine Tuberculosis Skin Test in England and Wales.

May E, Prosser A, Downs SH, Brunton LA.

Vet Sci. 2019 Nov 30;6(4). pii: E97. doi: 10.3390/vetsci6040097.


Assessing effects from four years of industry-led badger culling in England on the incidence of bovine tuberculosis in cattle, 2013-2017.

Downs SH, Prosser A, Ashton A, Ashfield S, Brunton LA, Brouwer A, Upton P, Robertson A, Donnelly CA, Parry JE.

Sci Rep. 2019 Oct 11;9(1):14666. doi: 10.1038/s41598-019-49957-6.


Exploring the Fate of Cattle Herds With Inconclusive Reactors to the Tuberculin Skin Test.

Brunton LA, Prosser A, Pfeiffer DU, Downs SH.

Front Vet Sci. 2018 Sep 28;5:228. doi: 10.3389/fvets.2018.00228. eCollection 2018.


Methodology and preliminary results of a systematic literature review of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis.

Downs SH, Parry JE, Upton PA, Broughan JM, Goodchild AV, Nuñez-Garcia J, Greiner M, Abernethy DA, Cameron AR, Cook AJ, de la Rua-Domenech R, Gunn J, Pritchard E, Rhodes S, Rolfe S, Sharp M, Vordermeier HM, Watson E, Welsh M, Whelan AO, Woolliams JA, More SJ, Clifton-Hadley RS.

Prev Vet Med. 2018 May 1;153:117-126. doi: 10.1016/j.prevetmed.2017.11.004. Epub 2017 Nov 9. Review.


Assessing the effects of the first 2 years of industry-led badger culling in England on the incidence of bovine tuberculosis in cattle in 2013-2015.

Brunton LA, Donnelly CA, O'Connor H, Prosser A, Ashfield S, Ashton A, Upton P, Mitchell A, Goodchild AV, Parry JE, Downs SH.

Ecol Evol. 2017 Aug 4;7(18):7213-7230. doi: 10.1002/ece3.3254. eCollection 2017 Sep.


Evaluation of the methodological quality of studies of the performance of diagnostic tests for bovine tuberculosis using QUADAS.

Downs SH, More SJ, Goodchild AV, Whelan AO, Abernethy DA, Broughan JM, Cameron A, Cook AJ, Ricardo de la Rua-Domenech R, Greiner M, Gunn J, Nuñez-Garcia J, Rhodes S, Rolfe S, Sharp M, Upton P, Watson E, Welsh M, Woolliams JA, Clifton-Hadley RS, Parry JE.

Prev Vet Med. 2018 May 1;153:108-116. doi: 10.1016/j.prevetmed.2017.03.006. Epub 2017 Mar 22.


Meta-analyses of the sensitivity and specificity of ante-mortem and post-mortem diagnostic tests for bovine tuberculosis in the UK and Ireland.

Nuñez-Garcia J, Downs SH, Parry JE, Abernethy DA, Broughan JM, Cameron AR, Cook AJ, de la Rua-Domenech R, Goodchild AV, Gunn J, More SJ, Rhodes S, Rolfe S, Sharp M, Upton PA, Vordermeier HM, Watson E, Welsh M, Whelan AO, Woolliams JA, Clifton-Hadley RS, Greiner M.

Prev Vet Med. 2018 May 1;153:94-107. doi: 10.1016/j.prevetmed.2017.02.017. Epub 2017 Mar 6.


Responses to diagnostic tests for bovine tuberculosis in dairy and non-dairy cattle naturally exposed to Mycobacterium bovis in Great Britain.

Downs SH, Broughan JM, Goodchild AV, Upton PA, Durr PA.

Vet J. 2016 Oct;216:8-17. doi: 10.1016/j.tvjl.2016.06.010. Epub 2016 Jun 28.


A review of risk factors for bovine tuberculosis infection in cattle in the UK and Ireland.

Broughan JM, Judge J, Ely E, Delahay RJ, Wilson G, Clifton-Hadley RS, Goodchild AV, Bishop H, Parry JE, Downs SH.

Epidemiol Infect. 2016 Oct;144(14):2899-2926. Epub 2016 Jul 25. Review.


Assessing the impact of a cattle risk-based trading scheme on the movement of bovine tuberculosis infected animals in England and Wales.

Adkin A, Brouwer A, Downs SH, Kelly L.

Prev Vet Med. 2016 Jan 1;123:23-31. doi: 10.1016/j.prevetmed.2015.11.021. Epub 2015 Dec 3.


Development of risk-based trading farm scoring system to assist with the control of bovine tuberculosis in cattle in England and Wales.

Adkin A, Brouwer A, Simons RRL, Smith RP, Arnold ME, Broughan J, Kosmider R, Downs SH.

Prev Vet Med. 2016 Jan 1;123:32-38. doi: 10.1016/j.prevetmed.2015.11.020. Epub 2015 Dec 3.


Spatial Targeting for Bovine Tuberculosis Control: Can the Locations of Infected Cattle Be Used to Find Infected Badgers?

Smith CM, Downs SH, Mitchell A, Hayward AC, Fry H, Le Comber SC.

PLoS One. 2015 Nov 13;10(11):e0142710. doi: 10.1371/journal.pone.0142710. eCollection 2015.


Exploration of the power of routine surveillance data to assess the impacts of industry-led badger culling on bovine tuberculosis incidence in cattle herds.

Donnelly CA, Bento AI, Goodchild AV, Downs SH.

Vet Rec. 2015 Oct 24;177(16):417. doi: 10.1136/vr.103201. Epub 2015 Sep 15.


Specificity of the comparative skin test for bovine tuberculosis in Great Britain.

Goodchild AV, Downs SH, Upton P, Wood JL, de la Rua-Domenech R.

Vet Rec. 2015 Sep 12;177(10):258. doi: 10.1136/vr.102961. Epub 2015 Sep 2.


Bovine TB infection status in cattle in Great Britain in 2013.

Broughan JM, Harris KA, Brouwer A, Downs SH, Goodchild AV, Upton PA, Smith NH.

Vet Rec. 2015 Mar 28;176(13):326-30. doi: 10.1136/vr.h1145.


Bovine TB infection status in cattle in Great Britain in 2012.

Harris KA, Downs SH, Goodchild AV, Broughan JM, Upton PA, Smith NH.

Vet Rec. 2014 Jun 14;174(24):600-4. doi: 10.1136/vr.g3644.


Impact of Schmallenberg virus on British sheep farms during the 2011/2012 lambing season.

Harris KA, Eglin RD, Hayward S, Milnes A, Davies I, Cook AJ, Downs SH.

Vet Rec. 2014 Aug 16;175(7):172. doi: 10.1136/vr.102295. Epub 2014 May 2. Erratum in: Vet Rec. 2014 Sep 13;175(10):246.


Mycobacterium bovis infections in domesticated non-bovine mammalian species. Part 1: Review of epidemiology and laboratory submissions in Great Britain 2004-2010.

Broughan JM, Downs SH, Crawshaw TR, Upton PA, Brewer J, Clifton-Hadley RS.

Vet J. 2013 Nov;198(2):339-45. doi: 10.1016/j.tvjl.2013.09.006. Epub 2013 Sep 20. Review.


Mycobacterium bovis infections in domesticated non-bovine mammalian species. Part 2: A review of diagnostic methods.

Broughan JM, Crawshaw TR, Downs SH, Brewer J, Clifton-Hadley RS.

Vet J. 2013 Nov;198(2):346-51. doi: 10.1016/j.tvjl.2013.09.007. Epub 2013 Sep 17. Review.


Factors associated with bovine tuberculosis confirmation rates in suspect lesions found in cattle at routine slaughter in Great Britain, 2003-2008.

Shittu A, Clifton-Hadley RS, Ely ER, Upton PU, Downs SH.

Prev Vet Med. 2013 Jul 1;110(3-4):395-404. doi: 10.1016/j.prevetmed.2013.03.001. Epub 2013 Mar 26.


Tuberculin manufacturing source and breakdown incidence rate of bovine tuberculosis in British cattle, 2005-2009.

Downs SH, Clifton-Hadley RS, Upton PA, Milne IC, Ely ER, Gopal R, Goodchild AV, Sayers AR.

Vet Rec. 2013 Jan 26;172(4):98. doi: 10.1136/vr.100679. Epub 2012 Nov 16.


Bovine tuberculosis trends in the UK and the Republic of Ireland, 1995-2010.

Abernethy DA, Upton P, Higgins IM, McGrath G, Goodchild AV, Rolfe SJ, Broughan JM, Downs SH, Clifton-Hadley R, Menzies FD, de la Rua-Domenech R, Blissitt MJ, Duignan A, More SJ.

Vet Rec. 2013 Mar 23;172(12):312. doi: 10.1136/vr.100969. Epub 2013 Jan 5.


Evidence for genetic variance in resistance to tuberculosis in Great Britain and Irish Holstein-Friesian populations.

Bermingham ML, Brotherstone S, Berry DP, More SJ, Good M, Cromie AR, White IM, Higgins IM, Coffey M, Downs SH, Glass EJ, Bishop SC, Mitchell AP, Clifton-Hadley RS, Woolliams JA.

BMC Proc. 2011 Jun 3;5 Suppl 4:S15. doi: 10.1186/1753-6561-5-S4-S15.


HMOX1 and GST variants modify attenuation of FEF25-75% decline due to PM10 reduction.

Curjuric I, Imboden M, Schindler C, Downs SH, Hersberger M, Liu SL, Matyas G, Russi EW, Schwartz J, Thun GA, Postma DS, Rochat T, Probst-Hensch NM; SAPALDIA team.

Eur Respir J. 2010 Mar;35(3):505-14. doi: 10.1183/09031936.00044309. Erratum in: Eur Respir J. 2010 Nov;36(5):1225.


Evidence of genetic resistance of cattle to infection with Mycobacterium bovis.

Brotherstone S, White IM, Coffey M, Downs SH, Mitchell AP, Clifton-Hadley RS, More SJ, Good M, Woolliams JA.

J Dairy Sci. 2010 Mar;93(3):1234-42. doi: 10.3168/jds.2009-2609.


Trace micro-nutrients may affect susceptibility to bovine tuberculosis in cattle.

Downs SH, Durr P, Edwards J, Clifton-Hadley R.

Prev Vet Med. 2008 Nov 17;87(3-4):311-26. doi: 10.1016/j.prevetmed.2008.05.003. Epub 2008 Jul 2.


Blood-based assays to detect Mycobacterium bovis-infected cattle missed by tuberculin skin testing.

Coad M, Downs SH, Durr PA, Clifton-Hadley RS, Hewinson RG, Vordermeier HM, Whelan AO.

Vet Rec. 2008 Mar 22;162(12):382-4. No abstract available.


Reduced exposure to PM10 and attenuated age-related decline in lung function.

Downs SH, Schindler C, Liu LJ, Keidel D, Bayer-Oglesby L, Brutsche MH, Gerbase MW, Keller R, Künzli N, Leuenberger P, Probst-Hensch NM, Tschopp JM, Zellweger JP, Rochat T, Schwartz J, Ackermann-Liebrich U; SAPALDIA Team.

N Engl J Med. 2007 Dec 6;357(23):2338-47.


Glutathione S-transferase genotype increases risk of progression from bronchial hyperresponsiveness to asthma in adults.

Imboden M, Rochat T, Brutsche M, Schindler C, Downs SH, Gerbase MW, Berger W, Probst-Hensch NM; SAPALDIA Team.

Thorax. 2008 Apr;63(4):322-8. Epub 2007 Dec 5.


Pathology of naturally occurring bovine tuberculosis in England and Wales.

Liebana E, Johnson L, Gough J, Durr P, Jahans K, Clifton-Hadley R, Spencer Y, Hewinson RG, Downs SH.

Vet J. 2008 Jun;176(3):354-60. Epub 2007 Aug 28.


Glutathione S-transferase genotypes modify lung function decline in the general population: SAPALDIA cohort study.

Imboden M, Downs SH, Senn O, Matyas G, Brändli O, Russi EW, Schindler C, Ackermann-Liebrich U, Berger W, Probst-Hensch NM; SAPALDIA Team.

Respir Res. 2007 Jan 11;8:2.


Urban background particulate matter and allergic sensitization in adults of ECRHS II.

Bedada GB, Heinrich J, Götschi T, Downs SH, Forsberg B, Jarvis D, Luczynska C, Soon A, Sunyer J, Toren K, Künzli N.

Int J Hyg Environ Health. 2007 Dec;210(6):691-700. doi: 10.1016/j.ijheh.2006.11.005. Epub 2006 Dec 15.


Respiratory effects of environmental tobacco exposure are enhanced by bronchial hyperreactivity.

Gerbase MW, Schindler C, Zellweger JP, Künzli N, Downs SH, Brändli O, Schwartz J, Frey M, Burdet L, Rochat T, Ackermann-Liebrich U, Leuenberger P; SAPALDIA Team.

Am J Respir Crit Care Med. 2006 Nov 15;174(10):1125-31. Epub 2006 Aug 24.


Incidence of asthma and net change in symptoms in relation to changes in obesity.

Chinn S, Downs SH, Anto JM, Gerbase MW, Leynaert B, de Marco R, Janson C, Jarvis D, Künzli N, Sunyer J, Svanes C, Zemp E, Ackermann-Liebrich U, Burney P; ECRHS; SAPALDIA.

Eur Respir J. 2006 Oct;28(4):763-71. Epub 2006 Jul 26.


Bronchial hyperresponsiveness and the development of asthma and COPD in asymptomatic individuals: SAPALDIA cohort study.

Brutsche MH, Downs SH, Schindler C, Gerbase MW, Schwartz J, Frey M, Russi EW, Ackermann-Liebrich U, Leuenberger P; SAPALDIA Team.

Thorax. 2006 Aug;61(8):671-7. Epub 2006 May 2.


Prevalence of renal impairment and its association with cardiovascular risk factors in a general population: results of the Swiss SAPALDIA study.

Nitsch D, Felber Dietrich D, von Eckardstein A, Gaspoz JM, Downs SH, Leuenberger P, Tschopp JM, Brändli O, Keller R, Gerbase MW, Probst-Hensch NM, Stutz EZ, Ackermann-Liebrich U; SAPALDIA team.

Nephrol Dial Transplant. 2006 Apr;21(4):935-44. Epub 2006 Jan 3.


Follow-up of the Swiss Cohort Study on Air Pollution and Lung Diseases in Adults (SAPALDIA 2) 1991-2003: methods and characterization of participants.

Ackermann-Liebrich U, Kuna-Dibbert B, Probst-Hensch NM, Schindler C, Felber Dietrich D, Stutz EZ, Bayer-Oglesby L, Baum F, Brändli O, Brutsche M, Downs SH, Keidel D, Gerbase MW, Imboden M, Keller R, Knöpfli B, Künzli N, Nicod L, Pons M, Staedele P, Tschopp JM, Zellweger JP, Leuenberger P; SAPALDIA Team.

Soz Praventivmed. 2005;50(4):245-63.


Accelerated decline in lung function in smoking women with airway obstruction: SAPALDIA 2 cohort study.

Downs SH, Brändli O, Zellweger JP, Schindler C, Künzli N, Gerbase MW, Burdet L, Bettschart R, Zemp E, Frey M, Keller R, Tschopp JM, Leuenberger P, Ackermann-Liebrich U; SAPALDIA team.

Respir Res. 2005 May 26;6:45.


Increased prevalence of perennial allergic rhinitis in patients with obstructive sleep apnea.

Canova CR, Downs SH, Knoblauch A, Andersson M, Tamm M, Leuppi JD.

Respiration. 2004 Mar-Apr;71(2):138-43.


Predictors of house-dust-mite allergen concentrations in dry regions in Australia.

Vanlaar CH, Downs SH, Mitakakis TZ, Leuppi JD, Car NG, Peat JK, Marks GB.

Allergy. 2001 Dec;56(12):1211-5.


Clinical importance of Alternaria exposure in children.

Downs SH, Mitakakis TZ, Marks GB, Car NG, Belousova EG, Leüppi JD, Xuan W, Downie SR, Tobias A, Peat JK.

Am J Respir Crit Care Med. 2001 Aug 1;164(3):455-9.


Asthma and hayfever in Aboriginal and non-Aboriginal children living in non-remote rural towns.

Downs SH, Marks GB, Belosouva EG, Peat JK.

Med J Aust. 2001 Jul 2;175(1):10-3.


Thunderstorm outflows preceding epidemics of asthma during spring and summer.

Marks GB, Colquhoun JR, Girgis ST, Koski MH, Treloar AB, Hansen P, Downs SH, Car NG.

Thorax. 2001 Jun;56(6):468-71.


Having lived on a farm and protection against allergic diseases in Australia.

Downs SH, Marks GB, Mitakakis TZ, Lëuppi JD, Car NG, Peat JK.

Clin Exp Allergy. 2001 Apr;31(4):570-5.


Continued increase in the prevalence of asthma and atopy.

Downs SH, Marks GB, Sporik R, Belosouva EG, Car NG, Peat JK.

Arch Dis Child. 2001 Jan;84(1):20-23.


Thunderstorm-associated asthma in an inland town in south-eastern Australia. Who is at risk?

Girgis ST, Marks GB, Downs SH, Kolbe A, Car GN, Paton R.

Eur Respir J. 2000 Jul;16(1):3-8.


The effectiveness of surgery for stress incontinence in women: a systematic review.

Black NA, Downs SH.

Br J Urol. 1996 Oct;78(4):497-510.


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