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Four Decades After the Discovery of Regenerating Islet-Derived (Reg) Proteins: Current Understanding and Challenges.

Chen Z, Downing S, Tzanakakis ES.

Front Cell Dev Biol. 2019 Oct 22;7:235. doi: 10.3389/fcell.2019.00235. eCollection 2019. Review.


The InSituPlex® Staining Method for Multiplexed Immunofluorescence Cell Phenotyping and Spatial Profiling of Tumor FFPE Samples.

Manesse M, Patel KK, Bobrow M, Downing SR.

Methods Mol Biol. 2020;2055:585-592. doi: 10.1007/978-1-4939-9773-2_26.


Metabolism of the neurotoxic amino acid β-N-methylamino-L-alanine in human cell culture models.

Downing S, Van Onselen R, Kemp G, Downing TG.

Toxicon. 2019 Oct;168:131-139. doi: 10.1016/j.toxicon.2019.07.007. Epub 2019 Jul 19.


MicroRNA-7 directly targets Reg1 in pancreatic cells.

Downing S, Zhang F, Chen Z, Tzanakakis ES.

Am J Physiol Cell Physiol. 2019 Aug 1;317(2):C366-C374. doi: 10.1152/ajpcell.00013.2019. Epub 2019 Jun 5.


Apurinic endonuclease-1 preserves neural genome integrity to maintain homeostasis and thermoregulation and prevent brain tumors.

Dumitrache LC, Shimada M, Downing SM, Kwak YD, Li Y, Illuzzi JL, Russell HR, Wilson DM 3rd, McKinnon PJ.

Proc Natl Acad Sci U S A. 2018 Dec 26;115(52):E12285-E12294. doi: 10.1073/pnas.1809682115. Epub 2018 Dec 11.


Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors.

Ratnaparkhe M, Wong JKL, Wei PC, Hlevnjak M, Kolb T, Simovic M, Haag D, Paul Y, Devens F, Northcott P, Jones DTW, Kool M, Jauch A, Pastorczak A, Mlynarski W, Korshunov A, Kumar R, Downing SM, Pfister SM, Zapatka M, McKinnon PJ, Alt FW, Lichter P, Ernst A.

Nat Commun. 2018 Nov 12;9(1):4760. doi: 10.1038/s41467-018-06925-4.


Use of fetal fibronectin testing in women transferred for threatened preterm labour in remote far north Queensland.

Downing SG, Wright R, Marquardt T, Callander E.

Aust N Z J Obstet Gynaecol. 2019 Jun;59(3):403-407. doi: 10.1111/ajo.12878. Epub 2018 Sep 3.


Potential for dietary exposure to β-N-methylamino-L-alanine and microcystin from a freshwater system.

Scott LL, Downing S, Downing T.

Toxicon. 2018 Aug;150:261-266. doi: 10.1016/j.toxicon.2018.06.076. Epub 2018 Jun 18.


Human Scalp Hair as an Indicator of Exposure to the Environmental Toxin β-N-Methylamino-l-alanine.

Downing S, Scott LL, Zguna N, Downing TG.

Toxins (Basel). 2017 Dec 27;10(1). pii: E14. doi: 10.3390/toxins10010014.


Investigating β-N-Methylamino-l-alanine Misincorporation in Human Cell Cultures: A Comparative Study with Known Amino Acid Analogues.

Onselen RV, Downing S, Kemp G, Downing T.

Toxins (Basel). 2017 Dec 14;9(12). pii: E400. doi: 10.3390/toxins9120400.


The Evaluation of BMAA Inhalation as a Potential Exposure Route Using a rat Model.

Scott LL, Downing S, Downing TG.

Neurotox Res. 2018 Jan;33(1):6-14. doi: 10.1007/s12640-017-9742-9. Epub 2017 May 3.


Ten years on: a review of medical terminations of pregnancy performed in a sexual health clinic.

Downing SG, Cashman C, Russell DB.

Sex Health. 2017 Jun;14(3):208-212. doi: 10.1071/SH16177.


DNA-PKcs, ATM, and ATR Interplay Maintains Genome Integrity during Neurogenesis.

Enriquez-Rios V, Dumitrache LC, Downing SM, Li Y, Brown EJ, Russell HR, McKinnon PJ.

J Neurosci. 2017 Jan 25;37(4):893-905. doi: 10.1523/JNEUROSCI.4213-15.2016.


Chlamydia retest: how should we remind you?

Downing S, Cashman C.

Sex Transm Infect. 2016 Nov;92(7):553. doi: 10.1136/sextrans-2016-052666. No abstract available.


Death with dignity in Washington patients with amyotrophic lateral sclerosis.

Wang LH, Elliott MA, Jung Henson L, Gerena-Maldonado E, Strom S, Downing S, Vetrovs J, Kayihan P, Paul P, Kennedy K, Benditt JO, Weiss MD.

Neurology. 2016 Nov 15;87(20):2117-2122. Epub 2016 Oct 21.


Society Pages for March 2016 issue.

Downing S.

Hum Fertil (Camb). 2016 Apr;19(1):70-7. doi: 10.3109/14647273.2016.1161993. No abstract available.


The metabolism of the non-proteinogenic amino acid β-N-methylamino-L-alanine (BMAA) in the cyanobacterium Synechocystis PCC6803.

Downing S, Downing TG.

Toxicon. 2016 Jun 1;115:41-8. doi: 10.1016/j.toxicon.2016.03.005. Epub 2016 Mar 4.


Physician practice mergers in nephrology.

McGraw WA, Downing S.

Nephrol News Issues. 2015 Sep;29(10):18-20. No abstract available.


β-N-methylamino-L-alanine (BMAA) metabolism in the aquatic macrophyte Ceratophyllum demersum.

Downing S, Esterhuizen-Londt M, Grant Downing T.

Ecotoxicol Environ Saf. 2015 Oct;120:88-92. doi: 10.1016/j.ecoenv.2015.05.022. Epub 2015 May 31.


Supervising incoming first-year residents: faculty expectations versus residents' experiences.

Touchie C, De Champlain A, Pugh D, Downing S, Bordage G.

Med Educ. 2014 Sep;48(9):921-9. doi: 10.1111/medu.12503.


Environmental modulation of microcystin and β-N-methylamino-L-alanine as a function of nitrogen availability.

Scott LL, Downing S, Phelan RR, Downing TG.

Toxicon. 2014 Sep;87:1-5. doi: 10.1016/j.toxicon.2014.05.001. Epub 2014 May 28.


Aberrant topoisomerase-1 DNA lesions are pathogenic in neurodegenerative genome instability syndromes.

Katyal S, Lee Y, Nitiss KC, Downing SM, Li Y, Shimada M, Zhao J, Russell HR, Petrini JH, Nitiss JL, McKinnon PJ.

Nat Neurosci. 2014 Jun;17(6):813-21. doi: 10.1038/nn.3715. Epub 2014 May 4.


Response of an ERBB2-mutated inflammatory breast carcinoma to human epidermal growth factor receptor 2-targeted therapy.

Ali SM, Alpaugh RK, Downing SR, Stephens PJ, Yu JQ, Wu H, Buell JK, Miller VA, Lipson D, Palmer GA, Ross JS, Cristofanilli M.

J Clin Oncol. 2014 Sep 1;32(25):e88-91. doi: 10.1200/JCO.2013.49.0599. Epub 2014 Feb 10. No abstract available.


The fate of the cyanobacterial toxin β-N-methylamino-L-alanine in freshwater mussels.

Downing S, Contardo-Jara V, Pflugmacher S, Downing TG.

Ecotoxicol Environ Saf. 2014 Mar;101:51-8. doi: 10.1016/j.ecoenv.2013.11.028. Epub 2014 Jan 11.


Comprehensive genomic profiling of relapsed and metastatic adenoid cystic carcinomas by next-generation sequencing reveals potential new routes to targeted therapies.

Ross JS, Wang K, Rand JV, Sheehan CE, Jennings TA, Al-Rohil RN, Otto GA, Curran JC, Palmer G, Downing SR, Yelensky R, Lipson D, Balasubramanian S, Garcia L, Mahoney K, Ali SM, Miller VA, Stephens PJ.

Am J Surg Pathol. 2014 Feb;38(2):235-8. doi: 10.1097/PAS.0000000000000102.


A high frequency of activating extracellular domain ERBB2 (HER2) mutation in micropapillary urothelial carcinoma.

Ross JS, Wang K, Gay LM, Al-Rohil RN, Nazeer T, Sheehan CE, Jennings TA, Otto GA, Donahue A, He J, Palmer G, Ali S, Nahas M, Young G, Labrecque E, Frampton G, Erlich R, Curran JA, Brennan K, Downing SR, Yelensky R, Lipson D, Hawryluk M, Miller VA, Stephens PJ.

Clin Cancer Res. 2014 Jan 1;20(1):68-75. doi: 10.1158/1078-0432.CCR-13-1992. Epub 2013 Nov 5.


Development and validation of a clinical cancer genomic profiling test based on massively parallel DNA sequencing.

Frampton GM, Fichtenholtz A, Otto GA, Wang K, Downing SR, He J, Schnall-Levin M, White J, Sanford EM, An P, Sun J, Juhn F, Brennan K, Iwanik K, Maillet A, Buell J, White E, Zhao M, Balasubramanian S, Terzic S, Richards T, Banning V, Garcia L, Mahoney K, Zwirko Z, Donahue A, Beltran H, Mosquera JM, Rubin MA, Dogan S, Hedvat CV, Berger MF, Pusztai L, Lechner M, Boshoff C, Jarosz M, Vietz C, Parker A, Miller VA, Ross JS, Curran J, Cronin MT, Stephens PJ, Lipson D, Yelensky R.

Nat Biotechnol. 2013 Nov;31(11):1023-31. doi: 10.1038/nbt.2696. Epub 2013 Oct 20.


Novel methylation biomarker panel for the early detection of pancreatic cancer.

Yi JM, Guzzetta AA, Bailey VJ, Downing SR, Van Neste L, Chiappinelli KB, Keeley BP, Stark A, Herrera A, Wolfgang C, Pappou EP, Iacobuzio-Donahue CA, Goggins MG, Herman JG, Wang TH, Baylin SB, Ahuja N.

Clin Cancer Res. 2013 Dec 1;19(23):6544-6555. doi: 10.1158/1078-0432.CCR-12-3224. Epub 2013 Oct 2.


Is laparoscopy a risk factor for bile duct injury during cholecystectomy?

Fullum TM, Downing SR, Ortega G, Chang DC, Oyetunji TA, Van Kirk K, Tran DD, Woods I, Cornwell EE, Turner PL.

JSLS. 2013 Jul-Sep;17(3):365-70. doi: 10.4293/108680813X13654754535638.


Advanced urothelial carcinoma: next-generation sequencing reveals diverse genomic alterations and targets of therapy.

Ross JS, Wang K, Al-Rohil RN, Nazeer T, Sheehan CE, Otto GA, He J, Palmer G, Yelensky R, Lipson D, Ali S, Balasubramanian S, Curran JA, Garcia L, Mahoney K, Downing SR, Hawryluk M, Miller VA, Stephens PJ.

Mod Pathol. 2014 Feb;27(2):271-80. doi: 10.1038/modpathol.2013.135. Epub 2013 Jul 26.


Open versus laparoscopic hiatal hernia repair.

Fullum TM, Oyetunji TA, Ortega G, Tran DD, Woods IM, Obayomi-Davies O, Pessu O, Downing SR, Cornwell EE.

JSLS. 2013 Jan-Mar;17(1):23-9. doi: 10.4293/108680812X13517013316951.


Development and evaluation of a brief self-completed family history screening tool for common chronic disease prevention in primary care.

Walter FM, Prevost AT, Birt L, Grehan N, Restarick K, Morris HC, Sutton S, Rose P, Downing S, Emery JD.

Br J Gen Pract. 2013 Jun;63(611):e393-400. doi: 10.3399/bjgp13X668186.


Long-term health experience of jet engine manufacturing workers: IX. further investigation of general mortality patterns in relation to workplace exposures.

Youk AO, Marsh GM, Buchanich JM, Downing S, Kennedy KJ, Esmen NA, Hancock RP, Lacey SE.

J Occup Environ Med. 2013 Jun;55(6):709-21. doi: 10.1097/JOM.0b013e318289eeba.


Long-term health experience of jet engine manufacturing workers: VIII. glioblastoma incidence in relation to workplace experiences with parts and processes.

Marsh GM, Youk AO, Buchanich JM, Downing S, Kennedy KJ, Esmen NA, Hancock RP, Lacey SE, Pierce JS, Fleissner ML.

J Occup Environ Med. 2013 Jun;55(6):690-708. doi: 10.1097/JOM.0b013e3182871583.


Long-term health experience of jet engine manufacturing workers: results from a 12-year exploratory investigation.

Marsh GM, Buchanich JM, Youk AO, Downing S, Esmen NA, Kennedy KJ, Lacey SE, Hancock RP, Fleissner ML, Lieberman FS.

J Occup Environ Med. 2013 Jun;55(6):652-3. doi: 10.1097/JOM.0b013e3182851605. No abstract available.


Long-term health experience of jet engine manufacturing workers: VI: incidence of malignant central nervous system neoplasms in relation to estimated workplace exposures.

Marsh GM, Youk AO, Buchanich JM, Xu H, Downing S, Kennedy KJ, Esmen NA, Hancock RP, Lacey SE, Fleissner ML.

J Occup Environ Med. 2013 Jun;55(6):654-75. doi: 10.1097/JOM.0b013e3182749c4a.


Applying the Bookmark method to medical education: standard setting for an aseptic technique station.

Lypson ML, Downing SM, Gruppen LD, Yudkowsky R.

Med Teach. 2013 Jul;35(7):581-5. doi: 10.3109/0142159X.2013.778395. Epub 2013 Apr 18.


Relapsed classic E-cadherin (CDH1)-mutated invasive lobular breast cancer shows a high frequency of HER2 (ERBB2) gene mutations.

Ross JS, Wang K, Sheehan CE, Boguniewicz AB, Otto G, Downing SR, Sun J, He J, Curran JA, Ali S, Yelensky R, Lipson D, Palmer G, Miller VA, Stephens PJ.

Clin Cancer Res. 2013 May 15;19(10):2668-76. doi: 10.1158/1078-0432.CCR-13-0295. Epub 2013 Apr 10.


Enhanced surveillance for gonorrhoea in two diverse settings in Queensland in the 2000s: comparative epidemiology and selected management outcomes.

Fagan PS, Downing SG, McCall B, Carroll HJ, Howard TM, Palmer CM.

Commun Dis Intell Q Rep. 2013 Sep 30;37(3):E253-9.


Teaching of evidence-based medicine to medical students in Mexico: a randomized controlled trial.

Sánchez-Mendiola M, Kieffer-Escobar LF, Marín-Beltrán S, Downing SM, Schwartz A.

BMC Med Educ. 2012 Nov 6;12:107. doi: 10.1186/1472-6920-12-107.


Ageing and long-term CD4 cell count trends in HIV-positive patients with 5 years or more combination antiretroviral therapy experience.

Wright ST, Petoumenos K, Boyd M, Carr A, Downing S, O'Connor CC, Grotowski M, Law MG; Australian HIV Observational Database study group.

HIV Med. 2013 Apr;14(4):208-16. doi: 10.1111/j.1468-1293.2012.01053.x. Epub 2012 Oct 4.


Combination antiangiogenic therapy in advanced breast cancer: a phase 1 trial of vandetanib, a VEGFR inhibitor, and metronomic chemotherapy, with correlative platelet proteomics.

Mayer EL, Isakoff SJ, Klement G, Downing SR, Chen WY, Hannagan K, Gelman R, Winer EP, Burstein HJ.

Breast Cancer Res Treat. 2012 Nov;136(1):169-78. doi: 10.1007/s10549-012-2256-5. Epub 2012 Sep 23.


Targeted next-generation sequencing of advanced prostate cancer identifies potential therapeutic targets and disease heterogeneity.

Beltran H, Yelensky R, Frampton GM, Park K, Downing SR, MacDonald TY, Jarosz M, Lipson D, Tagawa ST, Nanus DM, Stephens PJ, Mosquera JM, Cronin MT, Rubin MA.

Eur Urol. 2013 May;63(5):920-6. doi: 10.1016/j.eururo.2012.08.053. Epub 2012 Sep 5.


Structured training on box trainers for first year surgical residents: does it improve retention of laparoscopic skills? A randomized controlled study.

Supe A, Prabhu R, Harris I, Downing S, Tekian A.

J Surg Educ. 2012 Sep-Oct;69(5):624-32. doi: 10.1016/j.jsurg.2012.05.002. Epub 2012 Jun 15.


Increasing chlamydia test of re-infection rates using SMS reminders and incentives.

Downing SG, Cashman C, McNamee H, Penney D, Russell DB, Hellard ME.

Sex Transm Infect. 2013 Feb;89(1):16-9. doi: 10.1136/sextrans-2011-050454. Epub 2012 Jun 23.


Suppression of heat shock protein 27 induces long-term dormancy in human breast cancer.

Straume O, Shimamura T, Lampa MJ, Carretero J, Øyan AM, Jia D, Borgman CL, Soucheray M, Downing SR, Short SM, Kang SY, Wang S, Chen L, Collett K, Bachmann I, Wong KK, Shapiro GI, Kalland KH, Folkman J, Watnick RS, Akslen LA, Naumov GN.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8699-704. doi: 10.1073/pnas.1017909109. Epub 2012 May 15.


Severe maternal hypothyroidism corrected prior to the third trimester is associated with normal cognitive outcome in the offspring.

Downing S, Halpern L, Carswell J, Brown RS.

Thyroid. 2012 Jun;22(6):625-30. doi: 10.1089/thy.2011.0257. Epub 2012 May 10.


Systematic analysis of cell cycle effects of common drugs leads to the discovery of a suppressive interaction between gemfibrozil and fluoxetine.

Hoose SA, Duran C, Malik I, Eslamfam S, Shasserre SC, Downing SS, Hoover EM, Dowd KE, Smith R 3rd, Polymenis M.

PLoS One. 2012;7(5):e36503. doi: 10.1371/journal.pone.0036503. Epub 2012 May 2.


Minimally invasive surgery using bipolar radiofrequency energy is effective treatment for refractory atrial fibrillation.

Kasirajan V, Spradlin EA, Mormando TE, Medina AE, Ovadia P, Schwartzman DS, Gaines TE, Mumtaz MA, Downing SW, Ellenbogen KA.

Ann Thorac Surg. 2012 May;93(5):1456-61. doi: 10.1016/j.athoracsur.2012.01.110.


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