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Items: 1 to 50 of 111

1.

How gender and religion impact uptake of family planning: results from a qualitative study in Northwestern Tanzania.

Sundararajan R, Yoder LM, Kihunrwa A, Aristide C, Kalluvya SE, Downs DJ, Mwakisole AH, Downs JA.

BMC Womens Health. 2019 Jul 22;19(1):99. doi: 10.1186/s12905-019-0802-6.

2.

Cascade of care for HIV-seroconverters in rural Tanzania: a longitudinal study.

Colombe S, Machemba R, Mtenga B, Lutonja P, Safari W, Beard J, Downs JA, Urassa M, Todd J, Changalucha J.

AIDS Care. 2019 Jul 10:1-6. doi: 10.1080/09540121.2019.1640842. [Epub ahead of print]

PMID:
31288545
3.

HIV-seroconversion among HIV-1 serodiscordant married couples in Tanzania: a cohort study.

Colombe S, Beard J, Mtenga B, Lutonja P, Mngara J, de Dood CJ, van Dam GJ, Corstjens PLAM, Kalluvya S, Urassa M, Todd J, Downs JA.

BMC Infect Dis. 2019 Jun 13;19(1):518. doi: 10.1186/s12879-019-4151-8.

4.

Predicting synthetic lethal interactions using conserved patterns in protein interaction networks.

Benstead-Hume G, Chen X, Hopkins SR, Lane KA, Downs JA, Pearl FMG.

PLoS Comput Biol. 2019 Apr 17;15(4):e1006888. doi: 10.1371/journal.pcbi.1006888. eCollection 2019 Apr.

5.

Schistosomiasis and HIV-1 viral load in HIV-infected outpatients with immunological failure in Tanzania: a case-control study.

Masikini P, Colombe S, Marti A, Desderius B, de Dood CJ, Corstjens PLAM, van Dam GJ, Seugendo M, Kalluvya S, Downs JA.

BMC Infect Dis. 2019 Mar 12;19(1):249. doi: 10.1186/s12879-019-3876-8.

6.

Female global health leadership: data-driven approaches to close the gender gap.

Mathad JS, Reif LK, Seo G, Walsh KF, McNairy ML, Lee MH, Hokororo A, Kinikar A, Riche CT, Deschamps MM, Nerette S, Nimkar S, Kayange N, Jaka H, Joseph G, Morona D, Peter TY, Suryavanshi N, Fitzgerald DW, Downs JA.

Lancet. 2019 Feb 9;393(10171):521-523. doi: 10.1016/S0140-6736(19)30203-X. No abstract available.

PMID:
30739680
7.

Altered Cervical Mucosal Gene Expression and Lower Interleukin 15 Levels in Women With Schistosoma haematobium Infection but Not in Women With Schistosoma mansoni Infection.

Dupnik KM, Lee MH, Mishra P, Reust MJ, Colombe S, Haider SR, Yao B, Vick K, Zhang T, Xiang J, Miyaye D, Magawa R, Lyimo E, Mukerebe C, Mngara J, Kalluvya SE, de Dood CJ, van Dam GJ, Corstjens PLAM, Downs JA.

J Infect Dis. 2019 May 5;219(11):1777-1785. doi: 10.1093/infdis/jiy742.

PMID:
30590736
8.

Repression of Transcription at DNA Breaks Requires Cohesin throughout Interphase and Prevents Genome Instability.

Meisenberg C, Pinder SI, Hopkins SR, Wooller SK, Benstead-Hume G, Pearl FMG, Jeggo PA, Downs JA.

Mol Cell. 2019 Jan 17;73(2):212-223.e7. doi: 10.1016/j.molcel.2018.11.001. Epub 2018 Dec 13.

9.

Refining Diagnosis of Schistosoma haematobium Infections: Antigen and Antibody Detection in Urine.

de Dood CJ, Hoekstra PT, Mngara J, Kalluvya SE, van Dam GJ, Downs JA, Corstjens PLAM.

Front Immunol. 2018 Nov 14;9:2635. doi: 10.3389/fimmu.2018.02635. eCollection 2018.

10.

Gene Expression Differences in Host Response to Schistosoma haematobium Infection.

Dupnik KM, Reust MJ, Vick KM, Yao B, Miyaye D, Lyimo E, Mukerebe C, Mngara J, Kalluvya SE, de Dood CJ, Corstjens PLAM, van Dam GJ, Zhang T, Xiang J, Lee MH, Downs JA.

Infect Immun. 2018 Dec 19;87(1). pii: e00291-18. doi: 10.1128/IAI.00291-18. Print 2019 Jan.

11.

HIV-1 Viral Loads Are Not Elevated in Individuals Co-infected With Schistosoma spp. After Adjustment for Duration of HIV-1 Infection.

Colombe S, Corstjens PLAM, de Dood CJ, Miyaye D, Magawa RG, Mngara J, Kalluvya SE, van Lieshout L, van Dam GJ, Downs JA.

Front Immunol. 2018 Sep 6;9:2005. doi: 10.3389/fimmu.2018.02005. eCollection 2018.

12.

Pre-post effects of a tetanus care protocol implementation in a sub-Saharan African intensive care unit.

Aziz R, Colombe S, Mwakisambwe G, Ndezi S, Todd J, Kalluvya S, Mangat HS, Magleby R, Koebler A, Kenemo B, Peck RN, Downs JA.

PLoS Negl Trop Dis. 2018 Aug 30;12(8):e0006667. doi: 10.1371/journal.pntd.0006667. eCollection 2018 Aug.

13.

Impact of schistosome infection on long-term HIV/AIDS outcomes.

Colombe S, Machemba R, Mtenga B, Lutonja P, Kalluvya SE, de Dood CJ, Hoekstra PT, van Dam GJ, Corstjens PLAM, Urassa M, Changalucha JM, Todd J, Downs JA.

PLoS Negl Trop Dis. 2018 Jul 2;12(7):e0006613. doi: 10.1371/journal.pntd.0006613. eCollection 2018 Jul.

14.

Schistosomiasis and hydration status: Schistosoma haematobium, but not Schistosoma mansoni increases urine specific gravity among rural Tanzanian women.

Rosinger AY, Young SL, Collins SM, Haider SR, Mishra P, Nagai HT, Petro M, Downs JA.

Am J Phys Anthropol. 2018 Aug;166(4):952-959. doi: 10.1002/ajpa.23479. Epub 2018 Apr 17.

15.

Dried Blood Spot RNA Transcriptomes Correlate with Transcriptomes Derived from Whole Blood RNA.

Reust MJ, Lee MH, Xiang J, Zhang W, Xu D, Batson T, Zhang T, Downs JA, Dupnik KM.

Am J Trop Med Hyg. 2018 May;98(5):1541-1546. doi: 10.4269/ajtmh.17-0653. Epub 2018 Mar 1.

16.

Decreased Sensitivity of Schistosoma sp. Egg Microscopy in Women and HIV-Infected Individuals.

Colombe S, Lee MH, Masikini PJ, van Lieshout L, de Dood CJ, Hoekstra PT, Corstjens PLAM, Mngara J, van Dam GJ, Downs JA.

Am J Trop Med Hyg. 2018 Apr;98(4):1159-1164. doi: 10.4269/ajtmh.17-0790. Epub 2018 Feb 1.

17.

Tetanus in adult males, Bugando Medical Centre, United Republic of Tanzania.

Aziz R, Peck RN, Kalluvya S, Kenemo B, Chandika A, Downs JA.

Bull World Health Organ. 2017 Nov 1;95(11):779-783. doi: 10.2471/BLT.16.185546. Epub 2017 Oct 3.

18.

Effects of schistosomiasis on susceptibility to HIV-1 infection and HIV-1 viral load at HIV-1 seroconversion: A nested case-control study.

Downs JA, Dupnik KM, van Dam GJ, Urassa M, Lutonja P, Kornelis D, de Dood CJ, Hoekstra P, Kanjala C, Isingo R, Peck RN, Lee MH, Corstjens PLAM, Todd J, Changalucha JM, Johnson WD Jr, Fitzgerald DW.

PLoS Negl Trop Dis. 2017 Sep 25;11(9):e0005968. doi: 10.1371/journal.pntd.0005968. eCollection 2017 Sep.

19.

Chromatin modifiers and remodellers in DNA repair and signalling.

Jeggo PA, Downs JA, Gasser SM.

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731). pii: 20160279. doi: 10.1098/rstb.2016.0279. No abstract available.

20.

Increased hepatotoxicity among HIV-infected adults co-infected with Schistosoma mansoni in Tanzania: A cross-sectional study.

Marti AI, Colombe S, Masikini PJ, Kalluvya SE, Smart LR, Wajanga BM, Jaka H, Peck RN, Downs JA.

PLoS Negl Trop Dis. 2017 Aug 17;11(8):e0005867. doi: 10.1371/journal.pntd.0005867. eCollection 2017 Aug.

21.

Educating religious leaders to promote uptake of male circumcision in Tanzania: a cluster randomised trial.

Downs JA, Mwakisole AH, Chandika AB, Lugoba S, Kassim R, Laizer E, Magambo KA, Lee MH, Kalluvya SE, Downs DJ, Fitzgerald DW.

Lancet. 2017 Mar 18;389(10074):1124-1132. doi: 10.1016/S0140-6736(16)32055-4. Epub 2017 Feb 15.

22.

Epigenetic changes in histone acetylation underpin resistance to the topoisomerase I inhibitor irinotecan.

Meisenberg C, Ashour ME, El-Shafie L, Liao C, Hodgson A, Pilborough A, Khurram SA, Downs JA, Ward SE, El-Khamisy SF.

Nucleic Acids Res. 2017 Feb 17;45(3):1159-1176. doi: 10.1093/nar/gkw1026.

23.

Schistosomiasis and Human Immunodeficiency Virus in Men in Tanzania.

Downs JA, de Dood CJ, Dee HE, McGeehan M, Khan H, Marenga A, Adel PE, Faustine E, Issarow B, Kisanga EF, Kisigo GA, Ngahyolerwa S, Zahoro F, Miyaye D, Magawa RG, Mngara J, Lee MH, Corstjens PLAM, van Dam GJ, Fitzgerald DW.

Am J Trop Med Hyg. 2017 Apr;96(4):856-862. doi: 10.4269/ajtmh.16-0897. Epub 2017 Feb 6.

24.

The ripple effect: why promoting female leadership in global health matters.

Downs JA, Mathad JS, Reif LK, McNairy ML, Celum C, Boutin-Foster C, Deschamps MM, Gupta A, Hokororo A, Katz IT, Konopasek L, Nelson R, Riviere C, Glimcher LH, Fitzgerald DW.

Public Health Action. 2016 Dec 21;6(4):210-211. doi: 10.5588/pha.16.0072.

25.

Linkage to Primary Care and Survival After Hospital Discharge for HIV-Infected Adults in Tanzania: A Prospective Cohort Study.

Peck RN, Wang RJ, Mtui G, Smart L, Yango M, Elchaki R, Wajanga B, Downs JA, Mteta K, Fitzgerald DW.

J Acquir Immune Defic Syndr. 2016 Dec 15;73(5):522-530.

26.

No more neglect of helminths and HIV.

Downs JA, Fitzgerald DW.

Lancet. 2016 Oct 15;388(10054):1857-1859. doi: 10.1016/S0140-6736(16)31253-3. Epub 2016 Aug 3. No abstract available.

PMID:
27495353
27.

Pattern, Clinical Characteristics, and Outcome of Meningitis among HIV-Infected Adults Admitted in a Tertiary Hospital in North Western Tanzania: A Cross-Sectional Study.

Boaz MM, Kalluvya S, Downs JA, Mpondo BC, Mshana SE.

J Trop Med. 2016;2016:6573672. doi: 10.1155/2016/6573672. Epub 2016 Aug 29.

28.

Discovery and Optimization of a Selective Ligand for the Switch/Sucrose Nonfermenting-Related Bromodomains of Polybromo Protein-1 by the Use of Virtual Screening and Hydration Analysis.

Myrianthopoulos V, Gaboriaud-Kolar N, Tallant C, Hall ML, Grigoriou S, Brownlee PM, Fedorov O, Rogers C, Heidenreich D, Wanior M, Drosos N, Mexia N, Savitsky P, Bagratuni T, Kastritis E, Terpos E, Filippakopoulos P, Müller S, Skaltsounis AL, Downs JA, Knapp S, Mikros E.

J Med Chem. 2016 Oct 13;59(19):8787-8803. Epub 2016 Sep 27.

29.

Novel synthetic lethality screening method identifies TIP60-dependent radiation sensitivity in the absence of BAF180.

Hopkins SR, McGregor GA, Murray JM, Downs JA, Savic V.

DNA Repair (Amst). 2016 Oct;46:47-54. doi: 10.1016/j.dnarep.2016.05.030. Epub 2016 Jun 25.

PMID:
27461052
30.

Short-term and long-term cardiovascular risk, metabolic syndrome and HIV in Tanzania.

Kingery JR, Alfred Y, Smart LR, Nash E, Todd J, Naguib MR, Downs JA, Kalluvya S, Kataraihya JB, Peck RN.

Heart. 2016 Aug 1;102(15):1200-5. doi: 10.1136/heartjnl-2015-309026. Epub 2016 Apr 22.

31.

Malaria and HIV among pediatric inpatients in two Tanzanian referral hospitals: A prospective study.

Smart LR, Orgenes N, Mazigo HD, Minde M, Hokororo A, Shakir M, Verweij JJ, Downs JA, Peck RN.

Acta Trop. 2016 Jul;159:36-43. doi: 10.1016/j.actatropica.2016.03.019. Epub 2016 Mar 18.

32.

Renal dysfunction and schistosomiasis among HIV-infected patients starting antiretroviral therapy in Mwanza, Tanzania.

Downs JA, Msango L, Kalluvya SE, Kidenya BR, Kabangila R, Peck RN.

AIDS. 2015 Nov 28;29(18):2532-3. doi: 10.1097/QAD.0000000000000926. No abstract available.

PMID:
26558550
33.

Shortening Turnaround Times for Newborn HIV Testing in Rural Tanzania: A Report from the Field.

Manumbu S, Smart LR, Mwale A, Mate KS, Downs JA.

PLoS Med. 2015 Nov 3;12(11):e1001897. doi: 10.1371/journal.pmed.1001897. eCollection 2015 Nov. No abstract available.

34.

Mapping eastern equine encephalitis virus risk for white-tailed deer in Michigan.

Downs JA, Hyzer G, Marion E, Smith ZJ, Kelen PV, Unnasch TR.

Appl Geogr. 2015 Oct 1;64:66-73.

35.

Six-month outcomes of HIV-infected patients given short-course fluconazole therapy for asymptomatic cryptococcal antigenemia.

Kapoor SW, Magambo KA, Kalluvya SE, Fitzgerald DW, Peck RN, Downs JA.

AIDS. 2015 Nov 28;29(18):2473-8. doi: 10.1097/QAD.0000000000000872.

36.

Glucose Metabolism Disorders, HIV and Antiretroviral Therapy among Tanzanian Adults.

Maganga E, Smart LR, Kalluvya S, Kataraihya JB, Saleh AM, Obeid L, Downs JA, Fitzgerald DW, Peck RN.

PLoS One. 2015 Aug 19;10(8):e0134410. doi: 10.1371/journal.pone.0134410. eCollection 2015.

37.

Fork rotation and DNA precatenation are restricted during DNA replication to prevent chromosomal instability.

Schalbetter SA, Mansoubi S, Chambers AL, Downs JA, Baxter J.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):E4565-70. doi: 10.1073/pnas.1505356112. Epub 2015 Aug 3.

38.

Correlation of serum and dried blood spot results for quantitation of Schistosoma circulating anodic antigen: a proof of principle.

Downs JA, Corstjens PL, Mngara J, Lutonja P, Isingo R, Urassa M, Kornelis D, van Dam GJ.

Acta Trop. 2015 Oct;150:59-63. doi: 10.1016/j.actatropica.2015.06.026. Epub 2015 Jul 3.

39.

Removal of H2A.Z by INO80 promotes homologous recombination.

Alatwi HE, Downs JA.

EMBO Rep. 2015 Aug;16(8):986-94. doi: 10.15252/embr.201540330. Epub 2015 Jul 3.

40.

The BAH domain of BAF180 is required for PCNA ubiquitination.

Niimi A, Hopkins SR, Downs JA, Masutani C.

Mutat Res. 2015 Sep;779:16-23. doi: 10.1016/j.mrfmmm.2015.06.006. Epub 2015 Jun 17.

PMID:
26117423
41.

The SWI/SNF chromatin remodelling complex: Its role in maintaining genome stability and preventing tumourigenesis.

Brownlee PM, Meisenberg C, Downs JA.

DNA Repair (Amst). 2015 Aug;32:127-133. doi: 10.1016/j.dnarep.2015.04.023. Epub 2015 May 1. Review.

PMID:
25981841
42.

High prevalence of sexually transmitted infections in pregnant adolescent girls in Tanzania: a multi-community cross-sectional study.

Hokororo A, Kihunrwa A, Hoekstra P, Kalluvya SE, Changalucha JM, Fitzgerald DW, Downs JA.

Sex Transm Infect. 2015 Nov;91(7):473-8. doi: 10.1136/sextrans-2014-051952. Epub 2015 Apr 1.

43.

The influence of HIV and schistosomiasis on renal function: a cross-sectional study among children at a hospital in Tanzania.

Kayange NM, Smart LR, Downs JA, Maskini M, Fitzgerald DW, Peck RN.

PLoS Negl Trop Dis. 2015 Jan 22;9(1):e0003472. doi: 10.1371/journal.pntd.0003472. eCollection 2015 Jan.

44.

The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks.

Kakarougkas A, Downs JA, Jeggo PA.

Mol Cell Oncol. 2015 Jan 23;2(1):e970072. doi: 10.4161/23723548.2014.970072. eCollection 2015 Jan-Mar.

45.

Barriers to access reproductive health care for pregnant adolescent girls: a qualitative study in Tanzania.

Hokororo A, Kihunrwa AF, Kalluvya S, Changalucha J, Fitzgerald DW, Downs JA.

Acta Paediatr. 2015 Dec;104(12):1291-7. doi: 10.1111/apa.12886. Epub 2015 Feb 7.

46.

Inpatient mortality of HIV-infected adults in sub-Saharan Africa and possible interventions: a mixed methods review.

Wajanga BM, Webster LE, Peck RN, Downs JA, Mate K, Smart LR, Fitzgerald DW.

BMC Health Serv Res. 2014 Dec 3;14:627. doi: 10.1186/s12913-014-0627-9. Review.

47.

Roles of chromatin remodellers in DNA double strand break repair.

Jeggo PA, Downs JA.

Exp Cell Res. 2014 Nov 15;329(1):69-77. doi: 10.1016/j.yexcr.2014.09.023. Epub 2014 Sep 30. Review.

PMID:
25278484
48.

Utility of urine and serum lateral flow assays to determine the prevalence and predictors of cryptococcal antigenemia in HIV-positive outpatients beginning antiretroviral therapy in Mwanza, Tanzania.

Magambo KA, Kalluvya SE, Kapoor SW, Seni J, Chofle AA, Fitzgerald DW, Downs JA.

J Int AIDS Soc. 2014 Aug 8;17:19040. doi: 10.7448/IAS.17.1.19040. eCollection 2014.

49.

Hypertension, kidney disease, HIV and antiretroviral therapy among Tanzanian adults: a cross-sectional study.

Peck RN, Shedafa R, Kalluvya S, Downs JA, Todd J, Suthanthiran M, Fitzgerald DW, Kataraihya JB.

BMC Med. 2014 Jul 29;12:125. doi: 10.1186/s12916-014-0125-2.

50.

Requirement for PBAF in transcriptional repression and repair at DNA breaks in actively transcribed regions of chromatin.

Kakarougkas A, Ismail A, Chambers AL, Riballo E, Herbert AD, Künzel J, Löbrich M, Jeggo PA, Downs JA.

Mol Cell. 2014 Sep 4;55(5):723-32. doi: 10.1016/j.molcel.2014.06.028. Epub 2014 Jul 24.

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