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A Novel Tree Shrew (Tupaia belangeri) Model of Glaucoma.

Samuels BC, Siegwart JT, Zhan W, Hethcox L, Chimento M, Whitley R, Downs JC, Girkin CA.

Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):3136-3143. doi: 10.1167/iovs.18-24261.


Impact of schistosome infection on long-term HIV/AIDS outcomes.

Colombe S, Machemba R, Mtenga B, Lutonja P, Kalluvya SE, de Dood CJ, Hoekstra PT, van Dam GJ, Corstjens PLAM, Urassa M, Changalucha JM, Todd J, Downs JA.

PLoS Negl Trop Dis. 2018 Jul 2;12(7):e0006613. doi: 10.1371/journal.pntd.0006613. eCollection 2018 Jul.


Impact of Gastrostomy Placement on Nutritional Status, Physical Health, and Parental Well-Being of Females with Rett Syndrome: A Longitudinal Study of an Australian Population.

Wong K, Downs J, Ellaway C, Baikie G, Ravikumara M, Jacoby P, Christodoulou J, Elliott EJ, Leonard H.

J Pediatr. 2018 Jun 22. pii: S0022-3476(18)30604-8. doi: 10.1016/j.jpeds.2018.04.050. [Epub ahead of print]


Detection of Suicidality in Adolescents with Autism Spectrum Disorders: Developing a Natural Language Processing Approach for Use in Electronic Health Records.

Downs J, Velupillai S, George G, Holden R, Kikoler M, Dean H, Fernandes A, Dutta R.

AMIA Annu Symp Proc. 2018 Apr 16;2017:641-649. eCollection 2017.


Evolving Trends of Gastrostomy Insertion Within a Pediatric Population.

Glasson EJ, Wong K, Leonard H, Forbes D, Ravikumara M, Mews C, Jacoby P, Bourke J, Trollor J, Srasuebkul P, Wilson A, Nagarajan L, Downs J.

J Pediatr Gastroenterol Nutr. 2018 May 30. doi: 10.1097/MPG.0000000000002042. [Epub ahead of print]


Validation of a Risk Index Model for Predicting Eastern Equine Encephalitis Virus Transmission to Horses in Florida.

Downs J, Vaziri M, Jenkins A, Unnasch T.

J Med Entomol. 2018 May 2. doi: 10.1093/jme/tjy067. [Epub ahead of print]


Sleep disturbances in Rett syndrome: Impact and management including use of sleep hygiene practices.

Boban S, Leonard H, Wong K, Wilson A, Downs J.

Am J Med Genet A. 2018 Apr 28. doi: 10.1002/ajmg.a.38829. [Epub ahead of print]


Schistosomiasis and hydration status: Schistosoma haematobium, but not Schistosoma mansoni increases urine specific gravity among rural Tanzanian women.

Rosinger AY, Young SL, Collins SM, Haider SR, Mishra P, Nagai HT, Petro M, Downs JA.

Am J Phys Anthropol. 2018 Apr 17. doi: 10.1002/ajpa.23479. [Epub ahead of print]


Society for Translational Medicine Expert Consensus on the prevention and treatment of postoperative pulmonary infection in esophageal cancer patients.

Yu Z, Li S, Liu D, Liu L, He J, Huang Y, Xu S, Mao W, Tan Q, Chen C, Li X, Zhang Z, Jiang G, Xu L, Zhang L, Fu J, Li H, Wang Q, Tan L, Li D, Zhou Q, Fu X, Jiang Z, Chen H, Fang W, Zhang X, Li Y, Tong T, Liu Y, Zhi X, Yan T, Zhang X, Gong L, Zhang H, Downs JB, Villamizar N, Gao S, He J.

J Thorac Dis. 2018 Feb;10(2):1050-1057. doi: 10.21037/jtd.2018.01.34. Review. No abstract available.


Respiratory morbidity in Rett syndrome: an observational study.

MacKay J, Leonard H, Wong K, Wilson A, Downs J.

Dev Med Child Neurol. 2018 Mar 14. doi: 10.1111/dmcn.13726. [Epub ahead of print]


Psychological consequences of child trafficking: An historical cohort study of trafficked children in contact with secondary mental health services.

Ottisova L, Smith P, Shetty H, Stahl D, Downs J, Oram S.

PLoS One. 2018 Mar 8;13(3):e0192321. doi: 10.1371/journal.pone.0192321. eCollection 2018.


Dried Blood Spot RNA Transcriptomes Correlate with Transcriptomes Derived from Whole Blood RNA.

Reust MJ, Lee MH, Xiang J, Zhang W, Xu D, Batson T, Zhang T, Downs JA, Dupnik KM.

Am J Trop Med Hyg. 2018 May;98(5):1541-1546. doi: 10.4269/ajtmh.17-0653. Epub 2018 Mar 1.


Decreased Sensitivity of Schistosoma sp. Egg Microscopy in Women and HIV-Infected Individuals.

Colombe S, Lee MH, Masikini PJ, van Lieshout L, de Dood CJ, Hoekstra PT, Corstjens PLAM, Mngara J, van Dam GJ, Downs JA.

Am J Trop Med Hyg. 2018 Apr;98(4):1159-1164. doi: 10.4269/ajtmh.17-0790. Epub 2018 Feb 1.


Negative Symptoms in Early-Onset Psychosis and Their Association With Antipsychotic Treatment Failure.

Downs J, Dean H, Lechler S, Sears N, Patel R, Shetty H, Hotopf M, Ford T, Kyriakopoulos M, Diaz-Caneja CM, Arango C, MacCabe JH, Hayes RD, Pina-Camacho L.

Schizophr Bull. 2018 Jan 24. doi: 10.1093/schbul/sbx197. [Epub ahead of print]


Parent-reported health-related quality of life of children with Down syndrome: a descriptive study.

Shields N, Leonard H, Munteanu S, Bourke J, Lim P, Taylor NF, Downs J.

Dev Med Child Neurol. 2018 Apr;60(4):402-408. doi: 10.1111/dmcn.13670. Epub 2018 Jan 23.


Environmental enrichment intervention for Rett syndrome: an individually randomised stepped wedge trial.

Downs J, Rodger J, Li C, Tan X, Hu N, Wong K, de Klerk N, Leonard H.

Orphanet J Rare Dis. 2018 Jan 10;13(1):3. doi: 10.1186/s13023-017-0752-8.


CDKL5 variants: Improving our understanding of a rare neurologic disorder.

Hector RD, Kalscheuer VM, Hennig F, Leonard H, Downs J, Clarke A, Benke TA, Armstrong J, Pineda M, Bailey MES, Cobb SR.

Neurol Genet. 2017 Dec 15;3(6):e200. doi: 10.1212/NXG.0000000000000200. eCollection 2017 Dec.


The Magnitude and Time Course of IOP Change in Response to Body Position Change in Nonhuman Primates Measured Using Continuous IOP Telemetry.

Turner DC, Samuels BC, Huisingh C, Girkin CA, Downs JC.

Invest Ophthalmol Vis Sci. 2017 Dec 1;58(14):6232-6240. doi: 10.1167/iovs.17-22858.


The Society for Translational Medicine: clinical practice guidelines for the postoperative management of chest tube for patients undergoing lobectomy.

Gao S, Zhang Z, Aragón J, Brunelli A, Cassivi S, Chai Y, Chen C, Chen C, Chen G, Chen H, Chen JS, Cooke DT, Downs JB, Falcoz PE, Fang W, Filosso PL, Fu X, Force SD, Garutti MI, Gonzalez-Rivas D, Gossot D, Hansen HJ, He J, He J, Holbek BL, Hu J, Huang Y, Ibrahim M, Imperatori A, Ismail M, Jiang G, Jiang H, Jiang Z, Kim HK, Li D, Li G, Li H, Li Q, Li X, Li Y, Li Z, Lim E, Liu CC, Liu D, Liu L, Liu Y, Lobdell KW, Ma H, Mao W, Mao Y, Mou J, Ng CSH, Novoa NM, Petersen RH, Oizumi H, Papagiannopoulos K, Pompili C, Qiao G, Refai M, Rocco G, Ruffini E, Salati M, Seguin-Givelet A, Sihoe ADL, Tan L, Tan Q, Tong T, Tsakiridis K, Venuta F, Veronesi G, Villamizar N, Wang H, Wang Q, Wang R, Wang S, Wright GM, Xie D, Xue Q, Xue T, Xu L, Xu S, Xu S, Yan T, Yu F, Yu Z, Zhang C, Zhang L, Zhang T, Zhang X, Zhao X, Zhao X, Zhi X, Zhou Q.

J Thorac Dis. 2017 Sep;9(9):3255-3264. doi: 10.21037/jtd.2017.08.165. Review.


The Society for Translational Medicine: clinical practice guidelines for mechanical ventilation management for patients undergoing lobectomy.

Gao S, Zhang Z, Brunelli A, Chen C, Chen C, Chen G, Chen H, Chen JS, Cassivi S, Chai Y, Downs JB, Fang W, Fu X, Garutti MI, He J, He J, Hu J, Huang Y, Jiang G, Jiang H, Jiang Z, Li D, Li G, Li H, Li Q, Li X, Li Y, Li Z, Liu CC, Liu D, Liu L, Liu Y, Ma H, Mao W, Mao Y, Mou J, Ng CSH, Petersen RH, Qiao G, Rocco G, Ruffini E, Tan L, Tan Q, Tong T, Wang H, Wang Q, Wang R, Wang S, Xie D, Xue Q, Xue T, Xu L, Xu S, Xu S, Yan T, Yu F, Yu Z, Zhang C, Zhang L, Zhang T, Zhang X, Zhao X, Zhao X, Zhi X, Zhou Q.

J Thorac Dis. 2017 Sep;9(9):3246-3254. doi: 10.21037/jtd.2017.08.166. Review.


Sandfly fever in Afghanistan-a sometimes overlooked disease of military importance: a case series and review of the literature.

Downs JW, Flood DT, Orr NH, Constantineau JA, Caviness JW.

US Army Med Dep J. 2017 Oct-Dec;(3-17):60-66. Review.


Attitudes toward mandatory ignition interlocks for all offenders convicted of driving while intoxicated.

Downs J, Shults R, West B.

J Safety Res. 2017 Dec;63:99-103. doi: 10.1016/j.jsr.2017.08.002. Epub 2017 Aug 24.


Comparing Parental Well-Being and Its Determinants Across Three Different Genetic Disorders Causing Intellectual Disability.

Mori Y, Downs J, Wong K, Heyworth J, Leonard H.

J Autism Dev Disord. 2018 May;48(5):1651-1665. doi: 10.1007/s10803-017-3420-x.


Hospital-Based Physicians' Intubation Decisions and Associated Mental Models when Managing a Critically and Terminally Ill Older Patient.

Haliko S, Downs J, Mohan D, Arnold R, Barnato AE.

Med Decis Making. 2018 Apr;38(3):344-354. doi: 10.1177/0272989X17738958. Epub 2017 Nov 22.


Tetanus in adult males, Bugando Medical Centre, United Republic of Tanzania.

Aziz R, Peck RN, Kalluvya S, Kenemo B, Chandika A, Downs JA.

Bull World Health Organ. 2017 Nov 1;95(11):779-783. doi: 10.2471/BLT.16.185546. Epub 2017 Oct 3.


Video Intervention to Increase Perceived Self-Efficacy for Condom Use in a Randomized Controlled Trial of Female Adolescents.

Downs JS, Ashcraft AM, Murray PJ, Berlan ED, Bruine de Bruin W, Eichner J, Fischhoff B, Leary JM, McCall RB, Miller E, Salaway J, Smith-Jones J, Sucato GS.

J Pediatr Adolesc Gynecol. 2018 Jun;31(3):291-298.e2. doi: 10.1016/j.jpag.2017.10.008. Epub 2017 Nov 7.


The Association Between Comorbid Autism Spectrum Disorders and Antipsychotic Treatment Failure in Early-Onset Psychosis: A Historical Cohort Study Using Electronic Health Records.

Downs JM, Lechler S, Dean H, Sears N, Patel R, Shetty H, Simonoff E, Hotopf M, Ford TJ, Diaz-Caneja CM, Arango C, MacCabe JH, Hayes RD, Pina-Camacho L.

J Clin Psychiatry. 2017 Nov/Dec;78(9):e1233-e1241. doi: 10.4088/JCP.16m11422.


What effect does regular exercise have on oxidative stress in people with Down syndrome? A systematic review with meta-analyses.

Shields N, Downs J, de Haan JB, Taylor NF, Torr J, Fernhall B, Kingsley M, Mnatzaganian G, Leonard H.

J Sci Med Sport. 2018 Jun;21(6):596-603. doi: 10.1016/j.jsams.2017.10.015. Epub 2017 Oct 19. Review.


Complete Genome Sequences of Cluster A Mycobacteriophages BobSwaget, Fred313, KADY, Lokk, MyraDee, Stagni, and StepMih.

Butela KA, Gurney SMR, Hendrickson HL, LeBlanc-Straceski JM, Zimmerman AM, Conant SB, Freed NE, Silander OK, Thomson JJ, Berkes CA, Bertolez C, Davies CG, Elinsky A, Hanlon AJ, Nersesyan J, Patel P, Sherwood J, Tieu Ngo T, Wisniewski KA, Yacoo K, Arendse PM, Bowlen NW, Cunmulaj J, Downs JL, Ferrenberg CA, Gassman AE, Gilligan CER, Gorkiewicz E, Harness C, Huffman A, Jones C, Julien A, Kupic AE, Latu SF, Manning TJ, Maxwell D; Merrimack College SEA-PHAGES Annotators 2016, Meyer CE, Reardon M, Slaughter M, Swasey R, Tennent RI, Torres V, Waller T, Worcester RM, Yost BL, Cresawn SG, Garlena RA, Jacobs-Sera D, Pope WH, Russell DA, Hatfull GF, Kagey JD.

Genome Announc. 2017 Oct 26;5(43). pii: e01182-17. doi: 10.1128/genomeA.01182-17.


Parent-observed thematic data on quality of life in children with autism spectrum disorder.

Epstein A, Whitehouse A, Williams K, Murphy N, Leonard H, Davis E, Reddihough D, Downs J.

Autism. 2017 Oct 1:1362361317722764. doi: 10.1177/1362361317722764. [Epub ahead of print]


Patterns of sedentary time and ambulatory physical activity in a Danish population of girls and women with Rett syndrome.

Stahlhut M, Downs J, Aadahl M, Leonard H, Bisgaard AM, Nordmark E.

Disabil Rehabil. 2017 Oct 2:1-9. doi: 10.1080/09638288.2017.1381181. [Epub ahead of print]


Effects of schistosomiasis on susceptibility to HIV-1 infection and HIV-1 viral load at HIV-1 seroconversion: A nested case-control study.

Downs JA, Dupnik KM, van Dam GJ, Urassa M, Lutonja P, Kornelis D, de Dood CJ, Hoekstra P, Kanjala C, Isingo R, Peck RN, Lee MH, Corstjens PLAM, Todd J, Changalucha JM, Johnson WD Jr, Fitzgerald DW.

PLoS Negl Trop Dis. 2017 Sep 25;11(9):e0005968. doi: 10.1371/journal.pntd.0005968. eCollection 2017 Sep.


Rural and Urban Differences in Passenger-Vehicle-Occupant Deaths and Seat Belt Use Among Adults - United States, 2014.

Beck LF, Downs J, Stevens MR, Sauber-Schatz EK.

MMWR Surveill Summ. 2017 Sep 22;66(17):1-13. doi: 10.15585/mmwr.ss6617a1.


The prevalence of mental health disorders and symptoms in children and adolescents with cerebral palsy: a systematic review and meta-analysis.

Downs J, Blackmore AM, Epstein A, Skoss R, Langdon K, Jacoby P, Whitehouse AJO, Leonard H, Rowe PW, Glasson EJ; Cerebral Palsy Mental Health Group.

Dev Med Child Neurol. 2018 Jan;60(1):30-38. doi: 10.1111/dmcn.13555. Epub 2017 Sep 15. Review.


Measurement of Sedentary Behaviors or "Downtime" in Rett Syndrome.

Stahlhut M, Hill K, Bisgaard AM, Jensen AK, Andersen M, Leonard H, Downs J.

J Child Neurol. 2017 Oct;32(12):1009-1013. doi: 10.1177/0883073817728861.



Downs J, Wilson K, Made F, Malherbe F, Panieri E, Cairncross L.

S Afr J Surg. 2017 Sep;55(3):74.


Chromatin modifiers and remodellers in DNA repair and signalling.

Jeggo PA, Downs JA, Gasser SM.

Philos Trans R Soc Lond B Biol Sci. 2017 Oct 5;372(1731). pii: 20160279. doi: 10.1098/rstb.2016.0279. No abstract available.


Increased hepatotoxicity among HIV-infected adults co-infected with Schistosoma mansoni in Tanzania: A cross-sectional study.

Marti AI, Colombe S, Masikini PJ, Kalluvya SE, Smart LR, Wajanga BM, Jaka H, Peck RN, Downs JA.

PLoS Negl Trop Dis. 2017 Aug 17;11(8):e0005867. doi: 10.1371/journal.pntd.0005867. eCollection 2017 Aug.


Considerations for ADHD in the child with epilepsy and the child with migraine.

Downs J, Giust J, Dunn DW.

Expert Rev Neurother. 2017 Sep;17(9):861-869. doi: 10.1080/14737175.2017.1360136. Epub 2017 Aug 7.


Exploring quality of life of children with cerebral palsy and intellectual disability: What are the important domains of life?

Davis E, Reddihough D, Murphy N, Epstein A, Reid SM, Whitehouse A, Williams K, Leonard H, Downs J.

Child Care Health Dev. 2017 Nov;43(6):854-860. doi: 10.1111/cch.12501. Epub 2017 Jul 26.


Variation in the Three-Dimensional Histomorphometry of the Normal Human Optic Nerve Head With Age and Race: Lamina Cribrosa and Peripapillary Scleral Thickness and Position.

Girkin CA, Fazio MA, Yang H, Reynaud J, Burgoyne CF, Smith B, Wang L, Downs JC.

Invest Ophthalmol Vis Sci. 2017 Jul 1;58(9):3759-3769. doi: 10.1167/iovs.17-21842.


Incidence and prevalence of falls in adults with intellectual disability living in the community: a systematic review protocol.

Ho P, Patman S, Bulsara C, Downs J, Bulsara M, Hill AM.

JBI Database System Rev Implement Rep. 2017 Jul;15(7):1819-1823. doi: 10.11124/JBISRIR-2016-003155. Review.


The Magnitude of Hypotony and Time Course of Intraocular Pressure Recovery Following Anterior Chamber Cannulation in Nonhuman Primates.

Jasien JV, Huisingh C, Girkin CA, Downs JC.

Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):3225-3230. doi: 10.1167/iovs.17-21833.


Use of the ketogenic diet to manage refractory epilepsy in CDKL5 disorder: Experience of >100 patients.

Lim Z, Wong K, Olson HE, Bergin AM, Downs J, Leonard H.

Epilepsia. 2017 Aug;58(8):1415-1422. doi: 10.1111/epi.13813. Epub 2017 Jun 12.


Autonomic breathing abnormalities in Rett syndrome: caregiver perspectives in an international database study.

Mackay J, Downs J, Wong K, Heyworth J, Epstein A, Leonard H.

J Neurodev Disord. 2017 Apr 28;9:15. doi: 10.1186/s11689-017-9196-7. eCollection 2017.


Effect of caloric restriction on plasma melatonin levels in aged rhesus macaques.

Aghazadeh-Sanai N, Downs JL, Mattison JA, Ingram DK, Kohama SG, Urbanski HF.

Neurobiol Aging. 2017 Jul;55:213-216. doi: 10.1016/j.neurobiolaging.2017.03.032. Epub 2017 Apr 8.


Applicability of the IMPROVE-IT Trial to Current Patients With Acute Coronary Syndrome: An NCDR Research to Practice Project.

Maddox TM, Tang F, Downs JR, Masoudi FA, Virani SS, Daugherty SL, Rumsfeld JS.

JAMA Intern Med. 2017 Jun 1;177(6):887-889. doi: 10.1001/jamainternmed.2017.0754. No abstract available.


Zero-tolerance biosecurity protects high-conservation-value island nature reserve.

Scott JK, McKirdy SJ, van der Merwe J, Green R, Burbidge AA, Pickles G, Hardie DC, Morris K, Kendrick PG, Thomas ML, Horton KL, O'Connor SM, Downs J, Stoklosa R, Lagdon R, Marks B, Nairn M, Mengersen K.

Sci Rep. 2017 Apr 10;7(1):772. doi: 10.1038/s41598-017-00450-y.


Severe Systemic Lead Toxicity Resulting From Extra-Articular Retained Shrapnel Presenting as Jaundice and Hepatitis: A Case Report and Review of the Literature.

Grasso IA, Blattner MR, Short T, Downs JW.

Mil Med. 2017 Mar;182(3):e1843-e1848. doi: 10.7205/MILMED-D-16-00231.


Educating religious leaders to promote uptake of male circumcision in Tanzania: a cluster randomised trial.

Downs JA, Mwakisole AH, Chandika AB, Lugoba S, Kassim R, Laizer E, Magambo KA, Lee MH, Kalluvya SE, Downs DJ, Fitzgerald DW.

Lancet. 2017 Mar 18;389(10074):1124-1132. doi: 10.1016/S0140-6736(16)32055-4. Epub 2017 Feb 15.

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